Publications


Effects of Exercise on the Immune Function of Pediatric Patients With Solid Tumors: Insights From the PAPEC Randomized Trial.
Am J Phys Med Rehabil 2017 Nov;96(11):831-837
From the Research Institute of the Hospital '12 de Octubre' (i+12), Madrid, Spain (CF-L, ES-S, AS-L, FS-G, HP-G, A. Lucia); Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, Spain (CF-L); European University, Madrid, Spain (JRP, ES-S, HP-G, JSM, MP, A. Lucia); Innate Immune Research Group, IdiPAZ, Madrid, Spain (JV); i+HeALTH Department of Health Sciences, European University Miguel de Cervantes, Valladolid, Spain (AS-L); Department of Physiology, Faculty of Medicine, University of Valencia and Fundación de Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain (FS-G); Andrews Research and Education Foundation, Gulf Breeze, Florida (SJF); Department of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital Niño Jesús, Madrid, Spain (A. Lassaletta); Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, Porto, Portugal (LS-M); and Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, University Hospital La Paz, Madrid, Spain (AP-M).

Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
Cancer Med 2017 Nov 4;6(11):2606-2624. Epub 2017 Oct 4.
CNIO-HNJ Clinical Research Unit, Pediatric Oncology, Hematology and Stem Cell Transplant Department, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo, 65, 28009, Madrid, Spain.


Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas.
J Clin Oncol 2017 Sep 20;35(25):2934-2941. Epub 2017 Jul 20.
Alvaro Lassaletta, Michal Zapotocky, Matthew Mistry, Vijay Ramaswamy, Marion Honnorat, Rahul Krishnatry, Ana Guerreiro Stucklin, Nataliya Zhukova, Anthony Arnoldo, Scott Ryall, Catriona Ling, Tara McKeown, Jim Loukides, James T. Rutka, Peter Dirks, Michael D. Taylor, Shiyi Chen, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, and Uri Tabori, The Hospital for Sick Children, Toronto; Adam Fleming, McMaster Children's Hospital, McMaster University, Hamilton; Shayna Zelcer, Children's Hospital of Western Ontario, London, Ontario; David Eisenstat and Bev Wilson, Stollery Children's Hospital, University of Alberta, Edmonton, Alberta; Anne Sophie Carret, Hospital Sainte Justine; Nada Jabado, McGill University, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec City, Quebec, Canada; Ofelia Cruz and Carmen de Torres, Hospital Sant Joan de Déu, Barcelona, Spain; Cheng-Ying Ho, University of Maryland School of Medicine, Baltimore, MD; Roger J. Packer, Children's National Health System, Washington, DC; Ruth Tatevossian, Ibrahim Qaddoumi, Julie H. Harreld, James D. Dalton, and David W. Ellison, St Jude Children's Research Hospital, Memphis, TN; Jean Mulcahy-Levy and Nicholas Foreman, Children's Hospital Colorado, Aurora, CO; Matthias A. Karajannis, Shiyang Wang, and Matija Snuderl, New York University Langone Medical Center, New York, NY; Amulya Nageswara Rao and Caterina Giannini, The Mayo Clinic, Rochester, MN; Mark Kieran and Keith L. Ligon, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, MA; Maria Luisa Garre, Paolo Nozza, Samantha Mascelli, and Alessandro Raso, Istituto Giannina Gaslini, Genoa, Italy; Sabine Mueller and Theodore Nicolaides, University of California, San Francisco, San Francisco, CA; Karen Silva and Romain Perbet, Hospices Civils de Lyon; Alexandre Vasiljevic, Cécile Faure Conter, and Didier Frappaz, Institute of Pediatric Hematology and Oncology, Lyon, France; Sarah Leary and Courtney Crane, Seattle Children's Hospital, Seattle, WA; Aden Chan and Ho-Keung Ng, The Chinese University of Hong Kong, Hong Kong; Zhi-Feng Shi and Ying Mao, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Elizabeth Finch, University of North Carolina, School of Medicine, Chapel Hill, NC; Peter Hauser, Semmelweis University, Budapest, Hungary; and David Sumerauer and Lenka Krskova, University Hospital Motol, Charles University, 2nd Medical School, Prague, Czech Republic.

Multiplex Detection of Pediatric Low-Grade Glioma Signature Fusion Transcripts and Duplications Using the NanoString nCounter System.
J Neuropathol Exp Neurol 2017 Jul;76(7):562-570
Department of Cancer and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Divisions of Pathology and Genome Diagnostics, Department of Paediatric Laboratory Medicine; and Division of Hematology and Oncology, The Division of Hematology and Oncology should be followed by Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada. Hospital for Sick Children, Toronto, Ontario, Canada; Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai, India; and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

Intertumoral Heterogeneity within Medulloblastoma Subgroups.
Cancer Cell 2017 Jun;31(6):737-754.e6
The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:


An Adolescent Presenting With Seizures as a Symptom of Gliomatosis Cerebri.
Pediatr Emerg Care 2017 May 8. Epub 2017 May 8.
From the *Pediatric Intensive Care Unit and Departments of †Radiology, ‡Pathology, §Pediatric Oncology and Hematology, and ∥Pediatric Neurosurgery, and ¶Pediatric Intensive Care Unit, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.

Exercise Intervention in Pediatric Patients with Solid Tumors: The Physical Activity in Pediatric Cancer Trial.
Med Sci Sports Exerc 2017 Feb;49(2):223-230
1Research Institute of the Hospital '12 de Octubre' (i + 12), Madrid, SPAIN; 2Spanish Network for Biomedical Research in Rare Diseases (CIBERER), U723, SPAIN; 3School of Doctorate Studies and Research, European University, Madrid, SPAIN; 4Research Centre in Physical Activity, Health and Leisure, Faculty of Sport, University of Porto, PORTUGAL; 5Innate Immune Research Group, IdiPAZ, Madrid, SPAIN; 6Department of Health Sciences, GIDFYS, European University Miguel de Cervantes, Valladolid, SPAIN; 7Department of Hematology-Oncology and Stem Cell Transplantation, Children's Hospital Niño Jesús, Madrid, SPAIN; 8Andrews Research and Education Foundation, Gulf Breeze, FL; and 9Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, University Hospital La Paz, Madrid, SPAIN.


Phase II Weekly Vinblastine for Chemotherapy-Naïve Children With Progressive Low-Grade Glioma: A Canadian Pediatric Brain Tumor Consortium Study.
J Clin Oncol 2016 Oct;34(29):3537-3543
Alvaro Lassaletta, Cynthia E. Hawkins, Rahul Krishnatry, Matthew Mistry, Anthony Arnoldo, Vijay Ramaswamy, Annie Huang, Ute Bartels, Uri Tabori, and Eric Bouffet, The Hospital for Sick Children, Toronto; Katrin Scheinemann, McMaster Children's Hospital; Shayna M. Zelcer, Children's Hospital of Western Ontario, London; Gregory Russell Pond, Ontario Clinical Oncology Group, McMaster University, Hamilton; Daniel Keene and Donna L. Johnston, Children's Hospital of Eastern Ontario, Ottawa, Ontario; Juliette Hukin and Ken Poskitt, British Columbia Children's Hospital, Vancouver, British Columbia; Beverley A. Wilson, University of Alberta Hospital; Lucie Lafay-Cousin, Alberta Children's Hospital, Calgary; David D. Eisenstat, Stollery Children's Hospital, Edmonton; Alberta; Nada Jabado, McGill University; Anne Sophie Carret, Hospital Sainte Justine, Montreal; Valerie Larouche, Centre Hospitalier Universitaire de Québec, Québec, Québec; and David D. Eisenstat, Cancer Care Manitoba, Winnipeg, Manitoba, Canada.


Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
J Clin Oncol 2016 Jul 6;34(21):2468-77. Epub 2016 Jun 6.
Vijay Ramaswamy, Stephen C. Mack, Alvaro Lassaletta, Betty Luu, Florence M.G. Cavalli, Uri Tabori, Ute Bartels, Eric Bouffet, Cynthia E. Hawkins, James T. Rutka, Peter Dirks, and Michael D. Taylor, The Hospital for Sick Children; Vijay Ramaswamy, Kenneth Aldape, James T. Rutka, and Michael D. Taylor, University of Toronto; Kenneth Aldape, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario; Christopher Dunham and Juliette Hukin, British Columbia Children's Hospital; Juliette Hukin, University of British Columbia, Vancouver, British Columbia; David D. Eisenstat, Dorcas Fulton, and Frank K.H. van Landeghem, University of Alberta, Edmonton; Jennifer A. Chan, University of Calgary, Calgary, Alberta; Nada Jabado and Kevin Petrecca, McGill University, Montreal, Quebec, Canada; Thomas Hielscher, Kristian W. Pajtler, David T.W. Jones, Marcel Kool, Stefan M. Pfister, and Andrey Korshunov, German Cancer Research Center; Stefan M. Pfister, University Hospital Heidelberg, Heidelberg; Marc Remke, University Hospital Düsseldorf, Düsseldorf; Martin Mynarek, Stefan Rutkowski, and Katja von Hoff, University Medical Center Hamburg-Eppendorf, Hamburg; Ulrich Schüller, Ludwig-Maximilians-Universität, Munich, Germany; Stephen C. Mack, Cleveland Clinic Foundation, Cleveland; Maryam Fouladi, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Tong Lin, Amar Gajjar, Thomas E. Merchant, and David W. Ellison, St Jude Children's Research Hospital, Memphis; Lola B. Chambless, Vanderbilt Medical Center, Nashville, TN; Sridharan Gururangan, Roger E. McLendon, and Eric S. Lipp, Duke University, Durham; Jing Wu, University of North Carolina at Chapel Hill, Chapel Hill, NC; Mariarita Santi, Children's Hospital of Philadelphia; Lyndsey Emery, Hospital of the University of Pennsylvania, Philadelphia; Ronald L. Hamilton and Ian F. Pollack, University of Pittsburgh School of Medicine; Frank Lieberman, University of Pittsburgh Medical Cen


No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients.
Hum Genet 2016 May 11;135(5):469-75. Epub 2016 Mar 11.
Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.
Lancet Oncol 2016 Apr 12;17(4):484-95. Epub 2016 Mar 12.
Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Electronic address:

Influence of carrier cells on the clinical outcome of children with neuroblastoma treated with high dose of oncolytic adenovirus delivered in mesenchymal stem cells.
Cancer Lett 2016 Feb 3;371(2):161-70. Epub 2015 Dec 3.
Instituto de Investigación Sanitaria La Princesa, Madrid, Spain; Oncohematología, Hospital Universitario Niño Jesús, Madrid, Spain. Electronic address:

Chemokines and relapses in childhood acute lymphoblastic leukemia: A role in migration and in resistance to antileukemic drugs.
Blood Cells Mol Dis 2015 Oct 2;55(3):220-7. Epub 2015 Jul 2.
Servicio de Oncohematología, Hospital Universitario Niño Jesús, Madrid, Spain. Electronic address:

Building a National Pediatric Cancer Center and Network in Paraguay: Lessons for Addressing Challenges in a Low-income Country.
J Pediatr Hematol Oncol 2015 Jul;37(5):383-90
*Hospital de Clínicas, Facultad de Medicina, Universidad Nacional de Asunción, Asunción, Paraguay †Hospital Niño Jesús, Madrid, Spain ‡School of Public Health, The University of Memphis §Department of Oncology ∥International Outreach Program #Department of Infectious Diseases, St. Jude Children's Research Hospital **Department of Pediatrics, University of Tennessee Health Science Center, College of Medicine, Memphis, TN ¶Department of Pediatrics, Center of Biostatistics, University of Milan-Bicocca, San Gerardo Hospital, Monza, Italy.

Cunninghamella bertholletiae infection in children: review and report of 2 cases with disseminated infection.
J Pediatr Hematol Oncol 2014 Mar;36(2):e109-14
*Pediatric Hematology-Oncology Unit †Pediatric Intensive Care Unit §Hematopoietic Transplant Unit, Niño Jesús Children's Hospital ‡Mycology Reference Laboratory, National Centre of Microbiology Carlos III, Madrid, Spain.




High-dose busulfan and melphalan as conditioning regimen for autologous peripheral blood progenitor cell transplantation in high-risk neuroblastoma patients.
Pediatr Hematol Oncol 2011 Mar;28(2):115-23
Division of Pediatric Hematology-Oncology and Hematopoietic Stem Cell Transplantation, Hospital Infantil Universitario Nino Jesus, Madrid, Spain.

High-dose busulfan and melphalan as conditioning regimen for autologous peripheral blood progenitor cell transplantation in high-risk ewing sarcoma patients: a long-term follow-up single-center study.
Pediatr Hematol Oncol 2010 May;27(4):272-82
Department of Pediatrics, Division of Pediatric Hematology-Oncology and Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Hospital Infantil Universitario Niño Jesus, Madrid, Spain.

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene.
J Exp Med 2009 Dec 7;206(13):3131-41. Epub 2009 Dec 7.
Andalusian Stem Cell Bank, Centro de Investigación Biomédica, Consejería de Salud-Universidad de Granada, 18100 Granada, Spain.


Allogeneic cord blood transplantation in children with hematological malignancies: a long-term follow-up single-center study.
Pediatr Hematol Oncol 2009 Jun;26(4):165-74
Department of Pediatrics, Division of Pediatric Hematology-Oncology and Hematopoietic Stem Cell Transplantation and Cell Therapy Unit, Hospital Infantil Universitario Niño Jesus, Madrid, Spain.



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