Publications by authors named "Allan Lawrie"

65Publications

Editorial: Pulmonary Hypertension: Mechanisms and Management, History and Future.

Front Med (Lausanne) 2020 21;7:125. Epub 2020 Apr 21.

Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.3389/fmed.2020.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186409PMC
April 2020

A machine learning cardiac magnetic resonance approach to extract disease features and automate pulmonary arterial hypertension diagnosis.

Eur Heart J Cardiovasc Imaging 2020 Jan 30. Epub 2020 Jan 30.

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Rd, Sheffield S10 2JF, UK.

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http://dx.doi.org/10.1093/ehjci/jeaa001DOI Listing
January 2020

Screening strategies for pulmonary arterial hypertension.

Eur Heart J Suppl 2019 Dec 17;21(Suppl K):K9-K20. Epub 2019 Dec 17.

Univ. Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Le Kremlin Bicêtre, France.

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http://dx.doi.org/10.1093/eurheartj/suz204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915059PMC
December 2019

Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling.

Circ Res 2020 01 6;126(2):243-257. Epub 2019 Dec 6.

From the Biosciences Institute (S.T.-C., R.E.R., E.S., B.D., C.P., H.L., H.M.A.), Faculty of Medical Sciences, Newcastle University, United Kingdom.

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970547PMC
January 2020

The role of chemokines and chemokine receptors in pulmonary arterial hypertension.

Br J Pharmacol 2019 Aug 10. Epub 2019 Aug 10.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1111/bph.14826DOI Listing
August 2019

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 03 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391516PMC
March 2019

Toll-like Receptor 3 Is a Therapeutic Target for Pulmonary Hypertension.

Am J Respir Crit Care Med 2019 01;199(2):199-210

1 Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.

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http://dx.doi.org/10.1164/rccm.201707-1370OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353001PMC
January 2019

The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells.

Sci Rep 2018 08 28;8(1):12972. Epub 2018 Aug 28.

Vascular Biology Group, National Heart and Lung Institute, Imperial College London, Faculty of Medicine, Guy Scadding Building, London, SW3 6LY, UK.

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http://dx.doi.org/10.1038/s41598-018-31095-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113242PMC
August 2018

Divergent Roles for TRAIL in Lung Diseases.

Front Med (Lausanne) 2018 27;5:212. Epub 2018 Jul 27.

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield, United Kingdom.

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http://dx.doi.org/10.3389/fmed.2018.00212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072839PMC
July 2018

Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data.

Front Med (Lausanne) 2018 6;5:175. Epub 2018 Jun 6.

Pulmonary Vascular Diseases Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom.

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https://www.frontiersin.org/article/10.3389/fmed.2018.00175/
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http://dx.doi.org/10.3389/fmed.2018.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997816PMC
June 2018

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension.

BMC Pulm Med 2018 Mar 2;18(1):41. Epub 2018 Mar 2.

Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Aulweg 130, 35392, Giessen, Germany.

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http://dx.doi.org/10.1186/s12890-018-0604-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833097PMC
March 2018

Incremental shuttle walk test distance and autonomic dysfunction predict survival in pulmonary arterial hypertension.

J Heart Lung Transplant 2017 Aug 24;36(8):871-879. Epub 2017 Apr 24.

Sheffield Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Medical School, Sheffield; Insigneo Institute for in silico Medicine, University of Sheffield, Sheffield, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.healun.2017.04.008DOI Listing
August 2017

Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice.

Exp Physiol 2017 02;102(2):180-189

Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Giessen, Germany.

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http://dx.doi.org/10.1113/EP085963DOI Listing
February 2017

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension.

Trends Mol Med 2017 01 16;23(1):31-45. Epub 2016 Dec 16.

Pulmonary Vascular Research Group, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.11.005DOI Listing
January 2017

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.

Circulation 2017 01 21;135(5):460-475. Epub 2016 Nov 21.

From the Department of Medicine, Imperial College London, Hammersmith Campus, United Kingdom (C.J.R., P.G., J.W., K.C.R.-A., G.W., M.R.W.); Department of Medicine, University of Cambridge School of Clinical Medicine, United Kingdom (C.H., M.B., M.H., M.R.T., S.G., N.W.M.); Cardiology Department, Royal Free Hospital, London, United Kingdom (G.C.); Institute of Cellular Medicine, Newcastle University and the Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom (P.A.C.); National Pulmonary Hypertension Service, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, United Kingdom (L.S.H., J.S.R.G.); National Heart and Lung Institute, Imperial College London, Hammersmith Campus, United Kingdom (L.S.H., J.S.R.G.); Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, United Kingdom (D.G.K.); Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, United Kingdom (D.G.K., A.L.); Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom (A.J.P.); Pulmonary Vascular Disease Unit, Papworth Hospital, Cambridge, United Kingdom (J.P.Z., M.R.T.); Pulmonary Hypertension Service, Royal Brompton Hospital, London, United Kingdom (S.J.W.); and Department of Haematology, University of Cambridge, United Kingdom (S.G.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287439PMC
January 2017

Bosutinib therapy resulting in severe deterioration of pre-existing pulmonary arterial hypertension.

Eur Respir J 2016 11 22;48(5):1514-1516. Epub 2016 Sep 22.

Pulmonary Vascular Disease Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK

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http://dx.doi.org/10.1183/13993003.01004-2016DOI Listing
November 2016

miRNA-140-5p: new avenue for pulmonary arterial hypertension drug development?

Epigenomics 2016 10 7;8(10):1311-1313. Epub 2016 Sep 7.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, S10 2RX, UK.

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http://dx.doi.org/10.2217/epi-2016-0089DOI Listing
October 2016

From bones to blood pressure, developing novel biologic approaches targeting the osteoprotegein pathway for pulmonary vascular disease.

Pharmacol Ther 2017 01 1;169:78-82. Epub 2016 Jul 1.

Department of Infection, Immunity and Cardiovascular Disease, Faculty of Medicine Dentistry and Health, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX,UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2016.06.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243145PMC
January 2017

Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries.

Thromb Haemost 2016 07 14;116(1):181-90. Epub 2016 Apr 14.

Prof. Paul Evans, Department of Cardiovascular Science, Faculty of Medicine, Dentistry & Health, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, UK, Tel.: +44 114 271 2591, Fax: +44 114 271 1863, E-mail:

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http://dx.doi.org/10.1160/TH16-03-0214DOI Listing
July 2016

Pulmonary Artery Denervation Attenuates Pulmonary Arterial Remodeling in Dogs With Pulmonary Arterial Hypertension Induced by Dehydrogenized Monocrotaline.

JACC Cardiovasc Interv 2015 Dec;8(15):2013-2023

Division of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Division of Cardiology, Nanjing Heart Center, Nanjing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2015.09.015DOI Listing
December 2015

Pulmonary artery denervation reduces pulmonary artery pressure and induces histological changes in an acute porcine model of pulmonary hypertension.

Circ Cardiovasc Interv 2015 Nov;8(11):e002569

From the Department of Cardiovascular Science (A.M.K.R., N.D.A., O.W., S.K.S., J.G., A.L.), Academic Unit of Radiology (A.J.S.), and INSIGNEO, Institute for Insilico Medicine (A.M.K.R., A.J.S., J.G.), University of Sheffield, Sheffield, United Kingdom; Medtronic Inc, Santa Rosa, CA (W.C.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom (R.C., C.A.E., D.G.K.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.115.002569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648184PMC
November 2015

The role of the osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the pathogenesis of pulmonary arterial hypertension.

Authors:
Allan Lawrie

Vascul Pharmacol 2014 Dec 18;63(3):114-7. Epub 2014 Oct 18.

Department of Cardiovascular Science, Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield S10 2RX, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.vph.2014.10.002DOI Listing
December 2014

MicroRNA in pulmonary vascular disease.

Prog Mol Biol Transl Sci 2014 ;124:43-63

Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.

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http://dx.doi.org/10.1016/B978-0-12-386930-2.00003-3DOI Listing
April 2015

Blood flow suppresses vascular Notch signalling via dll4 and is required for angiogenesis in response to hypoxic signalling.

Cardiovasc Res 2013 Nov 30;100(2):252-61. Epub 2013 Jul 30.

Lab D38, MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Firth Court, Sheffield S10 2TN, UK.

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http://dx.doi.org/10.1093/cvr/cvt170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797625PMC
November 2013

No evidence for cardiac dysfunction in Kif6 mutant mice.

PLoS One 2013 23;8(1):e54636. Epub 2013 Jan 23.

Department of Cardiovascular Science, Medical School, University of Sheffield, Sheffield, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552957PMC
June 2013

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation.

J Leukoc Biol 2011 Nov 11;90(5):855-65. Epub 2011 May 11.

Academic Unit of Respiratory Medicine, Department of Infection and Immunity, University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1189/jlb.0211062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644175PMC
November 2011

Evidence of a role for osteoprotegerin in the pathogenesis of pulmonary arterial hypertension.

Am J Pathol 2008 Jan 21;172(1):256-64. Epub 2007 Dec 21.

Cardiovascular Research Unit, University of Sheffield School of Medicine and Biomedical Sciences, LU123, L-Floor Royal Hallamshire Hospital, Glossop Rd., Sheffield, S10 2JF, UK.

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http://dx.doi.org/10.2353/ajpath.2008.070395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189625PMC
January 2008

VP22-mediated intercellular transport correlates with enhanced biological activity of MybEngrailed but not (HSV-I) thymidine kinase fusion proteins in primary vascular cells following non-viral transfection.

J Gene Med 2005 Mar;7(3):375-85

Cardiovascular Research Unit, Division of Clinical Sciences (North), Clinical Sciences Centre, University of Sheffield, Northern General Hospital, Sheffield S5 7AU, UK.

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http://doi.wiley.com/10.1002/jgm.679
Publisher Site
http://dx.doi.org/10.1002/jgm.679DOI Listing
March 2005

Apolipoprotein D and platelet-derived growth factor-BB synergism mediates vascular smooth muscle cell migration.

Circ Res 2004 Jul 10;95(2):179-86. Epub 2004 Jun 10.

Cardiovascular Research Program, Research Institute, The Hospital for Sick Children, and the Department of Pediatrics, University of Toronto, Canada.

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http://dx.doi.org/10.1161/01.RES.0000135482.74178.14DOI Listing
July 2004

Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals.

Ultrasound Med Biol 2003 Oct;29(10):1453-61

Cardiovascular Research Group, Division of Clinical Sciences (North), University of Sheffield, Sheffield, UK.

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http://dx.doi.org/10.1016/s0301-5629(03)01032-9DOI Listing
October 2003