Publications by authors named "Alison H Harrill"

27Publications

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice.

Toxicol Sci 2020 06;175(2):220-235

Division of the National Toxicology Program, The National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

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http://dx.doi.org/10.1093/toxsci/kfaa037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253212PMC
June 2020

Urinary MicroRNAs in Environmental Health: Biomarkers of Emergent Kidney Injury and Disease.

Curr Environ Health Rep 2020 06;7(2):101-108

Departments of Environmental Medicine and Public Health and Pediatrics, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s40572-020-00271-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295087PMC
June 2020

RATEmiRs: the rat atlas of tissue-specific and enriched miRNAs for discerning baseline expression exclusivity of candidate biomarkers.

RNA Biol 2020 05 12;17(5):630-636. Epub 2020 Feb 12.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.

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http://dx.doi.org/10.1080/15476286.2020.1724715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237151PMC
May 2020

ToxPoint: In the Era of Precision Medicine, Diversity Should Not Be Neglected in Chemical Safety Assessment.

Authors:
Alison H Harrill

Toxicol Sci 2020 01;173(1):3-4

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park 27709, North Carolina.

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http://dx.doi.org/10.1093/toxsci/kfz232DOI Listing
January 2020

A cross-sector call to improve carcinogenicity risk assessment through use of genomic methodologies.

Regul Toxicol Pharmacol 2020 Feb 11;110:104526. Epub 2019 Nov 11.

Health and Environmental Sciences Institute, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.yrtph.2019.104526DOI Listing
February 2020

Mouse population-based evaluation of urinary protein and miRNA biomarker performance associated with cisplatin renal injury.

Exp Biol Med (Maywood) 2018 02 7;243(3):237-247. Epub 2017 Nov 7.

4 Experimental Pathology Laboratories, Inc., Research Triangle Park, NC 27709, USA.

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http://journals.sagepub.com/doi/10.1177/1535370217740854
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http://dx.doi.org/10.1177/1535370217740854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813868PMC
February 2018

New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures.

Environ Health Perspect 2017 08 15;125(8):086002. Epub 2017 Aug 15.

Genes, Environment, and Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services , Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/EHP1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783628PMC
August 2017

A Synopsis of the "Influence of Epigenetics, Genetics, and Immunology" Session Part A at the 35th Annual Society of Toxicologic Pathology Symposium.

Toxicol Pathol 2017 01 5;45(1):114-118. Epub 2016 Oct 5.

6 Drug Safety Research and Development, Pfizer, Andover, Massachusetts, USA.

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http://dx.doi.org/10.1177/0192623316670781DOI Listing
January 2017

MicroRNA Biomarkers of Toxicity in Biological Matrices.

Toxicol Sci 2016 08;152(2):264-72

*Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205;

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http://dx.doi.org/10.1093/toxsci/kfw090DOI Listing
August 2016

Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.

Toxicol Sci 2016 Mar 26;150(1):3-14. Epub 2015 Nov 26.

*Hamner-UNC Institute for Drug Safety Sciences, RTP, North Carolina 27709; Department of Environmental and Occupational Health, The University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205

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http://dx.doi.org/10.1093/toxsci/kfv260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009612PMC
March 2016

Circulating mitochondrial biomarkers for drug-induced liver injury.

Biomark Med 2015 28;9(11):1215-23. Epub 2015 Oct 28.

Division of Systems Biology, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2217/bmm.15.59DOI Listing
August 2016

A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.

PLoS Genet 2015 Feb 13;11(2):e1004850. Epub 2015 Feb 13.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Carolina Center for Genome Science, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1004850
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http://dx.doi.org/10.1371/journal.pgen.1004850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334553PMC
February 2015

Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.

BMC Pharmacol Toxicol 2014 Aug 3;15:42. Epub 2014 Aug 3.

The Hamner-University of North Carolina Institute for Drug Safety Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1186/2050-6511-15-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4130124PMC
August 2014

Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug.

Toxicol Appl Pharmacol 2014 Oct 23;280(1):21-9. Epub 2014 Jun 23.

Hamner-University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA; University of Arkansas for Medical Sciences, Little Rock, AR72205, USA.

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http://dx.doi.org/10.1016/j.taap.2014.06.013DOI Listing
October 2014

A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.

Toxicol Sci 2014 Aug 20;140(2):481-92. Epub 2014 May 20.

Hamner-University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 The University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205

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http://dx.doi.org/10.1093/toxsci/kfu094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168290PMC
August 2014

Liver biomarker and in vitro assessment confirm the hepatic origin of aminotransferase elevations lacking histopathological correlate in beagle dogs treated with GABAA receptor antagonist NP260.

Toxicol Appl Pharmacol 2014 Jun 31;277(2):131-7. Epub 2014 Mar 31.

The Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2014.03.015DOI Listing
June 2014

Green tea epigallocatechin gallate binds to and inhibits respiratory complexes in swelling but not normal rat hepatic mitochondria.

Biochem Biophys Res Commun 2014 Jan 31;443(3):1097-104. Epub 2013 Dec 31.

Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2013.12.110DOI Listing
January 2014

A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models.

Toxicol Sci 2012 Dec 31;130(2):416-26. Epub 2012 Aug 31.

The Hamner Institutes for Health Sciences, Hamner-University of North Carolina Institute for Drug Safety Sciences, Durham, North Carolina 27709, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfs238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498743PMC
December 2012

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.

J Pharmacokinet Pharmacodyn 2012 Oct 9;39(5):527-41. Epub 2012 Aug 9.

The Hamner-UNC Institute for Drug Safety Sciences, The Hamner Institutes, Durham, NC 27709, USA.

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http://dx.doi.org/10.1007/s10928-012-9266-0DOI Listing
October 2012

An analysis of N-acetylcysteine treatment for acetaminophen overdose using a systems model of drug-induced liver injury.

J Pharmacol Exp Ther 2012 Aug 16;342(2):529-40. Epub 2012 May 16.

The Hamner-University of North Carolina Institute for Drug Safety Sciences, The Hamner Institutes, Research Triangle Park, North Carolina, USA.

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http://jpet.aspetjournals.org/content/early/2012/05/16/jpet.
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http://jpet.aspetjournals.org/content/342/2/529.full.pdf
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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.112.19293
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http://dx.doi.org/10.1124/jpet.112.192930DOI Listing
August 2012

Replication and narrowing of gene expression quantitative trait loci using inbred mice.

Mamm Genome 2009 Jul 17;20(7):437-46. Epub 2009 Jul 17.

Department of Environmental Sciences & Engineering, University of North Carolina, CB 7431, Chapel Hill, NC 27599, USA.

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http://link.springer.com/10.1007/s00335-009-9199-0
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http://dx.doi.org/10.1007/s00335-009-9199-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745627PMC
July 2009

Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel.

Toxicol Sci 2009 Jul 6;110(1):235-43. Epub 2009 May 6.

Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1093/toxsci/kfp096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696330PMC
July 2009