Alice S Chen-Plotkin

Alice S Chen-Plotkin

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Alice S Chen-Plotkin

Alice S Chen-Plotkin

Publications by authors named "Alice S Chen-Plotkin"

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46Publications

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AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.

Mol Ther 2019 02 17;27(2):465-478. Epub 2018 Nov 17.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369714PMC
February 2019

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Alzheimers Dement 2018 08 28;14(8):1052-1062. Epub 2018 Mar 28.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097943PMC
August 2018

The Post-GWAS Era: From Association to Function.

Am J Hum Genet 2018 05;102(5):717-730

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183013
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http://dx.doi.org/10.1016/j.ajhg.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986732PMC
May 2018

Genetic Modifiers in Neurodegeneration.

Curr Genet Med Rep 2018 Mar 5;6(1):11-19. Epub 2018 Feb 5.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://link.springer.com/10.1007/s40142-018-0133-1
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http://dx.doi.org/10.1007/s40142-018-0133-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028053PMC
March 2018

APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease.

Mov Disord 2018 02 23;33(2):289-297. Epub 2017 Nov 23.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809205PMC
February 2018

Unlocking the mystery of biomarkers: A brief introduction, challenges and opportunities in Parkinson Disease.

Parkinsonism Relat Disord 2018 Jan 22;46 Suppl 1:S15-S18. Epub 2017 Jul 22.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849402PMC
January 2018

Parkinson disease: Blood transcriptomics for Parkinson disease?

Nat Rev Neurol 2018 Jan 1;14(1):5-6. Epub 2017 Dec 1.

Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831123PMC
January 2018

Updating Our Definitions of Parkinson's Disease for a Molecular Age.

J Parkinsons Dis 2018 ;8(s1):S53-S57

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JPD-181487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311368PMC
January 2018

Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study.

Mov Disord 2017 Nov 14;32(11):1636-1640. Epub 2017 Sep 14.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721350PMC
November 2017

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.

Hum Mol Genet 2016 07 28;25(13):2681-2697. Epub 2016 Apr 28.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1093/hmg/ddw127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181637PMC
July 2016

Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease.

Ann Clin Transl Neurol 2016 05 29;3(5):346-55. Epub 2016 Mar 29.

Department of Neurology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania.

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http://dx.doi.org/10.1002/acn3.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863747PMC
May 2016

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients.

Mov Disord 2015 Oct 24;30(12):1648-56. Epub 2015 Jul 24.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.26290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609229PMC
October 2015

Unbiased approaches to biomarker discovery in neurodegenerative diseases.

Neuron 2014 Nov 5;84(3):594-607. Epub 2014 Nov 5.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254637PMC
November 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Development and validation of pedigree classification criteria for frontotemporal lobar degeneration.

JAMA Neurol 2013 Nov;70(11):1411-7

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2013.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906581PMC
November 2013

Genetic influences on cognitive decline in Parkinson's disease.

Mov Disord 2012 Apr 16;27(4):512-8. Epub 2012 Feb 16.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvalia, USA.

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http://dx.doi.org/10.1002/mds.24946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323737PMC
April 2012

Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis.

Acta Neuropathol 2011 Mar 23;121(3):373-80. Epub 2010 Nov 23.

Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-010-0782-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095217PMC
March 2011

Age-correlated gene expression in normal and neurodegenerative human brain tissues.

PLoS One 2010 Sep 29;5(9). Epub 2010 Sep 29.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013098PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947518PMC
September 2010

TAR DNA-binding protein 43 in neurodegenerative disease.

Nat Rev Neurol 2010 Apr 16;6(4):211-20. Epub 2010 Mar 16.

Department of Neurology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.1038/nrneurol.2010.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892118PMC
April 2010

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.

Acta Neuropathol 2010 Jan 2;119(1):111-22. Epub 2009 Aug 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-009-0576-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104467PMC
January 2010

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.

Hum Mol Genet 2008 May 25;17(10):1349-62. Epub 2008 Jan 25.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddn023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900863PMC
May 2008

Delayed leukoencephalopathy after hypoxic-ischemic injury.

Arch Neurol 2008 Jan;65(1):144-5

Department of Neurology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1001/archneurol.2007.7DOI Listing
January 2008

Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.

Neurology 2007 Mar;68(11):859-61

Department of Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1212/01.wnl.0000256716.04218.5bDOI Listing
March 2007

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.

Neurobiol Dis 2006 May 24;22(2):233-41. Epub 2006 Jan 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital/B114-2000, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.nbd.2005.11.001DOI Listing
May 2006

Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain.

Methods Mol Biol 2004 ;277:261-76

Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, USA.

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http://dx.doi.org/10.1385/1-59259-804-8:261DOI Listing
September 2004