Publications by authors named "Allen B Reitz"

90Publications

Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor.

Eur J Med Chem 2020 Jan 21;186:111906. Epub 2019 Nov 21.

Department of Cell and Molecular Pharmacology & Experimental Therapeutics, College of Medicine, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212515PMC
January 2020

Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.

ACS Infect Dis 2020 02 16;6(2):302-312. Epub 2019 Dec 16.

Department of Microbiology and Molecular Genetics , University of Pittsburgh School of Medicine , Suite 523 Bridgeside Point II, 450 Technology Drive , Pittsburgh , Pennsylvania 15219 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.9b00382DOI Listing
February 2020

Current Topics in Medicinal Chemistry: The Six Most Cited Publications 2016-2019.

Authors:
Allen B Reitz

Curr Top Med Chem 2019 ;19(17):1487

Fox Chase Chemical Diversity Center, Inc. (FCCDC) 3805 Old Easton Rd. Doylestown, PA 18902, United States.

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http://dx.doi.org/10.2174/156802661917190828110645DOI Listing
October 2019

Effects of dopaminergic and serotonergic compounds in rats trained to discriminate a high and a low training dose of the synthetic cathinone mephedrone.

Psychopharmacology (Berl) 2019 Mar 13;236(3):1015-1029. Epub 2019 Apr 13.

Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA, 19140, USA.

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http://link.springer.com/10.1007/s00213-019-05241-z
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http://dx.doi.org/10.1007/s00213-019-05241-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589396PMC
March 2019

Preface.

Authors:
Allen B Reitz

Curr Top Med Chem 2019 ;19(1)

Fox Chase Chemical Diversity Center, Inc Doylestown, PA 18902, United States.

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http://dx.doi.org/10.2174/156802661901190326145545DOI Listing
April 2019

Non-NAD-like PARP-1 inhibitors in prostate cancer treatment.

Biochem Pharmacol 2019 09 15;167:149-162. Epub 2019 Mar 15.

University of North Dakota, Grand Forks, ND, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702078PMC
September 2019

Synthetic cathinone MDPV enhances reward function through purinergic P2X7 receptor-dependent pathway and increases P2X7 gene expression in nucleus accumbens.

Drug Alcohol Depend 2019 04 31;197:22-27. Epub 2019 Jan 31.

Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447078PMC
April 2019

Mutation and structure guided discovery of an antiviral small molecule that mimics an essential C-Terminal tripeptide of the vaccinia D4 processivity factor.

Antiviral Res 2019 02 20;162:178-185. Epub 2018 Dec 20.

Department of Microbiology, School of Dental Medicine and the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.antiviral.2018.12.011DOI Listing
February 2019

Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma.

Leukemia 2019 04 12;33(4):1011-1022. Epub 2018 Oct 12.

Department of Cell and Molecular Pharmacology & Experimental Therapeutics, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

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http://www.nature.com/articles/s41375-018-0263-1
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http://dx.doi.org/10.1038/s41375-018-0263-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194280PMC
April 2019

Dipeptide Prodrugs of the Glutamate Modulator Riluzole.

ACS Med Chem Lett 2018 Jul 15;9(7):752-756. Epub 2018 Jun 15.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047042PMC
July 2018

Cypin: A novel target for traumatic brain injury.

Neurobiol Dis 2018 11 19;119:13-25. Epub 2018 Jul 19.

Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854-8082, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214165PMC
November 2018

A Method for C2 Acylation of 1,3-Indandiones.

Tetrahedron 2018 May 17;74(22):2762-2768. Epub 2018 Apr 17.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.tet.2018.04.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947957PMC
May 2018

Preface.

Curr Top Med Chem 2018;18(1)

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http://dx.doi.org/10.2174/156802661801180322101825DOI Listing
May 2018

Chemokines and 'bath salts': CXCR4 receptor antagonist reduces rewarding and locomotor-stimulant effects of the designer cathinone MDPV in rats.

Drug Alcohol Depend 2018 05 10;186:75-79. Epub 2018 Mar 10.

Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drugalcdep.2018.01.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911211PMC
May 2018

PLDT (planarian light/dark test): an invertebrate assay to quantify defensive responding and study anxiety-like effects.

J Neurosci Methods 2018 Jan 16;293:284-288. Epub 2017 Oct 16.

Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2017.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705295PMC
January 2018

Synthetic cathinones and stereochemistry: S enantiomer of mephedrone reduces anxiety- and depressant-like effects in cocaine- or MDPV-abstinent rats.

Drug Alcohol Depend 2017 09 13;178:119-125. Epub 2017 Jun 13.

Department of Pharmacology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03768716173026
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http://dx.doi.org/10.1016/j.drugalcdep.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548612PMC
September 2017

Glutamate carboxypeptidase II (GCPII) inhibitor 2-PMPA reduces rewarding effects of the synthetic cathinone MDPV in rats: a role for N-acetylaspartylglutamate (NAAG).

Psychopharmacology (Berl) 2017 Jun 1;234(11):1671-1681. Epub 2017 Mar 1.

Department of Pharmacology, Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1007/s00213-017-4568-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433920PMC
June 2017

Preface.

Authors:
Allen B Reitz

Curr Top Med Chem 2017 ;17(1)

Fox Chase Chemical Diversity Center, Inc Doylestown, PA USA.

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http://dx.doi.org/10.2174/156802661701161114211346DOI Listing
February 2017

Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress.

Bioorg Med Chem Lett 2016 08 23;26(15):3429-35. Epub 2016 Jun 23.

Fox Chase Chemical Diversity Center, Inc, 3805 Old Easton Road, Doylestown, PA 18902, United States.

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http://dx.doi.org/10.1016/j.bmcl.2016.06.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955528PMC
August 2016

Synthetic cathinone MDPV downregulates glutamate transporter subtype I (GLT-1) and produces rewarding and locomotor-activating effects that are reduced by a GLT-1 activator.

Neuropharmacology 2016 09 13;108:111-9. Epub 2016 Apr 13.

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, United States; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912874PMC
September 2016

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Bioorg Med Chem Lett 2016 Mar 21;26(5):1480-1484. Epub 2016 Jan 21.

Department of Microbiology and Molecular Genetics, University of Pittsburgh School of School of Medicine, Pittsburgh, PA 15219 USA.

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http://dx.doi.org/10.1016/j.bmcl.2016.01.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756635PMC
March 2016

Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention.

PLoS Pathog 2015 Oct 29;11(10):e1005220. Epub 2015 Oct 29.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1005220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634230PMC
October 2015

Many, diverse topics have been covered in recent years in CTMC. Preface.

Authors:
Allen B Reitz

Curr Top Med Chem 2015 ;14(24):2751-7

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http://dx.doi.org/10.2174/156802661424150105115257DOI Listing
September 2015

Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents.

Bioorg Med Chem Lett 2015 Jan 22;25(2):378-83. Epub 2014 Nov 22.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.11.020DOI Listing
January 2015

Stereochemistry and neuropharmacology of a 'bath salt' cathinone: S-enantiomer of mephedrone reduces cocaine-induced reward and withdrawal in invertebrates.

Neuropharmacology 2015 Apr 9;91:109-16. Epub 2014 Dec 9.

Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418799PMC
April 2015

8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A.

Curr Top Med Chem 2014 ;14(18):2094-102

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.2174/1568026614666141022095114DOI Listing
July 2015

Inhibition of botulinum neurotoxin BoNT/A.

Curr Top Med Chem 2014 ;14(18):2043

Current Topics in Medicinal Chemistry The Scripps Research Institute La Jolla, CA USA.

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http://dx.doi.org/10.2174/1568026614666141022095612DOI Listing
July 2015

Stereochemistry of mephedrone neuropharmacology: enantiomer-specific behavioural and neurochemical effects in rats.

Br J Pharmacol 2015 Feb 15;172(3):883-94. Epub 2014 Dec 15.

Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/bph.12951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301696PMC
February 2015

Intramolecular Rearrangement of α-Amino Acid Amide Derivatives of 2-Aminobenzothiazoles.

Tetrahedron Lett 2014 Jul;55(30):4193-4195

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Rd., Doylestown, PA 18902.

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http://dx.doi.org/10.1016/j.tetlet.2014.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090782PMC
July 2014

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

J Virol 2014 Jul 16;88(13):7294-306. Epub 2014 Apr 16.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

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http://dx.doi.org/10.1128/JVI.00591-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4054416PMC
July 2014

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors.

Bioorg Med Chem Lett 2014 Feb 9;24(4):1116-21. Epub 2014 Jan 9.

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, United States.

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http://dx.doi.org/10.1016/j.bmcl.2014.01.001DOI Listing
February 2014

Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.

J Med Chem 2014 Feb 15;57(3):669-76. Epub 2014 Jan 15.

Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/jm4012164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983388PMC
February 2014

Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties.

J Mol Neurosci 2014 Mar 26;52(3):446-58. Epub 2013 Nov 26.

Fox Chase Chemical Diversity Center, Pennsylvania Biotechnology Center, 3805 Old Easton Road, Doylestown, PA, 18902, USA,

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http://dx.doi.org/10.1007/s12031-013-0180-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945118PMC
March 2014

Mephedrone interactions with cocaine: prior exposure to the 'bath salt' constituent enhances cocaine-induced locomotor activation in rats.

Behav Pharmacol 2013 Dec;24(8):684-8

aCenter for Substance Abuse Research bDepartment of Pharmacology, Temple University School of Medicine, Philadelphia cFox Chase Chemical Diversity Center, Doylestown, Pennsylvania, USA.

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http://dx.doi.org/10.1097/FBP.0000000000000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293121PMC
December 2013

Facile Synthesis of Mutagen X (MX): 3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one.

Tetrahedron Lett 2012 Jun;53(25):3144-3146

Fox Chase Chemical Diversity Center, Inc., 3805 Old Easton Road, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.tetlet.2012.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398704PMC
June 2012

Characterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.

Biochimie 2012 Sep 29;94(9):1974-81. Epub 2012 May 29.

ALS Biopharma, LLC, Pennsylvania Biotechnology Center, 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.biochi.2012.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402613PMC
September 2012

Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.

Drug Alcohol Depend 2012 Nov 29;126(1-2):257-62. Epub 2012 May 29.

Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2012.04.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478431PMC
November 2012

Novel inhibitors of heat shock protein Hsp70-mediated luciferase refolding that bind to DnaJ.

Bioorg Med Chem 2012 Jun 11;20(11):3609-14. Epub 2012 Apr 11.

ALS Biopharma, LLC, Pennsylvania Biotechnology Center, 3805 Old Easton Rd, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.bmc.2012.03.067DOI Listing
June 2012

Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards the β-exosite.

Bioorg Med Chem Lett 2012 Jun 11;22(11):3754-7. Epub 2012 Apr 11.

Fox Chase Chemical Diversity Center, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352981PMC
June 2012

Small molecule anticonvulsant agents with potent in vitro neuroprotection.

J Mol Neurosci 2012 Jun 26;47(2):368-79. Epub 2012 Apr 26.

Advanced Neural Dynamics, Inc., Pennsylvania Biotechnology Center, Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1007/s12031-012-9765-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377984PMC
June 2012

Preface.

Authors:
Allen B Reitz

Curr Top Med Chem 2012 ;12(1)

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http://dx.doi.org/10.2174/156802612798919222DOI Listing
May 2012

Future horizons in drug discovery research.

Authors:
Allen B Reitz

ACS Med Chem Lett 2012 Feb 20;3(2):80-2. Epub 2012 Jan 20.

Pennsylvania Drug Discovery Institute, Pennsylvania Biotechnology Center , 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States.

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http://dx.doi.org/10.1021/ml3000116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025813PMC
February 2012

Pseudomonas aeruginosa porphobilinogen synthase assembly state regulators: hit discovery and initial SAR studies.

ARKIVOC 2010 Jun;2010:175-188

Fox Chase Chemical Diversity Center, Inc., Pennsylvania Center for Drug Discovery, Pennsylvania Biotechnology Center, Doylestown, PA 18902 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106444PMC
June 2010

Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads.

Bioorg Med Chem Lett 2010 May 30;20(10):3158-60. Epub 2010 Mar 30.

Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.03.097DOI Listing
May 2010

Current nervous system related drug targets for the treatment of amyotrophic lateral sclerosis.

Curr Pharm Des 2010 ;16(18):2053-73

ALS Biopharma, LLC Pennsylvania Center for Drug Discovery Pennsylvania Biotechnology Center 3805 Old Easton Rd. Doylestown, PA 18902, USA.

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http://dx.doi.org/10.2174/138161210791293024DOI Listing
October 2010

Hit triage using efficiency indices after screening of compound libraries in drug discovery.

Curr Top Med Chem 2009 ;9(18):1718-24

Fox Chase Chemical Diversity Center, Inc., Pennsylvania Biotechnology Center, 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.2174/156802609790102365DOI Listing
September 2010

Editorial.

Authors:
Allen B Reitz

Curr Top Med Chem 2009 ;9(11):964

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http://dx.doi.org/10.2174/156802609789630965DOI Listing
January 2010

The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008).

Expert Opin Ther Pat 2009 Oct;19(10):1449-53

ALS Biopharma, LLC, 3805 Old Easton Rd., Doylestown, PA 18902, USA.

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http://dx.doi.org/10.1517/13543770903185920DOI Listing
October 2009

Metabolic fate of the antipsychotic agent, mazapertine, in man--API-MS and MS/MS identification of urinary metabolites.

Eur J Drug Metab Pharmacokinet 2007 Jul-Sep;32(3):171-6

Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1007/BF03190479DOI Listing
December 2007

The preparation and human muscarinic receptor profiling of oxybutynin and N-desethyloxybutynin enantiomers.

Med Chem 2007 Nov;3(6):543-5

Johnson & Johnson Pharmaceutical Research and Development, Welsh & McKean Rds., Spring House, PA 19477, USA.

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http://dx.doi.org/10.2174/157340607782360353DOI Listing
November 2007

Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant-submissive relationships.

Neurosci Biobehav Rev 2007 24;31(6):904-19. Epub 2007 May 24.

Drug Discovery, CNS Research Team, East Coast Research and Early Development, Johnson & Johnson Pharmaceutical Research & Development, P.O. Box 776, Welsh and McKean Rds., L.L.C., Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/j.neubiorev.2007.05.004DOI Listing
November 2007

8-(Heteroaryl)phenalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as opioid receptor modulators.

Med Chem 2005 Nov;1(6):601-10

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, LLC, P.O. Box 776, Welsh and McKean Rds., Spring House, PA 19477-0777, USA.

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http://dx.doi.org/10.2174/157340605774598207DOI Listing
November 2005

Synthesis and biological evaluation of type VI beta-turn templated RGD peptidomimetics.

Bioorg Med Chem Lett 2006 Aug 5;16(15):3971-4. Epub 2006 Jun 5.

Johnson & Johnson Pharmaceutical Research and Development, Box 0776, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.05.020DOI Listing
August 2006

3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.

Bioorg Med Chem Lett 2006 Jul 24;16(13):3524-8. Epub 2006 Apr 24.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C PO Box 300, 1000 Route 202, Raritan, NJ 08869, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.03.094DOI Listing
July 2006

Diarylacetylene piperidinyl amides as novel anxiolytics.

Bioorg Med Chem Lett 2006 Jun 31;16(11):3065-7. Epub 2006 Mar 31.

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development LLC, Welsh and McKean Roads, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.02.027DOI Listing
June 2006

Distribution and metabolism of the antipsychotic agent mazapertine succinate in rats.

J Pharm Biomed Anal 2006 May 28;41(2):500-9. Epub 2005 Dec 28.

Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/j.jpba.2005.10.052DOI Listing
May 2006

Linear interaction energy models for beta-secretase (BACE) inhibitors: Role of van der Waals, electrostatic, and continuum-solvation terms.

J Mol Graph Model 2006 May 15;24(6):475-84. Epub 2005 Nov 15.

Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, L.L.C., P.O. Box 776, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109332630500119
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http://dx.doi.org/10.1016/j.jmgm.2005.10.002DOI Listing
May 2006

Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor.

Bioorg Med Chem Lett 2005 Nov;15(22):5022-6

Johnson & Johnson Pharmaceutical Research and Development, L.L.C, PO Box 300, 1000 Route 202, Raritan, NJ 08869, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0501023
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http://dx.doi.org/10.1016/j.bmcl.2005.08.009DOI Listing
November 2005

The synthesis and evaluation of 10- and 12-membered ring benzofused enediyne amino acids.

Bioorg Med Chem 2005 Nov;13(21):5936-48

Drug Discovery Division, Johnson, & Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/j.bmc.2005.07.016DOI Listing
November 2005

Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis.

Bioorg Med Chem 2004 Aug;12(16):4375-85

Drug Discovery Division, PO Box 776, Welsh and McKean Rds., Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, PA 19477-0777, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096808960400447
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http://dx.doi.org/10.1016/j.bmc.2004.06.015DOI Listing
August 2004

Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.

Bioorg Med Chem Lett 2004 Aug;14(15):4083-5

Drug Discovery, Johnson and Johnson Pharmaceutical, Research and Development, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.05.018DOI Listing
August 2004

A high-throughput monoamine oxidase inhibition assay using liquid chromatography with tandem mass spectrometry.

Rapid Commun Mass Spectrom 2004 ;18(8):834-40

Division of Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring House, PA 19477-0779, USA.

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http://doi.wiley.com/10.1002/rcm.1415
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http://dx.doi.org/10.1002/rcm.1415DOI Listing
May 2004

Noncovalent self-assembly of bicyclo[4.2.2]diketopiperazines: influence of saturation in the bridging carbacyclic ring.

Org Lett 2004 Feb;6(3):309-12

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, Spring House, Pennsylvania 19477, USA.

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http://dx.doi.org/10.1021/ol036101uDOI Listing
February 2004

Efficient conversion of substituted aryl thioureas to 2-aminobenzothiazoles using benzyltrimethylammonium tribromide.

J Org Chem 2003 Oct;68(22):8693-6

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, P.O. Box 0776, Welsh and McKean Roads, Spring House, Pennsylvania 19477-0776, USA.

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http://dx.doi.org/10.1021/jo0349431DOI Listing
October 2003

In-vitro metabolism of the new anxiolytic agent, RWJ-50172, in rat hepatic S9 fraction and microbial transformation in fungi, Cunninghamella sp.

J Pharm Pharmacol 2003 Aug;55(8):1099-105

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Spring House, PA 19477, USA.

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http://dx.doi.org/10.1211/002235703322277122DOI Listing
August 2003

Emerging beta-amyloid therapies for the treatment of Alzheimer's disease.

Curr Pharm Des 2003 ;9(6):427-47

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA.

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http://dx.doi.org/10.2174/1381612033391649DOI Listing
June 2003

In vitro metabolism of the new anxiolytic agent, RWJ-52763 in human hepatic S9 fraction-API-MS/MS identification of metabolites.

J Pharm Biomed Anal 2003 Feb;31(1):95-102

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Welsh McKean Rds, PO Pox 776, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/s0731-7085(02)00597-6DOI Listing
February 2003

2,3-Diaryl-5-anilino[1,2,4]thiadiazoles as melanocortin MC4 receptor agonists and their effects on feeding behavior in rats.

Bioorg Med Chem 2003 Jan;11(2):185-92

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, Welsh and McKean Rds., PO Box 776, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/s0968-0896(02)00428-5DOI Listing
January 2003

Synthesis of (-)-5,8-dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: an inhibitor of beta-amyloid(1-42) aggregation.

Bioorg Med Chem 2002 Nov;10(11):3565-9

Drug Discovery Division, Johnson and Johnson Pharmaceutical Research and Development, Spring House, PA 19477, USA.

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http://dx.doi.org/10.1016/s0968-0896(02)00251-1DOI Listing
November 2002

Potential anxiolytic agents. Part 4: novel orally-active N(5)-substituted pyrido[1,2-a]benzimidazoles with high GABA-A receptor affinity.

Bioorg Med Chem Lett 2002 Sep;12(17):2381-6

Drug Discovery Division, Johnson & Johnson Pharmaceutical Research and Development, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1016/s0960-894x(02)00463-8DOI Listing
September 2002