Thyroid cancer as the most common endocrine malignancy
usually appears as primary nodules within the gland
but less frequently presents with other features such
as metastases, which truly impoverishes the prognosis
of the patient.
Medullary thyroid carcinoma (MTC),
approximately 5-10% of all thyroid cancers, is
an aggressive rare tumor arising from parafollicular
cells (C-cells) with a neuroendocrine origin that secrete
The skin metastasis usually presents as
flesh-colored nodules that are tender; they may be itchy,
and can be ulcerated.
These lesions can metastasize to
regional lymph nodes, but may also spread hematogenously
to affect liver, lungs, bones, and rarely brain and skin.
The skin metastasis of MTC is very rare and only 16 cases
reported in English literature up to date.