Almer M van der Sloot

Almer M van der Sloot

UNVERIFIED PROFILE

Are you Almer M van der Sloot?   Register this Author

Register author
Almer M van der Sloot

Almer M van der Sloot

Publications by authors named "Almer M van der Sloot"

Are you Almer M van der Sloot?   Register this Author

23Publications

271Reads

14Profile Views

Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity.

Biochem Biophys Res Commun 2018 01 3;495(1):700-705. Epub 2017 Nov 3.

Apoptosis Research Centre, NUI, Galway, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2017.11.003DOI Listing
January 2018

Engineering of weak helper interactions for high-efficiency FRET probes.

Nat Methods 2013 Oct 1;10(10):1021-7. Epub 2013 Sep 1.

1] EMBL/CRG Systems Biology Research Unit, Center for Genomic Regulation, Barcelona, Spain. [2] Pompeu Fabra University, Barcelona, Spain. [3] Institut de Recherche en Immunologie et en Cancérologie, Université de Montréal, Montréal, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.2625DOI Listing
October 2013

The design and characterization of receptor-selective APRIL variants.

J Biol Chem 2012 Oct 7;287(44):37434-46. Epub 2012 Sep 7.

Laboratory of Experimental Oncology and Radiobiology, Center for Experimental Molecular Medicine, University of Amsterdam, Amsterdam 1105 A2, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.406090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481339PMC
October 2012

An improved understanding of TNFL/TNFR interactions using structure-based classifications.

Trends Biochem Sci 2012 Sep 11;37(9):353-63. Epub 2012 Jul 11.

Bioinformatics and Genomics Program, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2012.06.002DOI Listing
September 2012

A novel classification system to predict the pathogenic effects of CHD7 missense variants in CHARGE syndrome.

Hum Mutat 2012 Aug 11;33(8):1251-60. Epub 2012 May 11.

Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22106DOI Listing
August 2012

Targeting AML through DR4 with a novel variant of rhTRAIL.

J Cell Mol Med 2011 Oct;15(10):2216-31

Department of Biochemistry and the National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1582-4934.2010.01211.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394230PMC
October 2011

Protein design with fragment databases.

Curr Opin Struct Biol 2011 Aug 16;21(4):452-9. Epub 2011 Jun 16.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG) and UPF, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sbi.2011.05.002DOI Listing
August 2011

Computational design of peptide ligands.

Trends Biotechnol 2011 May 12;29(5):231-9. Epub 2011 Feb 12.

VIB SWITCH Laboratory, Flanders Institute of Biotechnology (VIB), Pleinlaan 2, 1050 Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibtech.2011.01.004DOI Listing
May 2011

Computational design of TNF ligand-based protein therapeutics.

Adv Exp Med Biol 2011 ;691:521-34

EMBL-CRG Systems Biology Program, Design of Biological Systems, Centre de Regulació Genòmica, Dr Aiguader 88, 08003, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4419-6612-4_54DOI Listing
April 2011

T-RMSD: a fine-grained, structure-based classification method and its application to the functional characterization of TNF receptors.

J Mol Biol 2010 Jul 13;400(3):605-17. Epub 2010 May 13.

EMBL/CRG Systems Biology Research Unit Center for Genomic Regulation, UPF, Barcelona, Catalunya, 08003, Spain.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00222836100049
Publisher Site
http://dx.doi.org/10.1016/j.jmb.2010.05.012DOI Listing
July 2010

Building blocks for protein interaction devices.

Nucleic Acids Res 2010 May 9;38(8):2645-62. Epub 2010 Mar 9.

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, Barcelona and Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gkq152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860130PMC
May 2010

Protein design in biological networks: from manipulating the input to modifying the output.

Protein Eng Des Sel 2009 Sep 2;22(9):537-42. Epub 2009 Jul 2.

CRG-EMBL Systems Biology Program, Design of Biological Systems, Centre de Regulació Genòmica, 08003 Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/protein/gzp032DOI Listing
September 2009

Enhancement of antitumor properties of rhTRAIL by affinity increase toward its death receptors.

Biochemistry 2009 Mar;48(10):2180-91

Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi801927xDOI Listing
March 2009

Loop grafting of Bacillus subtilis lipase A: inversion of enantioselectivity.

Chem Biol 2008 Aug;15(8):782-9

Department of Pharmaceutical Biology, Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S107455210800244
Publisher Site
http://dx.doi.org/10.1016/j.chembiol.2008.06.009DOI Listing
August 2008

DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design.

J Biol Chem 2008 Jul 12;283(29):20560-8. Epub 2008 May 12.

Centre for Genomic Regulation, CRG-EMBL Systems Biology Unit, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M800457200DOI Listing
July 2008

A novel genetic selection system for improved enantioselectivity of Bacillus subtilis lipase A.

Chembiochem 2008 May;9(7):1110-5

Department of Pharmaceutical Biology, University of Groningen, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200700754DOI Listing
May 2008

Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor.

Proc Natl Acad Sci U S A 2006 Jun 26;103(23):8634-9. Epub 2006 May 26.

Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0510187103
Publisher Site
http://dx.doi.org/10.1073/pnas.0510187103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482632PMC
June 2006

Stabilization of TRAIL, an all-beta-sheet multimeric protein, using computational redesign.

Protein Eng Des Sel 2004 Sep 14;17(9):673-80. Epub 2004 Oct 14.

Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/protein/gzh079DOI Listing
September 2004

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.

Chembiochem 2004 Jun;5(6):820-5

University of Groningen, University Centre for Pharmacy, Pharmaceutical Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200300764DOI Listing
June 2004

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.

Chembiochem 2004 Jun;5(6):820-5

University of Groningen, University Centre for Pharmacy, Pharmaceutical Biology, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cbic.200300764DOI Listing
June 2004