Publications by authors named "Amanda Dobbyn"

17Publications

Exome-wide evaluation of rare coding variants using electronic health records identifies new gene-phenotype associations.

Authors:
Joseph Park Anastasia M Lucas Xinyuan Zhang Kumardeep Chaudhary Judy H Cho Girish Nadkarni Amanda Dobbyn Geetha Chittoor Navya S Josyula Nathan Katz Joseph H Breeyear Shadi Ahmadmehrabi Theodore G Drivas Venkata R M Chavali Maria Fasolino Hisashi Sawada Alan Daugherty Yanming Li Chen Zhang Yuki Bradford JoEllen Weaver Anurag Verma Renae L Judy Rachel L Kember John D Overton Jeffrey G Reid Manuel A R Ferreira Alexander H Li Aris Baras Scott A LeMaire Ying H Shen Ali Naji Klaus H Kaestner Golnaz Vahedi Todd L Edwards Jinbo Chen Scott M Damrauer Anne E Justice Ron Do Marylyn D Ritchie Daniel J Rader

Nat Med 2021 01 11;27(1):66-72. Epub 2021 Jan 11.

Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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January 2021

Transethnic Transferability of a Genome-wide Polygenic Score for Coronary Artery Disease.

Authors:
Akl C Fahed Krishna G Aragam George Hindy Yii-Der Ida Chen Kumardeep Chaudhary Amanda Dobbyn Harlan M Krumholz Wayne H H Sheu Stephen S Rich Jerome I Rotter Rajiv Chowdhury Judy Cho Ron Do Patrick T Ellinor Sekar Kathiresan Amit V Khera

Circ Genom Precis Med 2020 Dec 7. Epub 2020 Dec 7.

Center for Genomic Medicine & Division of Cardiology, Department of Medicine, Massachusetts General Hospital & Department of Medicine, Harvard Medical School, Boston & Cardiovascular Disease Initiative, Program in Medical and Population Genetics, Broad Institute of MIT & Harvard, Cambridge, MA.

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December 2020

Tissue-specific genetic features inform prediction of drug side effects in clinical trials.

Authors:
Áine Duffy Marie Verbanck Amanda Dobbyn Hong-Hee Won Joshua L Rein Iain S Forrest Girish Nadkarni Ghislain Rocheleau Ron Do

Sci Adv 2020 Sep 10;6(37). Epub 2020 Sep 10.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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September 2020

mTADA is a framework for identifying risk genes from de novo mutations in multiple traits.

Authors:
Tan-Hoang Nguyen Amanda Dobbyn Ruth C Brown Brien P Riley Joseph D Buxbaum Dalila Pinto Shaun M Purcell Patrick F Sullivan Xin He Eli A Stahl

Nat Commun 2020 06 10;11(1):2929. Epub 2020 Jun 10.

Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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June 2020

Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease.

Authors:
Krishna G Aragam Amanda Dobbyn Renae Judy Mark Chaffin Kumardeep Chaudhary George Hindy Andrew Cagan Phoebe Finneran Lu-Chen Weng Ruth J F Loos Girish Nadkarni Judy H Cho Rachel L Kember Aris Baras Jeffrey Reid John Overton Anthony Philippakis Patrick T Ellinor Scott T Weiss Daniel J Rader Steven A Lubitz Jordan W Smoller Elizabeth W Karlson Amit V Khera Sekar Kathiresan Ron Do Scott M Damrauer Pradeep Natarajan

J Am Coll Cardiol 2020 06;75(22):2769-2780

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

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June 2020

Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts.

Authors:
Laura M Huckins Chris Chatzinakos Michael S Breen Jakob Hartmann Torsten Klengel Ana C da Silva Almeida Amanda Dobbyn Kiran Girdhar Gabriel E Hoffman Claudia Klengel Mark W Logue Adriana Lori Adam X Maihofer Filomene G Morrison Hoang T Nguyen Yongjin Park Douglas Ruderfer Laura G Sloofman Sanne J H van Rooij Dewleen G Baker Chia-Yen Chen Nancy Cox Laramie E Duncan Mark A Geyer Stephen J Glatt Hae Kyung Im Victoria B Risbrough Jordan W Smoller Dan J Stein Rachel Yehuda Israel Liberzon Karestan C Koenen Tanja Jovanovic Manolis Kellis Mark W Miller Silviu-Alin Bacanu Caroline M Nievergelt Joseph D Buxbaum Pamela Sklar Kerry J Ressler Eli A Stahl Nikolaos P Daskalakis

Cell Rep 2020 06;31(9):107716

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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June 2020

Collagenous Colitis Is Associated With HLA Signature and Shares Genetic Risks With Other Immune-Mediated Diseases.

Authors:
Eli Stahl Giulia Roda Amanda Dobbyn Jianzhong Hu Zhongyang Zhang Helga Westerlind Ferdinando Bonfiglio Towfique Raj Joana Torres Anli Chen Robert Petras Darrell S Pardi Alina C Iuga Gabriel S Levi Wenqing Cao Prantesh Jain Florian Rieder Ilyssa O Gordon Judy H Cho Mauro D'Amato Noam Harpaz Ke Hao Jean Frederic Colombel Inga Peter

Gastroenterology 2020 Aug 1;159(2):549-561.e8. Epub 2020 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

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August 2020

Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry.

Authors:
Scott M Damrauer Kumardeep Chaudhary Judy H Cho Lusha W Liang Edgar Argulian Lili Chan Amanda Dobbyn Marie A Guerraty Renae Judy Jenna Kay Rachel L Kember Michael G Levin Aparna Saha Tielman Van Vleck Shefali S Verma JoEllen Weaver Noura S Abul-Husn Aris Baras Julio A Chirinos Brian Drachman Eimear E Kenny Ruth J F Loos Jagat Narula John Overton Jeffrey Reid Marylyn Ritchie Giorgio Sirugo Girish Nadkarni Daniel J Rader Ron Do

JAMA 2019 12;322(22):2191-2202

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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December 2019

Synergistic effects of common schizophrenia risk variants.

Authors:
Nadine Schrode Seok-Man Ho Kazuhiko Yamamuro Amanda Dobbyn Laura Huckins Marliette R Matos Esther Cheng P J Michael Deans Erin Flaherty Natalie Barretto Aaron Topol Khaled Alganem Sonya Abadali James Gregory Emily Hoelzli Hemali Phatnani Vineeta Singh Deeptha Girish Bruce Aronow Robert Mccullumsmith Gabriel E Hoffman Eli A Stahl Hirofumi Morishita Pamela Sklar Kristen J Brennand

Nat Genet 2019 10 23;51(10):1475-1485. Epub 2019 Sep 23.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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October 2019

Global landscape and genetic regulation of RNA editing in cortical samples from individuals with schizophrenia.

Authors:
Michael S Breen Amanda Dobbyn Qin Li Panos Roussos Gabriel E Hoffman Eli Stahl Andrew Chess Pamela Sklar Jin Billy Li Bernie Devlin Joseph D Buxbaum

Nat Neurosci 2019 09 27;22(9):1402-1412. Epub 2019 Aug 27.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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September 2019

Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.

Authors:
Laura M Huckins Amanda Dobbyn Douglas M Ruderfer Gabriel Hoffman Weiqing Wang Antonio F Pardiñas Veera M Rajagopal Thomas D Als Hoang T Nguyen Kiran Girdhar James Boocock Panos Roussos Menachem Fromer Robin Kramer Enrico Domenici Eric R Gamazon Shaun Purcell Ditte Demontis Anders D Børglum James T R Walters Michael C O'Donovan Patrick Sullivan Michael J Owen Bernie Devlin Solveig K Sieberts Nancy J Cox Hae Kyung Im Pamela Sklar Eli A Stahl

Nat Genet 2019 Jun;51(6):1068

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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June 2019

Genome-wide association study identifies 30 loci associated with bipolar disorder.

Authors:
Eli A Stahl Gerome Breen Andreas J Forstner Andrew McQuillin Stephan Ripke Vassily Trubetskoy Manuel Mattheisen Yunpeng Wang Jonathan R I Coleman Héléna A Gaspar Christiaan A de Leeuw Stacy Steinberg Jennifer M Whitehead Pavlides Maciej Trzaskowski Enda M Byrne Tune H Pers Peter A Holmans Alexander L Richards Liam Abbott Esben Agerbo Huda Akil Diego Albani Ney Alliey-Rodriguez Thomas D Als Adebayo Anjorin Verneri Antilla Swapnil Awasthi Judith A Badner Marie Bækvad-Hansen Jack D Barchas Nicholas Bass Michael Bauer Richard Belliveau Sarah E Bergen Carsten Bøcker Pedersen Erlend Bøen Marco P Boks James Boocock Monika Budde William Bunney Margit Burmeister Jonas Bybjerg-Grauholm William Byerley Miquel Casas Felecia Cerrato Pablo Cervantes Kimberly Chambert Alexander W Charney Danfeng Chen Claire Churchhouse Toni-Kim Clarke William Coryell David W Craig Cristiana Cruceanu David Curtis Piotr M Czerski Anders M Dale Simone de Jong Franziska Degenhardt Jurgen Del-Favero J Raymond DePaulo Srdjan Djurovic Amanda L Dobbyn Ashley Dumont Torbjørn Elvsåshagen Valentina Escott-Price Chun Chieh Fan Sascha B Fischer Matthew Flickinger Tatiana M Foroud Liz Forty Josef Frank Christine Fraser Nelson B Freimer Louise Frisén Katrin Gade Diane Gage Julie Garnham Claudia Giambartolomei Marianne Giørtz Pedersen Jaqueline Goldstein Scott D Gordon Katherine Gordon-Smith Elaine K Green Melissa J Green Tiffany A Greenwood Jakob Grove Weihua Guan José Guzman-Parra Marian L Hamshere Martin Hautzinger Urs Heilbronner Stefan Herms Maria Hipolito Per Hoffmann Dominic Holland Laura Huckins Stéphane Jamain Jessica S Johnson Anders Juréus Radhika Kandaswamy Robert Karlsson James L Kennedy Sarah Kittel-Schneider James A Knowles Manolis Kogevinas Anna C Koller Ralph Kupka Catharina Lavebratt Jacob Lawrence William B Lawson Markus Leber Phil H Lee Shawn E Levy Jun Z Li Chunyu Liu Susanne Lucae Anna Maaser Donald J MacIntyre Pamela B Mahon Wolfgang Maier Lina Martinsson Steve McCarroll Peter McGuffin Melvin G McInnis James D McKay Helena Medeiros Sarah E Medland Fan Meng Lili Milani Grant W Montgomery Derek W Morris Thomas W Mühleisen Niamh Mullins Hoang Nguyen Caroline M Nievergelt Annelie Nordin Adolfsson Evaristus A Nwulia Claire O'Donovan Loes M Olde Loohuis Anil P S Ori Lilijana Oruc Urban Ösby Roy H Perlis Amy Perry Andrea Pfennig James B Potash Shaun M Purcell Eline J Regeer Andreas Reif Céline S Reinbold John P Rice Fabio Rivas Margarita Rivera Panos Roussos Douglas M Ruderfer Euijung Ryu Cristina Sánchez-Mora Alan F Schatzberg William A Scheftner Nicholas J Schork Cynthia Shannon Weickert Tatyana Shehktman Paul D Shilling Engilbert Sigurdsson Claire Slaney Olav B Smeland Janet L Sobell Christine Søholm Hansen Anne T Spijker David St Clair Michael Steffens John S Strauss Fabian Streit Jana Strohmaier Szabolcs Szelinger Robert C Thompson Thorgeir E Thorgeirsson Jens Treutlein Helmut Vedder Weiqing Wang Stanley J Watson Thomas W Weickert Stephanie H Witt Simon Xi Wei Xu Allan H Young Peter Zandi Peng Zhang Sebastian Zöllner Rolf Adolfsson Ingrid Agartz Martin Alda Lena Backlund Bernhard T Baune Frank Bellivier Wade H Berrettini Joanna M Biernacka Douglas H R Blackwood Michael Boehnke Anders D Børglum Aiden Corvin Nicholas Craddock Mark J Daly Udo Dannlowski Tõnu Esko Bruno Etain Mark Frye Janice M Fullerton Elliot S Gershon Michael Gill Fernando Goes Maria Grigoroiu-Serbanescu Joanna Hauser David M Hougaard Christina M Hultman Ian Jones Lisa A Jones René S Kahn George Kirov Mikael Landén Marion Leboyer Cathryn M Lewis Qingqin S Li Jolanta Lissowska Nicholas G Martin Fermin Mayoral Susan L McElroy Andrew M McIntosh Francis J McMahon Ingrid Melle Andres Metspalu Philip B Mitchell Gunnar Morken Ole Mors Preben Bo Mortensen Bertram Müller-Myhsok Richard M Myers Benjamin M Neale Vishwajit Nimgaonkar Merete Nordentoft Markus M Nöthen Michael C O'Donovan Ketil J Oedegaard Michael J Owen Sara A Paciga Carlos Pato Michele T Pato Danielle Posthuma Josep Antoni Ramos-Quiroga Marta Ribasés Marcella Rietschel Guy A Rouleau Martin Schalling Peter R Schofield Thomas G Schulze Alessandro Serretti Jordan W Smoller Hreinn Stefansson Kari Stefansson Eystein Stordal Patrick F Sullivan Gustavo Turecki Arne E Vaaler Eduard Vieta John B Vincent Thomas Werge John I Nurnberger Naomi R Wray Arianna Di Florio Howard J Edenberg Sven Cichon Roel A Ophoff Laura J Scott Ole A Andreassen John Kelsoe Pamela Sklar

Nat Genet 2019 05 1;51(5):793-803. Epub 2019 May 1.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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May 2019

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk.

Authors:
Laura M Huckins Amanda Dobbyn Douglas M Ruderfer Gabriel Hoffman Weiqing Wang Antonio F Pardiñas Veera M Rajagopal Thomas D Als Hoang T Nguyen Kiran Girdhar James Boocock Panos Roussos Menachem Fromer Robin Kramer Enrico Domenici Eric R Gamazon Shaun Purcell Ditte Demontis Anders D Børglum James T R Walters Michael C O'Donovan Patrick Sullivan Michael J Owen Bernie Devlin Solveig K Sieberts Nancy J Cox Hae Kyung Im Pamela Sklar Eli A Stahl

Nat Genet 2019 04 25;51(4):659-674. Epub 2019 Mar 25.

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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April 2019

Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS.

Authors:
Amanda Dobbyn Laura M Huckins James Boocock Laura G Sloofman Benjamin S Glicksberg Claudia Giambartolomei Gabriel E Hoffman Thanneer M Perumal Kiran Girdhar Yan Jiang Towfique Raj Douglas M Ruderfer Robin S Kramer Dalila Pinto Schahram Akbarian Panos Roussos Enrico Domenici Bernie Devlin Pamela Sklar Eli A Stahl Solveig K Sieberts

Am J Hum Genet 2018 06 24;102(6):1169-1184. Epub 2018 May 24.

Systems Biology, Sage Bionetworks, Seattle, WA 98109, USA. Electronic address:

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June 2018

Integrated Bayesian analysis of rare exonic variants to identify risk genes for schizophrenia and neurodevelopmental disorders.

Authors:
Hoang T Nguyen Julien Bryois April Kim Amanda Dobbyn Laura M Huckins Ana B Munoz-Manchado Douglas M Ruderfer Giulio Genovese Menachem Fromer Xinyi Xu Dalila Pinto Sten Linnarsson Matthijs Verhage August B Smit Jens Hjerling-Leffler Joseph D Buxbaum Christina Hultman Pamela Sklar Shaun M Purcell Kasper Lage Xin He Patrick F Sullivan Eli A Stahl

Genome Med 2017 Dec 20;9(1):114. Epub 2017 Dec 20.

Division of Psychiatric Genomics, Department of Genetics and Genomic Sciences, Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, USA.

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December 2017

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.

Authors:
Callum Tanner James Boocock Eli A Stahl Amanda Dobbyn Asim K Mandal Murray Cadzow Amanda J Phipps-Green Ruth K Topless Jennie Harré Hindmarsh Lisa K Stamp Nicola Dalbeth Hyon K Choi David B Mount Tony R Merriman

Arthritis Rheumatol 2017 07 31;69(7):1461-1469. Epub 2017 May 31.

University of Otago, Dunedin, New Zealand.

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July 2017

Disproportionate Contributions of Select Genomic Compartments and Cell Types to Genetic Risk for Coronary Artery Disease.

Authors:
Hong-Hee Won Pradeep Natarajan Amanda Dobbyn Daniel M Jordan Panos Roussos Kasper Lage Soumya Raychaudhuri Eli Stahl Ron Do

PLoS Genet 2015 Oct 28;11(10):e1005622. Epub 2015 Oct 28.

Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Icahn Institute for Genomics and Multiscale Biology, Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Charles Bronfman Institute for Personalized Medicine, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Center for Statistical Genetics, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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October 2015