Publications by authors named "Alonso Arroyo"

87 Publications

Worldwide production on sleep apnea from 2009-2018. Analysis of the ability to secure funding and international collaboration networks.

Respir Med 2021 May 28;185:106486. Epub 2021 May 28.

Unidad de Información e Investigación Social y Sanitaria (UISYS). Universitat de València, Valencia, Spain; Instituto de Gestión de La Innovación y Del Conocimiento-Ingenio (CSIC-Universitat Politècnica de València), Valencia, Spain.

Background: Obstructive sleep apnea (OSA) is an emerging health problem, but information on scientific production in this subject area is scarce. We aim to evaluate the scientific production on OSA from 2009 to 2018 to illustrate its worldwide distribution, topic areas, and ability to secure funding, as well as to describe international collaboration networks in this field.

Methods: Articles published between 2009 and 2018 were extracted from the Science Citation Index Expanded via Web of Science (WoS) using the search term "obstructive sleep apn*". Publication year, number and country of authors, journal, subject category, key words, funding source and number of citations received were recorded. We also conducted network analyses for key words and international collaboration.

Results: 12,666 articles on OSA were located, which had increased from 895 documents in 2009 to 1592 in 2018. The progressive growth in scientific production on OSA had outpaced the growth rate of total WoS production since 2012.50% of the articles declared some type of funding, with a citation index higher than manuscripts that were not funded. The manuscripts were distributed in journals from 135 subject categories of the WoS, and keyword distribution showed a dispersed pattern with a high number of nodes. The international collaboration rate was 18.2%, and the country network showed the United States as the hegemonic node.

Conclusion: World production on OSA has grown at a higher rate than global production and shows notable thematic dispersion as well as a high ability to secure funding, which increases its impact.
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http://dx.doi.org/10.1016/j.rmed.2021.106486DOI Listing
May 2021

Smoker, Former Smoker and COVID-19: Nicotine Does Not Protect Against SARS-CoV-2.

Arch Bronconeumol (Engl Ed) 2021 Mar 16. Epub 2021 Mar 16.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1016/j.arbr.2021.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7962544PMC
March 2021

Interatrial septal tachycardias following atrial fibrillation ablation or cardiac surgery: Electrophysiological features and ablation outcomes.

Heart Rhythm 2021 May 11. Epub 2021 May 11.

Electrophysiology Section, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Background: Interatrial septal tachycardias (IAS-ATs) following atrial fibrillation (AF) ablation or cardiac surgery are rare, and their management is challenging.

Objective: The purpose of this study was to investigate the electrophysiological features and outcomes associated with catheter ablation of IAS-AT.

Methods: We screened 338 patients undergoing catheter ablation of ATs following AF ablation or cardiac surgery. Diagnosis of IAS-AT was based on activation mapping and analysis of response to atrial overdrive pacing.

Results: Twenty-nine patients (9%) had IAS-AT (cycle length [CL] 311 ± 104 ms); 16 (55%) had prior AF ablation procedures (median 3; range 1-5), 3 (10%) had prior surgical maze, and 12 (41%) had prior cardiac surgery (including atrial septal defect surgical repair in 5 and left atrial myxoma resection in 1). IAS substrate abnormalities were documented in all patients. Activation mapping always demonstrated a diffuse early IAS breakout with centrifugal biatrial activation, and atrial overdrive pacing showed a good postpacing interval (equal or within 25 ms of the AT CL) only at 1 or 2 anatomically opposite IAS sites in all cases. Ablation was acutely successful in 27 patients (93%) (from only the right IAS in 2, only the left IAS in 9, both IAS sides with sequential ablation in 13, and both IAS sides with bipolar ablation in 3). After median follow-up of 15 (6-52) months, 17 patients (59%) remained free from recurrent arrhythmias.

Conclusion: IAS-ATs are rare and typically occur in patients with evidence of IAS substrate abnormalities and prior cardiac surgery. Catheter ablation can be challenging and may require sequential unipolar ablation or bipolar ablation.
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http://dx.doi.org/10.1016/j.hrthm.2021.04.036DOI Listing
May 2021

The sharing of research data facing the COVID-19 pandemic.

Scientometrics 2021 Apr 26:1-16. Epub 2021 Apr 26.

UISYS, Joint Research Unit CSIC-University of Valencia, Pza. Cisneros 4, 46003 Valencia, Spain.

During the previous Ebola and Zika outbreaks, researchers shared their data, allowing many published epidemiological studies to be produced only from open research data, to speed up investigations and control of these infections. This study aims to evaluate the dissemination of the COVID-19 research data underlying scientific publications. Analysis of COVID-19 publications from December 1, 2019, to April 30, 2020, was conducted through the PubMed Central repository to evaluate the research data available through its publication as supplementary material or deposited in repositories. The PubMed Central search generated 5,905 records, of which 804 papers included complementary research data, especially as supplementary material (77.4%). The most productive journals were , and , the most frequent keyword was pneumonia, and the most used repositories were GitHub and GenBank. An expected growth in the number of published articles following the course of the pandemics is confirmed in this work, while the underlying research data are only 13.6%. It can be deduced that data sharing is not a common practice, even in health emergencies, such as the present one. High-impact generalist journals have accounted for a large share of global publishing. The topics most often covered are related to epidemiological and public health concepts, genetics, virology and respiratory diseases, such as pneumonia. However, it is essential to interpret these data with caution following the evolution of publications and their funding in the coming months.
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http://dx.doi.org/10.1007/s11192-021-03971-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072296PMC
April 2021

Carotid glomus in childhood: presentation of a clinical case.

Cir Pediatr 2021 Apr 1;34(2):90-94. Epub 2021 Apr 1.

Pediatric Surgery Department. Valladolid Clinical Hospital (Spain).

Introduction: Carotid glomus is an exceptional extra-adrenal paraganglioma in childhood originating at the carotid body. Only 3% of paragangliomas occur in the head and the neck. Familial forms, associated with Succinate Dehydrogenase (SDH) gene mutations, account for 10% of cases, the proportion being higher in childhood. They are benign in 95% of patients, but they can extend to both carotids. Treatment is surgical with or without previous embolization. Metastasis is rare and associated with malignant cases, which are limited.

Clinical Case: 8-year-old patient with a cervical mass originating 4 months ago and normal serum levels. Regarding family history, she had an aunt who underwent cervical surgery. Ultrasound examination demonstrated a greatly vascularized hypoechoic mass most likely related to carotid glomus. Full surgical resection without embolization was decided upon, which proved uneventful. The genetic study was positive for SDH gene mutation.

Conclusion: Carotid glomus in childhood should be considered as a differential diagnosis in cervical masses. Surgical treatment without previous embolization represents a safe therapeutic option in selected cases.
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April 2021

Financed research from Government Delegation grants for the National Plan on Drugs: research assessment and scientific impact.

Adicciones 2021 Mar 11;0(0):1550. Epub 2021 Mar 11.

CSIC-Universitat de València. CSIC-Universitat Politècnica de València.

Addictive disorders are a serious health problem to which large amounts of research resources are devoted. This study aims to analyze the evolution and scientific impact of the publications derived from the funding of research projects by the Spanish National Plan on Drugs (PNSD). The list of grants awarded was provided by the PNSD. Derived publications were obtained by asking the principal investigators of the grants and searching in the Web of Science and Scopus. Bibliometric indicators and evolutive trends of scientific production per project were calculated. On average, the PNSD conferred 15 annual grants to research projects, with an annual amount close to one million euros (€944,200.64) and an average amount per grant of just over €60,000, being higher in basic research and in alcohol. 71,9% of the grants had derived publications and almost half of them produced between one and three publications, with basic research being the most prolific. The international journal in which most articles were published was Psychopharmacology (50) and among Spanish journals, Adicciones stood out (28). A high level of co-authorship and international collaboration was identified. Most of the PNSD-funded projects produced research articles, many of them in journals belonging to the first and second quartiles of the Journal Citation Reports. The results of this study have revealed the scientific impact of the PNSD research projects funding and may contribute to determining future funding priorities.
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http://dx.doi.org/10.20882/adicciones.1550DOI Listing
March 2021

Reply to "Smoker, Former Smoker and COVID-19".

Arch Bronconeumol 2021 Apr 25;57 Suppl 2:67-68. Epub 2021 Jan 25.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2021.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830217PMC
April 2021

Trend in Spanish cardiology research and global comparative analysis of major topics.

Rev Esp Cardiol (Engl Ed) 2020 Dec 31. Epub 2020 Dec 31.

Unidad de Investigación e Información Social y Sanitaria (UISYS), Universitat de València, Valencia, Spain; INGENIO, CSIC-Universitat Politècnica de València, Valencia, Spain.

Introduction And Objectives: We used bibliometric techniques to analyze the participation of Spanish institutions in research on major cardiovascular topics during the last 4 decades.

Methods: Bibliometric indicators of production, collaboration and impact were obtained from the Science Citation Index Expanded (SCIE) database. Search strategies were used in major topics and institutional collaboration networks were identified, represented using the Kamada-Kawai algorithm.

Results: Global cardiovascular publications doubled from 2000 to 2018. In 2018, those by Spanish authors represented 2.33%, with a participation of between 7% and 1.84%, depending on the topics analyzed. The offset with respect to global production was between 0 and 7 years. Annual growth rates were higher in more recent topics. Revista Española de Cardiología published the largest number of articles from Spanish institutions. The journals generating the highest number of citations in the chosen topics were the Journal of the American College of Cardiology, Europace, and the European Heart Journal. Analysis of collaboration revealed a close interrelation between Spanish and foreign institutions, as well as groups with high production publishing independently.

Conclusions: The analysis disaggregated by subject showed the sustained growth of Spanish cardiovascular scientific production and more rapid growth in recently appearing topics. Collaboration networks showed a high degree of interrelation between Spanish and foreign institutions, including hospitals, universities, research institutes, and scientific societies.
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http://dx.doi.org/10.1016/j.rec.2020.12.001DOI Listing
December 2020

Gender inequalities on editorial boards of indexed pediatrics journals.

Pediatr Res 2020 Nov 25. Epub 2020 Nov 25.

UISYS, Unidad Mixta de Investigación, Universitat de València, Valencia, Spain.

Background: The presence of women in decision-making positions, such as on editorial committees of biomedical journals, is not the same as that of men. This paper analyzes the gender composition of editorial committees (EBMs) and editors-in-chief (ECs) positions of pediatric journals.

Methods: The gender of EBMs and ECs of 125 journals classified in the pediatrics area of the Journal Citation Report (JCR) was analyzed. The following indicators were calculated: gender distribution of ECs and EBMs by journal, publisher, subject speciality, country, quartile of the journal in JCR and country of affiliation of the members.

Results: The total number of EBMs was 4242. The distribution by sex of the ECs was 19.44% women and 80.56% men, while that of the EBMs were 33.05% women and 66.95% men. Twenty journals exhibited a greater representation of women than of men, and in four there was parity. Journals with greater participation of women specialized in nursing and physical therapy and were related to nutrition (lactation and breastfeeding).

Conclusions: Only one-fifth of ECs and one-third of EBMs are females. Women's participation is higher in journals related to nursing, physical and occupational therapy, and nutrition. The United States has the highest number of EBMs, followed by the European Union.

Impact: Only one-fifth of Editors-in-chief in pediatrics journals are female. Only one-third of Editorial Board Members in pediatrics journals are female. Women's participation is higher in editorials committees in pediatrics journals related to nursing, physical and occupational therapy, and nutrition. Medical and pediatric associations and societies must work together to eliminate the disparities that exist between women and men. Achieving gender equity and empowering all women is one of the World Health Organization's Sustainable Development Goals.
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http://dx.doi.org/10.1038/s41390-020-01286-5DOI Listing
November 2020

COVID-19 and Smoking: A Systematic Review and Meta-Analysis of the Evidence.

Arch Bronconeumol 2021 Jan 25;57 Suppl 1:21-34. Epub 2020 Jul 25.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España. Electronic address:

Objective: The aim of this study was to determine if tobacco use in patients with Covid-19 is associated with a negative disease course and adverse outcome, and if smoking, current and past, is associated with a greater possibility of developing COVID-19.

Material And Methods: A systematic review (SR) and meta-analysis (MA) of previously published works were performed. The search strategy included all known descriptors for Covid-19 and tobacco and was conducted in different databases. Appropriate statistical models were used to address the effect size in meta-analysis, namely random effects and fixed effects model.

Results: Thirty-four articles were identified in the SR of which 19 were included in the MA. Being a smoker or former smoker was shown to be a risk factor for worse progression of Covid-19 infection (OR 1.96, 95% CI, 1.36 - 2.83) and a greater probability of presenting a more critical condition (OR 1.79 95% CI, 1.19 - 2.70). As limitations of the MA, we found that most of the studies analyzed were observational with limited publication bias. Two studies that disagreed with the rest were included, although after withdrawing them from the MA, smoking was maintained as a risk factor for worse progress.

Conclusion: Current and past smoking produces a more serious clinical form of Covid-19 and more frequently leads to intensive care admission, intubation, and death.
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http://dx.doi.org/10.1016/j.arbres.2020.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381922PMC
January 2021

Preduodenal Portal Vein Associated With Intestinal Malrotation as a Possible Cause of Intermittent Acholia.

J Pediatr Gastroenterol Nutr 2021 01;72(1):e21

Chief of the Pediatric Surgery Department, Hospital Clínico Universitario de, Valladolid, Valladolid, Spain.

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http://dx.doi.org/10.1097/MPG.0000000000002889DOI Listing
January 2021

Transhepatic right vein access for radiofrequency ablation of atrioventricular nodal reentry tachycardia in a patient with infrarenal vena cava agenesis.

J Interv Card Electrophysiol 2021 Jan 12;60(1):159-160. Epub 2020 Jul 12.

Electrophysiologist of International Arrhythmia Center, Cardioinfantil Foundation, Bogotá, Colombia.

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http://dx.doi.org/10.1007/s10840-020-00820-zDOI Listing
January 2021

Gender Differences in Original Archivos de Bronconeumología Publications, 2001-2018.

Arch Bronconeumol (Engl Ed) 2021 Feb 9;57(2):107-114. Epub 2020 Jun 9.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, España.

Introduction: Gender inequality exists in scientific publications. The aim of this study was to determine changing patterns in gender differences and factors associated with the positioning of authors' names in original articles published in Archivos de Bronconeumología (AB).

Methods: We performed a bibliometric study of articles published in AB between 2001 and 2018. Author gender was analysed in four scenarios: first author, last author, middle authors, and mentee authors. Comparisons were made by authors' specialties, funding received, multicentre studies, specialist areas, and others. Multivariate models adjusted for the percentage of registered physicians in the Spanish health system were created to predict the female gender of the first, middle, and last author.

Results: A total of 828 publications were analysed in which women appeared as first authors in 286 (34.5%) and last authors in 169 (20.4%). A gradual increase in women as first authors was observed (P = .0001), but not as last authors (P = .570). Overall, the average number of female authors increased over time (from 1.6 ± 1.4 in 2001-2005 to 3.3 ± 2.3 in 2016-2018, P = .0001), with no differences in male averages. The adjusted multivariate models reflected a positive bi-directional relationship between the first author and the middle authors, and a negative association between the first author being Spanish and the last author being female (OR 0.57; 95% CI 0.36-0.88, P = .012).

Conclusions: Gender differences were found in various aspects of authorship in AB, summarized by a greater participation of women as first and intermediate authors, but not as last authors.
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http://dx.doi.org/10.1016/j.arbres.2020.04.020DOI Listing
February 2021

Inferior approach instead of standard "pull-down" technique for transseptal puncture in difficult anatomy.

J Interv Card Electrophysiol 2020 Sep 12;58(3):363-364. Epub 2020 May 12.

Electrophysiologist of International Arrhythmia Center, Cardioinfantil Foundation, Bogota, Colombia.

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http://dx.doi.org/10.1007/s10840-020-00750-wDOI Listing
September 2020

[Scientific impact and bibliometric contextualisation of Paediatrics compared to other specialities].

An Pediatr (Engl Ed) 2020 Mar 14;92(3):172.e1-172.e12. Epub 2020 Feb 14.

UISYS, Unidad Mixta de Investigación, Universitat de València-CSIC, Valencia, España; Instituto de Gestión de la Innovación y del Conocimiento-Ingenio (CSIC-Universitat Politècnica de València), Valencia, España. Electronic address:

Introduction: The purpose of this paper is twofold. On the one hand, to identify and characterise the production, citation, impact and collaboration indicators of the Pediatrics area of the Journal Citation Reports, and on the other hand, to place the journal Anales de Pediatría in the context of the Spanish journals of another twenty areas and medical specialties.

Material And Method: The sources of information used to obtain the indicators were Science Citation Index-Expanded, Journal Citation Reports, and Scimago Journal & Country Rank. A regression analysis was performed to determine the correlation between the citation and other variables.

Results: Pediatrics ranked 8th in scientific production during the period 2009-2018. In citations per journal it ranks 17th, and the average citations per article approaches 27, occupying, in this case, the 18th position. Below Pediatrics are Emergency Medicine, Rehabilitation, and Primary Health Care. There are no citations for 12.47% of the articles. The average impact factor places the area in 18th place and its h index was 197, reaching 14th position, and standing above seven other areas. The percentage of works carried out with international collaboration was 17.71%, above Primary Health Care (12.88%), Oncology (16.37%), and Emergency Medicine (17.03%). Among the Spanish journals, Anales de Pediatría was the fourth most productive journal, and occupied an intermediate position in terms of the number of citations.

Conclusions: The indicators of citation and impact of the Pediatrics area tend to be above areas such as Emergency Medicine, Primary Health Care, Dentistry, Oral Surgery & Medicine, and Rehabilitation. Professional practice outside large hospitals, together with poor funding, as well as the low number of clinical trials due to the ethical requirements imposed on studies with children, may be the causes that result in moderate citation and impact indicators.
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http://dx.doi.org/10.1016/j.anpedi.2019.12.009DOI Listing
March 2020

Reproducible research practices, openness and transparency in health economic evaluations: study protocol for a cross-sectional comparative analysis.

BMJ Open 2020 02 13;10(2):e034463. Epub 2020 Feb 13.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Introduction: There has been a growing awareness of the need for rigorously and transparent reported health research, to ensure the reproducibility of studies by future researchers. Health economic evaluations, the comparative analysis of alternative interventions in terms of their costs and consequences, have been promoted as an important tool to inform decision-making. The objective of this study will be to investigate the extent to which articles of economic evaluations of healthcare interventions indexed in MEDLINE incorporate research practices that promote transparency, openness and reproducibility.

Methods And Analysis: This is the study protocol for a cross-sectional comparative analysis. We registered the study protocol within the Open Science Framework (osf.io/gzaxr). We will evaluate a random sample of 600 cost-effectiveness analysis publications, a specific form of health economic evaluations, indexed in MEDLINE during 2012 (n=200), 2019 (n=200) and 2022 (n=200). We will include published papers written in English reporting an incremental cost-effectiveness ratio in terms of costs per life years gained, quality-adjusted life years and/or disability-adjusted life years. Screening and selection of articles will be conducted by at least two researchers. Reproducible research practices, openness and transparency in each article will be extracted using a standardised data extraction form by multiple researchers, with a 33% random sample (n=200) extracted in duplicate. Information on general, methodological and reproducibility items will be reported, stratified by year, citation of the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement and journal. Risk ratios with 95% CIs will be calculated to represent changes in reporting between 2012-2019 and 2019-2022.

Ethics And Dissemination: Due to the nature of the proposed study, no ethical approval will be required. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences. Study findings will be disseminated at scientific conferences and published in peer-reviewed journals.
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http://dx.doi.org/10.1136/bmjopen-2019-034463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045222PMC
February 2020

Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping.

BMJ Open 2020 02 6;10(2):e033913. Epub 2020 Feb 6.

INCLIVA Health Research Institute, Valencia, Spain

Introduction: Acute brain injury is a challenging public health problem worldwide. Elevated intracranial pressure is a common complication after acute brain injury. Hyperosmolar therapy is one of the main therapeutic strategies for the management of intracranial hypertension. This study protocol outlines an umbrella review of meta-analyses which will investigate the benefits and harms of hyperosmolar therapy routinely used for the management of acute brain injury in the intensive care.

Methods And Analysis: We will search PubMed/MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews. We will include meta-analyses of primary research studies (eg, randomised controlled trials, observational studies or both) that evaluate one or more hyperosmolar solutions (including hypertonic saline and/or mannitol) for the treatment of adult patients with acute brain injury of any severity. Two researchers will independently screen all citations, full-text articles and abstract data. Potential conflicts will be resolved through discussion with a third researcher. Primary outcomes will be mortality and neurological outcomes at discharge. Secondary outcomes will include control of intracranial pressure, cerebral perfusion pressure, length of stay (in hospital an intensive care unit) and any adverse event. Quality of the included meta-analyses will be assessed using the AMSTAR-2 tool. An overall summary of methods and results will be performed using tabular and graphical approaches and will be supplemented by narrative description. We will analyse whether published meta-analyses present an outline of available evidence (eg, cited, described and discussed any previous meta-analysis). Where objectives from two or more meta-analyses overlap, we will assess the causes of any noted discrepancies between meta-analyses.

Ethics And Dissemination: No ethical approval will be required. Findings from this study will be published in a peer-reviewed journal. All data will be deposited in a cross-disciplinary public repository.

Prospero Registration Number: CRD42019148152.
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http://dx.doi.org/10.1136/bmjopen-2019-033913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045244PMC
February 2020

Global mapping of randomised trials related articles published in high-impact-factor medical journals: a cross-sectional analysis.

Trials 2020 Jan 7;21(1):34. Epub 2020 Jan 7.

Information and Social and Health Research Unit (UISYS), University of Valencia and Spanish National Research Council (CSIC), Valencia, Spain.

Background: Randomised controlled trials (RCTs) provide the most reliable information to inform clinical practice and patient care. We aimed to map global clinical research publication activity through RCT-related articles in high-impact-factor medical journals over the past five decades.

Methods: We conducted a cross-sectional analysis of articles published in the highest ranked medical journals with an impact factor > 10 (according to Journal Citation Reports published in 2017). We searched PubMed/MEDLINE (from inception to December 31, 2017) for all RCT-related articles (e.g. primary RCTs, secondary analyses and methodology papers) published in high-impact-factor medical journals. For each included article, raw metadata were abstracted from the Web of Science. A process of standardization was conducted to unify the different terms and grammatical variants and to remove typographical, transcription and/or indexing errors. Descriptive analyses were conducted (including the number of articles, citations, most prolific authors, countries, journals, funding sources and keywords). Network analyses of collaborations between countries and co-words are presented.

Results: We included 39,305 articles (for the period 1965-2017) published in forty journals. The Lancet (n = 3593; 9.1%), the Journal of Clinical Oncology (n = 3343; 8.5%) and The New England Journal of Medicine (n = 3275 articles; 8.3%) published the largest number of RCTs. A total of 154 countries were involved in the production of articles. The global productivity ranking was led by the United States (n = 18,393 articles), followed by the United Kingdom (n = 8028 articles), Canada (n = 4548 articles) and Germany (n = 4415 articles). Seventeen authors who had published 100 or more articles were identified; the most prolific authors were affiliated with Duke University (United States), Harvard University (United States) and McMaster University (Canada). The main funding institutions were the National Institutes of Health (United States), Hoffmann-La Roche (Switzerland), Pfizer (United States), Merck Sharp & Dohme (United States) and Novartis (Switzerland). The 100 most cited RCTs were published in nine journals, led by The New England Journal of Medicine (n = 78 articles), The Lancet (n = 9 articles) and JAMA (n = 7 articles). These landmark contributions focused on novel methodological approaches (e.g. the "Bland-Altman method") and trials on the management of chronic conditions (e.g. diabetes control, hormone replacement therapy in postmenopausal women, multiple therapies for diverse cancers, cardiovascular therapies such as lipid-lowering statins, antihypertensive medications, and antiplatelet and antithrombotic therapy).

Conclusions: Our analysis identified authors, countries, funding institutions, landmark contributions and high-impact-factor medical journals publishing RCTs. Over the last 50 years, publication production in leading medical journals has increased, with Western countries leading in research but with low- and middle-income countries showing very limited representation.
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http://dx.doi.org/10.1186/s13063-019-3944-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947860PMC
January 2020

Altmetrics Analysis of Archivos de Bronconeumología From 2014 to 2018.

Arch Bronconeumol (Engl Ed) 2020 May 18;56(5):298-305. Epub 2019 Nov 18.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España.

Introduction: Alternative metrics or altmetrics are non-traditional measurements of scientific production that reflect a publication's influence in social networks and similar channels of dissemination. The aim of this study was to analyze the media impact of Archivos de Bronconeumología according to 2 altmetric aggregators and website visits.

Methods: This was an observational study of the original articles and review and consensus articles published in Archivos de Bronconeumología during the period 2014-2018. Data from the PlumX Metrics and Altmetric aggregators and visits to the Archivos de Bronconeumología website were analyzed. Five comparisons were made: by specialty area, by funding received, by number of participating centers, by document type, and by topic. In a subanalysis, altmetrics were correlated with the conventional citation system.

Results: We analyzed 273 papers, of which 186 were original articles (68.1%). The papers that achieved greater media impact in the 2 aggregators analyzed, and in terms of website visits, were pulmonology papers and review and consensus articles. The mean Altmetric Attention Score was 1.9±4.4 (range 0-59), which is above average for the date of publication of the paper. A statistically significant weak to moderate correlation was identified between altmetrics and conventional citations.

Conclusions: Review articles, consensus documents, and pulmonology papers had a greater media impact. Mean Altmetric Attention Score was higher than the average based on the date of publication. A weak to moderate correlation between altmetrics and conventional citations was identified.
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http://dx.doi.org/10.1016/j.arbres.2019.08.024DOI Listing
May 2020

Correction to: A bibliometric analysis of scientific production in the field of lingual orthodontics.

Head Face Med 2019 Oct 21;15(1):24. Epub 2019 Oct 21.

UISYS Research Unit (UV-CSIC), Department of History of Science and Information Science, School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Following publication of the original article [1], the author informed.
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http://dx.doi.org/10.1186/s13005-019-0208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805469PMC
October 2019

[Multilayer repair of palatal fistula with an interpositional collagen matrix].

Cir Pediatr 2019 Oct 1;32(4):207-211. Epub 2019 Oct 1.

Hospital Clínico Universitario de Valladolid.

Objective: Palatal fistula after the repair of cleft palate appears in 7.7-35% of patients. We present two cases of palatal fistula, detailing a multi-layer repair with an interpositional collagen graft.

Material And Methods: Patient 1: girl with a cleft palate operated using a Furlow technique. A reintervention was performed due to a Pittsburgh type III fistula. Patient 2: male with cleft palate operated using a Furlow technique. A reintervention was performed due to a type V fistula.

Results: We used a multilayer repair with a local rotational flap and the interposition of a collagen matrix between the nasal and oral layers. The suture was reinforced with a fibrin hemostatic adhesive. No recurrence of the fistula after 2 years.

Conclusions: The three-layer closure is simple, safe, effective and avoids refistulizations. Interpositional grafts of a resorbable collagen membrane provide a "scaffold" for tissue growth, revascularization and epithelialization of the mucosa.
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October 2019

A bibliometric analysis of scientific production in the field of lingual orthodontics.

Head Face Med 2019 Sep 7;15(1):23. Epub 2019 Sep 7.

UISYS Research Unit (UV-CSIC), Department of History of Science and Information Science, School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Background: Due to the lack of bibliometric studies in the field of lingual orthodontics in dentistry, the aim of this study was to assess the evolution and current status of activity in this field during the period 1978-2017.

Methods: A bibliometric analysis of the scientific articles indexed in the Science Citation Index-Expanded of the Web of Science and in the Scopus® database was performed using the truncated terms "ling* apppli*" or "ling* orthod*" or "ling* bracket*". The types of texts included for analysis were limited to "articles" and "reviews". The following information was extracted from each article identified: title, authors' name(s), institutional affiliation(s), country of origin, journal title, year of publication, type of publication, and number of citations.

Results: A total of 341 articles were identified by 646 different authors, 6.2% were reviews and 93.8% were other types of journal articles. Bibliometric indicators showed a tremendous increase in the rate of publication over time with two peaks in productivity in 1989 and 2013. Fourteen authors and 15 institutional collaboration networks were identified in which European institutions were the most productive. Methodological articles were the most frequent types of research articles (28.1%), followed by case reports/series (17.1%), and narrative reviews (4.7%). Articles providing the highest quality evidence were interventional clinical trials (1.8%) and systematic reviews (0.9%). The remaining articles were non-research papers and were for information purposes only.

Conclusions: Bibliometric indicators point to an irregular increase in the numbers of published works in lingual orthodontics over time. Research output is dominated by methodological articles as a technique-driven subspecialty. Although articles on lingual orthodontics are published mainly in North American journals, lingual orthodontics is largely a European domain.
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http://dx.doi.org/10.1186/s13005-019-0207-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731571PMC
September 2019

The funding sources of implantology research in the period 2008-2017: A bibliometric analysis.

Clin Implant Dent Relat Res 2019 Aug 25;21(4):708-714. Epub 2019 Jun 25.

Department of History of Science and Information Science, School of Medicine and Dentistry, University of Valencia, Valencia, Spain.

Background: Implant dentistry is subject to major economic pressures as a result of the growth in the manufacturing and commercialization of dental implants.

Purpose: To examine research funding in implant dentistry by means of a bibliometric analysis of articles indexed in Web of Science (WoS) published during the period 2008-2017.

Materials And Methods: The search was conducted applying the truncated term "implant*" in the WoS dentistry area. Only items labeled as "article" or "review" were selected. Records were manually refined and normalized to unify terms and to remove typographical, transcription, and/or indexing errors.

Results: A total of 14 255 records were identified for analysis. About 5002 of the 14 255 published works received funding. Of these, 85.9% of funded research articles received at least one citation. Of the 7733 funding entities mentioned, 29.8% were government entities, 25% NGOs and Foundations, 23.7% private companies, 19.6% academic entities, and 1.9% hospitals and research centers. Clinical Oral Implants Research and the International Journal of Oral & Maxillofacial Implants published the highest numbers of funded articles.

Conclusions: This study revealed an overall increase in the funding of research in implant dentistry in recent years. Funded articles were cited more frequently and published in journals with higher impact factors.
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http://dx.doi.org/10.1111/cid.12810DOI Listing
August 2019

Prevalence and comorbidity of autism spectrum disorder in Spain: study protocol for a systematic review and meta-analysis of observational studies.

Syst Rev 2019 06 14;8(1):141. Epub 2019 Jun 14.

Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.

Background: Autism spectrum disorder (ASD) is a complex developmental disorder characterised by impaired social interaction and communication, and restrictive and repetitive behaviour. Previous systematic reviews have traditionally assessed the prevalence of ASD on global or regional context, with very few meta-analyses at the country level. The objective of this study will be to systematically evaluate published and unpublished observational studies that present prevalence and comorbidity of ASD among children, adolescent and adult population in Spain.

Methods/design: We designed and registered a study protocol for a systematic review and meta-analysis of descriptive epidemiology data. Observational studies (cohort, cross-sectional) reporting the prevalence of ASD and conducted in a wide range of people (e.g. general population, outpatient and/or school settings) will be included. The primary outcome will be the prevalence of ASD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ASD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in seven electronic databases (from January 1980 onwards), including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME-Spanish Medical Index and IBECS-Spanish Bibliographic Index of Health Sciences. Grey literature will be identified through searching dissertation databases, Google Scholar and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The study methodological quality (or bias) will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis of observational data. Prevalence estimates will be stratified according to gender, age and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g. methodological quality, sample size, diagnostic criteria).

Discussion: This systematic review and meta-analysis of observational data will identify, evaluate and integrate the epidemiological knowledge underlying the prevalence of ASD in Spain. The results of this study will be of interest to multiple audiences including patients, their families, caregivers, healthcare professional, scientists and policy makers. Results will be published in a peer-reviewed journal. Implications for future epidemiological research will be discussed.

Systematic Review Registration: PROSPERO CRD42018090372.
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http://dx.doi.org/10.1186/s13643-019-1061-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570970PMC
June 2019

Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis.

JAMA Netw Open 2019 06 5;2(6):e195313. Epub 2019 Jun 5.

Department of Medicine, University of Valencia, INCLIVA Health Research Institute, Centro de Investigación en Red de Salud Mental (CIBERSAM), Valencia, Spain.

Importance: Anorexia nervosa is recognized as an important cause of morbidity in young people. However, the risk of cancer in people with anorexia nervosa remains uncertain.

Objective: To evaluate the association of anorexia nervosa with the risk of developing or dying of cancer.

Data Sources: MEDLINE, Scopus, Embase, and Web of Science from database inception to January 9, 2019.

Study Selection: Published observational studies in humans examining the risk of cancer in people with anorexia nervosa compared with the general population or those without anorexia nervosa. Studies needed to report incidence or mortality rate ratios (RRs).

Data Extraction And Synthesis: Screening, data extraction, and methodological quality assessment were performed by at least 2 researchers independently. A random-effects model was used to synthesize individual studies. Heterogeneity (I2) was assessed and 95% prediction intervals (PIs) were calculated.

Main Outcomes And Measures: All cancer incidence and cancer mortality associated with anorexia nervosa. Secondary outcomes were site-specific cancer incidence and mortality.

Results: Seven cohort studies published in 10 articles (42 602 participants with anorexia nervosa) were included. Anorexia nervosa was not associated with risk of developing any cancer (4 studies in women; RR, 0.97; 95% CI, 0.89-1.06; P = .53; I2, 0%; 95% PI, 0.80-1.18; moderate confidence). Anorexia nervosa was associated with decreased breast cancer incidence (5 studies in women; RR, 0.60; 95% CI, 0.50-0.80; P < .001; I2, 0%; 95% PI, 0.44-0.83; high confidence). Conversely, anorexia nervosa was associated with increased risk of developing lung cancer (3 studies in women; RR, 1.50; 95% CI, 1.06-2.12; P = .001; I2, 0%; 95% PI, 0.19-16.46; low confidence) and esophageal cancer (2 studies in women; RR, 6.10; 95% CI, 2.30-16.18; P < .001; I2, 0%; low confidence).

Conclusions And Relevance: Among people with anorexia nervosa, risk of developing cancer did not differ compared with the general population, but a significantly reduced risk of breast cancer was observed. Understanding the mechanisms underlying these associations could have important preventive potential.
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http://dx.doi.org/10.1001/jamanetworkopen.2019.5313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563572PMC
June 2019

Reporting guidelines for health research: protocol for a cross-sectional analysis of the EQUATOR Network Library.

BMJ Open 2019 03 4;9(3):e022769. Epub 2019 Mar 4.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: Transparency and completeness of health research is highly variable, with important deficiencies in the reporting of methods and results of studies. Reporting guidelines aim to improve transparency and quality of research reports, and are often developed by consortia of journal editors, peer reviewers, authors, consumers and other key stakeholders. The objective of this study will be to investigate the characteristics of scientific collaboration among developers and the citation metrics of reporting guidelines of health research.

Methods And Analysis: This is the study protocol for a cross-sectional analysis of completed reporting guidelines indexed in the Enhancing the QUAlity and Transparency Of health Research Network Library. We will search PubMed/MEDLINE and the Web of Science. Screening, selection and data abstraction will be conducted by one researcher and verified by a second researcher. Potential discrepancies will be resolved via discussion. We will include published papers of reporting guidelines written in English. Published papers will have to meet the definition of a reporting guideline related to health research (eg, a checklist, flow diagram or explicit text), with no restrictions by study design, medical specialty, disease or condition. Raw data from each included paper (including title, publication year, journal, subject category, keywords, citations, and the authors' names, author's affiliated institution and country) will be exported from the Web of Science. Descriptive analyses will be conducted (including the number of papers, citations, authors, countries, journals, keywords and main collaboration metrics). We will identify the most prolific authors, institutions, countries, journals and the most cited papers. Network analyses will be carried out to study the structure of collaborations.

Ethics And Dissemination: No ethical approval will be required. Findings from this study will be published in peer-reviewed journals. All data will be deposited in a cross-disciplinary public repository. It is anticipated the study findings could be relevant to a variety of audiences.
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http://dx.doi.org/10.1136/bmjopen-2018-022769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429992PMC
March 2019

Roof-dependent atrial flutter with an epicardial component: Role of the septopulmonary bundle.

J Cardiovasc Electrophysiol 2019 Jul 5;30(7):1159-1163. Epub 2019 Mar 5.

International Arrhythmia Center, CardioInfantil Foundation, Bogotá, Colombia.

Catheter ablation of atrial fibrillation may predispose patients to the development of atypical atrial flutters (AFL). We describe two cases of roof dependent AFLs that failed to terminate despite posterior wall isolation. An epicardial breakthrough involving the septopulmonary bundle is proposed. The correlation between the electrophysiological findings and the anatomical substrate is described.
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http://dx.doi.org/10.1111/jce.13885DOI Listing
July 2019

[Half a century of ANALES DE PEDIATRÍA. Evolution of its main bibliometric indicators in the Web of Science and Scopus international databases].

An Pediatr (Engl Ed) 2019 Mar 15;90(3):194.e1-194.e11. Epub 2019 Feb 15.

UISYS, Unidad Mixta de Investigación, Universitat de València-CSIC, Valencia, España; Instituto de Gestión de la Innovación y del Conocimiento-Ingenio (CSIC-Universitat Politècnica de València), Valencia, España.

Purpose: To analyse the coverage and main bibliometric indicators of ANALES DE PEDIATRÍA in Scopus and Science Citation Index Expanded of the Web of Science (SCIE) databases.

Material And Method: The evolution of the journal production was identified according to the document types, collaboration indexes between authors and institutions, and citations, and impact indicators (number of citations, impact factor, 5-years impact factor and without self-citations, Scimago Journal Rank, quartile, h index and most cited works).

Results: A total of 10,128 papers were included in Scopus (a mean of around 225 per year) and 1,861 in SCIE (a mean of around 207 per year). The index of collaboration was 4.4 for authors and 2 for institutions. There was international collaboration in 4.2% of the papers. The number of citations received in Scopus (619) exceeded the number of citations received in SCIE (385) by 234. The mean number of citations per paper was lower in SCIE (2.27 in Scopus compared to 1.5 in SCIE). The h index was 18 in Scopus and 14 in SCIE.

Conclusions: Discrepancies were observed in the indicators obtained in both databases due to the different indexation policies, coverage, and classification methods of the papers. The number of citations, the mean number of citations per work, and the h index were higher in Scopus due to the longer life of the journal in that database. There is a positive evolution of the impact factor in SCIE, of the impact factor excluding self-citations, and of the 5-year impact factor.
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http://dx.doi.org/10.1016/j.anpedi.2018.12.012DOI Listing
March 2019

Prevalence and comorbidity of attention deficit hyperactivity disorder in Spain: study protocol for extending a systematic review with updated meta-analysis of observational studies.

Syst Rev 2019 02 11;8(1):49. Epub 2019 Feb 11.

Department of Medicine, University of Valencia/INCLIVA Health Research Institute and CIBERSAM, Valencia, Spain.

Background: Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder characterized by a persistent pattern of symptoms of developmentally inappropriate and impaired inattention and/or hyperactivity/impulsivity, with difficulties often continuing into adulthood. ADHD can come with other comorbid conditions. The aim of this study will be to quantify the prevalence and comorbidity of ADHD among children, adolescent, and adult population in Spain.

Methods/design: We designed and registered a study protocol for an update and expansion of a systematic review and meta-analysis of pooled prevalence data. We will include cross-sectional observational studies reporting prevalence of ADHD in Spain and conducted in the general population, outpatient, and/or school settings. The primary outcome will be the prevalence of ADHD. Secondary outcomes will be the prevalence of any physical or mental comorbidity in association with ADHD. No limitations will be imposed on publication status, study conduct period, and language of dissemination. Comprehensive literature searches will be conducted in multiple electronic databases, including PubMed/MEDLINE, EMBASE, Scopus, Web of Science, PsycINFO, IME - Spanish Medical Index, and IBECS - Spanish Bibliographic Index of Health Sciences. We will also search Google Scholar, dissertation databases, and conference abstracts. Two team members will independently screen all citations, full-text articles, and abstract data. Potential conflicts will be resolved through discussion. The methodological quality (or risk of bias) of individual studies will be appraised using an appropriate tool. If feasible, we will conduct random effects meta-analysis. Prevalence estimates will be stratified according to gender, age, and geographical location. Additional analyses will be conducted to explore the potential sources of heterogeneity (e.g., methodological quality, sample size, diagnostic criteria).

Discussion: This systematic review and meta-analysis of observational data will provide an updated synthesis of the prevalence and comorbidity of ADHD in Spain. This study will also examine factors that may explain potential variations in prevalence data. The findings of this study will be published in a peer-reviewed journal.

Systematic Review Registration: PROSPERO CRD42018106082 .
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http://dx.doi.org/10.1186/s13643-019-0967-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371515PMC
February 2019