Amanda Heslegrave

Amanda Heslegrave

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Amanda Heslegrave

Amanda Heslegrave

Publications by authors named "Amanda Heslegrave"

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Plasma pNfH levels differentiate SBMA from ALS.

J Neurol Neurosurg Psychiatry 2019 Oct 1. Epub 2019 Oct 1.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK

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http://dx.doi.org/10.1136/jnnp-2019-320624DOI Listing
October 2019

Plasma neurofilament light chain concentration is increased and correlates with the severity of neuropathy in hereditary transthyretin amyloidosis.

J Peripher Nerv Syst 2019 Oct 3. Epub 2019 Oct 3.

MRC Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.

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http://dx.doi.org/10.1111/jns.12350DOI Listing
October 2019

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.

Exp Gerontol 2019 Jul 11;121:91-98. Epub 2019 Apr 11.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2019.04.003DOI Listing
July 2019

Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate.

Neurol Neuroimmunol Neuroinflamm 2019 May 22;6(3):e562. Epub 2019 Apr 22.

Division of Brain Sciences (T.T., R.N., P.M.M.), Department of Medicine, Imperial College, London; St Edmund Hall (C.S., P.M.M.), Oxford University, Oxford, UK; MRC-NIHR National Phenome Centre (M.D., M.G.-R., M.R.L.), Department of Surgery and Cancer, Imperial College; University College London Queen Square Institute of Neurology (A.H., H.Z.); UK Dementia Research Institute, University College London (A.H., H.Z.), London, UK; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy, the University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; and UK Dementia Research Institute at Imperial College (P.M.M.), London.

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http://dx.doi.org/10.1212/NXI.0000000000000562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481230PMC
May 2019

Muscle and not neuronal biomarkers correlate with severity in spinal and bulbar muscular atrophy.

Neurology 2019 Mar 20;92(11):e1205-e1211. Epub 2019 Feb 20.

From the Institute of Neurology (V.L., O.J.Z., L.Z., C.H., M.F., C.-H.L., B.M., H.Z., A.H., L.G., M.H., P.F.), University College London Institute of Neurology, Queen Square, London; Blizard Institute (V.L., A.M.), Queen Mary, University of London, UK; Department of Neurosciences (G.Q., I.M., C.B., G.S.), University of Padova, Italy; Department of Neurology (C.-H.L.), China Medical University Hospital, Taiwan; Basildon Hospital (K.A.), UK; Department of Physiology, Anatomy and Genetics (C.R.), University of Oxford; UK Dementia Research Institute at UCL (H.Z., A.H.), London, UK; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital; and the Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511101PMC
March 2019

Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer's disease.

Alzheimers Res Ther 2019 02 20;11(1):19. Epub 2019 Feb 20.

Dementia Research Centre, Department of Neurodegenerative Diseases, UCL Institute of Neurology, Queen Square, Box 16, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1186/s13195-019-0472-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383280PMC
February 2019

CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection.

Neurol Neuroimmunol Neuroinflamm 2019 01 7;6(1):e512. Epub 2018 Nov 7.

Department of Infectious Diseases (M.G., A.Y., L.-M.A., L.H.), Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Sweden; Department of Molecular Neuroscience (A.H., E.V., H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (A.H., E.V., H.Z.), London, United Kingdom; Department of Neurology and Center for Neuroepidemiology and Clinical Neurological Research (S.S.), Yale University, New Haven, CT; Division of Biological Chemistry (D.F.), Biocenter, Medical University of Innsbruck, Austria; Department of Neurology (R.W.P.), University of California San Francisco; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital; and Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278890PMC
January 2019

CSF pro-orexin and amyloid-β38 expression in Alzheimer's disease and frontotemporal dementia.

Neurobiol Aging 2018 12 25;72:171-176. Epub 2018 Aug 25.

Centre for Translational Omics, Genetics & Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221294PMC
December 2018

Inflammatory markers of CHMP2B-mediated frontotemporal dementia.

J Neuroimmunol 2018 11 17;324:136-142. Epub 2018 Aug 17.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jneuroim.2018.08.009DOI Listing
November 2018

Plasma Markers of Neurodegeneration Are Raised in Friedreich's Ataxia.

Front Cell Neurosci 2018 30;12:366. Epub 2018 Oct 30.

Ataxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fncel.2018.00366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218876PMC
October 2018

Cerebrospinal fluid tau, Aβ, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration.

Alzheimers Dement 2018 09 23;14(9):1159-1170. Epub 2018 Jul 23.

Boston University Alzheimer's Disease Center and Boston University CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131058PMC
September 2018

Plasma tau is increased in frontotemporal dementia.

J Neurol Neurosurg Psychiatry 2018 08 13;89(8):804-807. Epub 2018 Feb 13.

Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.

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http://dx.doi.org/10.1136/jnnp-2017-317260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204947PMC
August 2018

Stability of blood-based biomarkers of Alzheimer's disease over multiple freeze-thaw cycles.

Alzheimers Dement (Amst) 2018 2;10:448-451. Epub 2018 Jul 2.

Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosurgery, London, UK.

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http://dx.doi.org/10.1016/j.dadm.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131984PMC
July 2018

Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome.

Alzheimers Res Ther 2018 04 10;10(1):39. Epub 2018 Apr 10.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

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https://alzres.biomedcentral.com/articles/10.1186/s13195-018
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http://dx.doi.org/10.1186/s13195-018-0367-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891918PMC
April 2018

Cerebrospinal fluid neurogranin and TREM2 in Huntington's disease.

Sci Rep 2018 03 9;8(1):4260. Epub 2018 Mar 9.

Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1038/s41598-018-21788-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844906PMC
March 2018

Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration.

J Alzheimers Dis 2017 ;56(3):885-891

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.3233/JAD-161126DOI Listing
February 2018

Blood Biomarkers for Alzheimer's Disease: Much Promise, Cautious Progress.

Mol Diagn Ther 2017 02;21(1):13-22

Dementia Research Centre, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, Box 16, Queen Square, London, WC1N 3BG, UK.

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http://dx.doi.org/10.1007/s40291-016-0241-0DOI Listing
February 2017

Combined tissue and fluid proteomics with Tandem Mass Tags to identify low-abundance protein biomarkers of disease in peripheral body fluid: An Alzheimer's Disease case study.

Rapid Commun Mass Spectrom 2017 Jan;31(2):153-159

Proteome Sciences plc, Institute of Psychiatry, Kings College London, South Wing Laboratories, De Crespigny Park, London, SE5 8AF, UK.

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http://dx.doi.org/10.1002/rcm.7777DOI Listing
January 2017

Soluble TREM-2 in cerebrospinal fluid from patients with multiple sclerosis treated with natalizumab or mitoxantrone.

Mult Scler 2016 10 11;22(12):1587-1595. Epub 2016 Jan 11.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden/UCL Institute of Neurology, University College London (UCL), London, UK.

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http://dx.doi.org/10.1177/1352458515624558DOI Listing
October 2016

Genetic Variants and Related Biomarkers in Sporadic Alzheimer's Disease.

Curr Genet Med Rep 2015;3:19-25

Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, WC1N 3BG UK ; Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1007/s40142-014-0062-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317514PMC
January 2015

Novel insights into fatty acid oxidation, amino acid metabolism, and insulin secretion from studying patients with loss of function mutations in 3-hydroxyacyl-CoA dehydrogenase.

J Clin Endocrinol Metab 2013 Feb 18;98(2):496-501. Epub 2012 Dec 18.

Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom.

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http://dx.doi.org/10.1210/jc.2012-3134DOI Listing
February 2013

Congenital hyperinsulinism due to mutations in HNF4A and HADH.

Rev Endocr Metab Disord 2010 Sep;11(3):185-91

Clinical and Molecular Genetics Unit, The Developmental Endocrinology Research Group, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK.

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http://dx.doi.org/10.1007/s11154-010-9148-yDOI Listing
September 2010