Publications by authors named "Allen F Ryan"

100Publications

Noise Exposures Causing Hearing Loss Generate Proteotoxic Stress and Activate the Proteostasis Network.

Cell Rep 2020 Nov;33(8):108431

Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108431DOI Listing
November 2020

Novel Risk Loci in Tinnitus and Causal Inference With Neuropsychiatric Disorders Among Adults of European Ancestry.

JAMA Otolaryngol Head Neck Surg 2020 Sep 24. Epub 2020 Sep 24.

Research Service, Veterans Affairs San Diego Healthcare System, San Diego, California.

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http://dx.doi.org/10.1001/jamaoto.2020.2920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516809PMC
September 2020

Macrophage depletion in CCR2-/- mice delays bacterial clearance and enhances neutrophil infiltration in an acute otitis media model.

J Infect Dis 2020 Jun 23. Epub 2020 Jun 23.

Department of Surgery and Otolaryngology, School of Medicine, University of California, San Diego, La Jolla, California, United States of America.

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http://dx.doi.org/10.1093/infdis/jiaa353DOI Listing
June 2020

Single-Cell Transcriptomes Reveal a Complex Cellular Landscape in the Middle Ear and Differential Capacities for Acute Response to Infection.

Front Genet 2020 15;11:358. Epub 2020 Apr 15.

Departments of Surgery/Otolaryngology, UC San Diego School of Medicine, VA Medical Center, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fgene.2020.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174727PMC
April 2020

Panel 3: Genomics, precision medicine and targeted therapies.

Int J Pediatr Otorhinolaryngol 2020 Mar 24;130 Suppl 1:109835. Epub 2019 Dec 24.

Center for Genomic Sciences, Institute for Molecular Medicine and Infectious Disease, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th St., Philadelphia, PA 19102, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijporl.2019.109835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155947PMC
March 2020

Panel 1: Biotechnology, biomedical engineering and new models of otitis media.

Int J Pediatr Otorhinolaryngol 2020 Mar 27;130 Suppl 1:109833. Epub 2019 Dec 27.

Department of Otolaryngology-Head and Neck Surgery, Samson Assuta Ashdod University Hospital, Faculty of Health Sciences Ben Gurion University, Ashdod, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ijporl.2019.109833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176743PMC
March 2020

Role of the PI3K/AKT pathway and PTEN in otitis media.

Exp Cell Res 2020 02 13;387(1):111758. Epub 2019 Dec 13.

Division of Otolaryngology, Department of Surgery, University of California, San Diego and San Diego VA Healthcare System, La Jolla, CA, 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2019.111758DOI Listing
February 2020

Inflammation associated with noise-induced hearing loss.

J Acoust Soc Am 2019 11;146(5):4020

Department of Surgery/Otolaryngology, University of California San Diego, School of Medicine, and Veterans Administration Medical Center, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1121/1.5132545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480080PMC
November 2019

Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'.

Purinergic Signal 2019 09 3;15(3):343-355. Epub 2019 Aug 3.

Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1007/s11302-019-09648-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737159PMC
September 2019

Lack of the hyaluronan receptor CD44 affects the course of bacterial otitis media and reduces leukocyte recruitment to the middle ear.

BMC Immunol 2019 06 21;20(1):20. Epub 2019 Jun 21.

Department of Surgery/Otolaryngology, University of California-San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA, 92093-0666, USA.

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http://dx.doi.org/10.1186/s12865-019-0302-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588864PMC
June 2019

FUT2 Variants Confer Susceptibility to Familial Otitis Media.

Am J Hum Genet 2018 11 25;103(5):679-690. Epub 2018 Oct 25.

Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183032
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http://dx.doi.org/10.1016/j.ajhg.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217759PMC
November 2018

Active Transport of Peptides Across the Intact Human Tympanic Membrane.

Sci Rep 2018 08 7;8(1):11815. Epub 2018 Aug 7.

University of California, San Diego, Division of Otolaryngology, Department of Surgery, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1038/s41598-018-30031-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081404PMC
August 2018

Screening Mammalian Cochlear Hair Cells to Identify Critical Processes in Aminoglycoside-Mediated Damage.

Front Cell Neurosci 2018 2;12:179. Epub 2018 Jul 2.

Division of Otolaryngology, Department of Surgery, University of California, San Diego, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fncel.2018.00179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036173PMC
July 2018

Screening antioxidants for the protection of cochlear sensory cells.

Neural Regen Res 2018 Jan;13(1):62-64

Department of Surgery / Otolaryngology, School of Medicine, University of California, San Diego, La Jolla; Research Service, Veterans Administration Medical Center, San Diego, CA, USA.

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http://dx.doi.org/10.4103/1673-5374.224371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840991PMC
January 2018

A kinase inhibitor library screen identifies novel enzymes involved in ototoxic damage to the murine organ of Corti.

PLoS One 2017 19;12(10):e0186001. Epub 2017 Oct 19.

Department of Surgery/Otolaryngology, University of California, San Diego, School of Medicine, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186001PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648133PMC
November 2017

An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity.

Front Cell Neurosci 2017 18;11:242. Epub 2017 Aug 18.

Department of Surgery and Otolaryngology, School of Medicine, University of California, San Diego, La JollaCA, United States.

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00
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http://dx.doi.org/10.3389/fncel.2017.00242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5563352PMC
August 2017

Otitis Media and Nasopharyngeal Colonization in Mice.

Infect Immun 2017 11 18;85(11). Epub 2017 Oct 18.

Department of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1128/IAI.00148-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649018PMC
November 2017

Optimisation of peptides that actively cross the tympanic membrane by random amino acid extension: a phage display study.

J Drug Target 2018 02 16;26(2):127-134. Epub 2017 Aug 16.

a Department of Surgery, Division of Otolaryngology , School of Medicine, University of California , La Jolla , CA , USA.

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http://dx.doi.org/10.1080/1061186X.2017.1347791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223256PMC
February 2018

Peptides actively transported across the tympanic membrane: Functional and structural properties.

PLoS One 2017 24;12(2):e0172158. Epub 2017 Feb 24.

University of California San Diego, School of Medicine, Department of Surgery, Division of Otolaryngology, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325213PMC
September 2017

Global Analysis of Protein Expression of Inner Ear Hair Cells.

J Neurosci 2017 02 30;37(5):1320-1339. Epub 2016 Dec 30.

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611,

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http://dx.doi.org/10.1523/JNEUROSCI.2267-16.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296798PMC
February 2017

Cellular mechanisms of noise-induced hearing loss.

Hear Res 2017 06 2;349:129-137. Epub 2016 Dec 2.

Division of Otolaryngology, Department of Surgery, UCSD School of Medicine and San Diego VA Medical Center, La Jolla, CA, 92093, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S03785955163030
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http://dx.doi.org/10.1016/j.heares.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750278PMC
June 2017

Both canonical and non-canonical NF-κB activation contribute to the proliferative response of the middle ear mucosa during bacterial infection.

Innate Immun 2016 11 23;22(8):626-634. Epub 2016 Sep 23.

2 Department of Surgery/Otolaryngology, University of California, San Diego (UCSD) School of Medicine and Veterans Administration (VA) Medical Center, USA.

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http://journals.sagepub.com/doi/10.1177/1753425916668581
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http://dx.doi.org/10.1177/1753425916668581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333768PMC
November 2016

The Promoter and Multiple Enhancers of the pou4f3 Gene Regulate Expression in Inner Ear Hair Cells.

Mol Neurobiol 2017 09 3;54(7):5414-5426. Epub 2016 Sep 3.

Departments of Surgery/Otolaryngology, UCSD School of Medicine, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s12035-016-0060-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336531PMC
September 2017

Temporary and Permanent Noise-induced Threshold Shifts: A Review of Basic and Clinical Observations.

Otol Neurotol 2016 09;37(8):e271-5

*Department of Surgery/Otolaryngology, University of California, San Diego, La Jolla †Veterans Administration, San Diego, California ‡Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts §Defense Hearing Center of Excellence, 59MDW/SG02O, JBSA Lackland ||Hearing Science Program, Callier Center for Communication Disorders, Dallas, Texas ¶Sound Pharmaceuticals, Seattle, Washington.

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http://dx.doi.org/10.1097/MAO.0000000000001071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988324PMC
September 2016

Impulse Noise Injury Model.

Mil Med 2016 05;181(5 Suppl):59-69

UCSD School of Medicine and San Diego VA Medical Center, 9500 Gilman Drive, La Jolla, CA 92093.

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http://dx.doi.org/10.7205/MILMED-D-15-00139DOI Listing
May 2016

Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear.

Sci Rep 2016 Mar 7;6:22663. Epub 2016 Mar 7.

University of California San Diego, Department of Surgery/Otolaryngology, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/srep22663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780071PMC
March 2016

Tinnitus: Research supported by the Tinnitus Research Consortium.

Hear Res 2016 04 29;334. Epub 2015 Dec 29.

Department of Otolaryngology - Head & Neck Surgery, Loma Linda University Health, Senior Research Scientist Research Service VA, Loma Linda Healthcare System, Loma Linda, CA, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03785955150023
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http://dx.doi.org/10.1016/j.heares.2015.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743484PMC
April 2016

Innate Immunity: Orchestrating Inflammation and Resolution of Otitis Media.

Curr Allergy Asthma Rep 2016 Jan;16(1)

School of Medicine-Department of Medicine, Rheumatology, Allergy and Immunology Division, University of California San Diego, 9500 Gilman Drive-MC#0628, La Jolla, CA, 92093-0628, USA.

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http://dx.doi.org/10.1007/s11882-015-0585-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6752202PMC
January 2016

Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells.

Purinergic Signal 2015 Dec 1;11(4):551-60. Epub 2015 Oct 1.

Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, UNSW Australia, Sydney, NSW, 2052, Australia.

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http://dx.doi.org/10.1007/s11302-015-9473-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648790PMC
December 2015

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier.

Nat Commun 2015 May 12;6:7115. Epub 2015 May 12.

Translational Neuroscience Facility and Department of Physiology, School of Medical Sciences, UNSW Australia, Sydney, New South Wales 2052, Australia.

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http://dx.doi.org/10.1038/ncomms8115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432632PMC
May 2015

Mechanisms of sensorineural cell damage, death and survival in the cochlea.

Front Aging Neurosci 2015 21;7:58. Epub 2015 Apr 21.

Department of Surgery/Division of Otolaryngology, University of California, San Diego School of Medicine La Jolla, CA, USA ; Veterans Administration Medical Center La Jolla, CA, USA ; Department of Neurosciences, University of California, San Diego School of Medicine La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fnagi.2015.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404918PMC
May 2015

NOD-Like Receptor Signaling in Cholesteatoma.

Biomed Res Int 2015 2;2015:408169. Epub 2015 Apr 2.

Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum Bielefeld, Teutoburger Straße 50, 33604 Bielefeld, Germany.

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http://downloads.hindawi.com/journals/bmri/2015/408169.pdf
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http://www.hindawi.com/journals/bmri/2015/408169/
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http://dx.doi.org/10.1155/2015/408169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398947PMC
February 2016

The transcriptome of a complete episode of acute otitis media.

BMC Genomics 2015 Apr 3;16:259. Epub 2015 Apr 3.

Divisions of Surgery / Otolaryngology, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1186/s12864-015-1475-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394589PMC
April 2015

All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.

PLoS One 2015 26;10(3):e0121599. Epub 2015 Mar 26.

Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland; Clinic for Otolaryngology, Head and Neck Surgery, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121599PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374771PMC
February 2016

The regulation of gene expression in hair cells.

Hear Res 2015 Nov 21;329:33-40. Epub 2015 Jan 21.

Departments of Surgery/Otolaryngology, University of California, San Diego - School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S03785955150000
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http://dx.doi.org/10.1016/j.heares.2014.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510037PMC
November 2015

Skeletal muscle intermediate filaments form a stress-transmitting and stress-signaling network.

J Cell Sci 2015 Jan 20;128(2):219-24. Epub 2014 Nov 20.

Departments of Orthopaedics, Bioengineering, Medicine and the Biomedical Sciences Graduate Group, University of California and Veterans Administration Medical Centers, San Diego, CA 92093, USA

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.142463
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http://dx.doi.org/10.1242/jcs.142463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294770PMC
January 2015

Neural cell adhesion molecule NrCAM is expressed in the mammalian inner ear and modulates spiral ganglion neurite outgrowth in an in vitro alternate choice assay.

J Mol Neurosci 2015 Apr 20;55(4):836-44. Epub 2014 Nov 20.

Department of Surgery/Otolaryngology, UCSD School of Medicine, 9500 Gilman Drive, MC0666, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s12031-014-0436-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355056PMC
April 2015

A mouse model of otitis media identifies HB-EGF as a mediator of inflammation-induced mucosal proliferation.

PLoS One 2014 17;9(7):e102739. Epub 2014 Jul 17.

Division of Otolaryngology, University of California, San Diego School of Medicine and VA Medical Center, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102739PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102546PMC
November 2015

Inhibition of MMP-2 but not MMP-9 influences inner ear spiral ganglion neurons in vitro.

Cell Mol Neurobiol 2014 Oct 17;34(7):1011-21. Epub 2014 Jun 17.

Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031, Basel, Switzerland.

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http://dx.doi.org/10.1007/s10571-014-0077-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386629PMC
October 2014

The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.

Innate Immun 2015 Feb 20;21(2):203-14. Epub 2014 Mar 20.

Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1753425914526074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379507PMC
February 2015

Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.

J Mol Neurosci 2013 Nov 13;51(3):663-70. Epub 2013 Jun 13.

Department of Surgery/Otolaryngology, UCSD School of Medicine, 9500 Gilman Drive MC0666, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s12031-013-0040-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825176PMC
November 2013

Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.

PLoS One 2013 23;8(4):e61394. Epub 2013 Apr 23.

Department of Surgery, University of California, San Diego School of Medicine, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061394PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634077PMC
November 2013

ATP-gated ion channels mediate adaptation to elevated sound levels.

Proc Natl Acad Sci U S A 2013 Apr 16;110(18):7494-9. Epub 2013 Apr 16.

Department of Physiology and Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

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http://dx.doi.org/10.1073/pnas.1222295110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645545PMC
April 2013

Panel 4: Recent advances in otitis media in molecular biology, biochemistry, genetics, and animal models.

Otolaryngol Head Neck Surg 2013 Apr;148(4 Suppl):E52-63

Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1177/0194599813479772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006668PMC
April 2013

Changes in responsiveness of rat spiral ganglion neurons to neurotrophins across age: differential regulation of survival and neuritogenesis.

Int J Neurosci 2013 Jul 11;123(7):465-75. Epub 2013 Feb 11.

Division of Otolaryngology and Neurosciences, Department of Surgery and Veterans Administration Medical Center, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.

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http://www.tandfonline.com/doi/full/10.3109/00207454.2013.76
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http://dx.doi.org/10.3109/00207454.2013.764497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897193PMC
July 2013

Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM).

Mol Cell Neurosci 2013 May 20;54:30-43. Epub 2012 Dec 20.

Department of Surgery/Otolaryngology, University of California San Diego, School of Medicine, 9500 Gilman Drive #0666, La Jolla, CA 92093-0666, USA.

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http://dx.doi.org/10.1016/j.mcn.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857543PMC
May 2013

Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology.

Cell Tissue Res 2013 Jan 13;351(1):15-27. Epub 2012 Nov 13.

Department of Otolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00441-012-1526-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577061PMC
January 2013

Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse.

Hear Res 2012 Oct 28;292(1-2):71-9. Epub 2012 Aug 28.

Translational Neuroscience Facility, School of Medical Sciences, The University of New South Wales, UNSW Kensington Campus, Sydney, NSW Australia.

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http://dx.doi.org/10.1016/j.heares.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582347PMC
October 2012

Systemic immunity influences hearing preservation in cochlear implantation.

Otol Neurotol 2012 Jun;33(4):532-8

Department of Otolaryngology, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.

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http://dx.doi.org/10.1097/MAO.0b013e31824bac44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897157PMC
June 2012

Ras/p38 and PI3K/Akt but not Mek/Erk signaling mediate BDNF-induced neurite formation on neonatal cochlear spiral ganglion explants.

Brain Res 2012 Jan 6;1430:25-34. Epub 2011 Nov 6.

Surgery/Otolaryngology, UCSD School of Medicine, 9500 Gilman Drive MC0666, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.brainres.2011.10.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242932PMC
January 2012

The role of vascular endothelial growth factors and fibroblast growth factors in angiogenesis during otitis media.

Audiol Neurootol 2012 19;17(3):148-54. Epub 2011 Nov 19.

Department of Surgery/Otolaryngology, University of California, San Diego, USA.

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http://dx.doi.org/10.1159/000333805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238030PMC
August 2012

Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development.

Neural Dev 2011 Oct 11;6:33. Epub 2011 Oct 11.

Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://neuraldevelopment.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1749-8104-6-33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207869PMC
October 2011

ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas.

Otol Neurotol 2011 Jul;32(5):841-7

Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of California, San Diego, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584631PMC
July 2011

TNFA deletion alters apoptosis as well as caspase 3 and 4 expression during otitis media.

BMC Immunol 2011 Jan 26;12:12. Epub 2011 Jan 26.

Department of Otorhinolaryngology, Head and Neck Surgery Klinikum Bielefeld, Academic Teaching Hospital University of Münster, Bielefeld, Germany.

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http://dx.doi.org/10.1186/1471-2172-12-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040143PMC
January 2011

The role of DNA sensing and innate immune receptor TLR9 in otitis media.

Innate Immun 2012 Feb 14;18(1):3-13. Epub 2011 Jan 14.

Department of Surgery/Otolaryngology, University of Lübeck, Lübeck, Germany.

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http://dx.doi.org/10.1177/1753425910393539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041324PMC
February 2012

Estrogen receptor expression in sporadic vestibular schwannomas.

Otol Neurotol 2011 Jan;32(1):158-62

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, California 92161, USA.

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http://dx.doi.org/10.1097/MAO.0b013e3181feb92aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073320PMC
January 2011

Innate signaling in otitis media: pathogenesis and recovery.

Curr Allergy Asthma Rep 2011 Feb;11(1):78-84

Department of Otolaryngology, University of Lübeck, Ratzeburger Allee 160, 23564, Lübeck, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020300PMC
February 2011

Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections.

J Invest Dermatol 2010 Sep 13;130(9):2211-21. Epub 2010 May 13.

Division of Dermatology, Department of Medicine, University of California, San Diego and VA San Diego Healthcare System, San Diego, California 92161, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922455PMC
September 2010

Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis.

Otol Neurotol 2010 Apr;31(3):460-6

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California-San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873969PMC
April 2010

Type III intermediate filament peripherin inhibits neuritogenesis in type II spiral ganglion neurons in vitro.

Neurosci Lett 2010 Jul 2;478(2):51-5. Epub 2010 Feb 2.

Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902986PMC
July 2010

Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.

Nat Med 2009 Dec 22;15(12):1377-82. Epub 2009 Nov 22.

[Division of Dermatology, Department of Medicine, University of California-San Diego, San Diego, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880863PMC
December 2009

Reconstitution of the mast cell population in W/Wv mice.

Otol Neurotol 2010 Jan;31(1):42-7

Department of Otorhinoloaryngology, Head and Neck Surgery, Klinikum Bielefeld (Academic Teaching Hospital University of Münster), Bielefeld, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796298PMC
January 2010

The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery.

BMC Immunol 2009 Aug 5;10:45. Epub 2009 Aug 5.

Department of Surgery/Otolaryngology University of California, San Diego, 9500 Gilman Avenue, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1186/1471-2172-10-45DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736931PMC
August 2009

TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media.

Innate Immun 2009 Aug 8;15(4):205-15. Epub 2009 Jul 8.

Department of Surgery/Otolaryngology, University of California San Diego, La Jolla, California 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565845PMC
August 2009

Myeloid differentiation primary response gene 88 is required for the resolution of otitis media.

J Infect Dis 2008 Dec;198(12):1862-9

Department of Pediatrics, Division of Allergy, Immunology, Rheumatology, and Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584630PMC
December 2008

A catechol-O-methyltransferase that is essential for auditory function in mice and humans.

Proc Natl Acad Sci U S A 2008 Sep 15;105(38):14609-14. Epub 2008 Sep 15.

Department of Genetics, Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567147PMC
September 2008

Vestibular schwannoma quantitative polymerase chain reaction expression of estrogen and progesterone receptors.

Laryngoscope 2008 Aug;118(8):1458-63

Department of Surgery, Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570025PMC
August 2008

Spiral ganglion outgrowth and hearing development in p75-deficient mice.

Audiol Neurootol 2008 29;13(6):388-95. Epub 2008 Jul 29.

Department of Otolaryngology, Head and Neck Surgery, Ruhr-University Bochum, Bochum, Germany.

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December 2008

ErbB and Nrg: potential molecular targets for vestibular schwannoma pharmacotherapy.

Otol Neurotol 2008 Jan;29(1):50-7

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California, San Diego, USA.

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January 2008

Hearing development and spiral ganglion neurite growth in VASP deficient mice.

Brain Res 2007 Oct 5;1178:73-82. Epub 2007 Jul 5.

Department of Otorhinolaryngology-Head and Neck Surgery, Ruhr-Universitaet Bochum, St. Elisabeth-Hospital Bochum, Germany.

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October 2007

Neuronal expression of peripherin, a type III intermediate filament protein, in the mouse hindbrain.

Histochem Cell Biol 2007 Dec 26;128(6):541-50. Epub 2007 Sep 26.

Department of Physiology, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

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December 2007

Laminin and fibronectin modulate inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.

Dev Neurobiol 2007 Nov;67(13):1721-30

Department of Surgery/Otolaryngology, University of California San Diego, School of Medicine, and VA San Diego Health Care Systems, 9500 Gilman Drive, MC 0666, La Jolla, California 92093, USA.

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November 2007

N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution.

Mol Cell Biol 2007 Jun 9;27(12):4340-6. Epub 2007 Apr 9.

Glycobiology Research and Training Center, Department of Medicine, University of California San Diego, La Jolla, CA 92093-0687, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1900035PMC
June 2007

P2X receptor signaling inhibits BDNF-mediated spiral ganglion neuron development in the neonatal rat cochlea.

Development 2007 Apr 28;134(7):1407-17. Epub 2007 Feb 28.

Department of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand.

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April 2007

Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media.

Infect Immun 2007 May 26;75(5):2562-71. Epub 2007 Feb 26.

Department of Surgery, UCSD School of Medicine, Fir Bldg., Rm. 106, 9500 Gilman Dr. #0666, La Jolla, CA 92037, USA.

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May 2007

A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti.

J Assoc Res Otolaryngol 2006 Dec 20;7(4):373-82. Epub 2006 Oct 20.

Department of Surgery Otolaryngology, UCSD School of Medicine and VA Medical Center, 9500 Gilman Drive #0666, La Jolla, CA 92093-0666, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504631PMC
December 2006

Mouse models of induced otitis media.

Brain Res 2006 May 9;1091(1):3-8. Epub 2006 Jun 9.

Department of Surgery, Division of Otolaryngology, UCSD School of Medicine and VA Medical Center, La Jolla, CA 92093-0666, USA.

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May 2006

Environmental micro-patterning for the study of spiral ganglion neurite guidance.

Audiol Neurootol 2006 17;11(2):134-43. Epub 2006 Jan 17.

Department of Surgery/Otolaryngology, UCSD School of Medicine, La Jolla, CA 92093, USA.

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March 2006

Developmentally regulated expression of the P2X3 receptor in the mouse cochlea.

Histochem Cell Biol 2006 Jun 9;125(6):681-92. Epub 2005 Dec 9.

Department of Physiology, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://dx.doi.org/10.1007/s00418-005-0119-4DOI Listing
June 2006

Role of mast cells in otitis media.

J Allergy Clin Immunol 2005 Nov 28;116(5):1129-35. Epub 2005 Sep 28.

Department of Surgery, Division of Otolaryngology; Department of Otorhinolaryngology-Head and Neck Surgery, Julius-Maximilian University of Würzburg, Germany.

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http://dx.doi.org/10.1016/j.jaci.2005.07.026DOI Listing
November 2005

The role of Fas-mediated apoptosis in otitis media: observations in the lpr/lpr mouse.

Hear Res 2005 Sep;207(1-2):110-6

Department of Surgery, Division Otolaryngology, UCSD School of Medicine and VA Medical Center, 9500 Gilman Drive number 0666, Fir Building, Room 106, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.heares.2005.04.010DOI Listing
September 2005

A reusable microfluidic plate with alternate-choice architecture for assessing growth preference in tissue culture.

J Neurosci Methods 2005 May 8;144(1):79-89. Epub 2004 Dec 8.

Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093-0407, USA.

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http://dx.doi.org/10.1016/j.jneumeth.2004.10.010DOI Listing
May 2005

Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:56-9

Division of Otolaryngology, University of California, San Diego, La Jolla, USA.

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http://dx.doi.org/10.1177/00034894051140s108DOI Listing
January 2005

Recent advances in otitis media. 4B. Biochemistry.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:50-5

Division of Otolaryngology, University of California, San Diego, La Jolla, USA.

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January 2005

Recent advances in otitis media. 4A. Molecular biology.

Ann Otol Rhinol Laryngol Suppl 2005 Jan;194:42-9

Division of Otolaryngology, University of California, San Diego, La Jolla, USA.

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January 2005

Effects of amoxicillin on cytokine and osteocalcin expression in bone tissue during experimental acute otitis media.

Cytokine 2004 Mar;25(6):254-9

Department of Medical Microbiology, Lund University, Malmö University Hospital, S-205 02 Malmö, Sweden.

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http://dx.doi.org/10.1016/j.cyto.2003.11.009DOI Listing
March 2004