Publications by authors named "Amanda Littlewood-Evans"

32Publications

Targeting interleukin-4 to the arthritic joint.

J Control Release 2020 Oct 10;326:172-180. Epub 2020 Jul 10.

Institute of Pharmacy and Food Chemistry, University of Würzburg, DE-97074 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.07.005DOI Listing
October 2020

Structural basis of species-selective antagonist binding to the succinate receptor.

Nature 2019 10 23;574(7779):581-585. Epub 2019 Oct 23.

Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland.

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http://dx.doi.org/10.1038/s41586-019-1663-8DOI Listing
October 2019

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.

ACS Med Chem Lett 2017 Sep 25;8(9):975-980. Epub 2017 Aug 25.

Global Discovery Chemistry, PK Sciences, Chemical Biology and Therapeutics, and Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601375PMC
September 2017

Design and synthesis of potent and orally active GPR4 antagonists with modulatory effects on nociception, inflammation, and angiogenesis.

Bioorg Med Chem 2017 08 29;25(16):4512-4525. Epub 2017 Jun 29.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmc.2017.06.050DOI Listing
August 2017

Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis.

J Med Chem 2017 05 26;60(9):3672-3683. Epub 2017 Apr 26.

Global Discovery Chemistry, ‡Autoimmunity Transplantation Inflammation, §Musculoskeletal, ∥Metabolism and Pharmacokinetics, Novartis Institutes for BioMedical Research , CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01703DOI Listing
May 2017

Discovery and profiling of a selective and efficacious Syk inhibitor.

J Med Chem 2015 Feb 9;58(4):1950-63. Epub 2015 Feb 9.

Global Discovery Chemistry, ‡Analytical Sciences & Imaging, §Autoimmunity, Transplantation and Inflammation Research, Novartis Institutes for Biomedical Research , 4056 Basel, Switzerland.

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http://pubs.acs.org/doi/10.1021/jm5018863
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http://dx.doi.org/10.1021/jm5018863DOI Listing
February 2015

Contextual compound screening for improved therapeutic discovery.

Chembiochem 2013 Dec 12;14(18):2512-8. Epub 2013 Nov 12.

Department of Biomedicine, University of Bergen, Jonas Lies Vei 91, 5009 Bergen (Norway).

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http://dx.doi.org/10.1002/cbic.201300409DOI Listing
December 2013

Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo.

Clin Cancer Res 2010 Aug 3;16(16):4178-87. Epub 2010 Aug 3.

Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0456DOI Listing
August 2010

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.

Bioorg Med Chem Lett 2010 Aug 11;20(15):4719-23. Epub 2010 Apr 11.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2010.04.023DOI Listing
August 2010

Everolimus and PTK/ZK show synergistic growth inhibition in the orthotopic BL16/BL6 murine melanoma model.

Cancer Chemother Pharmacol 2011 Jan 30;67(1):193-200. Epub 2010 May 30.

Novartis Institutes for Biomedical Research, Oncology Research, 4002 Basel, Switzerland.

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http://link.springer.com/10.1007/s00280-010-1307-z
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http://dx.doi.org/10.1007/s00280-010-1307-zDOI Listing
January 2011

Beta1-integrins are critical for cerebellar granule cell precursor proliferation.

J Neurosci 2004 Mar;24(13):3402-12

Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5241-03.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693074PMC
March 2004

The Usher syndrome proteins cadherin 23 and harmonin form a complex by means of PDZ-domain interactions.

Proc Natl Acad Sci U S A 2002 Nov 29;99(23):14946-51. Epub 2002 Oct 29.

Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1073/pnas.232579599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137525PMC
November 2002