Publications by authors named "Amanda R Knapp"

2 Publications

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Nanoparticle encapsulated silver carbene complexes and their antimicrobial and anticancer properties: a perspective.

Dalton Trans 2012 Jan 6;41(2):327-36. Epub 2011 Oct 6.

Center for Silver Therapeutics Research, Department of Chemistry, University of Akron, Akron, OH 44325, USA.

This perspective discusses the uses of silver for both antimicrobial and anticancer applications. It focuses on the synthesis of silver N-heterocyclic carbene complexes (SCCs) and their in vitro efficacy against a broad spectrum of bacteria, as well as their antitumor properties. Finally, different polymeric nanoparticles are discussed as delivery vehicles for the encapsulation of SCCs and other therapeutic agents for use in vivo.
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http://dx.doi.org/10.1039/c1dt11100kDOI Listing
January 2012

Synthesis and antimicrobial studies of silver N-heterocyclic carbene complexes bearing a methyl benzoate substituent.

Inorganica Chim Acta 2010 Dec;364(1):125-131

The University of Akron, Akron, OH 44325-3601.

Due to the properties of silver as an antimicrobial, our research group has synthesized many different silver carbene complexes. Two new silver N-heterocyclic carbene complexes derived from 4,5-dichloroimidazole and theobromine bearing methyl benzoate substituents were synthesized by in situ carbene formation using silver acetate as the base in the reaction. The new compounds were fully characterized by several methods including NMR spectroscopy and X-ray crystallography. Preliminary antimicrobial efficacy studies against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli were conducted. The results of this study demonstrated antimicrobial efficacy of the two complexes comparable to silver nitrate, showing their potential for use in the treatment of bacterial infections.
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http://dx.doi.org/10.1016/j.ica.2010.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014616PMC
December 2010