Publications by authors named "Alistair G Rust"

54Publications

A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma.

Pigment Cell Melanoma Res 2019 03 19;32(2):332-335. Epub 2018 Oct 19.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pcmr.12737DOI Listing
March 2019

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Proc Natl Acad Sci U S A 2016 07 29;113(29):8290-5. Epub 2016 Jun 29.

Cancer Research UK Beatson Institute, Bearsden, Glasgow G61 1BD, United Kingdom; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, United Kingdom;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1601571113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961202PMC
July 2016

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development.

Proc Natl Acad Sci U S A 2016 Apr 22;113(14):E2057-65. Epub 2016 Mar 22.

Division of Genomics and Genetics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673; Cancer Research Program, Houston Methodist Research Institute, Houston, TX 77030

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1603223113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833248PMC
April 2016

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression.

J Exp Med 2015 Sep 24;212(10):1551-69. Epub 2015 Aug 24.

Department of Haematology, Cambridge Institute for Medical Research and Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0XY, England, UK Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1TN, England, UK

View Article

Download full-text PDF

Source
http://jem.rupress.org/content/212/10/1551.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20141661
Publisher Site
http://dx.doi.org/10.1084/jem.20141661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577832PMC
September 2015

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

Nat Genet 2015 May 13;47(5):486-95. Epub 2015 Apr 13.

1] Cancer Research Program, Houston Methodist Research Institute, Houston, Texas, USA. [2] Institute of Molecular and Cell Biology, Singapore.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844184PMC
May 2015

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

Nat Genet 2015 Feb 5;47(2):142-50. Epub 2015 Jan 5.

1] Division of Genomics and Genetics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore. [2] Cancer Research Program, Houston Methodist Research Institute, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.3175DOI Listing
February 2015

The mutational landscapes of genetic and chemical models of Kras-driven lung cancer.

Nature 2015 Jan 2;517(7535):489-92. Epub 2014 Nov 2.

1] Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158, USA [2] Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature13898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304785PMC
January 2015

Identification of FoxR2 as an oncogene in medulloblastoma.

Cancer Res 2014 Apr 5;74(8):2351-61. Epub 2014 Mar 5.

Authors' Affiliations: Division of Molecular and Developmental Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Division of Genetics and Genomics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore; Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom; and Cancer Research Program, The Methodist Hospital Research Institute, Houston, Texas.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/74/8/2351.full.pdf
Web Search
http://cancerres.aacrjournals.org/content/early/2014/03/05/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-1523DOI Listing
April 2014

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

PLoS Genet 2014 Feb 27;10(2):e1004167. Epub 2014 Feb 27.

Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937229PMC
February 2014

Cake: a bioinformatics pipeline for the integrated analysis of somatic variants in cancer genomes.

Bioinformatics 2013 Sep 25;29(17):2208-10. Epub 2013 Jun 25.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btt371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740632PMC
September 2013

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.

Authors:
Andrew V Biankin Nicola Waddell Karin S Kassahn Marie-Claude Gingras Lakshmi B Muthuswamy Amber L Johns David K Miller Peter J Wilson Ann-Marie Patch Jianmin Wu David K Chang Mark J Cowley Brooke B Gardiner Sarah Song Ivon Harliwong Senel Idrisoglu Craig Nourse Ehsan Nourbakhsh Suzanne Manning Shivangi Wani Milena Gongora Marina Pajic Christopher J Scarlett Anthony J Gill Andreia V Pinho Ilse Rooman Matthew Anderson Oliver Holmes Conrad Leonard Darrin Taylor Scott Wood Qinying Xu Katia Nones J Lynn Fink Angelika Christ Tim Bruxner Nicole Cloonan Gabriel Kolle Felicity Newell Mark Pinese R Scott Mead Jeremy L Humphris Warren Kaplan Marc D Jones Emily K Colvin Adnan M Nagrial Emily S Humphrey Angela Chou Venessa T Chin Lorraine A Chantrill Amanda Mawson Jaswinder S Samra James G Kench Jessica A Lovell Roger J Daly Neil D Merrett Christopher Toon Krishna Epari Nam Q Nguyen Andrew Barbour Nikolajs Zeps Nipun Kakkar Fengmei Zhao Yuan Qing Wu Min Wang Donna M Muzny William E Fisher F Charles Brunicardi Sally E Hodges Jeffrey G Reid Jennifer Drummond Kyle Chang Yi Han Lora R Lewis Huyen Dinh Christian J Buhay Timothy Beck Lee Timms Michelle Sam Kimberly Begley Andrew Brown Deepa Pai Ami Panchal Nicholas Buchner Richard De Borja Robert E Denroche Christina K Yung Stefano Serra Nicole Onetto Debabrata Mukhopadhyay Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Steven Gallinger Ralph H Hruban Anirban Maitra Christine A Iacobuzio-Donahue Richard D Schulick Christopher L Wolfgang Richard A Morgan Rita T Lawlor Paola Capelli Vincenzo Corbo Maria Scardoni Giampaolo Tortora Margaret A Tempero Karen M Mann Nancy A Jenkins Pedro A Perez-Mancera David J Adams David A Largaespada Lodewyk F A Wessels Alistair G Rust Lincoln D Stein David A Tuveson Neal G Copeland Elizabeth A Musgrove Aldo Scarpa James R Eshleman Thomas J Hudson Robert L Sutherland David A Wheeler John V Pearson John D McPherson Richard A Gibbs Sean M Grimmond

Nature 2012 Nov 24;491(7424):399-405. Epub 2012 Oct 24.

The Kinghorn Cancer Centre, 370 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature11547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530898PMC
November 2012

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells.

Proc Natl Acad Sci U S A 2012 Oct 8;109(44):E2998-3007. Epub 2012 Oct 8.

Division of Genetics and Genomics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore 138673.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1215899109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497753PMC
October 2012

Generation of the Sotos syndrome deletion in mice.

Mamm Genome 2012 Dec 29;23(11-12):749-57. Epub 2012 Aug 29.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00335-012-9416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510424PMC
December 2012

Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

Cancer Res 2012 Aug 18;72(15):3817-3827. Epub 2012 Jun 18.

Gray Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus, Oxford OX3 7DQ, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-11-3343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067151PMC
August 2012

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1.

Mol Cancer 2012 May 3;11:29. Epub 2012 May 3.

Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1476-4598-11-29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489691PMC
May 2012

Acute sensitivity of the oral mucosa to oncogenic K-ras.

J Pathol 2011 May 7;224(1):22-32. Epub 2011 Mar 7.

Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1HH, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.2853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3627303PMC
May 2011

Probabilistic inference of transcription factor binding from multiple data sources.

PLoS One 2008 Mar 26;3(3):e1820. Epub 2008 Mar 26.

Institute for Systems Biology, Seattle, Washington, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001820PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268002PMC
March 2008

Improving computational predictions of cis-regulatory binding sites.

Pac Symp Biocomput 2006 :391-402

Science and Technology Research Institute, University of Hertfordshire, College Lane Hatfield, Hertfordshire AL10 9AB, UK.

View Article

Download full-text PDF

Source
January 2007

Transcription binding site prediction using Markov models.

J Bioinform Comput Biol 2006 Apr;4(2):425-41

BSU MRC Cambridge, CB2 2SR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1142/s0219720006001813DOI Listing
April 2006

A data integration methodology for systems biology.

Proc Natl Acad Sci U S A 2005 Nov 21;102(48):17296-301. Epub 2005 Nov 21.

Institute for Systems Biology, Seattle, WA 98103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0508647102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1297682PMC
November 2005

Initial sequencing and comparative analysis of the mouse genome.

Authors:
Robert H Waterston Kerstin Lindblad-Toh Ewan Birney Jane Rogers Josep F Abril Pankaj Agarwal Richa Agarwala Rachel Ainscough Marina Alexandersson Peter An Stylianos E Antonarakis John Attwood Robert Baertsch Jonathon Bailey Karen Barlow Stephan Beck Eric Berry Bruce Birren Toby Bloom Peer Bork Marc Botcherby Nicolas Bray Michael R Brent Daniel G Brown Stephen D Brown Carol Bult John Burton Jonathan Butler Robert D Campbell Piero Carninci Simon Cawley Francesca Chiaromonte Asif T Chinwalla Deanna M Church Michele Clamp Christopher Clee Francis S Collins Lisa L Cook Richard R Copley Alan Coulson Olivier Couronne James Cuff Val Curwen Tim Cutts Mark Daly Robert David Joy Davies Kimberly D Delehaunty Justin Deri Emmanouil T Dermitzakis Colin Dewey Nicholas J Dickens Mark Diekhans Sheila Dodge Inna Dubchak Diane M Dunn Sean R Eddy Laura Elnitski Richard D Emes Pallavi Eswara Eduardo Eyras Adam Felsenfeld Ginger A Fewell Paul Flicek Karen Foley Wayne N Frankel Lucinda A Fulton Robert S Fulton Terrence S Furey Diane Gage Richard A Gibbs Gustavo Glusman Sante Gnerre Nick Goldman Leo Goodstadt Darren Grafham Tina A Graves Eric D Green Simon Gregory Roderic Guigó Mark Guyer Ross C Hardison David Haussler Yoshihide Hayashizaki LaDeana W Hillier Angela Hinrichs Wratko Hlavina Timothy Holzer Fan Hsu Axin Hua Tim Hubbard Adrienne Hunt Ian Jackson David B Jaffe L Steven Johnson Matthew Jones Thomas A Jones Ann Joy Michael Kamal Elinor K Karlsson Donna Karolchik Arkadiusz Kasprzyk Jun Kawai Evan Keibler Cristyn Kells W James Kent Andrew Kirby Diana L Kolbe Ian Korf Raju S Kucherlapati Edward J Kulbokas David Kulp Tom Landers J P Leger Steven Leonard Ivica Letunic Rosie Levine Jia Li Ming Li Christine Lloyd Susan Lucas Bin Ma Donna R Maglott Elaine R Mardis Lucy Matthews Evan Mauceli John H Mayer Megan McCarthy W Richard McCombie Stuart McLaren Kirsten McLay John D McPherson Jim Meldrim Beverley Meredith Jill P Mesirov Webb Miller Tracie L Miner Emmanuel Mongin Kate T Montgomery Michael Morgan Richard Mott James C Mullikin Donna M Muzny William E Nash Joanne O Nelson Michael N Nhan Robert Nicol Zemin Ning Chad Nusbaum Michael J O'Connor Yasushi Okazaki Karen Oliver Emma Overton-Larty Lior Pachter Genís Parra Kymberlie H Pepin Jane Peterson Pavel Pevzner Robert Plumb Craig S Pohl Alex Poliakov Tracy C Ponce Chris P Ponting Simon Potter Michael Quail Alexandre Reymond Bruce A Roe Krishna M Roskin Edward M Rubin Alistair G Rust Ralph Santos Victor Sapojnikov Brian Schultz Jörg Schultz Matthias S Schwartz Scott Schwartz Carol Scott Steven Seaman Steve Searle Ted Sharpe Andrew Sheridan Ratna Shownkeen Sarah Sims Jonathan B Singer Guy Slater Arian Smit Douglas R Smith Brian Spencer Arne Stabenau Nicole Stange-Thomann Charles Sugnet Mikita Suyama Glenn Tesler Johanna Thompson David Torrents Evanne Trevaskis John Tromp Catherine Ucla Abel Ureta-Vidal Jade P Vinson Andrew C Von Niederhausern Claire M Wade Melanie Wall Ryan J Weber Robert B Weiss Michael C Wendl Anthony P West Kris Wetterstrand Raymond Wheeler Simon Whelan Jamey Wierzbowski David Willey Sophie Williams Richard K Wilson Eitan Winter Kim C Worley Dudley Wyman Shan Yang Shiaw-Pyng Yang Evgeny M Zdobnov Michael C Zody Eric S Lander

Nature 2002 Dec;420(6915):520-62

Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature01262DOI Listing
December 2002

Genome annotation techniques: new approaches and challenges.

Drug Discov Today 2002 Jun;7(11):S70-6

European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton CB101SD, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1359-6446(02)02289-4DOI Listing
June 2002