Publications by authors named "Aliya N Husain"

100Publications

One Step Forward, Two Steps Back: Bronchial Thermoplasty for Asthma.

Am J Respir Crit Care Med 2020 Aug 25. Epub 2020 Aug 25.

The University of Chicago, Department of Pathology , Chicago, Illinois, United States.

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http://dx.doi.org/10.1164/rccm.202008-3173EDDOI Listing
August 2020

Left ventricular summit arrhythmias with an abrupt V transition: Anatomy of the aortic interleaflet triangle vantage point.

Heart Rhythm 2020 Jul 21. Epub 2020 Jul 21.

Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Academy of Medical Sciences, Guangzhou, P.R. China; Section of Cardiology, Pritzker School of Medicine, The University of Chicago Medicine, Chicago, Illinois. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2020.07.021DOI Listing
July 2020

Update on the pathologic diagnosis of malignant mesothelioma.

Transl Lung Cancer Res 2020 Jun;9(3):917-923

Department of Pathology, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.21037/tlcr-19-620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7354126PMC
June 2020

Educational Case: Asthma: Clinical Features and Morphologic Findings.

Acad Pathol 2020 Jan-Dec;7:2374289520921533. Epub 2020 Jun 1.

Department of Pathology, The University of Chicago, IL, USA.

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http://dx.doi.org/10.1177/2374289520921533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265076PMC
June 2020

Metastatic HPV-Associated Oropharyngeal Versus Primary Pulmonary Squamous Cell Carcinoma: is p16 Immunostain Useful?

Head Neck Pathol 2020 Apr 29. Epub 2020 Apr 29.

Department of Pathology, The University of Chicago, 5841 S. Maryland Ave , Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1007/s12105-020-01165-9DOI Listing
April 2020

Application of immunohistochemistry in diagnosis and management of malignant mesothelioma.

Transl Lung Cancer Res 2020 Feb;9(Suppl 1):S3-S27

Department of Pathology, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.21037/tlcr.2019.11.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7082260PMC
February 2020

Connective Tissue Disease Related Interstitial Lung Disease.

Surg Pathol Clin 2020 Mar;13(1):165-188

Department of Pathology, University of Chicago, 5841 South Maryland, Room S627, MC6101, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.path.2019.11.005DOI Listing
March 2020

Idiopathic pulmonary fibrosis is associated with tight junction protein alterations.

Biochim Biophys Acta Biomembr 2020 05 28;1862(5):183205. Epub 2020 Jan 28.

Department of Pathology, University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2020.183205DOI Listing
May 2020

An Unusual Lung Mass of Heterotopic Pancreatic Tissue in a Neonate With an Elevated Immunoreactive Trypsinogen on Newborn Screen.

Pediatr Dev Pathol 2020 Mar-Apr;23(2):163-166. Epub 2019 Sep 12.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, The University of Chicago Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1177/1093526619876820DOI Listing
September 2019

Tumor PD-L1 expression in malignant pleural and peritoneal mesothelioma by Dako PD-L1 22C3 pharmDx and Dako PD-L1 28-8 pharmDx assays.

Hum Pathol 2019 05 20;87:11-17. Epub 2019 Feb 20.

Department of Pathology, University of Utah, Salt Lake City, UT 84112; ARUP Laboratories, Salt Lake City, UT, 84108.

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http://dx.doi.org/10.1016/j.humpath.2019.02.001DOI Listing
May 2019

Molecular pathways and diagnosis in malignant mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group.

Lung Cancer 2019 01 26;127:69-75. Epub 2018 Nov 26.

Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.lungcan.2018.11.032DOI Listing
January 2019

Immunohistochemical evaluation of nuclear 5-hydroxymethylcytosine (5-hmC) accurately distinguishes malignant pleural mesothelioma from benign mesothelial proliferations.

Mod Pathol 2019 03 12;32(3):376-386. Epub 2018 Oct 12.

Department of Pathology, University of Chicago, 5841 S. Maryland Ave, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/s41379-018-0159-7DOI Listing
March 2019

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma.

J Clin Oncol 2018 10 16;36(28):2863-2871. Epub 2018 Aug 16.

Vasiliki Panou and Oluf D. Røe, Aalborg University Hospital, Aalborg, Denmark; Meghana Gadiraju, Arthur Wolin, Caroline M. Weipert, Emily Skarda, Aliya N. Husain, Jyoti D. Patel, Buerkley Rose, Shannon R. Zhang, Madison Weatherly, Viswateja Nelakuditi, Amy Knight Johnson, Maria Helgeson, David Fischer, Arpita Desai, Nanna Sulai, Lauren Ritterhouse, Kiran K. Turaga, Dezheng Huo, Jeremy Segal, Sabah Kadri, Zejuan Li, Hedy L. Kindler, and Jane E. Churpek, The University of Chicago, Chicago, IL; Oluf D. Røe, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger; and Oluf D. Røe, Norwegian University of Science and Technology, Trondheim, Norway.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.5204
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http://dx.doi.org/10.1200/JCO.2018.78.5204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804864PMC
October 2018

Mucolipidosis Type II Affecting 1 Fetus and Placental Disk of a Dichorionic-Diamnionic Twin Gestation: A Case Report and Review of the Literature.

Int J Gynecol Pathol 2019 Jul;38(4):346-352

Department of Pathology, The University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1097/PGP.0000000000000506DOI Listing
July 2019

CT-Pathologic Correlation of Major Types of Pulmonary Fibrosis: Insights for Revisions to Current Guidelines.

AJR Am J Roentgenol 2018 May 16;210(5):1034-1041. Epub 2018 Mar 16.

2 Department of Medicine, Section of Pulmonary/Critical Care, University of California at Davis, Sacramento, CA.

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https://www.ajronline.org/doi/10.2214/AJR.17.18947
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http://dx.doi.org/10.2214/AJR.17.18947DOI Listing
May 2018

CT Features of the Usual Interstitial Pneumonia Pattern: Differentiating Connective Tissue Disease-Associated Interstitial Lung Disease From Idiopathic Pulmonary Fibrosis.

AJR Am J Roentgenol 2018 Feb 15;210(2):307-313. Epub 2017 Nov 15.

3 Department of Medicine, Section of Pulmonary/Critical Care, The University of Chicago Medical Center, Chicago, IL.

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http://dx.doi.org/10.2214/AJR.17.18384DOI Listing
February 2018

Autoimmune Hypothyroidism As a Predictor of Mortality in Chronic Hypersensitivity Pneumonitis.

Front Med (Lausanne) 2017 16;4:170. Epub 2017 Oct 16.

Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, United States.

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http://dx.doi.org/10.3389/fmed.2017.00170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650730PMC
October 2017

Routine C4d immunohistochemistry in cardiac allografts: Long-term outcomes.

J Heart Lung Transplant 2017 Dec 14;36(12):1329-1335. Epub 2017 Sep 14.

Department of Medicine, The University of Chicago Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1016/j.healun.2017.09.004DOI Listing
December 2017

PAX8 Expression in a Subset of Malignant Peritoneal Mesotheliomas and Benign Mesothelium has Diagnostic Implications in the Differential Diagnosis of Ovarian Serous Carcinoma.

Am J Surg Pathol 2017 Dec;41(12):1675-1682

*Department of Pathology, The University of Chicago, Chicago, IL †Department of Pathology and Laboratory Medicine, Wisconsin Institute for Medical Research, The University of Wisconsin-Madison, Madison, WI.

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http://dx.doi.org/10.1097/PAS.0000000000000935DOI Listing
December 2017

CT findings associated with survival in chronic hypersensitivity pneumonitis.

Eur Radiol 2017 Dec 7;27(12):5127-5135. Epub 2017 Jul 7.

Section of Pulmonary/Critical Care; Department of Medicine, The University of Chicago Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1007/s00330-017-4936-3DOI Listing
December 2017

Late presentation of constrictive pericarditis after limited epicardial ablation for inappropriate sinus tachycardia.

HeartRhythm Case Rep 2016 Sep 16;2(5):441-445. Epub 2016 Jul 16.

Center for Arrhythmia Care, Heart and Vascular Center, The University of Chicago Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.hrcr.2016.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419970PMC
September 2016

Interstitial Pneumonia With Autoimmune Features: Value of Histopathology.

Arch Pathol Lab Med 2017 Jul 3;141(7):960-969. Epub 2017 May 3.

From the Section of Pulmonary and Critical Care Medicine, Department of Medicine (Drs Adegunsoye, Witt, Noth, Vij, and Strek and Ms Chen) and the Departments of Medicine (Drs Valenzi and Lee), Radiology (Drs Montner and Chung), and Pathology (Dr Husain), University of Chicago, Chicago, Illinois; and the Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, Davis (Dr Oldham). Drs Adegunsoye and Oldham contributed equally to this article.

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http://dx.doi.org/10.5858/arpa.2016-0427-OADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554445PMC
July 2017

Amount of Epithelioid Differentiation Is a Predictor of Survival in Malignant Pleural Mesothelioma.

Ann Thorac Surg 2017 Mar 17;103(3):962-966. Epub 2016 Oct 17.

Department of Pathology, University of Chicago Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1016/j.athoracsur.2016.08.063DOI Listing
March 2017

BAP1 Immunostain and CDKN2A (p16) FISH Analysis: Clinical Applicability for the Diagnosis of Malignant Mesothelioma in Effusions.

Diagn Cytopathol 2016 Jul 28;44(7):599-606. Epub 2016 Apr 28.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1002/dc.23491DOI Listing
July 2016

Characterisation of patients with interstitial pneumonia with autoimmune features.

Eur Respir J 2016 06 21;47(6):1767-75. Epub 2016 Apr 21.

Dept of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL, USA These authors contributed equally.

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http://dx.doi.org/10.1183/13993003.01565-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515625PMC
June 2016

Lung Transplantation: The State of the Airways.

Arch Pathol Lab Med 2016 Mar;140(3):241-4

From the Departments of Pathology (Dr Husain) and Medicine (Dr Garrity), University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.5858/arpa.2015-0295-SADOI Listing
March 2016

Specimen weight and volume: important predictors of survival in malignant pleural mesothelioma.

Eur J Cardiothorac Surg 2016 Jun 21;49(6):1642-7. Epub 2016 Jan 21.

Section of Cardiac and Thoracic Surgery, Department of Surgery, University of Chicago, Chicago, IL, USA

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http://dx.doi.org/10.1093/ejcts/ezv422DOI Listing
June 2016

BAP1 facilitates diagnostic objectivity, classification, and prognostication in malignant pleural mesothelioma.

Hum Pathol 2015 Nov 21;46(11):1670-8. Epub 2015 Jul 21.

Department of Pathology, University of Chicago Hospitals, Chicago, IL, 60637. Electronic address:

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http://dx.doi.org/10.1016/j.humpath.2015.06.024DOI Listing
November 2015

A Brief Review and Update of the Clinicopathologic Diagnosis of Arrhythmogenic Cardiomyopathy.

Arch Pathol Lab Med 2015 Sep;139(9):1181-6

From the Department of Pathology, University of Chicago Medicine, Chicago, Illinois.

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http://dx.doi.org/10.5858/arpa.2014-0114-RSDOI Listing
September 2015

Malignant Mesothelioma Diagnosis.

Arch Pathol Lab Med 2015 Aug;139(8):978-80

From the Department of Pathology, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.5858/arpa.2013-0381-RADOI Listing
August 2015

Spontaneous restoration of transplantation tolerance after acute rejection.

Nat Commun 2015 Jul 7;6:7566. Epub 2015 Jul 7.

Section of Transplantation, Department of Surgery, The University of Chicago, 5841 S. Maryland Avenue, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ncomms8566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498267PMC
July 2015

Radiologic-pathologic correlation of mesothelioma tumor volume.

Lung Cancer 2015 Mar 20;87(3):278-82. Epub 2015 Jan 20.

Department of Surgery, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.lungcan.2014.11.019DOI Listing
March 2015

The spectrum of lung disease due to chronic occult aspiration.

Ann Am Thorac Soc 2014 Jul;11(6):865-73

1 Department of Pulmonary and Critical Care.

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http://dx.doi.org/10.1513/AnnalsATS.201310-360OCDOI Listing
July 2014

Carbonic anhydrase IX (CAIX) does not differentiate between benign and malignant mesothelium.

Am J Clin Pathol 2014 Jul;142(1):82-7

From the Department of Pathology, University of Chicago, Chicago, IL, and

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http://dx.doi.org/10.1309/AJCP8BJ8CJXUEHZDDOI Listing
July 2014

Mesothelial proliferations: useful marker is not the same as a diagnostic one.

Authors:
Aliya N Husain

Am J Clin Pathol 2014 Feb;141(2):152-3

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http://dx.doi.org/10.1309/AJCPOI1DESU8MTHZDOI Listing
February 2014

Combined MET inhibition and topoisomerase I inhibition block cell growth of small cell lung cancer.

Mol Cancer Ther 2014 Mar 10;13(3):576-84. Epub 2013 Dec 10.

Corresponding Author: Ravi Salgia, Section of Hematology/Oncology, Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC 2115, Chicago, IL 60637.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286701PMC
March 2014

A novel algorithm for simplification of complex gene classifiers in cancer.

Cancer Res 2013 Sep 2;73(18):5625-32. Epub 2013 Aug 2.

Authors' Affiliations: Division of Hematology/Oncology, Department of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, Texas; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Department of Pathology, University of Southern California and Children's Hospital of Los Angeles, Los Angeles, California; Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital and Department of Pathology and Pediatrics, The Ohio State University, Columbus, Ohio; National Cancer Institute, Bethesda, Maryland; Division of Hematology/Oncology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, Washington; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska; The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Department of Pathology, Center for Research Informatics, and The Computation Institute, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233649PMC
September 2013

Bronchial thermoplasty failure in severe persistent asthma: a case report.

J Asthma 2013 Sep 14;50(7):799-801. Epub 2013 Jun 14.

Department of Medicine, The University of Chicago, Chicago, IL Chicago, IL 60637, USA.

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http://dx.doi.org/10.3109/02770903.2013.796974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842589PMC
September 2013

Endobronchial biopsy: a guide for asthma therapy selection in the era of bronchial thermoplasty.

J Asthma 2013 Aug 20;50(6):634-41. Epub 2013 May 20.

Department of Pathology, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.3109/02770903.2013.794239DOI Listing
August 2013

Lymphatic endothelial differentiation in pulmonary lymphangioleiomyomatosis cells.

J Histochem Cytochem 2013 Aug 22;61(8):580-90. Epub 2013 Apr 22.

Department of Pathology, Biological Sciences Division, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1369/0022155413489311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724387PMC
August 2013

SaLUTaRy: survey of lung transplant rejection.

J Heart Lung Transplant 2012 Sep;31(9):972-9

Department of Pathology, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.healun.2012.05.014DOI Listing
September 2012

Persistence of complex vascular lesions despite prolonged prostacyclin therapy of pulmonary arterial hypertension.

Histopathology 2012 Oct;61(4):597-609

Department of PathologySection of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1111/j.1365-2559.2012.04246.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143476PMC
October 2012

The clinical and immunologic features of pulmonary fibrosis in sarcoidosis.

Transl Res 2012 Nov 10;160(5):321-31. Epub 2012 Apr 10.

Section of Pulmonary and Critical Care, University of Chicago, Chicago, Ill.

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http://dx.doi.org/10.1016/j.trsl.2012.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910531PMC
November 2012

Differential expression of RON in small and non-small cell lung cancers.

Genes Chromosomes Cancer 2012 Sep 14;51(9):841-51. Epub 2012 May 14.

Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1002/gcc.21968DOI Listing
September 2012

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer.

FASEB J 2012 May 9;26(5):2175-86. Epub 2012 Feb 9.

Section of Cardiology, University of Chicago, 5841 South Maryland Ave., MC6080, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1096/fj.11-196543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336787PMC
May 2012

MET and phosphorylated MET as potential biomarkers in lung cancer.

J Environ Pathol Toxicol Oncol 2011 ;30(4):341-54

University of Chicago, Department of Pathology, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1615/jenvironpatholtoxicoloncol.v30.i4.70DOI Listing
February 2012

A sphingosine 1-phosphate 1 receptor agonist modulates brain death-induced neurogenic pulmonary injury.

Am J Respir Cell Mol Biol 2011 Nov 26;45(5):1022-7. Epub 2011 May 26.

Section of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, 60612, USA.

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http://dx.doi.org/10.1165/rcmb.2010-0267OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262681PMC
November 2011

Urothelial neoplasms of the urinary bladder occurring in young adult and pediatric patients: a comprehensive review of literature with implications for patient management.

Adv Anat Pathol 2011 Jan;18(1):79-89

Department of Pathology, Section of Urology, The University of Chicago Hospitals, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1097/PAP.0b013e318204c0cfDOI Listing
January 2011

Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension.

Chest 2010 Nov;138(5):1234-9

Department of Medicine, University of Chicago, Section of Cardiology, 5841 S Maryland Ave, Ste LO 8; MC 5403, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1378/chest.09-2815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972625PMC
November 2010

Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung.

Arch Pathol Lab Med 2010 Nov;134(11):1702-5

Department of Pathology, University of Chicago Medical Center, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049158PMC
http://dx.doi.org/10.1043/2009-0664-OAR1.1DOI Listing
November 2010

S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program.

Arterioscler Thromb Vasc Biol 2011 Feb 21;31(2):337-44. Epub 2010 Oct 21.

Department of Medicine, Section of Cardiology, University of Chicago, 5841 S Maryland Avenue, Chicago IL 60637, USA.

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http://dx.doi.org/10.1161/ATVBAHA.110.217745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364048PMC
February 2011

Diagnosis in Pediatric Transplant Biopsies.

Surg Pathol Clin 2010 Sep 20;3(3):797-866. Epub 2010 Oct 20.

Department of Pathology, Room B258, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.

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http://dx.doi.org/10.1016/j.path.2010.06.010DOI Listing
September 2010

Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility.

J Allergy Clin Immunol 2010 Aug 10;126(2):241-9, 249.e1-3. Epub 2010 Jul 10.

Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Ill, USA.

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http://dx.doi.org/10.1016/j.jaci.2010.04.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495167PMC
August 2010

Diagnosis and management of pulmonary hypertension in systemic sclerosis.

Curr Rheumatol Rep 2010 Feb;12(1):8-18

Section of Rheumatology, University of Chicago, 5841 South Maryland Avenue (MC6080), Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s11926-009-0078-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865259PMC
February 2010