Publications by authors named "Althea Goosen"

17Publications

Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?

Circ Cardiovasc Genet 2016 Aug;9(4):330-9

From the Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan (L.C., C.S., P.J.S.); Department of Molecular Medicine (L.C.) and Department of Public Health (M.C.M., C.M.), Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia; Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital IRCCS Istituto Auxologico Italiano, Milan, Italy (L.C., G.P.); Department of Medicine, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland (A.M.L., K.K.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (E.M., P.L., T.M.); Department of Medicine and Surgery University of Milano-Bicocca, Milan, Italy (G.P.); Department of Internal Medicine, University of Stellenbosch, South Africa (M.H., A.G., P.A.B.); Institute of Human Genetics, Technische Universität München (T.M.); DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany (T.M.); and Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland (H.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.116.001419DOI Listing
August 2016

Diagnostic disparity and identification of two TNNI3 gene mutations, one novel and one arising de novo, in South African patients with restrictive cardiomyopathy and focal ventricular hypertrophy.

Cardiovasc J Afr 2015 Mar-Apr;26(2):63-9

SA MRC Centre for Tuberculosis Research, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2015-019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815569PMC
February 2016

Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1.

J Am Coll Cardiol 2015 Feb;65(4):367-374

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312415PMC
February 2015

AKAP9 is a genetic modifier of congenital long-QT syndrome type 1.

Circ Cardiovasc Genet 2014 Oct 2;7(5):599-606. Epub 2014 Aug 2.

From the Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Medical Research Council (MRC) Centre for Molecular and Cellular Biology, (C.P.d.V., L.v.d.M., J.C.M.-S., V.A.C.), and Department of Internal Medicine (A.G., P.A.B.), Stellenbosch University, Stellenbosch, South Africa; Department of Statistics, University of Western Cape, Bellville, South Africa (L.v.d.M.); IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (L.C., P.J.S.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (L.C.); and Departments of Medicine and Pharmacology, and Institute for Integrative Genomics, Vanderbilt University, Nashville, TN (A.L.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270884PMC
October 2014

Long QT syndrome in South Africa: the results of comprehensive genetic screening.

Cardiovasc J Afr 2013 Jul;24(6):231-7

US/MRC Centre for Molecular and Cellular Biology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5830/CVJA-2013-032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772322PMC
July 2013

Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure.

J Renin Angiotensin Aldosterone Syst 2011 Sep 16;12(3):274-80. Epub 2010 Dec 16.

MRC Centre for Molecular and Cellular Biology, Department of Biomedical Sciences, University of Stellenbosch Health Sciences Faculty, Tygerberg, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1470320310390725DOI Listing
September 2011

Does pregnancy increase cardiac risk for LQT1 patients with the KCNQ1-A341V mutation?

J Am Coll Cardiol 2006 Oct 14;48(7):1410-5. Epub 2006 Sep 14.

Department of Internal Medicine, University of Stellenbosch, Stellenbosch, South Africa.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2006.05.060DOI Listing
October 2006