Publications by authors named "Alicia Oshlack"

89Publications

Accuracy of short tandem repeats genotyping tools in whole exome sequencing data.

F1000Res 2020 23;9:200. Epub 2020 Mar 23.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.12688/f1000research.22639.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327730PMC
March 2020

Sierra: discovery of differential transcript usage from polyA-captured single-cell RNA-seq data.

Genome Biol 2020 07 8;21(1):167. Epub 2020 Jul 8.

School of Mathematics and Statistics, Faculty of Science, The University of Sydney, Camperdown, 2006, Australia.

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http://dx.doi.org/10.1186/s13059-020-02071-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341584PMC
July 2020

SuperFreq: Integrated mutation detection and clonal tracking in cancer.

PLoS Comput Biol 2020 02 13;16(2):e1007603. Epub 2020 Feb 13.

Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.

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http://dx.doi.org/10.1371/journal.pcbi.1007603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043783PMC
February 2020

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.

Pediatr Blood Cancer 2019 10 28;66(10):e27897. Epub 2019 Jun 28.

Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Australia.

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http://dx.doi.org/10.1002/pbc.27897DOI Listing
October 2019

Using equivalence class counts for fast and accurate testing of differential transcript usage.

F1000Res 2019 7;8:265. Epub 2019 Mar 7.

Murdoch Childrens Research Institute, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.12688/f1000research.18276.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524746PMC
June 2020

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.

Development 2019 06 12;146(12). Epub 2019 Jun 12.

Department of Anatomy & Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia

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http://dx.doi.org/10.1242/dev.178673DOI Listing
June 2019

Bazam: a rapid method for read extraction and realignment of high-throughput sequencing data.

Genome Biol 2019 04 18;20(1):78. Epub 2019 Apr 18.

Bioinformatics, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.1186/s13059-019-1688-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472072PMC
April 2019

Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1.

Kidney Int 2019 05 28;95(5):1153-1166. Epub 2019 Feb 28.

Murdoch Children's Research Institute, Parkville, Melbourne, Australia; Division of Genomics of Development and Disease, Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia; Department of Pediatrics, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.11.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478531PMC
May 2019

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney.

Genome Med 2019 01 23;11(1). Epub 2019 Jan 23.

Department of Anatomy & Neuroscience, University of Melbourne, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/s13073-019-0615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345028PMC
January 2019

Ximmer: a system for improving accuracy and consistency of CNV calling from exome data.

Gigascience 2018 10 1;7(10). Epub 2018 Oct 1.

Bioinformatics, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052 Australia.

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http://dx.doi.org/10.1093/gigascience/giy112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177737PMC
October 2018

Clustering trees: a visualization for evaluating clusterings at multiple resolutions.

Gigascience 2018 07;7(7)

Bioinformatics, Murdoch Children's Research Institute, Flemington Road, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1093/gigascience/giy083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057528PMC
July 2018

Clinker: visualizing fusion genes detected in RNA-seq data.

Gigascience 2018 07;7(7)

Murdoch Children's Research Institute, The Royal Children's Hospital, Flemington, Road, Parkville Vic 3052 Australia.

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http://dx.doi.org/10.1093/gigascience/giy079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065480PMC
July 2018

Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database.

PLoS Comput Biol 2018 06 25;14(6):e1006245. Epub 2018 Jun 25.

Bioinformatics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1371/journal.pcbi.1006245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034903PMC
June 2018

Necklace: combining reference and assembled transcriptomes for more comprehensive RNA-Seq analysis.

Gigascience 2018 05;7(5)

Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1093/gigascience/giy045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946861PMC
May 2018

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms.

Am J Hum Genet 2018 05 26;102(5):816-831. Epub 2018 Apr 26.

Kidney Development, Disease, and Regeneration Group, Murdoch Children's Research Institute, Parkville, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183010
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http://dx.doi.org/10.1016/j.ajhg.2018.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986969PMC
May 2018

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.

Kidney Int 2018 03 6;93(3):589-598. Epub 2017 Dec 6.

Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361385PMC
March 2018

Splatter: simulation of single-cell RNA sequencing data.

Genome Biol 2017 09 12;18(1):174. Epub 2017 Sep 12.

Murdoch Childrens Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1186/s13059-017-1305-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596896PMC
September 2017

Erratum to: SuperTranscripts: a data driven reference for analysis and visualisation of transcriptomes.

Genome Biol 2017 08 24;18(1):160. Epub 2017 Aug 24.

Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.1186/s13059-017-1303-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571508PMC
August 2017

SuperTranscripts: a data driven reference for analysis and visualisation of transcriptomes.

Genome Biol 2017 Aug 4;18(1):148. Epub 2017 Aug 4.

Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC, Australia.

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http://genomebiology.biomedcentral.com/articles/10.1186/s130
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http://dx.doi.org/10.1186/s13059-017-1284-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543425PMC
August 2017

Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.

Mol Cell Neurosci 2017 09 23;83:103-112. Epub 2017 Jul 23.

Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, VIC 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2017.07.004DOI Listing
September 2017

Gene length and detection bias in single cell RNA sequencing protocols.

F1000Res 2017 28;6:595. Epub 2017 Apr 28.

Murdoch Childrens Research Institute, Parkville, Victoria, 3052, Australia.

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http://dx.doi.org/10.12688/f1000research.11290.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428526PMC
April 2017

A cross-package Bioconductor workflow for analysing methylation array data.

F1000Res 2016 8;5:1281. Epub 2016 Jun 8.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.

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http://dx.doi.org/10.12688/f1000research.8839.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916993PMC
June 2016

Limb patterning genes and heterochronic development of the emu wing bud.

Evodevo 2016 20;7:26. Epub 2016 Dec 20.

Environmental Futures Research Institute, Griffith University, Nathan, QLD 4111 Australia.

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http://dx.doi.org/10.1186/s13227-016-0063-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5168868PMC
December 2016

Disorders of sex development: insights from targeted gene sequencing of a large international patient cohort.

Genome Biol 2016 11 29;17(1):243. Epub 2016 Nov 29.

Murdoch Childrens Research Institute, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1186/s13059-016-1105-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126855PMC
November 2016

Erratum to: 'Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq'.

BMC Genomics 2016 Mar 2;17:169. Epub 2016 Mar 2.

Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3168, Australia.

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http://dx.doi.org/10.1186/s12864-016-2439-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774124PMC
March 2016

missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform.

Bioinformatics 2016 Jan 30;32(2):286-8. Epub 2015 Sep 30.

Bioinformatics Group, Murdoch Childrens Research Institute, Royal Children's Hospital, 50 Flemington Road, Parkville, Victoria, 3052, Australia.

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http://bioinformatics.oxfordjournals.org/content/early/2015/
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btv560DOI Listing
January 2016

Identification of candidate gonadal sex differentiation genes in the chicken embryo using RNA-seq.

BMC Genomics 2015 Sep 16;16:704. Epub 2015 Sep 16.

Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3168, Australia.

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http://dx.doi.org/10.1186/s12864-015-1886-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574023PMC
September 2015

Cpipe: a shared variant detection pipeline designed for diagnostic settings.

Genome Med 2015 10;7(1):68. Epub 2015 Jul 10.

Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, 3052 Australia ; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3010 Australia ; Melbourne Genomics Health Alliance, Melbourne, Australia ; Walter and Eliza Hall Institute, Parkville, VIC 3052 Australia.

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http://dx.doi.org/10.1186/s13073-015-0191-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515933PMC
July 2015

JAFFA: High sensitivity transcriptome-focused fusion gene detection.

Genome Med 2015 11;7(1):43. Epub 2015 May 11.

Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052 Australia ; Department of Genetics, The University of Melbourne, Parkville, Victoria 3010 Australia.

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http://dx.doi.org/10.1186/s13073-015-0167-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445815PMC
May 2015

Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data.

Nucleic Acids Res 2015 Sep 18;43(16):e106. Epub 2015 May 18.

Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, VIC 3052, Australia Department of Genetics, The University of Melbourne, VIC 3010, Australia

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http://dx.doi.org/10.1093/nar/gkv526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652745PMC
September 2015

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2.

Blood 2015 Mar 2;125(12):1890-900. Epub 2015 Feb 2.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia;

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http://dx.doi.org/10.1182/blood-2014-10-603969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424268PMC
March 2015

A comparison of control samples for ChIP-seq of histone modifications.

Front Genet 2014 25;5:329. Epub 2014 Sep 25.

Bioinformatics Group, Murdoch Childrens Research Institute Melbourne, VIC, Australia ; Department of Genetics, University of Melbourne Melbourne, VIC, Australia.

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http://biorxiv.org/content/biorxiv/early/2014/08/01/007609.f
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http://journal.frontiersin.org/article/10.3389/fgene.2014.00
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http://dx.doi.org/10.3389/fgene.2014.00329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174756PMC
October 2014

The polycomb repressive complex 2 governs life and death of peripheral T cells.

Blood 2014 Jul 20;124(5):737-49. Epub 2014 Jun 20.

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia; and.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-12-54
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http://dx.doi.org/10.1182/blood-2013-12-544106DOI Listing
July 2014

Identification, expression, and regulation of anti-Müllerian hormone type-II receptor in the embryonic chicken gonad.

Biol Reprod 2014 May 12;90(5):106. Epub 2014 Mar 12.

Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia Department of Paediatrics, The University of Melbourne, Melbourne, Victoria, Australia Department of Zoology, The University of Melbourne, Melbourne, Victoria, Australia Poultry Cooperative Research Centre, Armidale, New South Wales, Australia

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http://dx.doi.org/10.1095/biolreprod.113.116491DOI Listing
May 2014

Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy.

Genome Med 2013 18;5(10):96. Epub 2013 Oct 18.

Early Life Epigenetics Group, Murdoch Childrens Research Institute (MCRI), Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia ; Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1186/gm500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978871PMC
May 2014

Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes.

Nat Commun 2013 ;4:2537

1] Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Melbourne, Victoria 3052, Australia [2] Department of Paediatrics, University of Melbourne, Parkville, Melbourne, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/ncomms3537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038772PMC
May 2014

miRNA-Seq normalization comparisons need improvement.

RNA 2013 Jun 24;19(6):733-4. Epub 2013 Apr 24.

Institute of Molecular Life Sciences, University of Zurich, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1261/rna.037895.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683906PMC
June 2013

A 10-step guide to party conversation for bioinformaticians.

Authors:
Alicia Oshlack

Genome Biol 2013 Jan 29;14(1):104. Epub 2013 Jan 29.

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http://dx.doi.org/10.1186/gb-2013-14-1-104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663102PMC
January 2013

SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips.

Genome Biol 2012 Jun 15;13(6):R44. Epub 2012 Jun 15.

Murdoch Childrens Research Institute, Parkville, Australia.

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http://dx.doi.org/10.1186/gb-2012-13-6-r44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446316PMC
June 2012

Bpipe: a tool for running and managing bioinformatics pipelines.

Bioinformatics 2012 Jun 12;28(11):1525-6. Epub 2012 Apr 12.

Murdoch Childrens Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1093/bioinformatics/bts167DOI Listing
June 2012

Women in science.

Genome Biol 2012 ;13(3):148

John Innes Centre in Norwich, UK.

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http://dx.doi.org/10.1186/gb-2012-13-3-148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439960PMC
September 2012

ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity.

Nucleic Acids Res 2011 Sep 7;39(17):7415-27. Epub 2011 Jun 7.

Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3052, Australia.

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http://dx.doi.org/10.1093/nar/gkr416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177187PMC
September 2011

From RNA-seq reads to differential expression results.

Genome Biol 2010 22;11(12):220. Epub 2010 Dec 22.

Bioinformatics Division, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville 3052, Australia.

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http://dx.doi.org/10.1186/gb-2010-11-12-220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046478PMC
June 2011

Optimizing the noise versus bias trade-off for Illumina whole genome expression BeadChips.

Nucleic Acids Res 2010 Dec 6;38(22):e204. Epub 2010 Oct 6.

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkq871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001098PMC
December 2010

A scaling normalization method for differential expression analysis of RNA-seq data.

Genome Biol 2010 2;11(3):R25. Epub 2010 Mar 2.

Bioinformatics Division, Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Australia.

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http://dx.doi.org/10.1186/gb-2010-11-3-r25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864565PMC
September 2010

Gene ontology analysis for RNA-seq: accounting for selection bias.

Genome Biol 2010 4;11(2):R14. Epub 2010 Feb 4.

Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Australia.

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http://dx.doi.org/10.1186/gb-2010-11-2-r14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872874PMC
August 2010

Transcript length bias in RNA-seq data confounds systems biology.

Biol Direct 2009 Apr 16;4:14. Epub 2009 Apr 16.

Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.

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http://dx.doi.org/10.1186/1745-6150-4-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2678084PMC
April 2009

Segmental duplications contribute to gene expression differences between humans and chimpanzees.

Genetics 2009 Jun 30;182(2):627-30. Epub 2009 Mar 30.

Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1534/genetics.108.099960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691770PMC
June 2009

Gene regulation in primates evolves under tissue-specific selection pressures.

PLoS Genet 2008 Nov 21;4(11):e1000271. Epub 2008 Nov 21.

Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581600PMC
November 2008

A comparison of background correction methods for two-colour microarrays.

Bioinformatics 2007 Oct 25;23(20):2700-7. Epub 2007 Aug 25.

Department of Oncology, University of Cambridge, CRUK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1093/bioinformatics/btm412DOI Listing
October 2007

Using DNA microarrays to study gene expression in closely related species.

Bioinformatics 2007 May 23;23(10):1235-42. Epub 2007 Mar 23.

Walter and Eliza Hall Institute of Medical Research, Parkville, Vic 3050, Australia.

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http://dx.doi.org/10.1093/bioinformatics/btm111DOI Listing
May 2007

Statistical analysis of an RNA titration series evaluates microarray precision and sensitivity on a whole-array basis.

BMC Bioinformatics 2006 Nov 22;7:511. Epub 2006 Nov 22.

Ian Potter Foundation Centre for Cancer Genomics and Predictive Medicine, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Victoria 3002, Australia.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-7-511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664592PMC
November 2006

Natural selection on gene expression.

Trends Genet 2006 Aug 27;22(8):456-61. Epub 2006 Jun 27.

Department of Human Genetics, University of Chicago, Chicago, Il 60637, USA.

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http://dx.doi.org/10.1016/j.tig.2006.06.002DOI Listing
August 2006

Expression profiling in primates reveals a rapid evolution of human transcription factors.

Nature 2006 Mar;440(7081):242-5

Department of Genetics, Yale University, New Haven, Connecticut 06510, USA.

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http://dx.doi.org/10.1038/nature04559DOI Listing
March 2006