Allan Bradley

Allan Bradley

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PiggyBac Transposon-Based Insertional Mutagenesis in Mice.

Methods Mol Biol 2019 ;1907:171-183

Department of Medicine II, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1007/978-1-4939-8967-6_14DOI Listing
July 2019

Genome-Scale CRISPRa Screen Identifies Novel Factors for Cellular Reprogramming.

Stem Cell Reports 2019 Apr 21;12(4):757-771. Epub 2019 Mar 21.

Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK; UK Dementia Research Institute, Department of Clinical Neuroscience, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450436PMC
April 2019

Inter-homologue repair in fertilized human eggs?

Nature 2018 08 8;560(7717):E5-E7. Epub 2018 Aug 8.

Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://www.nature.com/articles/s41586-018-0379-5
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http://dx.doi.org/10.1038/s41586-018-0379-5DOI Listing
August 2018

Author Correction: Revealing hidden complexities of genomic rearrangements generated with Cas9.

Sci Rep 2018 Apr 5;8(1):5765. Epub 2018 Apr 5.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1038/s41598-018-23232-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886976PMC
April 2018

Corrigendum: High-throughput discovery of novel developmental phenotypes.

Nature 2017 11 8;551(7680):398. Epub 2017 Nov 8.

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http://dx.doi.org/10.1038/nature24643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849394PMC
November 2017

Revealing hidden complexities of genomic rearrangements generated with Cas9.

Sci Rep 2017 10 9;7(1):12867. Epub 2017 Oct 9.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1038/s41598-017-12740-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5634419PMC
October 2017

Disentangling -cooperating tumor suppressor gene networks in cancer.

Mol Cell Oncol 2017 4;4(4):e1325550. Epub 2017 May 4.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1080/23723556.2017.1325550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540202PMC
May 2017

Aneuploid embryonic stem cells exhibit impaired differentiation and increased neoplastic potential.

EMBO J 2016 11 24;35(21):2285-2300. Epub 2016 Aug 24.

State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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http://dx.doi.org/10.15252/embj.201593103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090214PMC
November 2016

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice.

Science 2016 09 8;353(6307):1557-1560. Epub 2016 Sep 8.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA. Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, CA 92037, USA. Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard, Cambridge, MA 02129, USA.

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http://dx.doi.org/10.1126/science.aah3945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404394PMC
September 2016

High-throughput discovery of novel developmental phenotypes.

Nature 2016 09 14;537(7621):508-514. Epub 2016 Sep 14.

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/nature19356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295821PMC
September 2016

Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.

Genome Biol 2016 05 31;17(1):115. Epub 2016 May 31.

European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands.

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http://dx.doi.org/10.1186/s13059-016-0971-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888588PMC
May 2016

Chromosome engineering in zygotes with CRISPR/Cas9.

Genesis 2016 Feb 25;54(2):78-85. Epub 2016 Jan 25.

Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, CB10 1SA, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/dvg.22915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819711PMC
February 2016

High-density P300 enhancers control cell state transitions.

BMC Genomics 2015 Nov 6;16:903. Epub 2015 Nov 6.

Integrative Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

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http://www.biomedcentral.com/content/pdf/s12864-015-1905-6.p
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http://www.biomedcentral.com/1471-2164/16/903
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http://dx.doi.org/10.1186/s12864-015-1905-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636788PMC
November 2015

Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.

Genesis 2015 Feb 10;53(2):225-36. Epub 2014 Dec 10.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1002/dvg.22835DOI Listing
February 2015

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.

PLoS Genet 2014 Oct 23;10(10):e1004705. Epub 2014 Oct 23.

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Australia; Department of Anatomy and Developmental Biology, Monash University, Clayton, Melbourne, Australia.

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http://dx.doi.org/10.1371/journal.pgen.1004705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207618PMC
October 2014

MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.

J Immunol 2013 Sep 19;191(6):3037-3048. Epub 2013 Aug 19.

Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0XY, UK.

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http://dx.doi.org/10.4049/jimmunol.1301289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162006PMC
September 2013

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.

Genes Dev 2013 Jul;27(13):1484-94

Division of Stem Cell Biology and Developmental Genetics, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom;

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http://dx.doi.org/10.1101/gad.219477.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713429PMC
July 2013

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):2928-33. Epub 2013 Feb 4.

Mouse Genomics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1217388110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581953PMC
February 2013

The mammalian gene function resource: the International Knockout Mouse Consortium.

Mamm Genome 2012 Oct 12;23(9-10):580-6. Epub 2012 Sep 12.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1007/s00335-012-9422-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463800PMC
October 2012

Isolation of homozygous mutant mouse embryonic stem cells using a dual selection system.

Nucleic Acids Res 2012 Feb 29;40(3):e21. Epub 2011 Nov 29.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkr908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3273828PMC
February 2012

Mobilization of giant piggyBac transposons in the mouse genome.

Nucleic Acids Res 2011 Dec 24;39(22):e148. Epub 2011 Sep 24.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK, CB10 1SA.

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https://academic.oup.com/nar/article/39/22/e148/2409515
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http://dx.doi.org/10.1093/nar/gkr764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239208PMC
December 2011

A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.

Nat Methods 2011 Oct 23;8(12):1071-7. Epub 2011 Oct 23.

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

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http://dx.doi.org/10.1038/nmeth.1739DOI Listing
October 2011

Stella-Cre mice are highly efficient Cre deleters.

Genesis 2011 Aug 22;49(8):689-95. Epub 2011 Jul 22.

College of Animal Science and Technology, Huazhong Agriculture University, Wuhan, China.

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http://doi.wiley.com/10.1002/dvg.20741
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http://dx.doi.org/10.1002/dvg.20741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674523PMC
August 2011

A resource of vectors and ES cells for targeted deletion of microRNAs in mice.

Nat Biotechnol 2011 Aug 7;29(9):840-5. Epub 2011 Aug 7.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://www.nature.com/nbt/journal/v29/n9/pdf/nbt.1929.pdf?WT
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http://www.nature.com/doifinder/10.1038/nbt.1929
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http://dx.doi.org/10.1038/nbt.1929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242032PMC
August 2011

The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice.

Curr Biol 2011 May 28;21(9):787-93. Epub 2011 Apr 28.

Division of Stem Cell Biology and Developmental Genetics, Medical Research Council National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S096098221100361
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http://dx.doi.org/10.1016/j.cub.2011.03.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176893PMC
May 2011

Genetic screens using the piggyBac transposon.

Methods 2011 Apr 23;53(4):366-71. Epub 2010 Dec 23.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK.

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http://dx.doi.org/10.1016/j.ymeth.2010.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650578PMC
April 2011

A hyperactive piggyBac transposase for mammalian applications.

Proc Natl Acad Sci U S A 2011 Jan 4;108(4):1531-6. Epub 2011 Jan 4.

Wellcome Trust Sanger Institute, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1008322108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029773PMC
January 2011

Crafting rat genomes with zinc fingers.

Nat Biotechnol 2011 Jan;29(1):39-41

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http://dx.doi.org/10.1038/nbt.1749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024535PMC
January 2011

The use of DNA transposons for cancer gene discovery in mice.

Methods Enzymol 2010 ;477:91-106

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(10)77006-3DOI Listing
December 2010

Genome-wide forward genetic screens in mouse ES cells.

Methods Enzymol 2010 ;477:217-42

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/S0076-6879(10)77012-9DOI Listing
December 2010

Evidence that meiotic sex chromosome inactivation is essential for male fertility.

Curr Biol 2010 Dec 18;20(23):2117-23. Epub 2010 Nov 18.

Department of Stem Cell Research and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

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http://dx.doi.org/10.1016/j.cub.2010.11.010DOI Listing
December 2010

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Mol Cell Biol 2010 Oct 16;30(20):4851-63. Epub 2010 Aug 16.

Department of Biochemistry, University of Leicester, Leicester, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00521-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950538PMC
October 2010

Agouti C57BL/6N embryonic stem cells for mouse genetic resources.

Nat Methods 2009 Jul 14;6(7):493-5. Epub 2009 Jun 14.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.1342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555078PMC
July 2009

Transposon-mediated genome manipulation in vertebrates.

Nat Methods 2009 Jun;6(6):415-22

Max Delbrück Center for Molecular Medicine, Berlin, Germany.

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http://dx.doi.org/10.1038/nmeth.1332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867038PMC
June 2009

Chromosome engineering in ES cells.

Methods Mol Biol 2009 ;530:49-77

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1007/978-1-59745-471-1_4DOI Listing
May 2009

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.

Nat Methods 2009 May 31;6(5):363-9. Epub 2009 Mar 31.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/nmeth.1323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677165PMC
May 2009

A piggyBac transposon-based genome-wide library of insertionally mutated Blm-deficient murine ES cells.

Genome Res 2009 Apr 20;19(4):667-73. Epub 2009 Feb 20.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1101/gr.085621.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665785PMC
April 2009

A DNA transposon-based approach to validate oncogenic mutations in the mouse.

Proc Natl Acad Sci U S A 2008 Dec 8;105(50):19904-9. Epub 2008 Dec 8.

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, England.

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http://dx.doi.org/10.1073/pnas.0807785105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597691PMC
December 2008

Extensive genomic copy number variation in embryonic stem cells.

Proc Natl Acad Sci U S A 2008 Nov 6;105(45):17453-6. Epub 2008 Nov 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0805638105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582305PMC
November 2008

Increased insulin action in SKIP heterozygous knockout mice.

Mol Cell Biol 2008 Sep 23;28(17):5184-95. Epub 2008 Jun 23.

Division of Lipid Biochemistry, Kobe University Graduate School of Medicine, Kobe 650-0017, Hyogo, Japan.

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http://dx.doi.org/10.1128/MCB.01990-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519744PMC
September 2008

Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster.

Mol Cell Biol 2008 Aug 27;28(15):4688-96. Epub 2008 May 27.

Wellcome Trust/Cancer Research UK Gurdon Institute of Cancer & Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, United Kingdom.

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http://dx.doi.org/10.1128/MCB.00272-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493357PMC
August 2008

Chromosomal transposition of PiggyBac in mouse embryonic stem cells.

Proc Natl Acad Sci U S A 2008 Jul 25;105(27):9290-5. Epub 2008 Jun 25.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0801017105
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http://dx.doi.org/10.1073/pnas.0801017105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2440425PMC
July 2008

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.

Mol Cell Biol 2008 Mar 26;28(5):1702-12. Epub 2007 Dec 26.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

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http://dx.doi.org/10.1128/MCB.01282-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258769PMC
March 2008

Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation.

Eur J Neurosci 2007 Dec 4;26(12):3339-44. Epub 2007 Dec 4.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

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http://dx.doi.org/10.1111/j.1460-9568.2007.05958.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228368PMC
December 2007

A recessive genetic screen for host factors required for retroviral infection in a library of insertionally mutated Blm-deficient embryonic stem cells.

Genome Biol 2007 ;8(4):R48

Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, PR China.

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http://dx.doi.org/10.1186/gb-2007-8-4-r48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895998PMC
November 2007

Alpha3-integrins are required for hippocampal long-term potentiation and working memory.

Learn Mem 2007 Sep 6;14(9):606-15. Epub 2007 Sep 6.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1101/lm.648607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994082PMC
September 2007

Generation of an inducible and optimized piggyBac transposon system.

Nucleic Acids Res 2007 18;35(12):e87. Epub 2007 Jun 18.

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK.

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http://dx.doi.org/10.1093/nar/gkm446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1919496PMC
August 2007