Amanda J Macfarlane

Amanda J Macfarlane

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Amanda J Macfarlane

Amanda J Macfarlane

Publications by authors named "Amanda J Macfarlane"

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Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model.

Hum Reprod 2019 May;34(5):851-862

Child Health and Human Development Program (CHHD), Research Institute of the McGill University Health Centre, 1001 Décarie Boulevard, Montréal QC, Canada.

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http://dx.doi.org/10.1093/humrep/dez036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505447PMC
May 2019

Association of maternal risk factors with the recent rise of neural tube defects in Canada.

Paediatr Perinat Epidemiol 2019 03;33(2):145-153

Department of Obstetrics and Gynaecology and the School of Population and Public Health, University of British Columbia and the Children's and Women's Hospital of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/ppe.12543DOI Listing
March 2019

Prevalence rates of spina bifida in Alberta, Canada: 2001-2015. Can we achieve more prevention?

Birth Defects Res 2019 Feb 18;111(3):151-158. Epub 2018 Dec 18.

Analytics and Reporting Branch, Alberta Health, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1002/bdr2.1438DOI Listing
February 2019

A genetic deficiency in folic acid metabolism impairs recovery after ischemic stroke.

Exp Neurol 2018 11 25;309:14-22. Epub 2018 Jul 25.

Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.

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http://dx.doi.org/10.1016/j.expneurol.2018.07.014DOI Listing
November 2018

Folate deficiency increases chromosomal damage and mutations in hematopoietic cells in the transgenic mutamouse model.

Environ Mol Mutagen 2018 06 18;59(5):366-374. Epub 2018 Apr 18.

Nutrition Research Division, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.1002/em.22190DOI Listing
June 2018

B-vitamin and choline supplementation increases neuroplasticity and recovery after stroke.

Neurobiol Dis 2017 Jul 7;103:89-100. Epub 2017 Apr 7.

Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.

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http://dx.doi.org/10.1016/j.nbd.2017.04.001DOI Listing
July 2017

Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women.

Am J Clin Nutr 2017 05 15;105(5):1101-1109. Epub 2017 Mar 15.

Nutrition Research Division,

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http://dx.doi.org/10.3945/ajcn.116.137968DOI Listing
May 2017

Murine MTHFD1-synthetase deficiency, a model for the human MTHFD1 R653Q polymorphism, decreases growth of colorectal tumors.

Mol Carcinog 2017 03 1;56(3):1030-1040. Epub 2016 Nov 1.

Departments of Human Genetics and Pediatrics, The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1002/mc.22568DOI Listing
March 2017

The elephant in the room: using nutritional biomarker cutoffs to assess status.

Am J Clin Nutr 2016 12 16;104(6):1493-1494. Epub 2016 Nov 16.

Nutrition Research Division, Health Canada, Ottawa, Canada

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http://dx.doi.org/10.3945/ajcn.116.146357DOI Listing
December 2016

Serum and red-blood-cell folate demonstrate differential associations with BMI in pregnant women.

Public Health Nutr 2016 10 18;19(14):2572-9. Epub 2016 Apr 18.

1Department of Epidemiology and Health Statistics,School of Public Health,Central South University,Changsha,Hunan,People's Republic of China.

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http://dx.doi.org/10.1017/S1368980016000756DOI Listing
October 2016

Effect of folic acid on human trophoblast health and function in vitro.

Placenta 2016 Jan 27;37:7-15. Epub 2015 Nov 27.

Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, K1N 6N5, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, K1H 8M5, Canada; Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, K1Y 4E9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.placenta.2015.11.012DOI Listing
January 2016

Heme Oxygenase-1 Induction Prevents Autoimmune Diabetes in Association With Pancreatic Recruitment of M2-Like Macrophages, Mesenchymal Cells, and Fibrocytes.

Endocrinology 2015 Nov 7;156(11):3937-49. Epub 2015 Aug 7.

Chronic Disease Program (M.H., G.-S.W., C.P., J.A.C., J.A.N., A.S., F.W.S.), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada K1H 8L6 and Departments of Biochemistry, Microbiology, and Immunology (M.H., C.P., A.J.M., J.A.N., F.W.S.) and Medicine (F.W.S.), University of Ottawa, Ottawa, Ontario, Canada K1H 8L6; Food Directorate (A.J.M.), Health Products and Food Branch, Health Canada, Ottawa, Ontario, Canada K1A 0K9.

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http://dx.doi.org/10.1210/en.2015-1304DOI Listing
November 2015

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.

Hum Mol Genet 2015 Nov 24;24(22):6301-13. Epub 2015 Aug 24.

Department of Human Genetics, Departments of Pediatrics and Pharmacology & Therapeutics, McGill University, Montreal, QC, Canada H4A 3J1, Montreal Children's Hospital and Research Institute of the McGill University Health Centre, Montreal, QC, Canada H4A 3J1,

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http://dx.doi.org/10.1093/hmg/ddv338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614702PMC
November 2015

Modeling Demonstrates That Folic Acid Fortification of Whole-Wheat Flour Could Reduce the Prevalence of Folate Inadequacy in Canadian Whole-Wheat Consumers.

J Nutr 2015 Nov 30;145(11):2622-9. Epub 2015 Sep 30.

Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada; The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; and

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http://dx.doi.org/10.3945/jn.115.217851DOI Listing
November 2015

Dietary folic acid protects against genotoxicity in the red blood cells of mice.

Mutat Res 2015 Sep 29;779:105-11. Epub 2015 Jun 29.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.1016/j.mrfmmm.2015.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094184PMC
September 2015

Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.

Br J Nutr 2015 Sep 24;114(6):844-52. Epub 2015 Aug 24.

1Nutrition Research Division,Health Canada,Ottawa,ON,CanadaK1A 0K9.

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http://dx.doi.org/10.1017/S0007114515002688DOI Listing
September 2015

Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.

Am J Clin Nutr 2015 Jun 6;101(6):1295-304. Epub 2015 May 6.

From the Science Integration Division, Public Health Agency of Canada, Ottawa, ON, Canada (JWRZ and MdG), and Nutrition Research Division, Health Canada, Ottawa, ON, Canada (JWRZ and AJM).

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http://dx.doi.org/10.3945/ajcn.115.107219DOI Listing
June 2015

Bringing clarity to the role of MTHFR variants in neural tube defect prevention.

Am J Clin Nutr 2015 Jun 13;101(6):1111-2. Epub 2015 May 13.

From the Cornell University Division of Nutritional Sciences, Ithaca, NY (PJS and MSF), and the Nutrition Research Division, Health Canada, Ottawa, Canada (AJM).

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http://dx.doi.org/10.3945/ajcn.115.111088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441815PMC
June 2015

Approaches for the identification of genetic modifiers of nutrient dependent phenotypes: examples from folate.

Front Nutr 2014 14;1. Epub 2014 Jul 14.

Nutrition Research Division, Health Canada , Ottawa, ON , Canada.

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http://dx.doi.org/10.3389/fnut.2014.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428393PMC
May 2015

Formate metabolism in fetal and neonatal sheep.

Am J Physiol Endocrinol Metab 2015 May 24;308(10):E921-7. Epub 2015 Mar 24.

Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.

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http://dx.doi.org/10.1152/ajpendo.00046.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436996PMC
May 2015

In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.

J Biol Chem 2015 Jan 5;290(4):2244-50. Epub 2014 Dec 5.

From the Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3X9, Canada,

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http://dx.doi.org/10.1074/jbc.M114.600718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303675PMC
January 2015

High-dose compared with low-dose vitamin B-12 supplement use is not associated with higher vitamin B-12 status in children, adolescents, and older adults.

J Nutr 2014 Jun 3;144(6):915-20. Epub 2014 Apr 3.

Division of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada Department of Biology, Faculty of Science, Carleton University, Ottawa, ON, Canada; and.

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http://dx.doi.org/10.3945/jn.113.190256DOI Listing
June 2014

Azoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.

J Nutr 2014 Apr 5;144(4):419-24. Epub 2014 Feb 5.

Division of Nutritional Sciences, Cornell University, Ithaca, NY.

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http://dx.doi.org/10.3945/jn.113.186007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083238PMC
April 2014

Dietary folate does not significantly affect the intestinal microbiome, inflammation or tumorigenesis in azoxymethane-dextran sodium sulphate-treated mice.

Br J Nutr 2013 Feb 5;109(4):630-8. Epub 2012 Jul 5.

Food Directorate, Health Products and Food Branch, Health Canada, 251 Sir Frederick Banting Drive, AL 2203E, Ottawa, ON, Canada K1A 0K9.

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http://dx.doi.org/10.1017/S0007114512001857DOI Listing
February 2013

Investigating the effects of dietary folic acid on sperm count, DNA damage and mutation in Balb/c mice.

Mutat Res 2012 Sep 20;737(1-2):1-7. Epub 2012 Jul 20.

Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1016/j.mrfmmm.2012.07.002DOI Listing
September 2012

Seed storage proteins of the globulin family are cleaved post-translationally in wheat embryos.

BMC Res Notes 2012 Jul 28;5:385. Epub 2012 Jul 28.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1186/1756-0500-5-385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434096PMC
July 2012

Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA.

J Biol Chem 2011 Dec 4;286(51):44015-22. Epub 2011 Nov 4.

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1074/jbc.M111.307629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243516PMC
December 2011

Vitamin B-12 and homocysteine status in a folate-replete population: results from the Canadian Health Measures Survey.

Am J Clin Nutr 2011 Oct 7;94(4):1079-87. Epub 2011 Sep 7.

Nutrition Research Division, Health Canada, Ottawa, Canada.

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http://dx.doi.org/10.3945/ajcn.111.020230DOI Listing
October 2011

Mthfd1 is a modifier of chemically induced intestinal carcinogenesis.

Carcinogenesis 2011 Mar 14;32(3):427-33. Epub 2010 Dec 14.

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1093/carcin/bgq270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047240PMC
March 2011

Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

Cancer Res 2011 Mar;71(6):2098-107

Division of Nutritional Sciences and Department of Biomedical Sciences, Cornell University, Ithaca, New York 14850, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-1886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059437PMC
March 2011

Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes.

Mamm Genome 2009 Sep-Oct;20(9-10):624-32. Epub 2009 Aug 22.

Nutrition Research Division, Food Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON K1A0K9, Canada.

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http://dx.doi.org/10.1007/s00335-009-9213-6DOI Listing
March 2010

Identification of three wheat globulin genes by screening a Triticum aestivum BAC genomic library with cDNA from a diabetes-associated globulin.

BMC Plant Biol 2009 Jul 17;9:93. Epub 2009 Jul 17.

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.

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http://dx.doi.org/10.1186/1471-2229-9-93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729749PMC
July 2009

Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

J Biol Chem 2009 Jan 25;284(3):1533-9. Epub 2008 Nov 25.

Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1074/jbc.M808281200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615521PMC
January 2009

Mouse models to elucidate mechanisms of folate-related cancer pathologies.

Nutr Rev 2008 Aug;66 Suppl 1:S54-8

Cornell University, Division of Nutritional Sciences, Ithaca, New York 14853, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2008.00069.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421381PMC
August 2008

Convergence of genetic, nutritional and inflammatory factors in gastrointestinal cancers.

Nutr Rev 2007 Dec;65(12 Pt 2):S157-66

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2007.tb00355.xDOI Listing
December 2007

A type 1 diabetes-related protein from wheat (Triticum aestivum). cDNA clone of a wheat storage globulin, Glb1, linked to islet damage.

J Biol Chem 2003 Jan 29;278(1):54-63. Epub 2002 Oct 29.

Ottawa Health Research Institute, Ottawa, Ontario K1H 8L6, Canada.

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http://dx.doi.org/10.1074/jbc.M210636200DOI Listing
January 2003