Publications by authors named "Aline Bourgeois"

3 Publications

  • Page 1 of 1

Burden of adult neurofibromatosis 1: development and validation of a burden assessment tool.

Orphanet J Rare Dis 2019 05 3;14(1):94. Epub 2019 May 3.

Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Background: Neurofibromatosis Type 1 (NF1) is a common genetic neurocutaneous disease, with an autosomal dominant inheritance mode. Quality of life has been shown impaired in NF1, due to severe complications, cosmetic features, and uncertainty about the disorder.

Methods: This study sought to develop a self-administered questionnaire in French to assess the burden of NF1 (BoN), then translate and linguistically and cross-culturally validate it into American English, standardized methodology applied, as outlined in the report.

Results: Based on several discussions with NF1 patients, a 17-item conceptual questionnaire was first produced. Of the 91 NF1 adult patients who responded to the conceptual questionnaire, 65 (64.6% females) were accessible. Subsequent confirmatory analyses generated a 15-item questionnaire grouped into four domains, demonstrating internal consistency (Cronbach's alpha: 091), discriminant validity, and high reliability. The BoN was likewise shown to significantly correlate with other validated questionnaires, such as Dermatology Life Quality Index, Perceived Stress Scale, and SF12 mental score, indicating good external validity.

Conclusions: BoN is a specific tool for assessing the burden that NF1 generates on many practical aspects of the patient daily activities, beyond the notion of quality of life". Given the increasing relevance that regulatory authorities attribute to patient-reported outcomes, the BoN questionnaire provides such supplementary information while accounting for the burden of NF1 patients in the broadest sense.
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May 2019

Outcome evaluation in shoulder surgery using 3D kinematics sensors.

Gait Posture 2007 Apr 28;25(4):523-32. Epub 2006 Aug 28.

Laboratory of Movement Analysis and Measurement, Ecole Polytechnique Fédérale de Lausanne (EPFL), STI-Bat ELG, CH-1015 Lausanne, Switzerland.

A new method of scoring systems for the functional assessment of the shoulder is presented. 3D accelerometers and gyroscopes attached on the humerus were used to differentiate a healthy from a painful shoulder. The method was first tested on 10 healthy volunteer subjects with no shoulder pathology. The system was then tested on 10 patients with unilateral shoulder pathology (rotator cuff disease, osteoarthritis) before and after surgery (3, 6 months). In order to evaluate the system, nine tests based on the Simple Shoulder Test (SST) were performed on each shoulder for each patient. Three scores were defined: the P score was based on the angular velocities and accelerations of the humerus; the RAV score was based only on the angular velocities of the humerus; the M score was based on the sum of all moments of the humerus. Our kinematic scores indicated significant differences between baseline and follow-up (p<0.05) and differentiated between patients with varying severity of the same condition. We demonstrated a reliable technique of evaluating shoulder pathology and the results of surgery.
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April 2007

[Predonation of autologous blood in knee arthroplasty].

Rev Med Suisse Romande 2003 Feb;123(2):105-8

Hôpital de St-Loup Service d'orthopédie-traumatologie.

During knee arthroplasty, autologous blood donation is frequently used as an alternative to homologous blood transfusion. The hemoglobin level determines the organism answer to the anemia induced by the iteratives phlebotomies. We reviewed retrospectively 140 patients to correlate the hemoglobin levels before the predonations, pre- and postoperatively. In our series, the hemoglobin thresholds to evaluate the risks for an allo- or autotransfusion are consistent with previous findings. We set up a transfusional program for the patient undergoing knee arthroplasty.
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February 2003