Publications by authors named "Alykhan F Shamji"

48Publications

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

ACS Med Chem Lett 2016 Oct 18;7(10):944-949. Epub 2016 Aug 18.

Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts 02142, United States; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States; Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.6b00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066158PMC
October 2016

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Immunity 2015 Oct;43(4):715-26

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00405-7.pdf
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http://www.cell.com/cms/attachment/2038955196/2052729543/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500405
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http://dx.doi.org/10.1016/j.immuni.2015.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672733PMC
October 2015

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.

Proc Natl Acad Sci U S A 2015 Aug 20;112(31):E4281-7. Epub 2015 Jul 20.

Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142; Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1512289112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534235PMC
August 2015

Discovery of a Small-Molecule Probe for V-ATPase Function.

J Am Chem Soc 2015 Apr 20;137(16):5563-8. Epub 2015 Apr 20.

∥Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/jacs.5b02150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416280PMC
April 2015

Small-molecule control of cytokine function: new opportunities for treating immune disorders.

Curr Opin Chem Biol 2014 Dec 15;23:23-30. Epub 2014 Sep 15.

Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087273PMC
http://dx.doi.org/10.1016/j.cbpa.2014.08.013DOI Listing
December 2014

NAMPT is the cellular target of STF-31-like small-molecule probes.

ACS Chem Biol 2014 Oct 7;9(10):2247-54. Epub 2014 Aug 7.

Center for the Science of Therapeutics and ∥Howard Hughes Medical Institute, Broad Institute , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/cb500347pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201331PMC
October 2014

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.

Proc Natl Acad Sci U S A 2014 May 12;111(21):7741-6. Epub 2014 May 12.

Broad Institute, Cambridge, MA 02142;Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114;Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1407001111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040621PMC
May 2014

Regulation of ferroptotic cancer cell death by GPX4.

Cell 2014 Jan;156(1-2):317-331

Department of Biological Sciences, Columbia University, 1208 Northwest Corner Building, 12 Floor, 550 West 120 Street, MC 4846, New York, NY 10027, USA.

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http://dx.doi.org/10.1016/j.cell.2013.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076414PMC
January 2014

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.

Gastroenterology 2013 Dec 21;145(6):1347-57. Epub 2013 Aug 21.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1053/j.gastro.2013.08.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840157PMC
December 2013

Discovery of small-molecule modulators of the Sonic Hedgehog pathway.

J Am Chem Soc 2013 Jul 25;135(26):9675-80. Epub 2013 Jun 25.

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja400034kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703668PMC
July 2013

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.

Proc Natl Acad Sci U S A 2012 Sep 4;109(38):15115-20. Epub 2012 Sep 4.

Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1212802109
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http://dx.doi.org/10.1073/pnas.1212802109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458345PMC
September 2012

Selective killing of cancer cells by a small molecule targeting the stress response to ROS.

Nature 2011 Jul 13;475(7355):231-4. Epub 2011 Jul 13.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Building 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nature10167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316487PMC
July 2011

Rpd3p relocation mediates a transcriptional response to rapamycin in yeast.

Chem Biol 2004 Mar;11(3):295-9

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.chembiol.2004.03.001DOI Listing
March 2004

Integration of growth factor and nutrient signaling: implications for cancer biology.

Mol Cell 2003 Aug;12(2):271-80

Harvard Biophysics Program, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.molcel.2003.08.016DOI Listing
August 2003

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis.

J Am Chem Soc 2003 Jul;125(28):8420-1

Department of Chemistry and Chemical Biology, Harvard Biophysics Program, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja0352698DOI Listing
July 2003

Dissecting glucose signalling with diversity-oriented synthesis and small-molecule microarrays.

Nature 2002 Apr;416(6881):653-7

Howard Hughes Medical Institute, Institute for Chemistry and Cell Biology, Bauer Center for Genomics Research, Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138, USA.

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http://www.nature.com/articles/416653a
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http://dx.doi.org/10.1038/416653aDOI Listing
April 2002