Alistair N Hume

Alistair N Hume

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Alistair N Hume

Alistair N Hume

Publications by authors named "Alistair N Hume"

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The adaptor protein melanophilin regulates dynamic myosin-Va:cargo interaction and dendrite development in melanocytes.

Mol Biol Cell 2019 03 30;30(6):742-752. Epub 2019 Jan 30.

School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, United Kingdom.

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http://dx.doi.org/10.1091/mbc.E18-04-0237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589771PMC
March 2019

Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport.

J Cell Sci 2017 Jun 10;130(12):2056-2065. Epub 2017 May 10.

School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK

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http://dx.doi.org/10.1242/jcs.186064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482976PMC
June 2017

Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.

Proc Natl Acad Sci U S A 2017 06 30;114(24):E4714-E4723. Epub 2017 May 30.

Physik Department E22, Technische Universität München, D-85748 Garching, Germany;

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http://dx.doi.org/10.1073/pnas.1619473114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474823PMC
June 2017

A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.

PLoS One 2014 22;9(7):e102851. Epub 2014 Jul 22.

Molecular Medicine, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College London, London, United Kingdom; CEDOC, Faculdade de Ciencias Medicas, FCM, Universidade Nova de Lisboa, Lisboa, Portugal.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102851PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106853PMC
December 2015

Myosin--a monarch of pigment transport?

Authors:
Alistair N Hume

Pigment Cell Melanoma Res 2015 Mar 29;28(2):126-7. Epub 2014 Dec 29.

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http://eprints.nottingham.ac.uk/30212/1/pcmr12339.pdf
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http://doi.wiley.com/10.1111/pcmr.12339
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http://dx.doi.org/10.1111/pcmr.12339DOI Listing
March 2015

Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise.

Pigment Cell Melanoma Res 2014 Nov 18;27(6):1012-3. Epub 2014 Sep 18.

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http://dx.doi.org/10.1111/pcmr.12310DOI Listing
November 2014

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.

J Invest Dermatol 2014 Apr 18;134(4):1056-1066. Epub 2013 Oct 18.

CEDOC, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal; Instituto Gulbenkian de Ciência, Oeiras, Portugal; Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1038/jid.2013.432DOI Listing
April 2014

Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

FEBS J 2013 Feb 2;280(3):892-903. Epub 2013 Jan 2.

Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/febs.12081DOI Listing
February 2013

Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

Biochem Soc Trans 2012 Dec;40(6):1383-8

Molecular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1042/BST20120200DOI Listing
December 2012

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment.

J Cell Sci 2012 Apr 28;125(Pt 7):1652-6. Epub 2012 Feb 28.

Molecular Medicine, National Heart and Lung Institute (NHLI), Imperial College, London, UK.

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http://dx.doi.org/10.1242/jcs.100438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346826PMC
April 2012

Exosome signaling in mammary gland development and cancer.

Int J Dev Biol 2011 ;55(7-9):879-87

Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium.

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http://dx.doi.org/10.1387/ijdb.113391ahDOI Listing
March 2012

Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function.

Traffic 2011 Dec 11;12(12):1686-701. Epub 2011 Oct 11.

Molecular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1600-0854.2011.01283.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264752PMC
December 2011

Melanosomes on the move: a model to understand organelle dynamics.

Biochem Soc Trans 2011 Oct;39(5):1191-6

School of Biomedical Sciences, Queen's Medical Centre, Nottingham NG7 2UH, UK.

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http://dx.doi.org/10.1042/BST0391191DOI Listing
October 2011

Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Am J Physiol Cell Physiol 2011 Aug 27;301(2):C507-21. Epub 2011 Apr 27.

School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1152/ajpcell.00355.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154548PMC
August 2011

Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding.

Traffic 2011 Aug 15;12(8):1056-66. Epub 2011 Jun 15.

Molecular Medicine, National Heart and Lung Institute (NHLI), Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1111/j.1600-0854.2011.01216.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509405PMC
August 2011

Loss of Rab27 function results in abnormal lung epithelium structure in mice.

Am J Physiol Cell Physiol 2011 Mar 15;300(3):C466-76. Epub 2010 Dec 15.

Molecular Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1152/ajpcell.00446.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063958PMC
March 2011

A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.

Biochem Biophys Res Commun 2010 Jun 13;397(1):34-41. Epub 2010 May 13.

Department of Pathology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X1000936
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http://dx.doi.org/10.1016/j.bbrc.2010.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908739PMC
June 2010

Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

Pigment Cell Melanoma Res 2009 Aug 21;22(4):461-73. Epub 2009 Mar 21.

Centre of Ophthalmology, Biomedical Institute for Research in Light and Image, University of Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1111/j.1755-148X.2009.00567.xDOI Listing
August 2009

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

Blood 2009 May 6;113(20):5010-8. Epub 2009 Mar 6.

Medical Research Council Laboratory of Molecular Cell Biology, Cell Biology Unit, Department of Cell and Developmental Biology, University College London, London, United Kingdom. [corrected]

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2008-09-18
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http://dx.doi.org/10.1182/blood-2008-09-181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686148PMC
May 2009

Melanosomes at a glance.

J Cell Sci 2008 Dec;121(Pt 24):3995-9

Molecular Medicine, National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.

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http://dx.doi.org/10.1242/jcs.040667DOI Listing
December 2008

Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes.

J Cell Sci 2007 Sep 14;120(Pt 17):3111-22. Epub 2007 Aug 14.

Molecular and Cellular Medicine, National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK.

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http://www.pawelserver.com/rabs/files/0682.pdf
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http://jcs.biologists.org/cgi/doi/10.1242/jcs.010207
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http://dx.doi.org/10.1242/jcs.010207DOI Listing
September 2007

Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

J Immunol 2006 Dec;177(12):8476-83

Division of Cell and Molecular Biology, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, UK.

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http://dx.doi.org/10.4049/jimmunol.177.12.8476DOI Listing
December 2006

A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.

Mol Biol Cell 2006 Nov 16;17(11):4720-35. Epub 2006 Aug 16.

Molecular and Cellular Medicine, Division of Biomedical Sciences, Imperial College London, London SW7 2AZ, United Kingdom.

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http://www.molbiolcell.org/doi/10.1091/mbc.e06-05-0457
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http://dx.doi.org/10.1091/mbc.e06-05-0457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635380PMC
November 2006

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.

J Biol Chem 2003 Nov 25;278(47):46798-804. Epub 2003 Aug 25.

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, U.K.

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http://dx.doi.org/10.1074/jbc.M307799200DOI Listing
November 2003

Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type.

J Cell Sci 2003 Oct 19;116(Pt 19):3939-48. Epub 2003 Aug 19.

MRC Laboratory of Molecular Cell Biology, Cell Biology Unit, University College London, Gower St, London WC1E 6BT, UK.

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http://dx.doi.org/10.1242/jcs.00711DOI Listing
October 2003

Membrane targeting of Rab GTPases is influenced by the prenylation motif.

Mol Biol Cell 2003 May 6;14(5):1882-99. Epub 2003 Feb 6.

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1091/mbc.e02-10-0639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165084PMC
May 2003

A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.

J Biol Chem 2002 Jul 29;277(28):25423-30. Epub 2002 Apr 29.

Department of Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M202574200DOI Listing
July 2002

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.

Traffic 2002 Mar;3(3):193-202

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London SW7 2AZ, UK.

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http://dx.doi.org/10.1034/j.1600-0854.2002.030305.xDOI Listing
March 2002

Rab GTPases, intracellular traffic and disease.

Trends Mol Med 2002 Jan;8(1):23-30

Cell and Molecular Biology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, Exhibition Road, London, UK SW7 2AZ.

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http://www.pawelserver.com/rabs/files/0072.pdf
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http://dx.doi.org/10.1016/s1471-4914(01)02227-4DOI Listing
January 2002