Alysson R Muotri

Alysson R Muotri

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Alysson R Muotri

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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Cell Stem Cell 2019 Oct 29;25(4):558-569.e7. Epub 2019 Aug 29.

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Kavli Institute for Brain and Mind and Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.002DOI Listing
October 2019

Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders.

Physiology (Bethesda) 2019 Sep;34(5):365-375

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California San Diego, San Diego, California.

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http://dx.doi.org/10.1152/physiol.00005.2019DOI Listing
September 2019

Getting to the Cores of Autism.

Cell 2019 Sep;178(6):1287-1298

University of California San Diego, Department of Psychiatry, La Jolla, CA 92093, USA; University of California San Diego, School of Medicine, Department of Cellular & Molecular Medicine, La Jolla, CA 92093, USA; University of California San Diego, Beyster Center for Psychiatric Genomics, La Jolla, CA 92093. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.07.037DOI Listing
September 2019

Exosomes regulate neurogenesis and circuit assembly.

Proc Natl Acad Sci U S A 2019 Aug 18;116(32):16086-16094. Epub 2019 Jul 18.

Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92093;

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http://dx.doi.org/10.1073/pnas.1902513116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689941PMC
August 2019

Transposable Elements, Inflammation, and Neurological Disease.

Front Neurol 2019 20;10:894. Epub 2019 Aug 20.

Department of Pediatrics, Rady Children's Hospital San Diego, University of California, San Diego, San Diego, CA, United States.

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http://dx.doi.org/10.3389/fneur.2019.00894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710400PMC
August 2019

Frequency and association of mitochondrial genetic variants with neurological disorders.

Mitochondrion 2019 05 13;46:345-360. Epub 2018 Sep 13.

Experimental Multiuser Laboratory (LEM), Graduate Program in Health Sciences (PPGCS), School of Medicine (PPGCS), Pontifícia Universidade Católica do Paraná (PUCPR), Curitiba, Paraná 80215-901, Brazil; Lico Kaesemodel Institute (ILK), Curitiba, Paraná 80240-000, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15677249183011
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http://dx.doi.org/10.1016/j.mito.2018.09.005DOI Listing
May 2019

Brain organoids and insights on human evolution.

Authors:
Alysson R Muotri

F1000Res 2019 30;8. Epub 2019 May 30.

Department of Pediatrics/Rady Children's Hospital San Diego, University of California San Diego, School of Medicine, La Jolla, CA, USA.

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http://dx.doi.org/10.12688/f1000research.18495.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544132PMC
May 2019

Brain organoids as a model system for human neurodevelopment and disease.

Semin Cell Dev Biol 2019 Mar 22. Epub 2019 Mar 22.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, La Jolla, CA, 92093, USA; University of California San Diego, Kavli Institute for Brain and Mind, La Jolla, CA, 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA, 92093, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10849521183006
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http://dx.doi.org/10.1016/j.semcdb.2019.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755075PMC
March 2019

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease.

Cell Rep 2019 Jan;26(5):1189-1202.e6

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA; Duke Center for Neurodegeneration & Neurotherapeutics, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420346PMC
January 2019

Brain Organoids and the Study of Neurodevelopment.

Trends Mol Med 2018 12 28;24(12):982-990. Epub 2018 Oct 28.

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California San Diego, San Diego, CA 92037-0695, USA; Department of Cellular & Molecular Medicine, Stem Cell Program, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, La Jolla, CA 92037-0695, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14714914183018
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http://dx.doi.org/10.1016/j.molmed.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289846PMC
December 2018

Direct Generation of Human Cortical Organoids from Primary Cells.

Stem Cells Dev 2018 11 22;27(22):1549-1556. Epub 2018 Sep 22.

1 Department of Pediatrics, Rady Children's Hospital San Diego, University of California San Diego School of Medicine , La Jolla, California.

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https://www.liebertpub.com/doi/10.1089/scd.2018.0112
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http://dx.doi.org/10.1089/scd.2018.0112DOI Listing
November 2018

The contribution of GTF2I haploinsufficiency to Williams syndrome.

Mol Cell Probes 2018 08 3;40:45-51. Epub 2018 Jan 3.

University of California San Diego, School of Medicine, UCSD Stem Cell Program, Department of Pediatrics/Rady Children's Hospital San Diego, La Jolla, CA 92037, USA; University of California San Diego, School of Medicine, Department of Cellular & Molecular Medicine, La Jolla, CA 92037, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.mcp.2017.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034994PMC
August 2018

LINE-1 retrotransposons in healthy and diseased human brain.

Dev Neurobiol 2018 May 29;78(5):434-455. Epub 2017 Dec 29.

Department of Pediatrics/Rady Children's Hospital San Diego, University of California San Diego, La Jolla, California, 92093.

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http://dx.doi.org/10.1002/dneu.22567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897138PMC
May 2018

Genetic variations on SETD5 underlying autistic conditions.

Dev Neurobiol 2018 05 5;78(5):500-518. Epub 2018 Mar 5.

Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, California, 92037-0695.

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http://dx.doi.org/10.1002/dneu.22584DOI Listing
May 2018

Stem cell contributions to neurological disease modeling and personalized medicine.

Prog Neuropsychopharmacol Biol Psychiatry 2018 Jan 31;80(Pt A):54-62. Epub 2017 May 31.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP 05508-000, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2017.05.025DOI Listing
January 2018

Modeling neuro-immune interactions during Zika virus infection.

Hum Mol Genet 2018 01;27(1):41-52

Department of Pediatrics/Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA 92093-0695, USA.

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http://dx.doi.org/10.1093/hmg/ddx382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886060PMC
January 2018

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation.

Cell Stem Cell 2017 09 10;21(3):319-331.e8. Epub 2017 Aug 10.

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular & Molecular Medicine, Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA, USA; Stem Cell Program, Center for Academic Research and Training in Anthropogeny (CARTA), University of California, San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591075PMC
September 2017

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

Hum Mol Genet 2017 07;26(13):2472-2479

Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, MC 0695, USA.

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http://dx.doi.org/10.1093/hmg/ddx142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075211PMC
July 2017

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

Hum Mol Genet 2017 07;26(13):2590

Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093, MC 0695, USA and.

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http://dx.doi.org/10.1093/hmg/ddx220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303434PMC
July 2017

Modeling autism spectrum disorders with human neurons.

Brain Res 2017 02 5;1656:49-54. Epub 2016 Feb 5.

Department of Pediatrics/Rady Children׳s Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, School of Medicine, University of California San Diego, La Jolla, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2016.01.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975680PMC
February 2017

Modeling Williams syndrome with induced pluripotent stem cells.

Neurogenesis (Austin) 2017 6;4(1):e1283187. Epub 2017 Feb 6.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, Center for Academic Research and Training in Anthropogeny (CARTA) , La Jolla, CA, USA.

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http://dx.doi.org/10.1080/23262133.2017.1283187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5305168PMC
February 2017

IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3.

Hum Mol Genet 2017 01;26(2):270-281

Department of Medicine, Laboratory of Endocrinology and Translational Medicine, Universidade Federal de São Paulo, UNIFESP/EPM, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1093/hmg/ddw384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075524PMC
January 2017

L1 Retrotransposition in Neural Progenitor Cells.

Authors:
Alysson R Muotri

Methods Mol Biol 2016 ;1400:157-63

Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, Pediatrics/Rady Children's Hospital San Diego, Sanford Consortium 2880 Torrey Pines Scenic Drive: room 3005, MC, 0695, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/978-1-4939-3372-3_11DOI Listing
December 2016

The Na/HCO co-transporter is protective during ischemia in astrocytes.

Neuroscience 2016 Dec 4;339:329-337. Epub 2016 Oct 4.

Departments of Pediatrics & Neuroscience, University of California-San Diego, La Jolla, CA 92093, United States; Rady Children's Hospital-San Diego, San Diego, CA 92123, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118130PMC
December 2016

Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

J Cell Sci 2016 09 15;129(18):3437-48. Epub 2016 Aug 15.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo 05508-900, Brazil

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047680PMC
http://dx.doi.org/10.1242/jcs.192534DOI Listing
September 2016

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony.

Hum Mol Genet 2016 Apr 10;25(7):1271-80. Epub 2016 Jan 10.

Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular and Molecular Medicine, Stem Cell Program, University of California San Diego, School of Medicine, La Jolla, CA 92037, USA,

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http://dx.doi.org/10.1093/hmg/ddw008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787902PMC
April 2016

Frequency and Complexity of De Novo Structural Mutation in Autism.

Am J Hum Genet 2016 Apr 24;98(4):667-79. Epub 2016 Mar 24.

Beyster Center for Genomics of Psychiatric Diseases, University of California, San Diego, La Jolla, CA 92093, USA; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833290PMC
April 2016

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome.

Proc Natl Acad Sci U S A 2016 Jan 5;113(3):751-6. Epub 2016 Jan 5.

Department of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA 16802;

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http://dx.doi.org/10.1073/pnas.1524013113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725523PMC
January 2016

Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.

Hum Mol Genet 2015 Dec 18;24(24):6877-85. Epub 2015 Sep 18.

Northeast Biotechnology Network (RENORBIO), Federal University of Paraiba (UFPB), Joao Pessoa, PB 58051-900, Brazil, Department of Biology, Paraiba State University (UEPB), Campina Grande, PB 58429-500, Brazil.

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http://dx.doi.org/10.1093/hmg/ddv388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296331PMC
December 2015

Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain.

Sci Rep 2015 Oct 14;5:14356. Epub 2015 Oct 14.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48202.

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http://dx.doi.org/10.1038/srep14356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604469PMC
October 2015

Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Sci Rep 2015 May 5;5:9834. Epub 2015 May 5.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular &Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.

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http://www.nature.com/articles/srep09834
Publisher Site
http://dx.doi.org/10.1038/srep09834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419516PMC
May 2015

Stem cells and modeling of autism spectrum disorders.

Exp Neurol 2014 Oct 2;260:33-43. Epub 2012 Oct 2.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2012.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568448PMC
October 2014

Micro RNA detection in long-term fixed tissue of cortical glutamatergic pyramidal neurons after targeted laser-capture neuroanatomical microdissection.

J Neurosci Methods 2014 Sep 30;235:76-82. Epub 2014 Jun 30.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2014.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150832PMC
September 2014

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.

Nat Neurosci 2014 Sep 10;17(9):1180-9. Epub 2014 Aug 10.

1] Department of Pediatrics, University of California, San Diego, La Jolla, California, USA. [2] Department of Cellular &Molecular Medicine, University of California, San Diego, La Jolla, California, USA. [3] Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. [4] Institute for Genomic Medicine, University of California, San Diego, La Jolla, California, USA. [5] Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California, USA. [6] Rady Children's Hospital, San Diego, California, USA. [7] Division of Biological Sciences, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180729PMC
September 2014

A quantitative framework to evaluate modeling of cortical development by neural stem cells.

Neuron 2014 Jul;83(1):69-86

Neurogenetics Program, Department of Neurology, Center for Autism Research and Treatment, Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.05.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277209PMC
July 2014

Novel tools, classic techniques: evolutionary studies using primate pluripotent stem cells.

Biol Psychiatry 2014 Jun 14;75(12):929-35. Epub 2013 Sep 14.

School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, University of California San Diego; Center for Academic Research and Training in Anthropogeny; Neuroscience Graduate Program, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.08.007DOI Listing
June 2014

Differential L1 regulation in pluripotent stem cells of humans and apes.

Nature 2013 Nov 23;503(7477):525-529. Epub 2013 Oct 23.

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/nature12686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064720PMC
November 2013

Evolution, development, and plasticity of the human brain: from molecules to bones.

Front Hum Neurosci 2013 Oct 30;7:707. Epub 2013 Oct 30.

Department of Anthropology, University of California at San Diego La Jolla, CA, USA ; Department of Pediatrics/Rady Children's Hospital San Diego Department of Cellular and Molecular Medicine Stem Cell Program, University of California at San Diego, School of Medicine La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fnhum.2013.00707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812990PMC
October 2013

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells.

Stem Cell Res 2013 Sep 16;11(2):743-57. Epub 2013 May 16.

Department of Biology, Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

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http://dx.doi.org/10.1016/j.scr.2013.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979966PMC
September 2013

Efficient generation of human iPSCs by a synthetic self-replicative RNA.

Cell Stem Cell 2013 Aug;13(2):246-54

Department of Cellular & Molecular Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0686, USA.

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http://dx.doi.org/10.1016/j.stem.2013.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845961PMC
August 2013

Feeder-free derivation of induced pluripotent stem cells from human immature dental pulp stem cells.

Cell Transplant 2011 1;20(11-12):1707-19. Epub 2011 Apr 1.

School of Arts, Science and Humanities, Department of Obstetrics, University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.3727/096368911X566235DOI Listing
June 2013

LINE-1 retrotransposition in the nervous system.

Annu Rev Cell Dev Biol 2012 ;28:555-73

Department of Pediatrics/Rady Children's Hospital San Diego, University of California San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1146/annurev-cellbio-101011-155822DOI Listing
March 2013

What makes each brain unique.

Sci Am 2012 Mar;306(3):26-31

Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, Calif., USA.

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http://dx.doi.org/10.1038/scientificamerican0312-26DOI Listing
March 2012

LINE-1: creators of neuronal diversity.

Front Biosci (Elite Ed) 2012 Jan 1;4:1663-8. Epub 2012 Jan 1.

Department of Pediatrics, Rady Children's Hospital San Diego and Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.

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January 2012

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.

Hum Mol Genet 2011 Sep 17;20(18):3642-52. Epub 2011 Jun 17.

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children’s Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, 9500 Gilman Dr, La Jolla, CA 92093, MC 0695, USA.

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http://dx.doi.org/10.1093/hmg/ddr284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159551PMC
September 2011

Maintenance and differentiation of neural stem cells.

Wiley Interdiscip Rev Syst Biol Med 2011 Jan-Feb;3(1):107-14

Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular and Molecular Medicine, University of California San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1002/wsbm.100DOI Listing
March 2011

L1 retrotransposition in neurons is modulated by MeCP2.

Nature 2010 Nov;468(7322):443-6

University of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, La Jolla, California 92093-0695, USA.

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http://dx.doi.org/10.1038/nature09544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059197PMC
November 2010

Gene expression profile of mesenchymal stem cells from paired umbilical cord units: cord is different from blood.

Stem Cell Rev Rep 2009 Dec;5(4):387-401

Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, 106 - Cidade Universitária, 05508-090 São Paulo, SP, Brazil.

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http://link.springer.com/10.1007/s12015-009-9098-5
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http://dx.doi.org/10.1007/s12015-009-9098-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803263PMC
December 2009

Environmental influence on L1 retrotransposons in the adult hippocampus.

Hippocampus 2009 Oct;19(10):1002-7

Department of Pediatrics/Cellular & Molecular Medicine, School of Medicine, UCSD Stem Cell Initiative, University of California, San Diego, 9500 Gilman Drive 0695, California, USA.

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http://doi.wiley.com/10.1002/hipo.20564
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http://dx.doi.org/10.1002/hipo.20564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758700PMC
October 2009

Transcriptional signature and memory retention of human-induced pluripotent stem cells.

PLoS One 2009 Sep 18;4(9):e7076. Epub 2009 Sep 18.

The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0007076PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741600PMC
September 2009

Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.

Cell Stem Cell 2008 Dec;3(6):649-57

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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December 2008

Multiple layers of molecular controls modulate self-renewal and neuronal lineage specification of embryonic stem cells.

Hum Mol Genet 2008 Apr;17(R1):R67-75

Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1093/hmg/ddn065DOI Listing
April 2008

Multipotent stem cells from umbilical cord: cord is richer than blood!

Stem Cells 2008 Jan 11;26(1):146-50. Epub 2007 Oct 11.

Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, Rua do Matão, n. 106, Cidade Universitária, São Paulo, SP, CEP 05508-090, Brazil.

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http://doi.wiley.com/10.1634/stemcells.2007-0381
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January 2008

Mesenchymal stem cells from umbilical cord: do not discard the cord!

Neuromuscul Disord 2008 Jan 21;18(1):17-8. Epub 2007 Dec 21.

Human Genome Research Center, Department of Genetic and Evolutive Biology, University of São Paulo, São Paulo, SP, Brazil.

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January 2008

Identification of small molecules from human embryonic stem cells using metabolomics.

Stem Cells Dev 2007 Dec;16(6):869-82

Department of Animal Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1089/scd.2007.0022DOI Listing
December 2007

Exploring DNA damage responses in human cells with recombinant adenoviral vectors.

Hum Exp Toxicol 2007 Nov;26(11):899-906

Department of Microbiology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil.

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November 2007

The necessary junk: new functions for transposable elements.

Hum Mol Genet 2007 Oct;16 Spec No. 2:R159-67

1-Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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October 2007

Alternative splicing events identified in human embryonic stem cells and neural progenitors.

PLoS Comput Biol 2007 Oct 24;3(10):1951-67. Epub 2007 Aug 24.

Crick-Jacobs Center for Theoretical and Computational Biology, Salk Institute, La Jolla, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2041973PMC
October 2007

LINE-1 retrotransposition in human embryonic stem cells.

Hum Mol Genet 2007 Jul 27;16(13):1569-77. Epub 2007 Apr 27.

Departments of Human Genetics and Internal Medicine, University of Michigan Medical School, 1241 E. Catherine Street, Ann Arbor, MI 48109, USA.

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July 2007

Functional lentiviral vectors for xeroderma pigmentosum gene therapy.

J Biotechnol 2006 Dec 3;126(4):424-30. Epub 2006 Jun 3.

The Salk Institute, Laboratory of Genetics, La Jolla, CA, USA.

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December 2006

Noncoding RNAs in the mammalian central nervous system.

Annu Rev Neurosci 2006 ;29:77-103

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

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September 2006

Generation of neuronal variability and complexity.

Nature 2006 Jun;441(7097):1087-93

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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June 2006

UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts.

Cell Cycle 2006 May 15;5(10):1085-9. Epub 2006 May 15.

The Salk Institute for Biological Studies, La Jolla, California, USA.

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May 2006

Unconventional translation of mammalian LINE-1 retrotransposons.

Genes Dev 2006 Jan;20(2):210-24

Department of Human Genetics and Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0618, USA.

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http://dx.doi.org/10.1101/gad.1380406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1356112PMC
January 2006

Development of functional human embryonic stem cell-derived neurons in mouse brain.

Proc Natl Acad Sci U S A 2005 Dec 13;102(51):18644-8. Epub 2005 Dec 13.

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1317971PMC
December 2005

Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition.

Nature 2005 Jun;435(7044):903-10

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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June 2005

DNA repair proteins affect the lifecycle of herpes simplex virus 1.

Proc Natl Acad Sci U S A 2005 Apr 11;102(16):5844-9. Epub 2005 Apr 11.

Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556126PMC
April 2005

Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice.

Proc Natl Acad Sci U S A 2004 Dec 14;101(51):17759-64. Epub 2004 Dec 14.

Department of Microbiology, Institute of Biomedical Sciences, Universidade de São Paulo, São Paulo 05508-900, SP, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539722PMC
December 2004

Vibrating in the background.

Nat Genet 2003 Nov;35(3):205-7

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November 2003

Low amounts of the DNA repair XPA protein are sufficient to recover UV-resistance.

Carcinogenesis 2002 Jun;23(6):1039-46

Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, SP, Brazil.

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June 2002