Publications by authors named "Alok Kumar Goyal"

4 Publications

  • Page 1 of 1

A Hospital-Based Multi-Centric Study to Determine the Clinico-Epidemiological Profile of Intussusception in Children < 2 Years in Rajasthan, India.

Indian J Pediatr 2021 Mar 6;88(Suppl 1):131-137. Epub 2021 Jan 6.

Christian Medical College, Vellore, Tamil Nadu, India.

Objective: To determine the clinical and epidemiological profile of Intussusception in children aged <2 y after introduction of rotavirus vaccine in Universal Immunization Programme of Rajasthan.

Method: This was a hospital-based multi-centric surveillance study conducted at three tertiary care sentinel sites in Rajasthan over a period of 2 y. Children <2 y of age admitted with intussusception as per Brighton's criteria 1 were enrolled. Demographic details including age, sex, clinical presentation, diagnostic methods, duration of symptoms, mode of treatment, and complications were recorded and analyzed.

Results: During the study period of 2 y, the authors identified 164 cases of intussusception based on level-1 Brighton's criteria. Median age at presentation was 7 mo [Interquartile range (IQR) 5-10 mo] with a male to female ratio of 2:1. Pain abdomen and blood stained stool were the commonest presenting complaints (88.4% and 81.7%, respectively). Commonest site of intussusception was Ileocolic (82.32%). Pathological lead point was identified in 18.9% cases. Distinct seasonality was observed as maximum cases of intussusception were detected in the months of Jan-March (34.1%). Surgical intervention was required in the 89.63% cases. The median time duration between onset of symptoms and admission at sentinel site was 2 d (IQR 1-3 d). Proportion of cases that required surgery increased as the time interval between onset of symptoms and admission increases.

Conclusion: Intussusception is a common surgical condition among children under-two years of age with majority of cases occurring during infancy. Case management is dependent primarily on time duration elapsed between symptoms onset and admission to tertiary care centre. Early case detection and timely referral may provide an opportunity to avoid surgical interventions.
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http://dx.doi.org/10.1007/s12098-020-03601-8DOI Listing
March 2021

Post Vaccination Epidemiology and Genotyping of Rotavirus Gastroenteritis at a Tertiary Care Centre of North-East Rajasthan.

Indian J Pediatr 2021 Mar 28;88(Suppl 1):90-96. Epub 2020 Nov 28.

Wellcome Trust Research Laboratory, Christian Medical College, Vellore, Tamil Nadu, India.

Objectives: To estimate the proportion of rotavirus diarrhea among hospitalized children aged under-five years, to determine the circulating rotavirus genotypes and to know impact rotavirus vaccine on prevalence and severity of rotavirus diarrhea.

Methods: This study was a hospital based cross-sectional observational study conducted over a period of 29 mo (September 2017 through January 2020). Stool samples were collected from children who fall within the age range of 0-59 mo with acute diarrhea attending emergency or needing admission. Stool samples were tested for rotavirus by the enzyme linked immune-sorbent assay (ELISA) and genotyped using published methods.

Results: Out of 1480 samples, 360 (24.32%) cases were positive for rotavirus by ELISA, majority of them were male (62.97%). Maximum rotavirus positivity was found in the age group of <11 mo (55.27%). Statistically significance difference was seen in episodes of diarrhea and experience of vomiting in rotavirus diarrhea cases. Highest prevalence has been seen during winter season. The most prevalent G and P type combinations were G3P [8] strains [122 (34.08%)], G2P [4] [83 (23.18%)], G1P [8] [27 (7.54%)] and G9P [4] [20 (5.59%)]. Mixed strains contribute a significant proportion of stool sample.

Conclusions: Rotavirus is an important cause of diarrhea in hospitalized children. There is continued circulation of G9 and G12 strains and the emergence of G3P [8] as most common strain.
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http://dx.doi.org/10.1007/s12098-020-03569-5DOI Listing
March 2021

Neonatal cholestasis due to plasmodium vivax malaria.

Indian J Pediatr 2014 Feb 25;81(2):213. Epub 2013 Apr 25.

Department of Pediatrics Medicine, Sir Padampat Mother & Child Health Institute, SMS Medical College, Jaipur, India.

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http://dx.doi.org/10.1007/s12098-013-1021-zDOI Listing
February 2014

Coexistence of nephrotic syndrome, celiac disease, and insulin-dependent diabetes mellitus.

Indian J Gastroenterol 2014 Mar;33(2):188-9

Sir Padampat Mother and Child Health Institute, Sawai Man Singh (SMS) Medical College, Jaipur, 302 004, India.

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http://dx.doi.org/10.1007/s12664-013-0326-1DOI Listing
March 2014