Amar B Singh

Amar B Singh

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Amar B Singh

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Molecular targeting of renal cell carcinoma by an oral combination.

Oncogenesis 2020 May 19;9(5):52. Epub 2020 May 19.

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, 1410 Laney Walker Blvd., Augusta, GA, 30912, USA.

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http://dx.doi.org/10.1038/s41389-020-0233-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237463PMC
May 2020

Role of Claudin Proteins in Regulating Cancer Stem Cells and Chemoresistance-Potential Implication in Disease Prognosis and Therapy.

Int J Mol Sci 2019 Dec 20;21(1). Epub 2019 Dec 20.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

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http://dx.doi.org/10.3390/ijms21010053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982342PMC
December 2019

Curcumin use in ulcerative colitis: is it ready for prime time? A systematic review and meta-analysis of clinical trials.

Ann Gastroenterol 2020 Jan-Feb;33(1):53-58. Epub 2019 Nov 29.

Division of Gastroenterology and Hepatology, University of Utah School of Medicine, Salt Lake City, Utah (Douglas G. Adler), USA.

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http://dx.doi.org/10.20524/aog.2019.0439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928475PMC
November 2019

Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR.

Int J Mol Med 2019 May 18;43(5):1927-1938. Epub 2019 Mar 18.

Department of Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.3892/ijmm.2019.4136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443341PMC
May 2019

Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease.

Acta Biomater 2018 12 17;82:158-170. Epub 2018 Oct 17.

Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183062
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http://dx.doi.org/10.1016/j.actbio.2018.10.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258327PMC
December 2018

Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation.

J Control Release 2018 11 21;290:165-179. Epub 2018 Aug 21.

Department of Pharmaceutical Sciences, College of Pharmacy & Allied Health Professions, South Dakota State University, Brookings SD-57007, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659183045
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http://dx.doi.org/10.1016/j.jconrel.2018.08.004DOI Listing
November 2018

HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation.

Oncotarget 2017 Oct 23;8(50):87718-87736. Epub 2017 Sep 23.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.

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http://dx.doi.org/10.18632/oncotarget.21190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675667PMC
October 2017

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching.

Sci Rep 2017 07 11;7(1):5125. Epub 2017 Jul 11.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

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http://dx.doi.org/10.1038/s41598-017-04989-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505957PMC
July 2017

Claudin proteins, outside-in signaling, and carcinogenesis.

Pflugers Arch 2017 01 17;469(1):69-75. Epub 2016 Dec 17.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68198-5870, USA.

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http://dx.doi.org/10.1007/s00424-016-1919-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166644PMC
January 2017

Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells.

Exp Cell Res 2016 Nov 11;349(1):119-127. Epub 2016 Oct 11.

From the Department of Veterans Affairs, University of Nebraska Medical Center, Omaha, NE 68022, United States; Departments of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68022, United States; Buffet Cancer Center, University of Nebraska Medical Center, Omaha, NE 68022, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166648PMC
November 2016

Potential of Mauritius Hemp (Furcraea gigantea Vent.) for the Remediation of Chromium Contaminated Soils.

Int J Phytoremediation 2015 ;17(7):709-15

a Indian Institute of Soil Science , Nabi bagh, Berasia Road, Bhopal , India.

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http://dx.doi.org/10.1080/15226514.2014.964842DOI Listing
August 2016

Cancer Stem Cell and Gastrointestinal Cancer: Current Status, Targeted Therapy and Future Implications.

Biochem Pharmacol (Los Angel) 2016 26;5(2). Epub 2016 Feb 26.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, USA.

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http://dx.doi.org/10.4172/2167-0501.1000202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814166PMC
February 2016

EGFR-Signaling and Autophagy: How they Fit in the Cancer Landscape.

Authors:
Amar B Singh

J Adenocarcinoma 2016 ;1(2)

Department of Biochemistry and Molecular Biology, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center and VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202024PMC
January 2016

Claudins and cancer: Fall of the soldiers entrusted to protect the gate and keep the barrier intact.

Semin Cell Dev Biol 2015 Jun 27;42:58-65. Epub 2015 May 27.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2015.05.001DOI Listing
June 2015

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling.

Gut 2014 Apr 13;63(4):622-34. Epub 2013 Jun 13.

Department of Cancer Biology, Vanderbilt University Medical Center, , Nashville, Tennessee, USA.

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http://dx.doi.org/10.1136/gutjnl-2012-304241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083824PMC
April 2014

Trichostatin-A modulates claudin-1 mRNA stability through the modulation of Hu antigen R and tristetraprolin in colon cancer cells.

Carcinogenesis 2013 Nov 23;34(11):2610-21. Epub 2013 Jul 23.

Department of Surgery, Vanderbilt University Medical Center, MCN, B-2211, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1093/carcin/bgt207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810835PMC
November 2013

High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway.

J Lipid Res 2013 May 20;54(5):1241-54. Epub 2013 Feb 20.

Department of Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1194/jlr.M032599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622321PMC
May 2013

Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats.

J Mol Cell Cardiol 2013 Apr 5;57:106-18. Epub 2013 Feb 5.

Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Central Texas Veterans Health Care System, Temple, TX, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2013.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594065PMC
April 2013

Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis through inhibition of NF-κB signaling pathway.

J Cell Physiol 2013 Feb;228(2):380-92

Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Temple, Texas 76504, USA.

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http://dx.doi.org/10.1002/jcp.24142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470832PMC
February 2013

Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells.

PLoS One 2012 15;7(6):e37174. Epub 2012 Jun 15.

Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037174PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376107PMC
December 2012

Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner.

Carcinogenesis 2012 Dec 31;33(12):2538-47. Epub 2012 Aug 31.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN-37232, USA.

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http://dx.doi.org/10.1093/carcin/bgs275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510734PMC
December 2012

High glucose-induced repression of RAR/RXR in cardiomyocytes is mediated through oxidative stress/JNK signaling.

J Cell Physiol 2012 Jun;227(6):2632-44

Division of Molecular Cardiology, Department of Medicine, College of Medicine, Texas A&M Health Science Center, Central Texas Veterans Health Care System, Temple, Texas 76504, USA.

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http://dx.doi.org/10.1002/jcp.23005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258345PMC
June 2012

Flavone-based novel antidiabetic and antidyslipidemic agents.

J Med Chem 2012 May 2;55(10):4551-67. Epub 2012 May 2.

Division of Medicinal & Process Chemistry, Central Drug Research Institute (CSIR), Lucknow-226001, India.

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http://dx.doi.org/10.1021/jm201107gDOI Listing
May 2012

Cancer stem cells and colorectal cancer: an overview.

Curr Top Med Chem 2011 ;11(13):1592-8

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.2174/156802611796117694DOI Listing
December 2011

Claudin family of proteins and cancer: an overview.

J Oncol 2010 8;2010:541957. Epub 2010 Jul 8.

Department of Surgery, Vanderbilt University Medical Center, Nashville, TN37232, USA.

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http://dx.doi.org/10.1155/2010/541957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910494PMC
July 2011

Tectone, a new antihyperglycemic anthraquinone from Tectona grandis leaves.

Nat Prod Commun 2010 Mar;5(3):427-30

Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India.

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March 2010

5,6-Diarylanthranilo-1,3-dinitriles as a new class of antihyperglycemic agents.

Bioorg Med Chem Lett 2009 Apr 4;19(8):2158-61. Epub 2009 Mar 4.

Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X090028
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http://dx.doi.org/10.1016/j.bmcl.2009.02.118DOI Listing
April 2009

The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology.

Exp Cell Res 2009 Feb 19;315(4):602-10. Epub 2008 Aug 19.

Department of Medicine, C-3121 Medical Center North, Vanderbilt University, Nashville, Tennessee 37232-4794, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448270800316
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http://dx.doi.org/10.1016/j.yexcr.2008.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654782PMC
February 2009

Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity.

Bioorg Med Chem Lett 2008 Dec 14;18(24):6534-7. Epub 2008 Oct 14.

Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.

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http://dx.doi.org/10.1016/j.bmcl.2008.10.050DOI Listing
December 2008

Synthesis and antihyperglycemic activity of novel N-acyl-2-arylethylamines and N-acyl-3-coumarylamines.

Bioorg Med Chem Lett 2008 Apr 6;18(7):2301-5. Epub 2008 Mar 6.

Medicinal and Process Chemistry Division, Central Drug Research Institute, M.G. Marg, P B No. 173, Lucknow 226001, India.

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http://dx.doi.org/10.1016/j.bmcl.2008.03.003DOI Listing
April 2008

ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis.

Mol Biol Cell 2007 Nov 29;18(11):4446-56. Epub 2007 Aug 29.

Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1091/mbc.e07-03-0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043549PMC
November 2007

Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial phenotype.

J Biol Chem 2007 Nov 11;282(45):32890-901. Epub 2007 Sep 11.

Department of Medicine, Vanderbilt University, C-3121 Medical Center North, Nashville, TN 37232, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M702677200
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http://dx.doi.org/10.1074/jbc.M702677200DOI Listing
November 2007

Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance.

Am J Physiol Cell Physiol 2007 Nov 13;293(5):C1660-8. Epub 2007 Sep 13.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-4794, USA.

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http://dx.doi.org/10.1152/ajpcell.00274.2007DOI Listing
November 2007

Endonuclease G promotes cell death of non-invasive human breast cancer cells.

Exp Cell Res 2006 Dec 20;312(20):4139-49. Epub 2006 Sep 20.

Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, slot #501, 4301 W. Markham St., Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1016/j.yexcr.2006.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839947PMC
December 2006

Autocrine, paracrine and juxtacrine signaling by EGFR ligands.

Cell Signal 2005 Oct;17(10):1183-93

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-4794, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680500076
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http://dx.doi.org/10.1016/j.cellsig.2005.03.026DOI Listing
October 2005

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer.

J Clin Invest 2005 Jul 16;115(7):1765-76. Epub 2005 Jun 16.

Surgical Oncology Research Laboratories, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1172/JCI24543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150288PMC
July 2005

Membrane-associated HB-EGF modulates HGF-induced cellular responses in MDCK cells.

J Cell Sci 2004 Mar 2;117(Pt 8):1365-79. Epub 2004 Mar 2.

Department of Medicine, Vanderbilt University, Nashville, TN 37232-4794, USA.

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http://dx.doi.org/10.1242/jcs.01037DOI Listing
March 2004

Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.

J Biol Chem 2004 Jan 30;279(5):3543-52. Epub 2003 Oct 30.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-4794, USA.

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http://dx.doi.org/10.1074/jbc.M308682200DOI Listing
January 2004

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.

Gastroenterology 2003 Apr;124(4):1020-36

Department of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1053/gast.2003.50150DOI Listing
April 2003

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression.

Cancer Res 2002 Dec;62(24):7335-42

Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.

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December 2002

Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury.

Kidney Int 2002 Jul;62(1):106-15

Department of Medicine, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1046/j.1523-1755.2002.00427.xDOI Listing
July 2002

Identification and expression of deoxyribonuclease (DNase) I alternative transcripts in the rat.

Gene 2002 May;289(1-2):87-96

Department of Internal Medicine, Division of Nephrology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 501, Little Rock, AR 72205, USA.

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http://dx.doi.org/10.1016/s0378-1119(02)00479-1DOI Listing
May 2002