Amar Gajjar

Amar Gajjar

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Amar Gajjar

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Diagnostic delay in children with central nervous system tumors and the need to improve education.

J Neurooncol 2019 Nov 5. Epub 2019 Nov 5.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-019-03329-2DOI Listing
November 2019

Pharmacokinetics and safety of erlotinib and its metabolite OSI-420 in infants and children with primary brain tumors.

Cancer Chemother Pharmacol 2019 Oct 7;84(4):829-838. Epub 2019 Aug 7.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-019-03921-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773504PMC
October 2019

Long-term visual acuity outcomes after radiation therapy for sporadic optic pathway glioma.

J Neurooncol 2019 Sep 14;144(3):603-610. Epub 2019 Aug 14.

Department of Radiation Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-019-03264-2DOI Listing
September 2019

Reoperation for Medulloblastoma Prior to Adjuvant Therapy.

Neurosurgery 2019 May;84(5):1050-1058

Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1093/neuros/nyy095DOI Listing
May 2019

Determining success rates of the current pharmacokinetically guided dosing approach of topotecan in pediatric oncology patients.

Pediatr Blood Cancer 2019 04 11;66(4):e27578. Epub 2018 Dec 11.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.27578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386591PMC
April 2019

Medulloblastoma.

Nat Rev Dis Primers 2019 02 14;5(1):11. Epub 2019 Feb 14.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41572-019-0063-6DOI Listing
February 2019

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children's Oncology Group Randomized ACNS0332 Trial.

J Clin Oncol 2018 Oct 17:JCO2017764720. Epub 2018 Oct 17.

Eugene I. Hwang and Roger J. Packer, Children's National Medical Center, Washington, DC; Marcel Kool, Lukas Chavez, Sebastian Brabetz, David T.W. Jones, and Stefan M. Pfister, German Cancer Research Center; David Capper, Andreas von Deimling, and Stefan M. Pfister, University Hospital Heidelberg; Stefan M. Pfister, National Center for Tumor Diseases, Heidelberg; David Capper, Charité Medical University, Berlin, Germany; Peter C. Burger, Johns Hopkins University, Baltimore, MD; Chris Williams-Hughes, Children's Oncology Group, Littleton, CO; Catherine Billups, Yimei Li, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Linda Heier, Weill Cornell Medical College, New York, NY; Alok Jaju, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Jeff Michalski, Washington University School of Medicine, St. Louis, MO; Sarah Leary and James M. Olson, Seattle Children's Hospital and Research Institute; Sarah Leary and James M. Olson, Fred Hutchinson Cancer Research Center, Seattle, WA; Tianni Zhou, California State University, Long Beach, Long Beach, CA; Maryam Fouladi, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and Ian F. Pollack, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.2017.76.4720DOI Listing
October 2018

Attainment of Functional and Social Independence in Adult Survivors of Pediatric CNS Tumors: A Report From the St Jude Lifetime Cohort Study.

J Clin Oncol 2018 09 9;36(27):2762-2769. Epub 2018 Aug 9.

Tara M. Brinkman, Kirsten K. Ness, Zhenghong Li, I-Chan Huang, Kevin R. Krull, Amar Gajjar, Thomas E. Merchant, James L. Klosky, Robyn E. Partin, Ingrid Tonning Olsson, Frederick Boop, Paul Klimo Jr, Wassim Chemaitilly, Raja Khan, Deokumar Srivastava, Leslie L. Robison, Melissa M. Hudson, and Gregory T. Armstrong, St Jude Children's Research Hospital; and Frederick Boop and Paul Klimo Jr, University of Tennessee Health Science Center, Memphis, TN.

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http://ascopubs.org/doi/10.1200/JCO.2018.77.9454
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http://dx.doi.org/10.1200/JCO.2018.77.9454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145833PMC
September 2018

Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis.

Acta Neuropathol Commun 2018 09 25;6(1):101. Epub 2018 Sep 25.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 260, Memphis, 38105-3678, TN, USA.

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http://dx.doi.org/10.1186/s40478-018-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154813PMC
September 2018

Ovulation induction and oocyte retrieval for fertility preservation in young adolescents newly diagnosed with medulloblastoma: a case series.

J Obstet Gynaecol 2018 Aug 2;38(6):878-879. Epub 2018 Feb 2.

g Department of Oncology , St. Jude Children's Research Hospital , Memphis , TN , USA.

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http://dx.doi.org/10.1080/01443615.2017.1398222DOI Listing
August 2018

Neurologic impairments from pediatric low-grade glioma by tumor location and timing of diagnosis.

Pediatr Blood Cancer 2018 08 9;65(8):e27063. Epub 2018 May 9.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.27063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310055PMC
August 2018

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Lancet Oncol 2018 06 9;19(6):785-798. Epub 2018 May 9.

Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Hopp Children's Cancer Center at the NCT Heidelberg, Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183024
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http://dx.doi.org/10.1016/S1470-2045(18)30242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984248PMC
June 2018

Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis: Retrospective Characterization and Analysis of Outcomes.

J Child Neurol 2018 05 5;33(6):375-382. Epub 2018 Mar 5.

1 Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1177/0883073818758737DOI Listing
May 2018

Profound hearing loss following surgery in pediatric patients with posterior fossa low-grade glioma.

Neurooncol Pract 2018 May 18;5(2):96-103. Epub 2017 Dec 18.

Department of Pediatric Medicine, Division of Neurology, St. Jude Children's Research Hospital, USA.

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http://dx.doi.org/10.1093/nop/npx025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946892PMC
May 2018

DNA methylation-based classification of central nervous system tumours.

Authors:
David Capper David T W Jones Martin Sill Volker Hovestadt Daniel Schrimpf Dominik Sturm Christian Koelsche Felix Sahm Lukas Chavez David E Reuss Annekathrin Kratz Annika K Wefers Kristin Huang Kristian W Pajtler Leonille Schweizer Damian Stichel Adriana Olar Nils W Engel Kerstin Lindenberg Patrick N Harter Anne K Braczynski Karl H Plate Hildegard Dohmen Boyan K Garvalov Roland Coras Annett Hölsken Ekkehard Hewer Melanie Bewerunge-Hudler Matthias Schick Roger Fischer Rudi Beschorner Jens Schittenhelm Ori Staszewski Khalida Wani Pascale Varlet Melanie Pages Petra Temming Dietmar Lohmann Florian Selt Hendrik Witt Till Milde Olaf Witt Eleonora Aronica Felice Giangaspero Elisabeth Rushing Wolfram Scheurlen Christoph Geisenberger Fausto J Rodriguez Albert Becker Matthias Preusser Christine Haberler Rolf Bjerkvig Jane Cryan Michael Farrell Martina Deckert Jürgen Hench Stephan Frank Jonathan Serrano Kasthuri Kannan Aristotelis Tsirigos Wolfgang Brück Silvia Hofer Stefanie Brehmer Marcel Seiz-Rosenhagen Daniel Hänggi Volkmar Hans Stephanie Rozsnoki Jordan R Hansford Patricia Kohlhof Bjarne W Kristensen Matt Lechner Beatriz Lopes Christian Mawrin Ralf Ketter Andreas Kulozik Ziad Khatib Frank Heppner Arend Koch Anne Jouvet Catherine Keohane Helmut Mühleisen Wolf Mueller Ute Pohl Marco Prinz Axel Benner Marc Zapatka Nicholas G Gottardo Pablo Hernáiz Driever Christof M Kramm Hermann L Müller Stefan Rutkowski Katja von Hoff Michael C Frühwald Astrid Gnekow Gudrun Fleischhack Stephan Tippelt Gabriele Calaminus Camelia-Maria Monoranu Arie Perry Chris Jones Thomas S Jacques Bernhard Radlwimmer Marco Gessi Torsten Pietsch Johannes Schramm Gabriele Schackert Manfred Westphal Guido Reifenberger Pieter Wesseling Michael Weller Vincent Peter Collins Ingmar Blümcke Martin Bendszus Jürgen Debus Annie Huang Nada Jabado Paul A Northcott Werner Paulus Amar Gajjar Giles W Robinson Michael D Taylor Zane Jaunmuktane Marina Ryzhova Michael Platten Andreas Unterberg Wolfgang Wick Matthias A Karajannis Michel Mittelbronn Till Acker Christian Hartmann Kenneth Aldape Ulrich Schüller Rolf Buslei Peter Lichter Marcel Kool Christel Herold-Mende David W Ellison Martin Hasselblatt Matija Snuderl Sebastian Brandner Andrey Korshunov Andreas von Deimling Stefan M Pfister

Nature 2018 03 14;555(7697):469-474. Epub 2018 Mar 14.

Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature26000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093218PMC
March 2018

Mortality in children with low-grade glioma or glioneuronal tumors: A single-institution study.

Pediatr Blood Cancer 2018 Jan 14;65(1). Epub 2017 Jul 14.

Division of Neuro-Oncology, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.26717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699960PMC
January 2018

Posterior fossa syndrome and long-term neuropsychological outcomes among children treated for medulloblastoma on a multi-institutional, prospective study.

Neuro Oncol 2017 Nov;19(12):1673-1682

Department of Psychology, Department of Biostatistics, and Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee, USA; Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada; Lady Cilento Children's Hospital, South Brisbane, Queensland, Australia; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA; Department of Pediatric Medicine, Texas Children's Hospital, Houston, Texas, USA.

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http://dx.doi.org/10.1093/neuonc/nox135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716082PMC
November 2017

Disrupted development and integrity of frontal white matter in patients treated for pediatric medulloblastoma.

Neuro Oncol 2017 Oct;19(10):1408-1418

Departments of Diagnostic Imaging, Biostatistics, Psychology, and Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1093/neuonc/nox062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596166PMC
October 2017

Pineoblastoma-The Experience at St. Jude Children's Research Hospital.

Neurosurgery 2017 Jul;81(1):120-128

Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee.

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http://dx.doi.org/10.1093/neuros/nyx005DOI Listing
July 2017

The whole-genome landscape of medulloblastoma subtypes.

Nature 2017 07;547(7663):311-317

Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature22973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905700PMC
July 2017

Children with dorsal midbrain syndrome as a result of pineal tumors.

J AAPOS 2017 02 7;21(1):34-38. Epub 2017 Jan 7.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1016/j.jaapos.2016.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654548PMC
February 2017

Constraint-Induced Movement Therapy for Children With Brain Tumors.

Pediatr Phys Ther 2017 01;29(1):55-61

Rehabilitation Services (Dr Sparrow), Department of Biostatistics (Dr Zhu), Department of Oncology (Dr. Gajjar), Department of Pediatric Medicine (Dr Mandrell), and Department of Epidemiology & Cancer Control (Dr Ness), St Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1097/PEP.0000000000000331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172401PMC
January 2017

Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors.

Pediatr Neurol 2016 12 22;65:71-77. Epub 2016 Aug 22.

Division of Neurology, Department of Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1016/j.pediatrneurol.2016.08.012DOI Listing
December 2016

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Authors:
Jonathon Torchia Brian Golbourn Shengrui Feng King Ching Ho Patrick Sin-Chan Alexandre Vasiljevic Joseph D Norman Paul Guilhamon Livia Garzia Natalia R Agamez Mei Lu Tiffany S Chan Daniel Picard Pasqualino de Antonellis Dong-Anh Khuong-Quang Aline C Planello Constanze Zeller Dalia Barsyte-Lovejoy Lucie Lafay-Cousin Louis Letourneau Mathieu Bourgey Man Yu Deena M A Gendoo Misko Dzamba Mark Barszczyk Tiago Medina Alexandra N Riemenschneider A Sorana Morrissy Young-Shin Ra Vijay Ramaswamy Marc Remke Christopher P Dunham Stephen Yip Ho-Keung Ng Jian-Qiang Lu Vivek Mehta Steffen Albrecht Jose Pimentel Jennifer A Chan Gino R Somers Claudia C Faria Lucia Roque Maryam Fouladi Lindsey M Hoffman Andrew S Moore Yin Wang Seung Ah Choi Jordan R Hansford Daniel Catchpoole Diane K Birks Nicholas K Foreman Doug Strother Almos Klekner Laszló Bognár Miklós Garami Péter Hauser Tibor Hortobágyi Beverly Wilson Juliette Hukin Anne-Sophie Carret Timothy E Van Meter Eugene I Hwang Amar Gajjar Shih-Hwa Chiou Hideo Nakamura Helen Toledano Iris Fried Daniel Fults Takafumi Wataya Chris Fryer David D Eisenstat Katrin Scheinemann Adam J Fleming Donna L Johnston Jean Michaud Shayna Zelcer Robert Hammond Samina Afzal David A Ramsay Nongnuch Sirachainan Suradej Hongeng Noppadol Larbcharoensub Richard G Grundy Rishi R Lulla Jason R Fangusaro Harriet Druker Ute Bartels Ronald Grant David Malkin C Jane McGlade Theodore Nicolaides Tarik Tihan Joanna Phillips Jacek Majewski Alexandre Montpetit Guillaume Bourque Gary D Bader Alyssa T Reddy G Yancey Gillespie Monika Warmuth-Metz Stefan Rutkowski Uri Tabori Mathieu Lupien Michael Brudno Ulrich Schüller Torsten Pietsch Alexander R Judkins Cynthia E Hawkins Eric Bouffet Seung-Ki Kim Peter B Dirks Michael D Taylor Anat Erdreich-Epstein Cheryl H Arrowsmith Daniel D De Carvalho James T Rutka Nada Jabado Annie Huang

Cancer Cell 2016 Dec;30(6):891-908

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G0A4, Canada; Department of Paediatrics, University of Toronto, Toronto, ON M5G0A4, Canada; Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON M5G1X8, Canada; Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, ON M5G1X8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500911PMC
December 2016

Hypothalamic-Pituitary Axis Dysfunction in Survivors of Childhood CNS Tumors: Importance of Systematic Follow-Up and Early Endocrine Consultation.

J Clin Oncol 2016 12 31;34(36):4315-4319. Epub 2016 Oct 31.

Wassim Chemaitilly, Gregory T. Armstrong, Amar Gajjar, and Melissa M. Hudson, St Jude Children's Research Hospital, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2016.70.1847DOI Listing
December 2016

Aprepitant reduces chemotherapy-induced vomiting in children and young adults with brain tumors.

J Pediatr Oncol Nurs 2014 Sep-Oct;31(5):277-83. Epub 2014 Jun 27.

St. Jude Children's Research Hospital, Memphis, TN, USA

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http://dx.doi.org/10.1177/1043454214531090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438752PMC
September 2016

Population Pharmacokinetics of Oral Topotecan in Infants and Very Young Children with Brain Tumors Demonstrates a Role of ABCG2 rs4148157 on the Absorption Rate Constant.

Drug Metab Dispos 2016 07 6;44(7):1116-22. Epub 2016 Apr 6.

Department of Pharmaceutical Sciences (J.K.R., A.V.B., V.M.D., J.C.P., C.F.S.), Department of Biostatistics (T.L.), and Department of Oncology (A.B., G.W.R., A.J.G.), St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.115.068676
Publisher Site
http://dx.doi.org/10.1124/dmd.115.068676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931885PMC
July 2016

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.

Authors:
Vijay Ramaswamy Thomas Hielscher Stephen C Mack Alvaro Lassaletta Tong Lin Kristian W Pajtler David T W Jones Betty Luu Florence M G Cavalli Kenneth Aldape Marc Remke Martin Mynarek Stefan Rutkowski Sridharan Gururangan Roger E McLendon Eric S Lipp Christopher Dunham Juliette Hukin David D Eisenstat Dorcas Fulton Frank K H van Landeghem Mariarita Santi Marie-Lise C van Veelen Erwin G Van Meir Satoru Osuka Xing Fan Karin M Muraszko Daniela P C Tirapelli Sueli M Oba-Shinjo Suely K N Marie Carlos G Carlotti Ji Yeoun Lee Amulya A Nageswara Rao Caterina Giannini Claudia C Faria Sofia Nunes Jaume Mora Ronald L Hamilton Peter Hauser Nada Jabado Kevin Petrecca Shin Jung Luca Massimi Massimo Zollo Giuseppe Cinalli László Bognár Almos Klekner Tibor Hortobágyi Sarah Leary Ralph P Ermoian James M Olson Jeffrey R Leonard Corrine Gardner Wieslawa A Grajkowska Lola B Chambless Jason Cain Charles G Eberhart Sama Ahsan Maura Massimino Felice Giangaspero Francesca R Buttarelli Roger J Packer Lyndsey Emery William H Yong Horacio Soto Linda M Liau Richard Everson Andrew Grossbach Tarek Shalaby Michael Grotzer Matthias A Karajannis David Zagzag Helen Wheeler Katja von Hoff Marta M Alonso Teresa Tuñon Ulrich Schüller Karel Zitterbart Jaroslav Sterba Jennifer A Chan Miguel Guzman Samer K Elbabaa Howard Colman Girish Dhall Paul G Fisher Maryam Fouladi Amar Gajjar Stewart Goldman Eugene Hwang Marcel Kool Harshad Ladha Elizabeth Vera-Bolanos Khalida Wani Frank Lieberman Tom Mikkelsen Antonio M Omuro Ian F Pollack Michael Prados H Ian Robins Riccardo Soffietti Jing Wu Phillipe Metellus Uri Tabori Ute Bartels Eric Bouffet Cynthia E Hawkins James T Rutka Peter Dirks Stefan M Pfister Thomas E Merchant Mark R Gilbert Terri S Armstrong Andrey Korshunov David W Ellison Michael D Taylor

J Clin Oncol 2016 07 6;34(21):2468-77. Epub 2016 Jun 6.

Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen

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http://dx.doi.org/10.1200/JCO.2015.65.7825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962737PMC
July 2016

Residual Strabismus in Children Following Improvement of Cranial Nerve Palsies Affecting Ocular Ductions.

Am Orthopt J 2015 ;65:87-93

From the Hamilton Eye Institute, Department of Ophthalmology, University of Tennessee Health and Science Center, Memphis, Tennessee; From the Department of Oncology, St. Jude Children's Research Hospital, Memphis and.

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http://dx.doi.org/10.3368/aoj.65.1.87DOI Listing
April 2016

Functional MRI in medulloblastoma survivors supports prophylactic reading intervention during tumor treatment.

Brain Imaging Behav 2016 Mar;10(1):258-71

Department of Radiological Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://link.springer.com/10.1007/s11682-015-9390-8
Publisher Site
http://dx.doi.org/10.1007/s11682-015-9390-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644520PMC
March 2016

Imaging Patterns and Outcome of Posterior Reversible Encephalopathy Syndrome During Childhood Cancer Treatment.

Pediatr Blood Cancer 2016 Mar 15;63(3):523-6. Epub 2015 Oct 15.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724342PMC
March 2016

Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas.

Acta Neuropathol 2016 Feb 7;131(2):299-307. Epub 2016 Jan 7.

Department of Pathology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00401-015-1532-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4886851PMC
February 2016

Redefining "rare" in paediatric cancers.

Lancet Oncol 2016 Feb;17(2):138-139

Departments of Pathology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/S1470-2045(15)00538-0DOI Listing
February 2016

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Authors:
Dominik Sturm Brent A Orr Umut H Toprak Volker Hovestadt David T W Jones David Capper Martin Sill Ivo Buchhalter Paul A Northcott Irina Leis Marina Ryzhova Christian Koelsche Elke Pfaff Sariah J Allen Gnanaprakash Balasubramanian Barbara C Worst Kristian W Pajtler Sebastian Brabetz Pascal D Johann Felix Sahm Jüri Reimand Alan Mackay Diana M Carvalho Marc Remke Joanna J Phillips Arie Perry Cynthia Cowdrey Rachid Drissi Maryam Fouladi Felice Giangaspero Maria Łastowska Wiesława Grajkowska Wolfram Scheurlen Torsten Pietsch Christian Hagel Johannes Gojo Daniela Lötsch Walter Berger Irene Slavc Christine Haberler Anne Jouvet Stefan Holm Silvia Hofer Marco Prinz Catherine Keohane Iris Fried Christian Mawrin David Scheie Bret C Mobley Matthew J Schniederjan Mariarita Santi Anna M Buccoliero Sonika Dahiya Christof M Kramm André O von Bueren Katja von Hoff Stefan Rutkowski Christel Herold-Mende Michael C Frühwald Till Milde Martin Hasselblatt Pieter Wesseling Jochen Rößler Ulrich Schüller Martin Ebinger Jens Schittenhelm Stephan Frank Rainer Grobholz Istvan Vajtai Volkmar Hans Reinhard Schneppenheim Karel Zitterbart V Peter Collins Eleonora Aronica Pascale Varlet Stephanie Puget Christelle Dufour Jacques Grill Dominique Figarella-Branger Marietta Wolter Martin U Schuhmann Tarek Shalaby Michael Grotzer Timothy van Meter Camelia-Maria Monoranu Jörg Felsberg Guido Reifenberger Matija Snuderl Lynn Ann Forrester Jan Koster Rogier Versteeg Richard Volckmann Peter van Sluis Stephan Wolf Tom Mikkelsen Amar Gajjar Kenneth Aldape Andrew S Moore Michael D Taylor Chris Jones Nada Jabado Matthias A Karajannis Roland Eils Matthias Schlesner Peter Lichter Andreas von Deimling Stefan M Pfister David W Ellison Andrey Korshunov Marcel Kool

Cell 2016 Feb;164(5):1060-1072

Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.

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http://www.cell.com/cell/pdf/S0092-8674(16)00055-6.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S009286741600055
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http://dx.doi.org/10.1016/j.cell.2016.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139621PMC
February 2016

Metastatic Low-Grade Gliomas in Children: 20 Years' Experience at St. Jude Children's Research Hospital.

Pediatr Blood Cancer 2016 Jan 27;63(1):62-70. Epub 2015 Aug 27.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122937PMC
January 2016

Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

J Neurooncol 2016 Jan 30;126(2):225-34. Epub 2015 Oct 30.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-015-1965-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718940PMC
January 2016

Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma.

Neuro Oncol 2015 Dec 4;17(12):1620-7. Epub 2015 Nov 4.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee (K.D.W., R.J.G., A.G.); Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee (V.M.D., D.C.T., C.F.S); Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee (A.O.-T.); Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee (N.B., R.J.G.); Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee (B.A.O.).

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http://neuro-oncology.oxfordjournals.org/content/17/12/1620.
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http://neuro-oncology.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/neuonc/nov181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633933PMC
December 2015

Germline Mutations in Predisposition Genes in Pediatric Cancer.

N Engl J Med 2015 Dec 18;373(24):2336-2346. Epub 2015 Nov 18.

Departments of Computational Biology (J.Z., G.W., M.N.E., D.H., X.M., X.Z., M.R.W., X.C., M.R., A.P., J.B.B., S.W.), Oncology (M.F.W., T.A.G., R.B.M., S.H.-D., R.N., E.Q., A.G., A.S.P., C.-H.P., K.E.N.), and Pathology (T.A.G., M.R.W., S.A.S., D.W.E., C.-H.P., J.R.D.) and the Pediatric Cancer Genome Project (J.Z., M.F.W., G.W., M.N.E., T.A.G., J.E., X.M., D.A.Y., B.V., X.C., R.B.M., S.H.-D., R.N., E.Q., S.A.S., M.R., A.P., J.B.B., S.W., M.S.W., A.G., D.W.E., A.S.P., C.-H.P., K.E.N., J.R.D.), St. Jude Children's Research Hospital, Memphis, TN; and the Department of Genetics and McDonnell Genome Institute, Washington University School of Medicine in St. Louis, St. Louis (L.D., E.R.M., R.K.W.).

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http://dx.doi.org/10.1056/NEJMoa1508054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734119PMC
December 2015

Pediatric Brain Tumors: Innovative Genomic Information Is Transforming the Diagnostic and Clinical Landscape.

J Clin Oncol 2015 Sep 24;33(27):2986-98. Epub 2015 Aug 24.

Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Daniel C. Bowers, University of Texas Southwestern Medical Center, Dallas, TX; Matthias A. Karajannis, New York University (NYU) Perlmutter Cancer Center and NYU Langone Medical Center, New York, NY; Sarah Leary, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, WA; Hendrik Witt, German Cancer Research Center and University of Heidelberg, Heidelberg, Germany; and Nicholas G. Gottardo, Princess Margaret Hospital for Children and The University of Western Australia, Perth, Western Australia, Australia.

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http://dx.doi.org/10.1200/JCO.2014.59.9217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567701PMC
September 2015

A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: a Children's Oncology Group study†.

Neuro Oncol 2015 Aug 7;17(8):1132-8. Epub 2015 Apr 7.

Texas Children's Cancer and Hematology Centers, Department of Pathology, Baylor College of Medicine, Houston, Texas (M.C., A.A., C.L.); Department of Preventive Medicine, University of Southern California, Los Angeles, California (S.P.E., M.K.); University of Texas Southwestern Medical Center, Dallas, Texas (M.M.); Children's National Medical Center, Washington DC (R.P.); St Jude Children's Research Hospital, Memphis, Tennessee (A.G.).

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http://dx.doi.org/10.1093/neuonc/nov057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490875PMC
August 2015

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

J Clin Oncol 2015 Aug 13;33(24):2646-54. Epub 2015 Jul 13.

Giles W. Robinson, Brent A. Orr, Gang Wu, Tong Lin, Ibrahim Qaddoumi, Sue C. Kaste, Michael Rusch, Sariah J. Allen, Arzu Onar-Thomas, Clinton F. Stewart, James M. Boyett, Richard J. Gilbertson, David W. Ellison, and Amar Gajjar, St Jude Children's Research Hospital, Memphis, TN; Sridharan Gururangan and Annick Desjardins, Duke University Medical Center, Durham, NC; Roger J. Packer, Children's National Medical Center, Washington, DC; Stewart Goldman, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL; Michael D. Prados, University of California San Francisco, San Francisco, CA; Murali Chintagumpala, Texas Children's Cancer Center, Houston, TX; Naoko Takebe, National Cancer Institute, Bethesda, MD; Maryam Fouladi, Cincinnati Children's Hospital, Cincinnati, OH; and Tom Curran, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2014.60.1591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534527PMC
August 2015

Delayed diagnosis of childhood low-grade glioma: causes, consequences, and potential solutions.

Childs Nerv Syst 2015 Jul 6;31(7):1067-77. Epub 2015 Mar 6.

Pediatric Oncology Education Program, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s00381-015-2670-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496265PMC
July 2015

Incidental diagnosis of diffuse intrinsic pontine glioma in children.

Pediatr Blood Cancer 2015 Jun 16;62(6):1081-3. Epub 2015 Jan 16.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405458PMC
June 2015

Alisertib is active as single agent in recurrent atypical teratoid rhabdoid tumors in 4 children.

Neuro Oncol 2015 Jun 16;17(6):882-8. Epub 2015 Feb 16.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee (C.W., A.G.); Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, Tennessee (J.B., S.L., T.L.); Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota (A.B.); Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee (B.A.O.).

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http://dx.doi.org/10.1093/neuonc/nov017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483126PMC
June 2015

The management of children and adolescents with medulloblastoma in low and middle income countries.

Pediatr Blood Cancer 2015 Apr 24;62(4):549-50. Epub 2014 Dec 24.

Department of Oncology, Division of Neuro-oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1002/pbc.25371DOI Listing
April 2015

Subsequent neoplasms in survivors of childhood central nervous system tumors: risk after modern multimodal therapy.

Neuro Oncol 2015 Mar 13;17(3):448-56. Epub 2014 Nov 13.

Department of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee (K.T., A.B., A.G., C.W.); Department of Biostatistics, St Jude Children's Research Hospital, Memphis, Tennessee (C.L., D.S.); Department of Radiological Sciences, St Jude Children's Research Hospital, Memphis, Tennessee (L.E.K., T.E.M.); Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee (D.W.E., B.A.O.); Department of Surgery, St Jude Children's Research Hospital, Memphis, Tennessee (F.A.B., P.K.); Semmes-Murphey Neurologic and Spine Institute, Memphis, Tennessee (F.A.B., P.K.); Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, Tennessee (F.A.B., P.K.); University of Tennessee Health Science Center, College of Medicine, Memphis, Tennessee (J.R.); Department of Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, Tennessee (L.L.R., G.T.A.).

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http://dx.doi.org/10.1093/neuonc/nou279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4483102PMC
March 2015

Brain tumors.

Pediatr Clin North Am 2015 Feb;62(1):167-78

Department of Oncology, St Jude Children's Research Hospital, Room 6024, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.pcl.2014.09.011DOI Listing
February 2015

Anterior hypopituitarism in adult survivors of childhood cancers treated with cranial radiotherapy: a report from the St Jude Lifetime Cohort study.

J Clin Oncol 2015 Feb 5;33(5):492-500. Epub 2015 Jan 5.

Wassim Chemaitilly, Zhenghong Li, Sujuan Huang, Kirsten K. Ness, Karen L. Clark, Daniel M. Green, Nicole Barnes, Gregory T. Armstrong, Matthew J. Krasin, Deo Kumar Srivastava, Ching-Hon Pui, Thomas E. Merchant, Larry E. Kun, Amar Gajjar, Melissa M. Hudson, and Leslie L. Robison, St Jude Children's Research Hospital, Memphis, TN; and Charles A. Sklar, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2014.56.7933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314596PMC
February 2015

Reirradiation of recurrent medulloblastoma: does clinical benefit outweigh risk for toxicity?

Cancer 2014 Dec 30;120(23):3731-7. Epub 2014 Jul 30.

Emory University/Children's Healthcare of Atlanta, Aflac Cancer & Blood Disorders Center, Atlanta, Georgia.

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http://dx.doi.org/10.1002/cncr.28907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364918PMC
December 2014

Medulloblastoma-translating discoveries from the bench to the bedside.

Nat Rev Clin Oncol 2014 Dec 28;11(12):714-22. Epub 2014 Oct 28.

Department of Oncology, Division of Neuro-Oncology, St Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/nrclinonc.2014.181DOI Listing
December 2014

Molecular insights into pediatric brain tumors have the potential to transform therapy.

Clin Cancer Res 2014 Nov;20(22):5630-40

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234174PMC
November 2014

Molecular characteristics of pediatric high-grade gliomas.

CNS Oncol 2014 Nov;3(6):433-43

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.2217/cns.14.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307752PMC
November 2014

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Nature 2014 Jul 22;511(7510):428-34. Epub 2014 Jun 22.

1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany [2] Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg 69120, Germany.

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http://www.abta.org/resources/enhancers-hijacking-activates.
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http://www.nature.com/doifinder/10.1038/nature13379
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http://dx.doi.org/10.1038/nature13379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201514PMC
July 2014