Almut Nebel

Almut Nebel

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Almut Nebel

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Early integration of pastoralism and millet cultivation in Bronze Age Eurasia.

Proc Biol Sci 2019 Sep 4;286(1910):20191273. Epub 2019 Sep 4.

Graduate School 'Human Development in Landscapes', Kiel University, Leibniz Straße 3, 24118 Kiel, Germany.

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http://dx.doi.org/10.1098/rspb.2019.1273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743000PMC
September 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Nat Commun 2019 Aug 14;10(1):3669. Epub 2019 Aug 14.

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.

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http://dx.doi.org/10.1038/s41467-019-11558-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694136PMC
August 2019

On a Western diet, APOEɛ4 is associated with low innate immune sensing, but not APOEɛ3.

J Allergy Clin Immunol 2018 10 19;142(4):1346-1349.e9. Epub 2018 Jun 19.

Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2018.05.033DOI Listing
October 2018

Involvement of SPATA31 copy number variable genes in human lifespan.

Aging (Albany NY) 2018 04;10(4):674-688

Max-Planck Institute for Evolutionary Biology, 24306 Plön, Germany.

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http://dx.doi.org/10.18632/aging.101421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940121PMC
April 2018

and as novel candidates for sarcoidosis-associated microbiota.

Eur Respir J 2017 Dec 14;50(6). Epub 2017 Dec 14.

Institute of Clinical Molecular Biology, Kiel University and University Hospital Schleswig-Holstein, Kiel, Germany

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http://dx.doi.org/10.1183/13993003.00746-2016DOI Listing
December 2017

Insights into early pig domestication provided by ancient DNA analysis.

Sci Rep 2017 03 16;7:44550. Epub 2017 Mar 16.

Institute of Clinical Molecular Biology, Kiel University, 24105 Kiel, Germany.

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http://dx.doi.org/10.1038/srep44550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353713PMC
March 2017

Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells.

Free Radic Biol Med 2016 07 26;96:264-72. Epub 2016 Apr 26.

Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Str. 6, 24118 Kiel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.04.031DOI Listing
July 2016

APOE genotype and stress response - a mini review.

Lipids Health Dis 2016 Jul 25;15:121. Epub 2016 Jul 25.

Institute of Human Nutrition and Food Science, Kiel University, Hermann-Rodewald-Str. 6, D-24118, Kiel, Germany.

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http://dx.doi.org/10.1186/s12944-016-0288-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960866PMC
July 2016

Family-Based Benchmarking of Copy Number Variation Detection Software.

PLoS One 2015 21;10(7):e0133465. Epub 2015 Jul 21.

Institute of Medical Informatics and Statistics, Christian-Albrechts University, Kiel, Germany; Cologne Center for Genomics, University of Cologne, Cologne, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133465PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510559PMC
May 2016

The more the merrier? How a few SNPs predict pigmentation phenotypes in the Northern German population.

Eur J Hum Genet 2016 May 19;24(5):739-47. Epub 2015 Aug 19.

Institute of Legal Medicine, Christian-Albrechts University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1038/ejhg.2015.167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930077PMC
May 2016

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.

Circ Res 2015 Jul 1;117(4):333-45. Epub 2015 Jun 1.

From the National Research Council, Institute for Biomedical Technologies, Segrate (MI), Italy (F.V., C.C.S., A.F.); IRCCS Neuromed, Department of Vascular Physiopathology, Pozzilli (IS), Italy (A.C., A.D., M.M., M.A., S.F., C.V.); Department of Industrial and Information Engineering, University of Pavia, Pavia, Italy (A. Malovini, F.M., R.B.); IRCCS Multimedica, Cardiovascular Department, Milan, Italy (A. Maciąg, G.S., E.S., A.A.P.); Department of Translational Medicine, "Federico II" University, Naples, Italy (A.A.); TIGEM (Telethon Institute of Genetics and Medicine), Naples, Italy (A.A.); Department of Experimental Cardiovascular Medicine, Bristol Heart Institute, University of Bristol, Bristol, United Kingdom (Z.D., P.M.); Department of Biochemistry and Molecular Pharmacology IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (L.S., P.B.); National Research Council, Institute of Experimental Endocrinology and Oncology (IEOS), Naples, Italy (G.C.); Institute of Clinical Molecular Biology, Christian-Albrechts University and the Schleswig-Holstein University Hospital, Kiel, Germany (S.S., A.N.); Geriatrics Section, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA (T.P.); Dipartimento di Fisiologia e Farmacologia, Sapienza Università di Roma, Rome, Italy (S.F.); and Dipartimento di Medicina e Chirurgia, Università degli Studi di Salerno, 84081 Baronissi (SA), Italy (C.V., A.A.P.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.305875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496930PMC
July 2015

Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis.

Eur J Hum Genet 2014 Sep 12;22(9):1131-6. Epub 2014 Feb 12.

1] Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark [2] Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.

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http://www.ideal-ageing.eu/uploads/publicaties/2014/2014_deb
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http://www.nature.com/doifinder/10.1038/ejhg.2013.299
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http://dx.doi.org/10.1038/ejhg.2013.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135411PMC
September 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

Genetics of sarcoidosis.

Semin Respir Crit Care Med 2014 Jun 9;35(3):296-306. Epub 2014 Jul 9.

Division of Pulmonary, Department of Medicine, University Medical Center, Freiburg, Germany.

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0034-1376860
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http://dx.doi.org/10.1055/s-0034-1376860DOI Listing
June 2014

Adjustment for smoking does not alter the FOXO3A association with longevity.

Age (Dordr) 2014 Apr 7;36(2):911-21. Epub 2013 Sep 7.

Institute of Medical Informatics and Statistics, Christian-Albrechts University, Brunswiker Straße 10, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s11357-013-9578-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039245PMC
April 2014

Polymorphisms in the superoxidase dismutase genes reveal no association with human longevity in Germans: a case-control association study.

Biogerontology 2013 Dec 22;14(6):719-27. Epub 2013 Oct 22.

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelmstraße 12, 24105, Kiel, Germany.

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http://link.springer.com/10.1007/s10522-013-9470-3
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http://dx.doi.org/10.1007/s10522-013-9470-3DOI Listing
December 2013

Effects of the APOE ε2 allele on mortality and cognitive function in the oldest old.

J Gerontol A Biol Sci Med Sci 2013 Apr 9;68(4):389-94. Epub 2012 Oct 9.

Danish Aging Research Center, Epidemiology, University of Southern Denmark, J.B. Winsløws Vej 9B, DK-5000 Odense C, Denmark.

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https://academic.oup.com/biomedgerontology/article-lookup/do
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http://dx.doi.org/10.1093/gerona/gls192DOI Listing
April 2013

Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B.

Eur J Hum Genet 2013 Feb 16;21(2):240-2. Epub 2012 May 16.

Institute of Clinical Molecular Biology, Christian-Albrechts-University, Schittenhelmstrasse 12,Kiel, Germany.

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http://dx.doi.org/10.1038/ejhg.2012.83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548564PMC
February 2013

Evolution of human longevity: lessons from Hydra.

Aging (Albany NY) 2012 Nov;4(11):730-1

Institute of Clinical Molecular Biology, University of Kiel D-24105 Kiel, Germany.

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http://www.aging-us.com/article/100510
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560441PMC
http://dx.doi.org/10.18632/aging.100510DOI Listing
November 2012

Genome-wide miRNA signatures of human longevity.

Aging Cell 2012 Aug 30;11(4):607-16. Epub 2012 May 30.

Institute of Clinical Molecular Biology, Christian-Albrechts-University, Schittenhelmstraße 12, D-24105 Kiel, Germany.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00824.xDOI Listing
August 2012

Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.

J Gerontol A Biol Sci Med Sci 2011 Nov 27;66(11):1186-91. Epub 2011 Jul 27.

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstraße 12, 24105 Kiel, Germany.

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https://academic.oup.com/biomedgerontology/article-lookup/do
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http://dx.doi.org/10.1093/gerona/glr117DOI Listing
November 2011

Candidate gene study of FOXO1, FOXO4, and FOXO6 reveals no association with human longevity in Germans.

Aging Cell 2011 Aug 12;10(4):622-8. Epub 2011 Apr 12.

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelmstrasse 12, Kiel, Germany.

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http://dx.doi.org/10.1111/j.1474-9726.2011.00698.xDOI Listing
August 2011

Association of TH01 with human longevity revisited.

Eur J Hum Genet 2011 Aug 16;19(8):924-7. Epub 2011 Mar 16.

Institute of Legal Medicine, Christian-Albrechts-University and the University Hospital Schleswig-Holstein, Kiel, Germany.

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http://www.nature.com/doifinder/10.1038/ejhg.2011.43
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http://dx.doi.org/10.1038/ejhg.2011.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172926PMC
August 2011

Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.

Eur J Hum Genet 2011 Jun 2;19(6):676-81. Epub 2011 Feb 2.

DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/MRC Centre of Molecular and Cellular Biology, Division of Molecular Biology and Human Genetics, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1038/ejhg.2011.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110050PMC
June 2011

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

Mutat Res 2010 Dec 26;694(1-2):13-9. Epub 2010 Aug 26.

Institute of Clinical Molecular Biology, Christian-Albrechts-University and University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1016/j.mrfmmm.2010.08.006DOI Listing
December 2010

Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.

BMC Infect Dis 2010 Jun 7;10:154. Epub 2010 Jun 7.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology, Faculty of Health Sciences, PO Box 19063, Stellenbosch University, Tygerberg 7505, South Africa.

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http://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-
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http://dx.doi.org/10.1186/1471-2334-10-154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891757PMC
June 2010

LINGO1 polymorphisms are associated with essential tremor in Europeans.

Mov Disord 2010 Apr;25(6):717-23

Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/mds.22887DOI Listing
April 2010

Low level of the mtDNA(4977) deletion in blood of exceptionally old individuals.

Mech Ageing Dev 2010 Mar 1;131(3):179-84. Epub 2010 Feb 1.

Institute of Legal Medicine, Christian-Albrechts-University and the University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1016/j.mad.2010.01.005DOI Listing
March 2010

A functional haplotype in the 3'untranslated region of TNFRSF1B is associated with tuberculosis in two African populations.

Am J Respir Crit Care Med 2010 Feb 10;181(4):388-93. Epub 2009 Dec 10.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and DST/NRF Centre of Excellence for Biomedical TB Research, Stellenbosch University, Stellenbosch, South Africa.

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http://dx.doi.org/10.1164/rccm.200905-0678OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822974PMC
February 2010

Depletion of potential A2M risk haplotype for Alzheimer's disease in long-lived individuals.

Eur J Hum Genet 2010 Jan;18(1):59-61

Institute of Clinical Molecular Biology, Christian-Albrechts University and University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

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http://dx.doi.org/10.1038/ejhg.2009.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987169PMC
January 2010

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review.

Lipids Health Dis 2010 Jan 28;9. Epub 2010 Jan 28.

Institute of Human Nutrition and Food Science, Christian-Albrechts-University, Hermann-Rodewald-Strasse 6, 24098 Kiel, Germany.

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http://dx.doi.org/10.1186/1476-511X-9-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830997PMC
January 2010

Human longevity and 11p15.5: a study in 1321 centenarians.

Eur J Hum Genet 2009 Nov 15;17(11):1515-9. Epub 2009 Apr 15.

Centro Interdipartimentale 'L.Galvani' per Studi Integrati di Bioinformatica, Biofisica e Biocomplessità - Alma Mater Studiorum Università di Bologna, Italy.

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http://www.nature.com/articles/ejhg200954
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http://dx.doi.org/10.1038/ejhg.2009.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2986679PMC
November 2009

Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population.

Tuberculosis (Edinb) 2009 Mar 14;89(2):189-94. Epub 2009 Jan 14.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.

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http://dx.doi.org/10.1016/j.tube.2008.10.001DOI Listing
March 2009

Association of FOXO3A variation with human longevity confirmed in German centenarians.

Proc Natl Acad Sci U S A 2009 Feb 5;106(8):2700-5. Epub 2009 Feb 5.

Institute of Clinical Molecular Biology, Institute of Medical Informatics and Statistics, and Popgen Biobank, Christian-Albrechts-University, 24105 Kiel, Germany.

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http://www.pnas.org/lookup/doi/10.1073/pnas.0809594106
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http://dx.doi.org/10.1073/pnas.0809594106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650329PMC
February 2009

Female-specific association of C-C chemokine receptor 5 gene polymorphisms with Löfgren's syndrome.

J Mol Med (Berl) 2008 May 1;86(5):553-61. Epub 2008 Mar 1.

Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Schittenhelmstrasse 12, 24105, Kiel, Germany.

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http://dx.doi.org/10.1007/s00109-008-0315-5DOI Listing
May 2008

Role of NOD2/CARD15 in coronary heart disease.

BMC Genet 2007 Nov 2;8:76. Epub 2007 Nov 2.

Department of Cardiology, University Hospital Schleswig-Holstein, Kiel, Germany.

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http://dx.doi.org/10.1186/1471-2156-8-76DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2204032PMC
November 2007

Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.

Mech Ageing Dev 2007 May-Jun;128(5-6):409-11. Epub 2007 Apr 7.

Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, Germany.

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http://dx.doi.org/10.1016/j.mad.2007.04.001DOI Listing
September 2007

Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans.

Thromb Haemost 2007 Jun;97(6):998-1002

Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn Sigmund Freud Str. 25, 53127 Bonn, Germany.

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June 2007

Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population.

Mol Cell Probes 2007 Apr 18;21(2):148-51. Epub 2006 Oct 18.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, PO Box 19063, Stellenbosch University, Tygerberg 7505, South Africa.

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http://dx.doi.org/10.1016/j.mcp.2006.10.001DOI Listing
April 2007

Allelic variation in BTNL2 and susceptibility to tuberculosis in a South African population.

Microbes Infect 2007 Apr 27;9(4):522-8. Epub 2007 Jan 27.

Molecular Biology and Human Genetics, MRC Centre for Molecular and Cellular Biology and the DST/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, P.O. Box 19063, Stellenbosch University, Tygerberg 7505, South Africa.

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http://dx.doi.org/10.1016/j.micinf.2007.01.011DOI Listing
April 2007

A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss.

Hum Mol Genet 2007 Mar 5;16(5):573-8. Epub 2007 Mar 5.

Institut für Humangenetik, Westfalian Wilhelms-University of Münster and University Clinic Münster, Münster, Germany.

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http://academic.oup.com/hmg/article/16/5/573/709076/A-common
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http://dx.doi.org/10.1093/hmg/ddm017DOI Listing
March 2007

Allelic variation in the CNDP1 gene and its lack of association with longevity and coronary heart disease.

Mech Ageing Dev 2006 Nov 11;127(11):817-20. Epub 2006 Sep 11.

Institute of Human Genetics, Ruprecht-Karls-University, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.mad.2006.08.002DOI Listing
November 2006

Aging at the interface of stem cell renewal, apoptosis, senescence, and cancer.

Sci Aging Knowledge Environ 2006 May 24;2006(9):pe14. Epub 2006 May 24.

Institute of Clinical Molecular Biology, University of Kiel, Germany.

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http://dx.doi.org/10.1126/sageke.2006.9.pe14DOI Listing
May 2006

Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.

Exp Gerontol 2006 Jan 27;41(1):98-102. Epub 2005 Oct 27.

Institute for Clinical Molecular Biology, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

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http://dx.doi.org/10.1016/j.exger.2005.09.008DOI Listing
January 2006

[Genetic factors in longevity. Healthy living into old age--what role do genes play?].

Med Monatsschr Pharm 2005 Dec;28(12):437-42

Institut für Klinische Molekularbiologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel.

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December 2005

Allelic variation and human longevity.

Sci Aging Knowledge Environ 2005 Jul 20;2005(29):pe23. Epub 2005 Jul 20.

Institute for Clinical Molecular Biology, University Hospital of the Christian-Albrechts-University, 24105 Kiel, Germany.

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http://dx.doi.org/10.1126/sageke.2005.29.pe23DOI Listing
July 2005

No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans.

Proc Natl Acad Sci U S A 2005 May 23;102(22):7906-9. Epub 2005 May 23.

Institutes for Clinical Molecular Biology and Medical Informatics and Statistics and Hospital for General Internal Medicine, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.

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http://dx.doi.org/10.1073/pnas.0408670102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142355PMC
May 2005

Y chromosome evidence for a founder effect in Ashkenazi Jews.

Eur J Hum Genet 2005 Mar;13(3):388-91

MRC/NHLS/Wits Human Genomic Diversity and Disease Research Unit, Division of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa.

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http://www.nature.com/articles/5201319
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http://dx.doi.org/10.1038/sj.ejhg.5201319DOI Listing
March 2005

GEHA--the pan-European "Genetics of Healthy Aging" project.

Sci Aging Knowledge Environ 2004 May 26;2004(21):pe23. Epub 2004 May 26.

Institute for Clinical Molecular Biology, University Hospital of the Christian Albrechts-University, 24105 Kiel, Germany.

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http://sageke.sciencemag.org/cgi/doi/10.1126/sageke.2004.21.
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http://dx.doi.org/10.1126/sageke.2004.21.pe23DOI Listing
May 2004

Genealogy and genes: tracing the founding fathers of Tristan da Cunha.

Eur J Hum Genet 2003 Sep;11(9):705-9

1MRC/NHLS/Wits Human Genomic Diversity and Disease Research Unit, Division of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, PO Box 1038, Johannesburg 2000, South Africa.

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http://www.nature.com/articles/5201022
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http://dx.doi.org/10.1038/sj.ejhg.5201022DOI Listing
September 2003