Alkes Price

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Reconciling S-LDSC and LDAK functional enrichment estimates.

Nat Genet 2019 Aug;51(8):1202-1204

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41588-019-0464-1DOI Listing
August 2019

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection.

Am J Hum Genet 2019 Jul 29. Epub 2019 Jul 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.07.003DOI Listing
July 2019

IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors.

Am J Hum Genet 2019 May 18;104(5):879-895. Epub 2019 Apr 18.

Center for Data Sciences, Harvard Medical School, Boston, MA 02115, USA; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA; Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA; Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193010
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http://dx.doi.org/10.1016/j.ajhg.2019.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506796PMC
May 2019

Genes with High Network Connectivity Are Enriched for Disease Heritability.

Am J Hum Genet 2019 May;104(5):896-913

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.03.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506868PMC
May 2019

Disease Heritability Enrichment of Regulatory Elements Is Concentrated in Elements with Ancient Sequence Age and Conserved Function across Species.

Am J Hum Genet 2019 Apr 21;104(4):611-624. Epub 2019 Mar 21.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451699PMC
April 2019

Estimating cross-population genetic correlations of causal effect sizes.

Genet Epidemiol 2019 03 25;43(2):180-188. Epub 2018 Nov 25.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1002/gepi.22173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375794PMC
March 2019

Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control.

Diabetes 2019 02 28;68(2):441-456. Epub 2018 Nov 28.

Massachusetts Eye and Ear Department of Ophthalmology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db18-0567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341299PMC
February 2019

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

Am J Hum Genet 2019 Jan 27;104(1):65-75. Epub 2018 Dec 27.

Department of Epidemiology. Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323418PMC
January 2019

Shared heritability and functional enrichment across six solid cancers.

Authors:
Xia Jiang Hilary K Finucane Fredrick R Schumacher Stephanie L Schmit Jonathan P Tyrer Younghun Han Kyriaki Michailidou Corina Lesseur Karoline B Kuchenbaecker Joe Dennis David V Conti Graham Casey Mia M Gaudet Jeroen R Huyghe Demetrius Albanes Melinda C Aldrich Angeline S Andrew Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Natalia N Antonenkova Susanne M Arnold Kristan J Aronson Banu K Arun Elisa V Bandera Rosa B Barkardottir Daniel R Barnes Jyotsna Batra Matthias W Beckmann Javier Benitez Sara Benlloch Andrew Berchuck Sonja I Berndt Heike Bickeböller Stephanie A Bien Carl Blomqvist Stefania Boccia Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Hiltrud Brauch Hermann Brenner James D Brenton Mark N Brook Joan Brunet Hans Brunnström Daniel D Buchanan Barbara Burwinkel Ralf Butzow Gabriella Cadoni Trinidad Caldés Maria A Caligo Ian Campbell Peter T Campbell Géraldine Cancel-Tassin Lisa Cannon-Albright Daniele Campa Neil Caporaso André L Carvalho Andrew T Chan Jenny Chang-Claude Stephen J Chanock Chu Chen David C Christiani Kathleen B M Claes Frank Claessens Judith Clements J Margriet Collée Marcia Cruz Correa Fergus J Couch Angela Cox Julie M Cunningham Cezary Cybulski Kamila Czene Mary B Daly Anna deFazio Peter Devilee Orland Diez Manuela Gago-Dominguez Jenny L Donovan Thilo Dörk Eric J Duell Alison M Dunning Miriam Dwek Diana M Eccles Christopher K Edlund Digna R Velez Edwards Carolina Ellberg D Gareth Evans Peter A Fasching Robert L Ferris Triantafillos Liloglou Jane C Figueiredo Olivia Fletcher Renée T Fortner Florentia Fostira Silvia Franceschi Eitan Friedman Steven J Gallinger Patricia A Ganz Judy Garber José A García-Sáenz Simon A Gayther Graham G Giles Andrew K Godwin Mark S Goldberg David E Goldgar Ellen L Goode Marc T Goodman Gary Goodman Kjell Grankvist Mark H Greene Henrik Gronberg Jacek Gronwald Pascal Guénel Niclas Håkansson Per Hall Ute Hamann Freddie C Hamdy Robert J Hamilton Jochen Hampe Aage Haugen Florian Heitz Rolando Herrero Peter Hillemanns Michael Hoffmeister Estrid Høgdall Yun-Chul Hong John L Hopper Richard Houlston Peter J Hulick David J Hunter David G Huntsman Gregory Idos Evgeny N Imyanitov Sue Ann Ingles Claudine Isaacs Anna Jakubowska Paul James Mark A Jenkins Mattias Johansson Mikael Johansson Esther M John Amit D Joshi Radka Kaneva Beth Y Karlan Linda E Kelemen Tabea Kühl Kay-Tee Khaw Elza Khusnutdinova Adam S Kibel Lambertus A Kiemeney Jeri Kim Susanne K Kjaer Julia A Knight Manolis Kogevinas Zsofia Kote-Jarai Stella Koutros Vessela N Kristensen Jolanta Kupryjanczyk Martin Lacko Stephan Lam Diether Lambrechts Maria Teresa Landi Philip Lazarus Nhu D Le Eunjung Lee Flavio Lejbkowicz Heinz-Josef Lenz Goska Leslie Davor Lessel Jenny Lester Douglas A Levine Li Li Christopher I Li Annika Lindblom Noralane M Lindor Geoffrey Liu Fotios Loupakis Jan Lubiński Lovise Maehle Christiane Maier Arto Mannermaa Loic Le Marchand Sara Margolin Taymaa May Lesley McGuffog Alfons Meindl Pooja Middha Austin Miller Roger L Milne Robert J MacInnis Francesmary Modugno Marco Montagna Victor Moreno Kirsten B Moysich Lorelei Mucci Kenneth Muir Anna Marie Mulligan Katherine L Nathanson David E Neal Andrew R Ness Susan L Neuhausen Heli Nevanlinna Polly A Newcomb Lisa F Newcomb Finn Cilius Nielsen Liene Nikitina-Zake Børge G Nordestgaard Robert L Nussbaum Kenneth Offit Edith Olah Ali Amin Al Olama Olufunmilayo I Olopade Andrew F Olshan Håkan Olsson Ana Osorio Hardev Pandha Jong Y Park Nora Pashayan Michael T Parsons Tanja Pejovic Kathryn L Penney Wilbert H M Peters Catherine M Phelan Amanda I Phipps Dijana Plaseska-Karanfilska Miranda Pring Darya Prokofyeva Paolo Radice Kari Stefansson Susan J Ramus Leon Raskin Gad Rennert Hedy S Rennert Elizabeth J van Rensburg Marjorie J Riggan Harvey A Risch Angela Risch Monique J Roobol Barry S Rosenstein Mary Anne Rossing Kim De Ruyck Emmanouil Saloustros Dale P Sandler Elinor J Sawyer Matthew B Schabath Johanna Schleutker Marjanka K Schmidt V Wendy Setiawan Hongbing Shen Erin M Siegel Weiva Sieh Christian F Singer Martha L Slattery Karina Dalsgaard Sorensen Melissa C Southey Amanda B Spurdle Janet L Stanford Victoria L Stevens Sebastian Stintzing Jennifer Stone Karin Sundfeldt Rebecca Sutphen Anthony J Swerdlow Eloiza H Tajara Catherine M Tangen Adonina Tardon Jack A Taylor M Dawn Teare Manuel R Teixeira Mary Beth Terry Kathryn L Terry Stephen N Thibodeau Mads Thomassen Line Bjørge Marc Tischkowitz Amanda E Toland Diana Torres Paul A Townsend Ruth C Travis Nadine Tung Shelley S Tworoger Cornelia M Ulrich Nawaid Usmani Celine M Vachon Els Van Nieuwenhuysen Ana Vega Miguel Elías Aguado-Barrera Qin Wang Penelope M Webb Clarice R Weinberg Stephanie Weinstein Mark C Weissler Jeffrey N Weitzel Catharine M L West Emily White Alice S Whittemore H-Erich Wichmann Fredrik Wiklund Robert Winqvist Alicja Wolk Penella Woll Michael Woods Anna H Wu Xifeng Wu Drakoulis Yannoukakos Wei Zheng Shanbeh Zienolddiny Argyrios Ziogas Kristin K Zorn Jacqueline M Lane Richa Saxena Duncan Thomas Rayjean J Hung Brenda Diergaarde James McKay Ulrike Peters Li Hsu Montserrat García-Closas Rosalind A Eeles Georgia Chenevix-Trench Paul J Brennan Christopher A Haiman Jacques Simard Douglas F Easton Stephen B Gruber Paul D P Pharoah Alkes L Price Bogdan Pasaniuc Christopher I Amos Peter Kraft Sara Lindström

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

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http://dx.doi.org/10.1038/s41467-018-08054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347624PMC
January 2019

Distinguishing genetic correlation from causation across 52 diseases and complex traits.

Nat Genet 2018 12 29;50(12):1728-1734. Epub 2018 Oct 29.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://www.nature.com/articles/s41588-018-0255-0
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http://dx.doi.org/10.1038/s41588-018-0255-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684375PMC
December 2018

Author Correction: Distinguishing genetic correlation from causation across 52 diseases and complex traits.

Nat Genet 2018 12;50(12):1753

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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http://www.nature.com/articles/s41588-018-0296-4
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http://dx.doi.org/10.1038/s41588-018-0296-4DOI Listing
December 2018

High-throughput inference of pairwise coalescence times identifies signals of selection and enriched disease heritability.

Nat Genet 2018 09 13;50(9):1311-1317. Epub 2018 Aug 13.

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41588-018-0177-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145075PMC
September 2018

Mixed-model association for biobank-scale datasets.

Nat Genet 2018 07;50(7):906-908

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.nature.com/articles/s41588-018-0144-6
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http://dx.doi.org/10.1038/s41588-018-0144-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309610PMC
July 2018

Analysis of shared heritability in common disorders of the brain.

Authors:
Verneri Anttila Brendan Bulik-Sullivan Hilary K Finucane Raymond K Walters Jose Bras Laramie Duncan Valentina Escott-Price Guido J Falcone Padhraig Gormley Rainer Malik Nikolaos A Patsopoulos Stephan Ripke Zhi Wei Dongmei Yu Phil H Lee Patrick Turley Benjamin Grenier-Boley Vincent Chouraki Yoichiro Kamatani Claudine Berr Luc Letenneur Didier Hannequin Philippe Amouyel Anne Boland Jean-François Deleuze Emmanuelle Duron Badri N Vardarajan Christiane Reitz Alison M Goate Matthew J Huentelman M Ilyas Kamboh Eric B Larson Ekaterina Rogaeva Peter St George-Hyslop Hakon Hakonarson Walter A Kukull Lindsay A Farrer Lisa L Barnes Thomas G Beach F Yesim Demirci Elizabeth Head Christine M Hulette Gregory A Jicha John S K Kauwe Jeffrey A Kaye James B Leverenz Allan I Levey Andrew P Lieberman Vernon S Pankratz Wayne W Poon Joseph F Quinn Andrew J Saykin Lon S Schneider Amanda G Smith Joshua A Sonnen Robert A Stern Vivianna M Van Deerlin Linda J Van Eldik Denise Harold Giancarlo Russo David C Rubinsztein Anthony Bayer Magda Tsolaki Petra Proitsi Nick C Fox Harald Hampel Michael J Owen Simon Mead Peter Passmore Kevin Morgan Markus M Nöthen Martin Rossor Michelle K Lupton Per Hoffmann Johannes Kornhuber Brian Lawlor Andrew McQuillin Ammar Al-Chalabi Joshua C Bis Agustin Ruiz Mercè Boada Sudha Seshadri Alexa Beiser Kenneth Rice Sven J van der Lee Philip L De Jager Daniel H Geschwind Matthias Riemenschneider Steffi Riedel-Heller Jerome I Rotter Gerhard Ransmayr Bradley T Hyman Carlos Cruchaga Montserrat Alegret Bendik Winsvold Priit Palta Kai-How Farh Ester Cuenca-Leon Nicholas Furlotte Tobias Kurth Lannie Ligthart Gisela M Terwindt Tobias Freilinger Caroline Ran Scott D Gordon Guntram Borck Hieab H H Adams Terho Lehtimäki Juho Wedenoja Julie E Buring Markus Schürks Maria Hrafnsdottir Jouke-Jan Hottenga Brenda Penninx Ville Artto Mari Kaunisto Salli Vepsäläinen Nicholas G Martin Grant W Montgomery Mitja I Kurki Eija Hämäläinen Hailiang Huang Jie Huang Cynthia Sandor Caleb Webber Bertram Muller-Myhsok Stefan Schreiber Veikko Salomaa Elizabeth Loehrer Hartmut Göbel Alfons Macaya Patricia Pozo-Rosich Thomas Hansen Thomas Werge Jaakko Kaprio Andres Metspalu Christian Kubisch Michel D Ferrari Andrea C Belin Arn M J M van den Maagdenberg John-Anker Zwart Dorret Boomsma Nicholas Eriksson Jes Olesen Daniel I Chasman Dale R Nyholt Andreja Avbersek Larry Baum Samuel Berkovic Jonathan Bradfield Russell J Buono Claudia B Catarino Patrick Cossette Peter De Jonghe Chantal Depondt Dennis Dlugos Thomas N Ferraro Jacqueline French Helle Hjalgrim Jennifer Jamnadas-Khoda Reetta Kälviäinen Wolfram S Kunz Holger Lerche Costin Leu Dick Lindhout Warren Lo Daniel Lowenstein Mark McCormack Rikke S Møller Anne Molloy Ping-Wing Ng Karen Oliver Michael Privitera Rodney Radtke Ann-Kathrin Ruppert Thomas Sander Steven Schachter Christoph Schankin Ingrid Scheffer Susanne Schoch Sanjay M Sisodiya Philip Smith Michael Sperling Pasquale Striano Rainer Surges G Neil Thomas Frank Visscher Christopher D Whelan Federico Zara Erin L Heinzen Anthony Marson Felicitas Becker Hans Stroink Fritz Zimprich Thomas Gasser Raphael Gibbs Peter Heutink Maria Martinez Huw R Morris Manu Sharma Mina Ryten Kin Y Mok Sara Pulit Steve Bevan Elizabeth Holliday John Attia Thomas Battey Giorgio Boncoraglio Vincent Thijs Wei-Min Chen Braxton Mitchell Peter Rothwell Pankaj Sharma Cathie Sudlow Astrid Vicente Hugh Markus Christina Kourkoulis Joana Pera Miriam Raffeld Scott Silliman Vesna Boraska Perica Laura M Thornton Laura M Huckins N William Rayner Cathryn M Lewis Monica Gratacos Filip Rybakowski Anna Keski-Rahkonen Anu Raevuori James I Hudson Ted Reichborn-Kjennerud Palmiero Monteleone Andreas Karwautz Katrin Mannik Jessica H Baker Julie K O'Toole Sara E Trace Oliver S P Davis Sietske G Helder Stefan Ehrlich Beate Herpertz-Dahlmann Unna N Danner Annemarie A van Elburg Maurizio Clementi Monica Forzan Elisa Docampo Jolanta Lissowska Joanna Hauser Alfonso Tortorella Mario Maj Fragiskos Gonidakis Konstantinos Tziouvas Hana Papezova Zeynep Yilmaz Gudrun Wagner Sarah Cohen-Woods Stefan Herms Antonio Julià Raquel Rabionet Danielle M Dick Samuli Ripatti Ole A Andreassen Thomas Espeseth Astri J Lundervold Vidar M Steen Dalila Pinto Stephen W Scherer Harald Aschauer Alexandra Schosser Lars Alfredsson Leonid Padyukov Katherine A Halmi James Mitchell Michael Strober Andrew W Bergen Walter Kaye Jin Peng Szatkiewicz Bru Cormand Josep Antoni Ramos-Quiroga Cristina Sánchez-Mora Marta Ribasés Miguel Casas Amaia Hervas Maria Jesús Arranz Jan Haavik Tetyana Zayats Stefan Johansson Nigel Williams Astrid Dempfle Aribert Rothenberger Jonna Kuntsi Robert D Oades Tobias Banaschewski Barbara Franke Jan K Buitelaar Alejandro Arias Vasquez Alysa E Doyle Andreas Reif Klaus-Peter Lesch Christine Freitag Olga Rivero Haukur Palmason Marcel Romanos Kate Langley Marcella Rietschel Stephanie H Witt Soeren Dalsgaard Anders D Børglum Irwin Waldman Beth Wilmot Nikolas Molly Claiton H D Bau Jennifer Crosbie Russell Schachar Sandra K Loo James J McGough Eugenio H Grevet Sarah E Medland Elise Robinson Lauren A Weiss Elena Bacchelli Anthony Bailey Vanessa Bal Agatino Battaglia Catalina Betancur Patrick Bolton Rita Cantor Patrícia Celestino-Soper Geraldine Dawson Silvia De Rubeis Frederico Duque Andrew Green Sabine M Klauck Marion Leboyer Pat Levitt Elena Maestrini Shrikant Mane Daniel Moreno- De-Luca Jeremy Parr Regina Regan Abraham Reichenberg Sven Sandin Jacob Vorstman Thomas Wassink Ellen Wijsman Edwin Cook Susan Santangelo Richard Delorme Bernadette Rogé Tiago Magalhaes Dan Arking Thomas G Schulze Robert C Thompson Jana Strohmaier Keith Matthews Ingrid Melle Derek Morris Douglas Blackwood Andrew McIntosh Sarah E Bergen Martin Schalling Stéphane Jamain Anna Maaser Sascha B Fischer Céline S Reinbold Janice M Fullerton José Guzman-Parra Fermin Mayoral Peter R Schofield Sven Cichon Thomas W Mühleisen Franziska Degenhardt Johannes Schumacher Michael Bauer Philip B Mitchell Elliot S Gershon John Rice James B Potash Peter P Zandi Nick Craddock I Nicol Ferrier Martin Alda Guy A Rouleau Gustavo Turecki Roel Ophoff Carlos Pato Adebayo Anjorin Eli Stahl Markus Leber Piotr M Czerski Cristiana Cruceanu Ian R Jones Danielle Posthuma Till F M Andlauer Andreas J Forstner Fabian Streit Bernhard T Baune Tracy Air Grant Sinnamon Naomi R Wray Donald J MacIntyre David Porteous Georg Homuth Margarita Rivera Jakob Grove Christel M Middeldorp Ian Hickie Michele Pergadia Divya Mehta Johannes H Smit Rick Jansen Eco de Geus Erin Dunn Qingqin S Li Matthias Nauck Robert A Schoevers Aartjan Tf Beekman James A Knowles Alexander Viktorin Paul Arnold Cathy L Barr Gabriel Bedoya-Berrio O Joseph Bienvenu Helena Brentani Christie Burton Beatriz Camarena Carolina Cappi Danielle Cath Maria Cavallini Daniele Cusi Sabrina Darrow Damiaan Denys Eske M Derks Andrea Dietrich Thomas Fernandez Martijn Figee Nelson Freimer Gloria Gerber Marco Grados Erica Greenberg Gregory L Hanna Andreas Hartmann Matthew E Hirschtritt Pieter J Hoekstra Alden Huang Chaim Huyser Cornelia Illmann Michael Jenike Samuel Kuperman Bennett Leventhal Christine Lochner Gholson J Lyon Fabio Macciardi Marcos Madruga-Garrido Irene A Malaty Athanasios Maras Lauren McGrath Eurípedes C Miguel Pablo Mir Gerald Nestadt Humberto Nicolini Michael S Okun Andrew Pakstis Peristera Paschou John Piacentini Christopher Pittenger Kerstin Plessen Vasily Ramensky Eliana M Ramos Victor Reus Margaret A Richter Mark A Riddle Mary M Robertson Veit Roessner Maria Rosário Jack F Samuels Paul Sandor Dan J Stein Fotis Tsetsos Filip Van Nieuwerburgh Sarah Weatherall Jens R Wendland Tomasz Wolanczyk Yulia Worbe Gwyneth Zai Fernando S Goes Nicole McLaughlin Paul S Nestadt Hans-Jorgen Grabe Christel Depienne Anuar Konkashbaev Nuria Lanzagorta Ana Valencia-Duarte Elvira Bramon Nancy Buccola Wiepke Cahn Murray Cairns Siow A Chong David Cohen Benedicto Crespo-Facorro James Crowley Michael Davidson Lynn DeLisi Timothy Dinan Gary Donohoe Elodie Drapeau Jubao Duan Lieuwe Haan David Hougaard Sena Karachanak-Yankova Andrey Khrunin Janis Klovins Vaidutis Kučinskas Jimmy Lee Chee Keong Svetlana Limborska Carmel Loughland Jouko Lönnqvist Brion Maher Manuel Mattheisen Colm McDonald Kieran C Murphy Igor Nenadic Jim van Os Christos Pantelis Michele Pato Tracey Petryshen Digby Quested Panos Roussos Alan R Sanders Ulrich Schall Sibylle G Schwab Kang Sim Hon-Cheong So Elisabeth Stögmann Mythily Subramaniam Draga Toncheva John Waddington James Walters Mark Weiser Wei Cheng Robert Cloninger David Curtis Pablo V Gejman Frans Henskens Morten Mattingsdal Sang-Yun Oh Rodney Scott Bradley Webb Gerome Breen Claire Churchhouse Cynthia M Bulik Mark Daly Martin Dichgans Stephen V Faraone Rita Guerreiro Peter Holmans Kenneth S Kendler Bobby Koeleman Carol A Mathews Alkes Price Jeremiah Scharf Pamela Sklar Julie Williams Nicholas W Wood Chris Cotsapas Aarno Palotie Jordan W Smoller Patrick Sullivan Jonathan Rosand Aiden Corvin Benjamin M Neale Jonathan M Schott Richard Anney Josephine Elia Maria Grigoroiu-Serbanescu Howard J Edenberg Robin Murray

Science 2018 06;360(6395)

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1126/science.aap8757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097237PMC
June 2018

Multiethnic polygenic risk scores improve risk prediction in diverse populations.

Genet Epidemiol 2017 12 7;41(8):811-823. Epub 2017 Nov 7.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.22083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726434PMC
December 2017

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk.

Authors:
Felix R Day Deborah J Thompson Hannes Helgason Daniel I Chasman Hilary Finucane Patrick Sulem Katherine S Ruth Sean Whalen Abhishek K Sarkar Eva Albrecht Elisabeth Altmaier Marzyeh Amini Caterina M Barbieri Thibaud Boutin Archie Campbell Ellen Demerath Ayush Giri Chunyan He Jouke J Hottenga Robert Karlsson Ivana Kolcic Po-Ru Loh Kathryn L Lunetta Massimo Mangino Brumat Marco George McMahon Sarah E Medland Ilja M Nolte Raymond Noordam Teresa Nutile Lavinia Paternoster Natalia Perjakova Eleonora Porcu Lynda M Rose Katharina E Schraut Ayellet V Segrè Albert V Smith Lisette Stolk Alexander Teumer Irene L Andrulis Stefania Bandinelli Matthias W Beckmann Javier Benitez Sven Bergmann Murielle Bochud Eric Boerwinkle Stig E Bojesen Manjeet K Bolla Judith S Brand Hiltrud Brauch Hermann Brenner Linda Broer Thomas Brüning Julie E Buring Harry Campbell Eulalia Catamo Stephen Chanock Georgia Chenevix-Trench Tanguy Corre Fergus J Couch Diana L Cousminer Angela Cox Laura Crisponi Kamila Czene George Davey Smith Eco J C N de Geus Renée de Mutsert Immaculata De Vivo Joe Dennis Peter Devilee Isabel Dos-Santos-Silva Alison M Dunning Johan G Eriksson Peter A Fasching Lindsay Fernández-Rhodes Luigi Ferrucci Dieter Flesch-Janys Lude Franke Marike Gabrielson Ilaria Gandin Graham G Giles Harald Grallert Daniel F Gudbjartsson Pascal Guénel Per Hall Emily Hallberg Ute Hamann Tamara B Harris Catharina A Hartman Gerardo Heiss Maartje J Hooning John L Hopper Frank Hu David J Hunter M Arfan Ikram Hae Kyung Im Marjo-Riitta Järvelin Peter K Joshi David Karasik Manolis Kellis Zoltan Kutalik Genevieve LaChance Diether Lambrechts Claudia Langenberg Lenore J Launer Joop S E Laven Stefania Lenarduzzi Jingmei Li Penelope A Lind Sara Lindstrom YongMei Liu Jian'an Luan Reedik Mägi Arto Mannermaa Hamdi Mbarek Mark I McCarthy Christa Meisinger Thomas Meitinger Cristina Menni Andres Metspalu Kyriaki Michailidou Lili Milani Roger L Milne Grant W Montgomery Anna M Mulligan Mike A Nalls Pau Navarro Heli Nevanlinna Dale R Nyholt Albertine J Oldehinkel Tracy A O'Mara Sandosh Padmanabhan Aarno Palotie Nancy Pedersen Annette Peters Julian Peto Paul D P Pharoah Anneli Pouta Paolo Radice Iffat Rahman Susan M Ring Antonietta Robino Frits R Rosendaal Igor Rudan Rico Rueedi Daniela Ruggiero Cinzia F Sala Marjanka K Schmidt Robert A Scott Mitul Shah Rossella Sorice Melissa C Southey Ulla Sovio Meir Stampfer Maristella Steri Konstantin Strauch Toshiko Tanaka Emmi Tikkanen Nicholas J Timpson Michela Traglia Thérèse Truong Jonathan P Tyrer André G Uitterlinden Digna R Velez Edwards Veronique Vitart Uwe Völker Peter Vollenweider Qin Wang Elisabeth Widen Ko Willems van Dijk Gonneke Willemsen Robert Winqvist Bruce H R Wolffenbuttel Jing Hua Zhao Magdalena Zoledziewska Marek Zygmunt Behrooz Z Alizadeh Dorret I Boomsma Marina Ciullo Francesco Cucca Tõnu Esko Nora Franceschini Christian Gieger Vilmundur Gudnason Caroline Hayward Peter Kraft Debbie A Lawlor Patrik K E Magnusson Nicholas G Martin Dennis O Mook-Kanamori Ellen A Nohr Ozren Polasek David Porteous Alkes L Price Paul M Ridker Harold Snieder Tim D Spector Doris Stöckl Daniela Toniolo Sheila Ulivi Jenny A Visser Henry Völzke Nicholas J Wareham James F Wilson Amanda B Spurdle Unnur Thorsteindottir Katherine S Pollard Douglas F Easton Joyce Y Tung Jenny Chang-Claude David Hinds Anna Murray Joanne M Murabito Kari Stefansson Ken K Ong John R B Perry

Nat Genet 2017 Jun 24;49(6):834-841. Epub 2017 Apr 24.

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.3841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841952PMC
June 2017

Functional Architectures of Local and Distal Regulation of Gene Expression in Multiple Human Tissues.

Am J Hum Genet 2017 Apr 23;100(4):605-616. Epub 2017 Mar 23.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384099PMC
April 2017

Dissecting the genetics of complex traits using summary association statistics.

Nat Rev Genet 2017 02 14;18(2):117-127. Epub 2016 Nov 14.

Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrg.2016.142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449190PMC
February 2017

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Authors:
Christian R Marshall Daniel P Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas S Greer Danny Antaki Aniket Shetty Peter A Holmans Dalila Pinto Madhusudan Gujral William M Brandler Dheeraj Malhotra Zhouzhi Wang Karin V Fuentes Fajarado Michelle S Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu A Bacanu Richard A Belliveau Sarah E Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B Bigdeli Donald W Black Richard Bruggeman Nancy G Buccola Randy L Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J Cairns Dominique Campion Rita M Cantor Vaughan J Carr Noa Carrera Stanley V Catts Kimberley D Chambert Wei Cheng C Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo-Facorro James J Crowley David Curtis Michael Davidson Kenneth L Davis Franziska Degenhardt Jurgen Del Favero Lynn E DeLisi Dimitris Dikeos Timothy Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan Eriksson Valentina Escott-Price Laurent Essioux Ayman H Fanous Kai-How Farh Martilias S Farrell Josef Frank Lude Franke Robert Freedman Nelson B Freimer Joseph I Friedman Andreas J Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S Gershon Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Jacob Gratten Lieuwe de Haan Marian L Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M Hartmann Frans A Henskens Stefan Herms Joel N Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K Kähler René S Kahn Luba Kalaydjieva Juha Karjalainen David Kavanagh Matthew C Keller Brian J Kelly James L Kennedy Yunjung Kim James A Knowles Bettina Konte Claudine Laurent Phil Lee S Hong Lee Sophie E Legge Bernard Lerer Deborah L Levy Kung-Yee Liang Jeffrey Lieberman Jouko Lönnqvist Carmel M Loughland Patrik K E Magnusson Brion S Maher Wolfgang Maier Jacques Mallet Manuel Mattheisen Morten Mattingsdal Robert W McCarley Colm McDonald Andrew M McIntosh Sandra Meier Carin J Meijer Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Younes Mokrab Derek W Morris Bertram Müller-Myhsok Kieran C Murphy Robin M Murray Inez Myin-Germeys Igor Nenadic Deborah A Nertney Gerald Nestadt Kristin K Nicodemus Laura Nisenbaum Annelie Nordin Eadbhard O'Callaghan Colm O'Dushlaine Sang-Yun Oh Ann Olincy Line Olsen F Anthony O'Neill Jim Van Os Christos Pantelis George N Papadimitriou Elena Parkhomenko Michele T Pato Tiina Paunio Diana O Perkins Tune H Pers Olli Pietiläinen Jonathan Pimm Andrew J Pocklington John Powell Alkes Price Ann E Pulver Shaun M Purcell Digby Quested Henrik B Rasmussen Abraham Reichenberg Mark A Reimers Alexander L Richards Joshua L Roffman Panos Roussos Douglas M Ruderfer Veikko Salomaa Alan R Sanders Adam Savitz Ulrich Schall Thomas G Schulze Sibylle G Schwab Edward M Scolnick Rodney J Scott Larry J Seidman Jianxin Shi Jeremy M Silverman Jordan W Smoller Erik Söderman Chris C A Spencer Eli A Stahl Eric Strengman Jana Strohmaier T Scott Stroup Jaana Suvisaari Dragan M Svrakic Jin P Szatkiewicz Srinivas Thirumalai Paul A Tooney Juha Veijola Peter M Visscher John Waddington Dermot Walsh Bradley T Webb Mark Weiser Dieter B Wildenauer Nigel M Williams Stephanie Williams Stephanie H Witt Aaron R Wolen Brandon K Wormley Naomi R Wray Jing Qin Wu Clement C Zai Rolf Adolfsson Ole A Andreassen Douglas H R Blackwood Elvira Bramon Joseph D Buxbaum Sven Cichon David A Collier Aiden Corvin Mark J Daly Ariel Darvasi Enrico Domenici Tõnu Esko Pablo V Gejman Michael Gill Hugh Gurling Christina M Hultman Nakao Iwata Assen V Jablensky Erik G Jönsson Kenneth S Kendler George Kirov Jo Knight Douglas F Levinson Qingqin S Li Steven A McCarroll Andrew McQuillin Jennifer L Moran Bryan J Mowry Markus M Nöthen Roel A Ophoff Michael J Owen Aarno Palotie Carlos N Pato Tracey L Petryshen Danielle Posthuma Marcella Rietschel Brien P Riley Dan Rujescu Pamela Sklar David St Clair James T R Walters Thomas Werge Patrick F Sullivan Michael C O'Donovan Stephen W Scherer Benjamin M Neale Jonathan Sebat

Nat Genet 2017 01 21;49(1):27-35. Epub 2016 Nov 21.

Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1038/ng.3725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737772PMC
January 2017

Mixed Model Association with Family-Biased Case-Control Ascertainment.

Am J Hum Genet 2017 Jan 22;100(1):31-39. Epub 2016 Dec 22.

Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223022PMC
January 2017

Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure.

Am J Hum Genet 2016 Nov 20;99(5):1130-1139. Epub 2016 Oct 20.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097941PMC
November 2016

Response to Shen et al.

Am J Hum Genet 2016 11;99(5):1220-1221

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097931PMC
November 2016

Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies.

Genetics 2016 07 6;203(3):1105-16. Epub 2016 May 6.

Department of Medicine, University of California, San Francisco, California 94158.

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http://dx.doi.org/10.1534/genetics.116.188292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937483PMC
July 2016

Fast and accurate long-range phasing in a UK Biobank cohort.

Nat Genet 2016 07 6;48(7):811-6. Epub 2016 Jun 6.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925291PMC
July 2016

Transethnic Genetic-Correlation Estimates from Summary Statistics.

Am J Hum Genet 2016 07 16;99(1):76-88. Epub 2016 Jun 16.

Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1016/j.ajhg.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005434PMC
July 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:
Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms10979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829663PMC
April 2016

Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.

Am J Hum Genet 2016 Mar 25;98(3):456-472. Epub 2016 Feb 25.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.12.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827102PMC
March 2016

Response to Day et al.

Am J Hum Genet 2016 Feb;98(2):394-5

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746361PMC
February 2016

Meta-Analysis of Rare Variant Association Tests in Multiethnic Populations.

Genet Epidemiol 2016 Jan 7;40(1):57-65. Epub 2015 Dec 7.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968883PMC
January 2016

Leveraging Distant Relatedness to Quantify Human Mutation and Gene-Conversion Rates.

Am J Hum Genet 2015 Dec 12;97(6):775-89. Epub 2015 Nov 12.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678427PMC
December 2015

Progress and promise in understanding the genetic basis of common diseases.

Proc Biol Sci 2015 Dec;282(1821):20151684

The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK

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http://dx.doi.org/10.1098/rspb.2015.1684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707742PMC
December 2015

An atlas of genetic correlations across human diseases and traits.

Nat Genet 2015 Nov 28;47(11):1236-41. Epub 2015 Sep 28.

Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797329PMC
November 2015

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.

Authors:
Felix R Day Katherine S Ruth Deborah J Thompson Kathryn L Lunetta Natalia Pervjakova Daniel I Chasman Lisette Stolk Hilary K Finucane Patrick Sulem Brendan Bulik-Sullivan Tõnu Esko Andrew D Johnson Cathy E Elks Nora Franceschini Chunyan He Elisabeth Altmaier Jennifer A Brody Lude L Franke Jennifer E Huffman Margaux F Keller Patrick F McArdle Teresa Nutile Eleonora Porcu Antonietta Robino Lynda M Rose Ursula M Schick Jennifer A Smith Alexander Teumer Michela Traglia Dragana Vuckovic Jie Yao Wei Zhao Eva Albrecht Najaf Amin Tanguy Corre Jouke-Jan Hottenga Massimo Mangino Albert V Smith Toshiko Tanaka Goncalo Abecasis Irene L Andrulis Hoda Anton-Culver Antonis C Antoniou Volker Arndt Alice M Arnold Caterina Barbieri Matthias W Beckmann Alicia Beeghly-Fadiel Javier Benitez Leslie Bernstein Suzette J Bielinski Carl Blomqvist Eric Boerwinkle Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Anne-Lise Borresen-Dale Thibaud S Boutin Hiltrud Brauch Hermann Brenner Thomas Brüning Barbara Burwinkel Archie Campbell Harry Campbell Stephen J Chanock J Ross Chapman Yii-Der Ida Chen Georgia Chenevix-Trench Fergus J Couch Andrea D Coviello Angela Cox Kamila Czene Hatef Darabi Immaculata De Vivo Ellen W Demerath Joe Dennis Peter Devilee Thilo Dörk Isabel Dos-Santos-Silva Alison M Dunning John D Eicher Peter A Fasching Jessica D Faul Jonine Figueroa Dieter Flesch-Janys Ilaria Gandin Melissa E Garcia Montserrat García-Closas Graham G Giles Giorgia G Girotto Mark S Goldberg Anna González-Neira Mark O Goodarzi Megan L Grove Daniel F Gudbjartsson Pascal Guénel Xiuqing Guo Christopher A Haiman Per Hall Ute Hamann Brian E Henderson Lynne J Hocking Albert Hofman Georg Homuth Maartje J Hooning John L Hopper Frank B Hu Jinyan Huang Keith Humphreys David J Hunter Anna Jakubowska Samuel E Jones Maria Kabisch David Karasik Julia A Knight Ivana Kolcic Charles Kooperberg Veli-Matti Kosma Jennifer Kriebel Vessela Kristensen Diether Lambrechts Claudia Langenberg Jingmei Li Xin Li Sara Lindström Yongmei Liu Jian'an Luan Jan Lubinski Reedik Mägi Arto Mannermaa Judith Manz Sara Margolin Jonathan Marten Nicholas G Martin Corrado Masciullo Alfons Meindl Kyriaki Michailidou Evelin Mihailov Lili Milani Roger L Milne Martina Müller-Nurasyid Michael Nalls Ben M Neale Heli Nevanlinna Patrick Neven Anne B Newman Børge G Nordestgaard Janet E Olson Sandosh Padmanabhan Paolo Peterlongo Ulrike Peters Astrid Petersmann Julian Peto Paul D P Pharoah Nicola N Pirastu Ailith Pirie Giorgio Pistis Ozren Polasek David Porteous Bruce M Psaty Katri Pylkäs Paolo Radice Leslie J Raffel Fernando Rivadeneira Igor Rudan Anja Rudolph Daniela Ruggiero Cinzia F Sala Serena Sanna Elinor J Sawyer David Schlessinger Marjanka K Schmidt Frank Schmidt Rita K Schmutzler Minouk J Schoemaker Robert A Scott Caroline M Seynaeve Jacques Simard Rossella Sorice Melissa C Southey Doris Stöckl Konstantin Strauch Anthony Swerdlow Kent D Taylor Unnur Thorsteinsdottir Amanda E Toland Ian Tomlinson Thérèse Truong Laufey Tryggvadottir Stephen T Turner Diego Vozzi Qin Wang Melissa Wellons Gonneke Willemsen James F Wilson Robert Winqvist Bruce B H R Wolffenbuttel Alan F Wright Drakoulis Yannoukakos Tatijana Zemunik Wei Zheng Marek Zygmunt Sven Bergmann Dorret I Boomsma Julie E Buring Luigi Ferrucci Grant W Montgomery Vilmundur Gudnason Tim D Spector Cornelia M van Duijn Behrooz Z Alizadeh Marina Ciullo Laura Crisponi Douglas F Easton Paolo P Gasparini Christian Gieger Tamara B Harris Caroline Hayward Sharon L R Kardia Peter Kraft Barbara McKnight Andres Metspalu Alanna C Morrison Alex P Reiner Paul M Ridker Jerome I Rotter Daniela Toniolo André G Uitterlinden Sheila Ulivi Henry Völzke Nicholas J Wareham David R Weir Laura M Yerges-Armstrong Alkes L Price Kari Stefansson Jenny A Visser Ken K Ong Jenny Chang-Claude Joanne M Murabito John R B Perry Anna Murray

Nat Genet 2015 Nov 28;47(11):1294-1303. Epub 2015 Sep 28.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.

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http://dx.doi.org/10.1038/ng.3412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4661791PMC
November 2015

Two-Variance-Component Model Improves Genetic Prediction in Family Datasets.

Am J Hum Genet 2015 Nov;97(5):677-90

Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667134PMC
November 2015

New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.

Authors:
S Hong Lee Enda M Byrne Christina M Hultman Anna Kähler Anna A E Vinkhuyzen Stephan Ripke Ole A Andreassen Thomas Frisell Alexander Gusev Xinli Hu Robert Karlsson Vasilis X Mantzioris John J McGrath Divya Mehta Eli A Stahl Qiongyi Zhao Kenneth S Kendler Patrick F Sullivan Alkes L Price Michael O'Donovan Yukinori Okada Bryan J Mowry Soumya Raychaudhuri Naomi R Wray William Byerley Wiepke Cahn Rita M Cantor Sven Cichon Paul Cormican David Curtis Srdjan Djurovic Valentina Escott-Price Pablo V Gejman Lyudmila Georgieva Ina Giegling Thomas F Hansen Andrés Ingason Yunjung Kim Bettina Konte Phil H Lee Andrew McIntosh Andrew McQuillin Derek W Morris Markus M Nöthen Colm O'Dushlaine Ann Olincy Line Olsen Carlos N Pato Michele T Pato Benjamin S Pickard Danielle Posthuma Henrik B Rasmussen Marcella Rietschel Dan Rujescu Thomas G Schulze Jeremy M Silverman Srinivasa Thirumalai Thomas Werge Ingrid Agartz Farooq Amin Maria H Azevedo Nicholas Bass Donald W Black Douglas H R Blackwood Richard Bruggeman Nancy G Buccola Khalid Choudhury Robert C Cloninger Aiden Corvin Nicholas Craddock Mark J Daly Susmita Datta Gary J Donohoe Jubao Duan Frank Dudbridge Ayman Fanous Robert Freedman Nelson B Freimer Marion Friedl Michael Gill Hugh Gurling Lieuwe De Haan Marian L Hamshere Annette M Hartmann Peter A Holmans René S Kahn Matthew C Keller Elaine Kenny George K Kirov Lydia Krabbendam Robert Krasucki Jacob Lawrence Todd Lencz Douglas F Levinson Jeffrey A Lieberman Dan-Yu Lin Don H Linszen Patrik K E Magnusson Wolfgang Maier Anil K Malhotra Manuel Mattheisen Morten Mattingsdal Steven A McCarroll Helena Medeiros Ingrid Melle Vihra Milanova Inez Myin-Germeys Benjamin M Neale Roel A Ophoff Michael J Owen Jonathan Pimm Shaun M Purcell Vinay Puri Digby J Quested Lizzy Rossin Douglas Ruderfer Alan R Sanders Jianxin Shi Pamela Sklar David St Clair T Scott Stroup Jim Van Os Peter M Visscher Durk Wiersma Stanley Zammit S Louis Bridges Hyon K Choi Marieke J H Coenen Niek de Vries Philippe Dieud Jeffrey D Greenberg Tom W J Huizinga Leonid Padyukov Katherine A Siminovitch Paul P Tak Jane Worthington Philip L De Jager Joshua C Denny Peter K Gregersen Lars Klareskog Xavier Mariette Robert M Plenge Mart van Laar Piet van Riel

Int J Epidemiol 2015 Oct;44(5):1706-21

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http://dx.doi.org/10.1093/ije/dyv136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881824PMC
October 2015

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores.

Am J Hum Genet 2015 Oct;97(4):576-92

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Electronic address:

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http://biorxiv.org/content/biorxiv/early/2015/03/01/015859.f
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http://dx.doi.org/10.1016/j.ajhg.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596916PMC
October 2015

Explicit Modeling of Ancestry Improves Polygenic Risk Scores and BLUP Prediction.

Genet Epidemiol 2015 Sep 21;39(6):427-38. Epub 2015 May 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734143PMC
September 2015

Mixed model with correction for case-control ascertainment increases association power.

Am J Hum Genet 2015 May 16;96(5):720-30. Epub 2015 Apr 16.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570278PMC
May 2015

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.

Nat Genet 2015 Mar 2;47(3):291-5. Epub 2015 Feb 2.

1] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [2] Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. [3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495769PMC
March 2015

Efficient Bayesian mixed-model analysis increases association power in large cohorts.

Nat Genet 2015 Mar 2;47(3):284-90. Epub 2015 Feb 2.

1] Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. [2] Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. [3] Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342297PMC
March 2015

Genetic and environmental components of family history in type 2 diabetes.

Hum Genet 2015 Feb 30;134(2):259-67. Epub 2014 Dec 30.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore, Suite 1400, Chicago, IL, 60611, USA,

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http://dx.doi.org/10.1007/s00439-014-1519-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293229PMC
February 2015

Adjusting for heritable covariates can bias effect estimates in genome-wide association studies.

Am J Hum Genet 2015 Feb 29;96(2):329-39. Epub 2015 Jan 29.

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ajhg.2014.12.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320269PMC
February 2015

Defining the role of common variation in the genomic and biological architecture of adult human height.

Authors:
Andrew R Wood Tonu Esko Jian Yang Sailaja Vedantam Tune H Pers Stefan Gustafsson Audrey Y Chu Karol Estrada Jian'an Luan Zoltán Kutalik Najaf Amin Martin L Buchkovich Damien C Croteau-Chonka Felix R Day Yanan Duan Tove Fall Rudolf Fehrmann Teresa Ferreira Anne U Jackson Juha Karjalainen Ken Sin Lo Adam E Locke Reedik Mägi Evelin Mihailov Eleonora Porcu Joshua C Randall André Scherag Anna A E Vinkhuyzen Harm-Jan Westra Thomas W Winkler Tsegaselassie Workalemahu Jing Hua Zhao Devin Absher Eva Albrecht Denise Anderson Jeffrey Baron Marian Beekman Ayse Demirkan Georg B Ehret Bjarke Feenstra Mary F Feitosa Krista Fischer Ross M Fraser Anuj Goel Jian Gong Anne E Justice Stavroula Kanoni Marcus E Kleber Kati Kristiansson Unhee Lim Vaneet Lotay Julian C Lui Massimo Mangino Irene Mateo Leach Carolina Medina-Gomez Michael A Nalls Dale R Nyholt Cameron D Palmer Dorota Pasko Sonali Pechlivanis Inga Prokopenko Janina S Ried Stephan Ripke Dmitry Shungin Alena Stancáková Rona J Strawbridge Yun Ju Sung Toshiko Tanaka Alexander Teumer Stella Trompet Sander W van der Laan Jessica van Setten Jana V Van Vliet-Ostaptchouk Zhaoming Wang Loïc Yengo Weihua Zhang Uzma Afzal Johan Arnlöv Gillian M Arscott Stefania Bandinelli Amy Barrett Claire Bellis Amanda J Bennett Christian Berne Matthias Blüher Jennifer L Bolton Yvonne Böttcher Heather A Boyd Marcel Bruinenberg Brendan M Buckley Steven Buyske Ida H Caspersen Peter S Chines Robert Clarke Simone Claudi-Boehm Matthew Cooper E Warwick Daw Pim A De Jong Joris Deelen Graciela Delgado Josh C Denny Rosalie Dhonukshe-Rutten Maria Dimitriou Alex S F Doney Marcus Dörr Niina Eklund Elodie Eury Lasse Folkersen Melissa E Garcia Frank Geller Vilmantas Giedraitis Alan S Go Harald Grallert Tanja B Grammer Jürgen Gräßler Henrik Grönberg Lisette C P G M de Groot Christopher J Groves Jeffrey Haessler Per Hall Toomas Haller Goran Hallmans Anke Hannemann Catharina A Hartman Maija Hassinen Caroline Hayward Nancy L Heard-Costa Quinta Helmer Gibran Hemani Anjali K Henders Hans L Hillege Mark A Hlatky Wolfgang Hoffmann Per Hoffmann Oddgeir Holmen Jeanine J Houwing-Duistermaat Thomas Illig Aaron Isaacs Alan L James Janina Jeff Berit Johansen Åsa Johansson Jennifer Jolley Thorhildur Juliusdottir Juhani Junttila Abel N Kho Leena Kinnunen Norman Klopp Thomas Kocher Wolfgang Kratzer Peter Lichtner Lars Lind Jaana Lindström Stéphane Lobbens Mattias Lorentzon Yingchang Lu Valeriya Lyssenko Patrik K E Magnusson Anubha Mahajan Marc Maillard Wendy L McArdle Colin A McKenzie Stela McLachlan Paul J McLaren Cristina Menni Sigrun Merger Lili Milani Alireza Moayyeri Keri L Monda Mario A Morken Gabriele Müller Martina Müller-Nurasyid Arthur W Musk Narisu Narisu Matthias Nauck Ilja M Nolte Markus M Nöthen Laticia Oozageer Stefan Pilz Nigel W Rayner Frida Renstrom Neil R Robertson Lynda M Rose Ronan Roussel Serena Sanna Hubert Scharnagl Salome Scholtens Fredrick R Schumacher Heribert Schunkert Robert A Scott Joban Sehmi Thomas Seufferlein Jianxin Shi Karri Silventoinen Johannes H Smit Albert Vernon Smith Joanna Smolonska Alice V Stanton Kathleen Stirrups David J Stott Heather M Stringham Johan Sundström Morris A Swertz Ann-Christine Syvänen Bamidele O Tayo Gudmar Thorleifsson Jonathan P Tyrer Suzanne van Dijk Natasja M van Schoor Nathalie van der Velde Diana van Heemst Floor V A van Oort Sita H Vermeulen Niek Verweij Judith M Vonk Lindsay L Waite Melanie Waldenberger Roman Wennauer Lynne R Wilkens Christina Willenborg Tom Wilsgaard Mary K Wojczynski Andrew Wong Alan F Wright Qunyuan Zhang Dominique Arveiler Stephan J L Bakker John Beilby Richard N Bergman Sven Bergmann Reiner Biffar John Blangero Dorret I Boomsma Stefan R Bornstein Pascal Bovet Paolo Brambilla Morris J Brown Harry Campbell Mark J Caulfield Aravinda Chakravarti Rory Collins Francis S Collins Dana C Crawford L Adrienne Cupples John Danesh Ulf de Faire Hester M den Ruijter Raimund Erbel Jeanette Erdmann Johan G Eriksson Martin Farrall Ele Ferrannini Jean Ferrières Ian Ford Nita G Forouhi Terrence Forrester Ron T Gansevoort Pablo V Gejman Christian Gieger Alain Golay Omri Gottesman Vilmundur Gudnason Ulf Gyllensten David W Haas Alistair S Hall Tamara B Harris Andrew T Hattersley Andrew C Heath Christian Hengstenberg Andrew A Hicks Lucia A Hindorff Aroon D Hingorani Albert Hofman G Kees Hovingh Steve E Humphries Steven C Hunt Elina Hypponen Kevin B Jacobs Marjo-Riitta Jarvelin Pekka Jousilahti Antti M Jula Jaakko Kaprio John J P Kastelein Manfred Kayser Frank Kee Sirkka M Keinanen-Kiukaanniemi Lambertus A Kiemeney Jaspal S Kooner Charles Kooperberg Seppo Koskinen Peter Kovacs Aldi T Kraja Meena Kumari Johanna Kuusisto Timo A Lakka Claudia Langenberg Loic Le Marchand Terho Lehtimäki Sara Lupoli Pamela A F Madden Satu Männistö Paolo Manunta André Marette Tara C Matise Barbara McKnight Thomas Meitinger Frans L Moll Grant W Montgomery Andrew D Morris Andrew P Morris Jeffrey C Murray Mari Nelis Claes Ohlsson Albertine J Oldehinkel Ken K Ong Willem H Ouwehand Gerard Pasterkamp Annette Peters Peter P Pramstaller Jackie F Price Lu Qi Olli T Raitakari Tuomo Rankinen D C Rao Treva K Rice Marylyn Ritchie Igor Rudan Veikko Salomaa Nilesh J Samani Jouko Saramies Mark A Sarzynski Peter E H Schwarz Sylvain Sebert Peter Sever Alan R Shuldiner Juha Sinisalo Valgerdur Steinthorsdottir Ronald P Stolk Jean-Claude Tardif Anke Tönjes Angelo Tremblay Elena Tremoli Jarmo Virtamo Marie-Claude Vohl Philippe Amouyel Folkert W Asselbergs Themistocles L Assimes Murielle Bochud Bernhard O Boehm Eric Boerwinkle Erwin P Bottinger Claude Bouchard Stéphane Cauchi John C Chambers Stephen J Chanock Richard S Cooper Paul I W de Bakker George Dedoussis Luigi Ferrucci Paul W Franks Philippe Froguel Leif C Groop Christopher A Haiman Anders Hamsten M Geoffrey Hayes Jennie Hui David J Hunter Kristian Hveem J Wouter Jukema Robert C Kaplan Mika Kivimaki Diana Kuh Markku Laakso Yongmei Liu Nicholas G Martin Winfried März Mads Melbye Susanne Moebus Patricia B Munroe Inger Njølstad Ben A Oostra Colin N A Palmer Nancy L Pedersen Markus Perola Louis Pérusse Ulrike Peters Joseph E Powell Chris Power Thomas Quertermous Rainer Rauramaa Eva Reinmaa Paul M Ridker Fernando Rivadeneira Jerome I Rotter Timo E Saaristo Danish Saleheen David Schlessinger P Eline Slagboom Harold Snieder Tim D Spector Konstantin Strauch Michael Stumvoll Jaakko Tuomilehto Matti Uusitupa Pim van der Harst Henry Völzke Mark Walker Nicholas J Wareham Hugh Watkins H-Erich Wichmann James F Wilson Pieter Zanen Panos Deloukas Iris M Heid Cecilia M Lindgren Karen L Mohlke Elizabeth K Speliotes Unnur Thorsteinsdottir Inês Barroso Caroline S Fox Kari E North David P Strachan Jacques S Beckmann Sonja I Berndt Michael Boehnke Ingrid B Borecki Mark I McCarthy Andres Metspalu Kari Stefansson André G Uitterlinden Cornelia M van Duijn Lude Franke Cristen J Willer Alkes L Price Guillaume Lettre Ruth J F Loos Michael N Weedon Erik Ingelsson Jeffrey R O'Connell Goncalo R Abecasis Daniel I Chasman Michael E Goddard Peter M Visscher Joel N Hirschhorn Timothy M Frayling

Nat Genet 2014 Nov 5;46(11):1173-86. Epub 2014 Oct 5.

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.

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November 2014

Fast and accurate imputation of summary statistics enhances evidence of functional enrichment.

Bioinformatics 2014 Oct 1;30(20):2906-14. Epub 2014 Jul 1.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90024, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, 90024, Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, 94143, Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, 02115, Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA, 02115, Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, 02142, Department of Genetics Harvard Medical School, Boston, MA, 02115 and Division of Population Health Sciences and Education, St George's, University of London, UK Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90024, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, 90024, Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, 94143, Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, 02115, Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, MA, 02115, Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, 02142, Department of Genetics Harvard Medical School, Boston, MA, 02115 and Division of Population Health Sciences and Education, St George's, University of London, UK Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, 90024, Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, 90024, Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, 94143, Program in Genetic Epidemiology and Statistical Genetics, Har

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October 2014

Integrating functional data to prioritize causal variants in statistical fine-mapping studies.

PLoS Genet 2014 Oct 30;10(10):e1004722. Epub 2014 Oct 30.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California, United States of America; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America.

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October 2014

Quantifying missing heritability at known GWAS loci.

PLoS Genet 2013 26;9(12):e1003993. Epub 2013 Dec 26.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America ; Medical and Population Genetics Program, Broad Institute, Cambridge, Massachusetts, United States of America.

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August 2014

Improving the power of GWAS and avoiding confounding from population stratification with PC-Select.

Genetics 2014 Jul 29;197(3):1045-9. Epub 2014 Apr 29.

*Department of Mathematics and Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

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July 2014

Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.

Hum Mol Genet 2014 Feb 20;23(3):796-809. Epub 2013 Sep 20.

Department of Clinical Laboratory Sciences, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

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February 2014

Advantages and pitfalls in the application of mixed-model association methods.

Nat Genet 2014 Feb;46(2):100-6

1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA. [3] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. [4].

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February 2014

Author reply to A commentary on Pitfalls of predicting complex traits from SNPs.

Nat Rev Genet 2013 Dec;14(12):894

The Queensland Brain Institute, The University of Queensland, QBI Building, St Lucia, Queensland 4071, Australia.

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December 2013

Estimating and interpreting FST: the impact of rare variants.

Genome Res 2013 Sep 16;23(9):1514-21. Epub 2013 Jul 16.

Harvard-Massachusetts Institute of Technology (MIT), Division of Health, Science, and Technology, Cambridge, Massachusetts 02139, USA.

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September 2013

Pitfalls of predicting complex traits from SNPs.

Nat Rev Genet 2013 07;14(7):507-15

Queensland Brain Institute, The University of Queensland, QBI Building, St Lucia, Queensland 4071, Australia.

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July 2013

Improved ancestry inference using weights from external reference panels.

Bioinformatics 2013 Jun 28;29(11):1399-406. Epub 2013 Mar 28.

Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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June 2013

Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits.

PLoS Genet 2013 May 30;9(5):e1003520. Epub 2013 May 30.

Department of Medicine, Lung Biology Center, University of California San Francisco, San Francisco, CA, USA.

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May 2013

Dietary fatty acid intake and prostate cancer survival in Örebro County, Sweden.

Am J Epidemiol 2012 Aug 10;176(3):240-52. Epub 2012 Jul 10.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

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August 2012

The landscape of recombination in African Americans.

Nature 2011 Jul 20;476(7359):170-5. Epub 2011 Jul 20.

Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK.

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July 2011

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Department of Biochemistry and Molecular Medicine, University of California Davis, Davis, California, USA.

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Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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April 2011

Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals.

PLoS Genet 2011 Feb 24;7(2):e1001317. Epub 2011 Feb 24.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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February 2011

Integrating common and rare genetic variation in diverse human populations.

Nature 2010 Sep;467(7311):52-8

Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts 02138, USA.

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September 2010

New approaches to population stratification in genome-wide association studies.

Nat Rev Genet 2010 Jul;11(7):459-63

Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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July 2010

Pooled association tests for rare variants in exon-resequencing studies.

Am J Hum Genet 2010 Jun 13;86(6):832-8. Epub 2010 May 13.

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.

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June 2010

Reconstructing Indian population history.

Nature 2009 Sep;461(7263):489-94

Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2009