Alvaro Segura

Alvaro Segura

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Alvaro Segura

Alvaro Segura

Publications by authors named "Alvaro Segura"

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Toxicological profile of medically relevant Crotalus species from Mexico and their neutralization by a Crotalus basiliscus/Bothrops asper antivenom.

Toxicon 2020 May 18;179:92-100. Epub 2020 Mar 18.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2020.03.006DOI Listing
May 2020

Venom from Russia: Venomics, Bioactivities and Preclinical Assessment of Microgen Antivenom.

Toxins (Basel) 2019 02 1;11(2). Epub 2019 Feb 1.

Laboratorio de Venómica Evolutiva y Traslacional, CSIC, Jaime Roig 11, 46010 Valencia, Spain.

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http://dx.doi.org/10.3390/toxins11020090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409582PMC
February 2019

Current technology for the industrial manufacture of snake antivenoms.

Toxicon 2018 Sep 28;151:63-73. Epub 2018 Jun 28.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.toxicon.2018.06.084DOI Listing
September 2018

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus.

J Proteomics 2018 06 12;181:104-117. Epub 2018 Apr 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.04.007DOI Listing
June 2018

A synthetic biology approach for consistent production of plant-made recombinant polyclonal antibodies against snake venom toxins.

Plant Biotechnol J 2018 03 22;16(3):727-736. Epub 2017 Sep 22.

Instituto de Biología Molecular y Celular de Plantas (IBMCP), Agencia Estatal Consejo Superior de Investigaciones Científicas, Universidad Politécnica de Valencia, Valencia, Spain.

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http://dx.doi.org/10.1111/pbi.12823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814581PMC
March 2018

An improved technique for the assessment of venom-induced haemorrhage in a murine model.

Toxicon 2017 Dec 9;139:87-93. Epub 2017 Oct 9.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2017.10.005DOI Listing
December 2017

Freeze-dried EchiTAb+ICP antivenom formulated with sucrose is more resistant to thermal stress than the liquid formulation stabilized with sorbitol.

Toxicon 2017 Jul 3;133:123-126. Epub 2017 May 3.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2017.05.006DOI Listing
July 2017

Effect of premedication with subcutaneous adrenaline on the pharmacokinetics and immunogenicity of equine whole IgG antivenom in a rabbit model.

Biomed Pharmacother 2017 Jun 15;90:740-743. Epub 2017 Apr 15.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2017.04.039DOI Listing
June 2017

Proteomics and antivenomics of Papuan black snake (Pseudechis papuanus) venom with analysis of its toxicological profile and the preclinical efficacy of Australian antivenoms.

J Proteomics 2017 01 17;150:201-215. Epub 2016 Sep 17.

Charles Campbell Toxinology Centre, School of Medicine & Health Sciences, University of Papua New Guinea, Boroko, NCD, Papua New Guinea; Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.09.007DOI Listing
January 2017

Expanding the neutralization scope of the EchiTAb-plus-ICP antivenom to include venoms of elapids from Southern Africa.

Toxicon 2017 Jan 24;125:59-64. Epub 2016 Nov 24.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2016.11.259DOI Listing
January 2017

Pathogenesis of dermonecrosis induced by venom of the spitting cobra, Naja nigricollis: An experimental study in mice.

Toxicon 2016 Sep 8;119:171-9. Epub 2016 Jun 8.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2016.06.006DOI Listing
September 2016

Development of a chicken-derived antivenom against the taipan snake (Oxyuranus scutellatus) venom and comparison with an equine antivenom.

Toxicon 2016 Sep 29;120:1-8. Epub 2016 Jun 29.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2016.06.018DOI Listing
September 2016

Lachesis stenophrys venom reduces the equine antibody response towards Bothrops asper venom used as co-immunogen in the production of polyspecific snake antivenom.

Toxicon 2015 Sep 19;103:99-105. Epub 2015 Jun 19.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.06.016DOI Listing
September 2015

Purification of equine whole IgG snake antivenom by using an aqueous two phase system as a primary purification step.

Biologicals 2015 Jan 12;43(1):37-46. Epub 2014 Nov 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biologicals.2014.10.003DOI Listing
January 2015

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.

Am J Trop Med Hyg 2014 Nov 25;91(5):887-94. Epub 2014 Aug 25.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Charles Campbell Toxinology Centre, School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea; Special Laboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Instituto Butantan, Sao Paulo, Brazil; Australian Venom Research Unit, Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, Victoria, Australia

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.14-0333
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http://dx.doi.org/10.4269/ajtmh.14-0333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228881PMC
November 2014

Toxicity of Bothrops sp snake venoms from Ecuador and preclinical assessment of the neutralizing efficacy of a polyspecific antivenom from Costa Rica.

Toxicon 2014 Sep 17;88:34-7. Epub 2014 Jun 17.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2014.06.008DOI Listing
September 2014

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms.

Toxicon 2013 Dec 20;76:63-76. Epub 2013 Sep 20.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2013.09.010DOI Listing
December 2013

Role of the animal model on the pharmacokinetics of equine-derived antivenoms.

Toxicon 2013 Aug 1;70:9-14. Epub 2013 Apr 1.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.toxicon.2013.03.013DOI Listing
August 2013

Assessing the preclinical efficacy of antivenoms: from the lethality neutralization assay to antivenomics.

Toxicon 2013 Jul 29;69:168-79. Epub 2012 Nov 29.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.toxicon.2012.11.016DOI Listing
July 2013

Assessment of snake antivenom purity by comparing physicochemical and immunochemical methods.

Biologicals 2013 Mar 26;41(2):93-7. Epub 2012 Nov 26.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biologicals.2012.11.001DOI Listing
March 2013

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation.

Biotechnol Prog 2012 Jul 22;28(4):1005-11. Epub 2012 Jun 22.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1002/btpr.1565DOI Listing
July 2012

Low pH formulation of whole IgG antivenom: impact on quality, safety, neutralizing potency and viral inactivation.

Biologicals 2012 Mar 21;40(2):129-33. Epub 2012 Jan 21.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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https://linkinghub.elsevier.com/retrieve/pii/S10451056110019
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http://dx.doi.org/10.1016/j.biologicals.2011.11.006DOI Listing
March 2012

Immune response towards snake venoms.

Inflamm Allergy Drug Targets 2011 Oct;10(5):381-98

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.2174/187152811797200605DOI Listing
October 2011

Intravenous administration of equine-derived whole IgG antivenom does not induce early adverse reactions in non-envenomed horses and cows.

Biologicals 2010 Nov 15;38(6):664-9. Epub 2010 Sep 15.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biologicals.2010.08.002DOI Listing
November 2010

Study of the design and analytical properties of the lethality neutralization assay used to estimate antivenom potency against Bothrops asper snake venom.

Biologicals 2010 Sep 16;38(5):577-85. Epub 2010 Jul 16.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biologicals.2010.05.006DOI Listing
September 2010

Neutralization of Bothrops mattogrossensis snake venom from Bolivia: experimental evaluation of llama and donkey antivenoms produced by caprylic acid precipitation.

Toxicon 2010 Feb-Mar;55(2-3):642-5. Epub 2009 Aug 5.

Laboratorio de Producción de Antiveninas, Instituto Nacional de Laboratorios de Salud, La Paz, Bolivia.

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http://dx.doi.org/10.1016/j.toxicon.2009.07.031DOI Listing
April 2010

Assessment of the impact of solvent/detergent treatment on the quality and potency of a whole IgG equine antivenom.

Biologicals 2009 Oct 21;37(5):306-12. Epub 2009 Jun 21.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biologicals.2009.05.003DOI Listing
October 2009