Publications by authors named "Aline Carsin-Vu"

5 Publications

  • Page 1 of 1

An inaugural diabetic ketoacidosis with acute pancreatitis during COVID-19.

Acta Diabetol 2021 03 13;58(3):389-391. Epub 2020 Nov 13.

Centre Hospitalier Universitaire de Reims, Service d'Endocrinologie - Diabète - Nutrition, Avenue du Général Koenig, 51092, Reims Cedex, France.

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http://dx.doi.org/10.1007/s00592-020-01624-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661328PMC
March 2021

Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population.

Eur J Radiol 2018 Apr 6;101:38-44. Epub 2018 Feb 6.

Univ Rennes1, Faculté de Médecine, F-35043 Rennes, France; INSERM, U 1228, ERL VISAGES, F-35042 Rennes, France; CNRS, IRISA, UMR 6074, F-35042 Rennes, France; INRIA, VISAGES Project-Team, F-35042 Rennes, France; CHU Rennes, Département de Radiologie, F-35033 Rennes, France. Electronic address:

Objectives: To investigate changes in cerebral blood flow (CBF) in gray matter (GM) between 6 months and 15 years of age and to provide CBF values for the brain, GM, white matter (WM), hemispheres and lobes.

Methods: Between 2013 and 2016, we retrospectively included all clinical MRI examinations with arterial spin labeling (ASL). We excluded subjects with a condition potentially affecting brain perfusion. For each subject, mean values of CBF in the brain, GM, WM, hemispheres and lobes were calculated. GM CBF was fitted using linear, quadratic and cubic polynomial regression against age. Regression models were compared with Akaike's information criterion (AIC), and Likelihood Ratio tests.

Results: 84 children were included (44 females/40 males). Mean CBF values were 64.2 ± 13.8 mL/100 g/min in GM, and 29.3 ± 10.0 mL/100 g/min in WM. The best-fit model of brain perfusion was the cubic polynomial function (AIC = 672.7, versus respectively AIC = 673.9 and AIC = 674.1 with the linear negative function and the quadratic polynomial function). A statistically significant difference between the tested models demonstrating the superiority of the quadratic (p = 0.18) or cubic polynomial model (p = 0.06), over the negative linear regression model was not found. No effect of general anesthesia (p = 0.34) or of gender (p = 0.16) was found.

Conclusion: we provided values for ASL CBF in the brain, GM, WM, hemispheres, and lobes over a wide pediatric age range, approximately showing inverted U-shaped changes in GM perfusion over the course of childhood.
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http://dx.doi.org/10.1016/j.ejrad.2018.02.003DOI Listing
April 2018

Magnetic resonance imaging in children presenting migraine with aura: Association of hypoperfusion detected by arterial spin labelling and vasospasm on MR angiography findings.

Cephalalgia 2018 04 24;38(5):949-958. Epub 2017 Jul 24.

1 CHU Rennes, Department of Radiology, Pediatric Imaging, Rennes, France.

Objective A child presenting with a first attack of migraine with aura usually undergoes magnetic resonance imaging (MRI) to rule out stroke. The purpose of this study was to report vascular and brain perfusion findings in children suffering from migraine with aura on time-of-flight MR angiography (TOF-MRA) and MR perfusion imaging using arterial spin labelling (ASL). Methods We retrospectively included all children who had undergone an emergency MRI examination with ASL and TOF-MRA sequences for acute neurological deficit and were given a final diagnosis of migraine with aura. The ASL perfusion maps and TOF-MRA images were independently assessed by reviewers blinded to clinical data. A mean cerebral blood flow (CBF) value was obtained for each cerebral lobe after automatic data post-processing. Results Seventeen children were finally included. Hypoperfusion was identified in one or more cerebral lobes on ASL perfusion maps by visual assessment in 16/17 (94%) children. Vasospasm was noted within the intracranial vasculature on the TOF-MRA images in 12/17 (71%) children. All (100%) of the abnormal TOF-MRA images were associated with homolateral hypoperfusion. Mean CBF values were significantly lower ( P < 0.05) in visually hypoperfused lobes than in normally perfused lobes. Conclusion ASL and TOF-MRA are two totally non-invasive, easy-to-use MRI sequences for children in emergency settings. Hypoperfusion associated with homolateral vasospasm may suggest a diagnosis of migraine with aura.
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http://dx.doi.org/10.1177/0333102417723570DOI Listing
April 2018

Usefulness of Hepatobiliary Scintigraphy in the Evaluation of Hepatic Cystic Lesions in Children.

J Pediatr 2016 10 28;177:332-332.e2. Epub 2016 Jul 28.

Nuclear Medicine DepartmentInstitut Jean Godinot; Biophysics Laboratory Unité de Formation et de Recherche de Médecine Université de Reims-Champagne Ardenne; Centre de Recherche en Science et Technologie de l'Information et de la Communication Equipe d'Accueil 3804 Université de Reims-Champagne Ardenne Reims, France.

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http://dx.doi.org/10.1016/j.jpeds.2016.06.031DOI Listing
October 2016

MDCT Linear and Volumetric Analysis of Adrenal Glands: Normative Data and Multiparametric Assessment.

Eur Radiol 2016 Aug 30;26(8):2494-501. Epub 2015 Oct 30.

Department of Radiology, Centre Hospitalier Universitaire Robert-Debré, 45, rue Cognacq-Jay, 51092, Reims Cedex, France.

Objectives: To study linear and volumetric adrenal measurements, their reproducibility, and correlations between total adrenal volume (TAV) and adrenal micronodularity, age, gender, body mass index (BMI), visceral (VAAT) and subcutaneous adipose tissue volume (SAAT), presence of diabetes, chronic alcoholic abuse and chronic inflammatory disease (CID).

Methods: We included 154 patients (M/F, 65/89; mean age, 57 years) undergoing abdominal multidetector row computed tomography (MDCT). Two radiologists prospectively independently performed adrenal linear and volumetric measurements with semi-automatic software. Inter-observer reliability was studied using inter-observer correlation coefficient (ICC). Relationships between TAV and associated factors were studied using bivariate and multivariable analysis.

Results: Mean TAV was 8.4 ± 2.7 cm(3) (3.3-18.7 cm(3)). ICC was excellent for TAV (0.97; 95 % CI: 0.96-0.98) and moderate to good for linear measurements. TAV was significantly greater in men (p < 0.0001), alcoholics (p = 0.04), diabetics (p = 0.0003) and those with micronodular glands (p = 0.001). TAV was lower in CID patients (p = 0.0001). TAV correlated positively with VAAT (r = 0.53, p < 0.0001), BMI (r = 0.42, p < 0.0001), SAAT (r = 0.29, p = 0.0003) and age (r = 0.23, p = 0.005). Multivariable analysis revealed gender, micronodularity, diabetes, age and BMI as independent factors influencing TAV.

Conclusions: Adrenal gland MDCT-based volumetric measurements are more reproducible than linear measurements. Gender, micronodularity, age, BMI and diabetes independently influence TAV.

Key Points: • Volumetric measurements are more reproducible than linear measurements for adrenal glands. • Inter-observer reproducibility of adrenal gland volume is excellent using semiautomatic software. • Gender, age, BMI, and diabetes independently influence total adrenal gland volume. • Adrenal micronodularity is associated with increased total adrenal gland volume.
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http://dx.doi.org/10.1007/s00330-015-4063-yDOI Listing
August 2016