Alice Kaganovich

Alice Kaganovich

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Alice Kaganovich

Alice Kaganovich

Publications by authors named "Alice Kaganovich"

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Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils.

Neurobiol Dis 2019 Sep 15;129:67-78. Epub 2019 May 15.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2019.05.012DOI Listing
September 2019

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.

NPJ Parkinsons Dis 2018 19;4:13. Epub 2018 Apr 19.

1Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD USA.

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http://dx.doi.org/10.1038/s41531-018-0049-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908918PMC
April 2018

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

Biochem J 2017 04 24;474(9):1547-1558. Epub 2017 Apr 24.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178381PMC
April 2017

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Nat Commun 2014 Dec 15;5:5827. Epub 2014 Dec 15.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, Maryland 20892-3707, USA.

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http://dx.doi.org/10.1038/ncomms6827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268884PMC
December 2014

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Proc Natl Acad Sci U S A 2014 Feb 7;111(7):2626-31. Epub 2014 Feb 7.

Cell Biology and Gene Expression Section, Computational Biology Core, Laboratory of Neurogenetics, and Molecular Genetics Section, National Institute on Aging/National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1318306111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932908PMC
February 2014

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.

Hum Mol Genet 2014 Jan 19;23(1):145-56. Epub 2013 Aug 19.

Cell Biology and Gene Expression Section and.

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http://dx.doi.org/10.1093/hmg/ddt407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857951PMC
January 2014

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.

Biochem J 2012 Aug;446(1):99-111

Cell Biology and Gene Expression Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1042/BJ20120637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667980PMC
August 2012

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD.

Neuron 2011 Oct 21;72(2):257-68. Epub 2011 Sep 21.

Neuromuscular Diseases Research Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.neuron.2011.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200438PMC
October 2011

A soluble α-synuclein construct forms a dynamic tetramer.

Proc Natl Acad Sci U S A 2011 Oct 17;108(43):17797-802. Epub 2011 Oct 17.

Department of Biochemistry and Molecular Biology, and Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1073/pnas.1113260108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203798PMC
October 2011

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

PLoS One 2010 Jan 15;5(1):e8730. Epub 2010 Jan 15.

Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008730PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806920PMC
January 2010

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

J Neurochem 2007 Jul 29;102(1):93-102. Epub 2007 Mar 29.

Cell Biology and Gene Expression Unit, National Institute on Aging, Bethesda, Maryland 20982-3707, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04523.xDOI Listing
July 2007