Alice Chen-Plotkin

Alice Chen-Plotkin

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Alice Chen-Plotkin

Alice Chen-Plotkin

Publications by authors named "Alice Chen-Plotkin"

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Cognitive Functional Abilities in Parkinson's Disease: Agreement Between Patients and Informants.

Mov Disord Clin Pract 2019 Jul 17;6(6):440-445. Epub 2019 May 17.

Departments of Neurology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.

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http://dx.doi.org/10.1002/mdc3.12781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660222PMC
July 2019

AAV-Mediated Progranulin Delivery to a Mouse Model of Progranulin Deficiency Causes T Cell-Mediated Toxicity.

Mol Ther 2019 02 17;27(2):465-478. Epub 2018 Nov 17.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369714PMC
February 2019

Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology.

Alzheimers Dement 2019 01 12;15(1):55-64. Epub 2018 Oct 12.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

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http://dx.doi.org/10.1016/j.jalz.2018.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333489PMC
January 2019

Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease.

Alzheimers Dement 2018 08 28;14(8):1052-1062. Epub 2018 Mar 28.

Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA; Department of Pathology, Peking University Health Science Centre and Third Hospital, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097943PMC
August 2018

Statins and Cognition in Parkinson's Disease.

J Parkinsons Dis 2017 ;7(4):661-667

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.3233/JPD-171113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675567PMC
June 2018

The Post-GWAS Era: From Association to Function.

Am J Hum Genet 2018 05;102(5):717-730

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297183013
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http://dx.doi.org/10.1016/j.ajhg.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986732PMC
May 2018

CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders.

Neurology 2018 03 21;90(12):e1038-e1046. Epub 2018 Feb 21.

From Penn Frontotemporal Degeneration Center (D.J.I., N.N., C.T.M., M.G.), Alzheimer's Disease Core Center (D.A.W., J.Q.T.), Department of Neurology (D.J.I., D.C., R.S.A., C.T.M., D.A.W., D.W., A.C.-P., M.S., A.S., H.I.H., M.G.), Penn Morris K. Udall Parkinson's Disease Research Center of Excellence (D.J.I., R.S.A., C.T.M., D.W., A.C.-P., J.E.D., M.G., J.Q.T.), Center for Neurodegenerative Disease Research (L.M.S., J.Q.T.), Translational Neuropathology Research Laboratory (E.B.L.), Department of Pathology and Laboratory Medicine (E.B.L., L.M.S., J.Q.T.), and Department of Biostatistics and Epidemiology Perelman School of Medicine (S.X.X.), University of Pennsylvania; and Parkinson's Disease Research, Education and Clinical Center (D.W., J.E.D.), Michael J. Crescenz VA Medical Center, Philadelphia, PA.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000005166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874449PMC
March 2018

Genetic Modifiers in Neurodegeneration.

Curr Genet Med Rep 2018 Mar 5;6(1):11-19. Epub 2018 Feb 5.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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http://link.springer.com/10.1007/s40142-018-0133-1
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http://dx.doi.org/10.1007/s40142-018-0133-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028053PMC
March 2018

APOE, thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease.

Mov Disord 2018 02 23;33(2):289-297. Epub 2017 Nov 23.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809205PMC
February 2018

Unlocking the mystery of biomarkers: A brief introduction, challenges and opportunities in Parkinson Disease.

Parkinsonism Relat Disord 2018 Jan 22;46 Suppl 1:S15-S18. Epub 2017 Jul 22.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, United States. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2017.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849402PMC
January 2018

Parkinson disease: Blood transcriptomics for Parkinson disease?

Nat Rev Neurol 2018 Jan 1;14(1):5-6. Epub 2017 Dec 1.

Department of Neurology, University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrneurol.2017.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831123PMC
January 2018

Updating Our Definitions of Parkinson's Disease for a Molecular Age.

J Parkinsons Dis 2018 ;8(s1):S53-S57

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.3233/JPD-181487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311368PMC
January 2018

Vitamin D in the Parkinson Associated Risk Syndrome (PARS) study.

Mov Disord 2017 Nov 14;32(11):1636-1640. Epub 2017 Sep 14.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.27127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721350PMC
November 2017

Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials.

Mov Disord 2017 03 24;32(3):319-324. Epub 2017 Feb 24.

Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital and The Edmond J. Safra Program in PD, Toronto, Ontario, Canada, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/mds.26913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359057PMC
March 2017

Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.

Hum Mol Genet 2016 07 28;25(13):2681-2697. Epub 2016 Apr 28.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA

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http://dx.doi.org/10.1093/hmg/ddw127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181637PMC
July 2016

Plasma EGF and cognitive decline in Parkinson's disease and Alzheimer's disease.

Ann Clin Transl Neurol 2016 05 29;3(5):346-55. Epub 2016 Mar 29.

Department of Neurology Perelman School of Medicine at the University of Pennsylvania Philadelphia Pennsylvania.

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http://dx.doi.org/10.1002/acn3.299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863747PMC
May 2016

Reply to letter: Plasma fasting cholesterol profiles and age at onset in Parkinson's disease.

Mov Disord 2015 Dec 19;30(14):1975-6. Epub 2015 Nov 19.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.26447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715726PMC
December 2015

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients.

Mov Disord 2015 Oct 24;30(12):1648-56. Epub 2015 Jul 24.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1002/mds.26290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609229PMC
October 2015

Longitudinal study of normal cognition in Parkinson disease.

Neurology 2015 Oct 11;85(15):1276-82. Epub 2015 Sep 11.

From the Departments of Neurology (K.P., J.R., H.H., A.C.-P., J.E.D., J.F.M., L.M.C., N.D., R.S.A., D.W.), Pathology and Laboratory Medicine (J.Q.T.), and Psychiatry (D.W.), Perelman School of Medicine at the University of Pennsylvania; the Department of Biostatistics and Epidemiology (S.X.X.), University of Pennsylvania; Philadelphia Veterans Affairs Medical Center (J.E.D., J.F.M., D.W.); and Avid Radiopharmaceuticals (A.S.), Philadelphia, PA.

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http://www.neurology.org/content/85/15/1276.full.pdf
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http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000200
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000002001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617168PMC
October 2015

Caregiver report of apathy predicts dementia in Parkinson's disease.

Parkinsonism Relat Disord 2015 Aug 9;21(8):992-5. Epub 2015 Jun 9.

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2015.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4509809PMC
August 2015

Unbiased approaches to biomarker discovery in neurodegenerative diseases.

Neuron 2014 Nov 5;84(3):594-607. Epub 2014 Nov 5.

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, 3 West Gates, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2014.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254637PMC
November 2014

What can biomarkers tell us about cognition in Parkinson's disease?

Mov Disord 2014 Apr;29(5):622-33

Paracelsus-Elena-Klinik, Kassel and University Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1002/mds.25846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384332PMC
April 2014

TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.

Acta Neuropathol 2014 Mar 19;127(3):407-18. Epub 2014 Jan 19.

Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00401-013-1239-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003885PMC
March 2014

Blood-based biomarkers for Parkinson's disease.

Parkinsonism Relat Disord 2014 Jan;20 Suppl 1:S99-103

Parkinson's Disease and Movement Disorders Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1353-8020(13)70025-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4070332PMC
January 2014

Development and validation of pedigree classification criteria for frontotemporal lobar degeneration.

JAMA Neurol 2013 Nov;70(11):1411-7

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1001/jamaneurol.2013.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906581PMC
November 2013

Genetic influences on cognitive decline in Parkinson's disease.

Mov Disord 2012 Apr 16;27(4):512-8. Epub 2012 Feb 16.

Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvalia, USA.

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http://dx.doi.org/10.1002/mds.24946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323737PMC
April 2012

Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis.

Acta Neuropathol 2011 Mar 23;121(3):373-80. Epub 2010 Nov 23.

Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-010-0782-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095217PMC
March 2011

Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.

J Clin Invest 2011 Feb 4;121(2):726-38. Epub 2011 Jan 4.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1172/JCI44867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026736PMC
February 2011

Hypertrophic pachymeningitis and cerebral venous sinus thrombosis in inflammatory bowel disease.

J Clin Neurosci 2010 Nov 19;17(11):1454-6. Epub 2010 Aug 19.

Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jocn.2010.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946484PMC
November 2010

Age-correlated gene expression in normal and neurodegenerative human brain tissues.

PLoS One 2010 Sep 29;5(9). Epub 2010 Sep 29.

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013098PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947518PMC
September 2010

TAR DNA-binding protein 43 in neurodegenerative disease.

Nat Rev Neurol 2010 Apr 16;6(4):211-20. Epub 2010 Mar 16.

Department of Neurology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104-4283, USA.

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http://dx.doi.org/10.1038/nrneurol.2010.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892118PMC
April 2010

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.

Authors:
Vivianna M Van Deerlin Patrick M A Sleiman Maria Martinez-Lage Alice Chen-Plotkin Li-San Wang Neill R Graff-Radford Dennis W Dickson Rosa Rademakers Bradley F Boeve Murray Grossman Steven E Arnold David M A Mann Stuart M Pickering-Brown Harro Seelaar Peter Heutink John C van Swieten Jill R Murrell Bernardino Ghetti Salvatore Spina Jordan Grafman John Hodges Maria Grazia Spillantini Sid Gilman Andrew P Lieberman Jeffrey A Kaye Randall L Woltjer Eileen H Bigio Marsel Mesulam Safa Al-Sarraj Claire Troakes Roger N Rosenberg Charles L White Isidro Ferrer Albert Lladó Manuela Neumann Hans A Kretzschmar Christine Marie Hulette Kathleen A Welsh-Bohmer Bruce L Miller Ainhoa Alzualde Adolfo Lopez de Munain Ann C McKee Marla Gearing Allan I Levey James J Lah John Hardy Jonathan D Rohrer Tammaryn Lashley Ian R A Mackenzie Howard H Feldman Ronald L Hamilton Steven T Dekosky Julie van der Zee Samir Kumar-Singh Christine Van Broeckhoven Richard Mayeux Jean Paul G Vonsattel Juan C Troncoso Jillian J Kril John B J Kwok Glenda M Halliday Thomas D Bird Paul G Ince Pamela J Shaw Nigel J Cairns John C Morris Catriona Ann McLean Charles DeCarli William G Ellis Stefanie H Freeman Matthew P Frosch John H Growdon Daniel P Perl Mary Sano David A Bennett Julie A Schneider Thomas G Beach Eric M Reiman Bryan K Woodruff Jeffrey Cummings Harry V Vinters Carol A Miller Helena C Chui Irina Alafuzoff Päivi Hartikainen Danielle Seilhean Douglas Galasko Eliezer Masliah Carl W Cotman M Teresa Tuñón M Cristina Caballero Martínez David G Munoz Steven L Carroll Daniel Marson Peter F Riederer Nenad Bogdanovic Gerard D Schellenberg Hakon Hakonarson John Q Trojanowski Virginia M-Y Lee

Nat Genet 2010 Mar 14;42(3):234-9. Epub 2010 Feb 14.

[1] Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. [2] These authors contributed equally to this work.

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http://dx.doi.org/10.1038/ng.536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828525PMC
March 2010

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.

Acta Neuropathol 2010 Jan 2;119(1):111-22. Epub 2009 Aug 2.

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1007/s00401-009-0576-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104467PMC
January 2010

Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies.

J Biol Chem 2009 Mar 21;284(13):8516-24. Epub 2009 Jan 21.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, USA.

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http://dx.doi.org/10.1074/jbc.M809462200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659210PMC
March 2009

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.

Hum Mol Genet 2008 May 25;17(10):1349-62. Epub 2008 Jan 25.

Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
Publisher Site
http://dx.doi.org/10.1093/hmg/ddn023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900863PMC
May 2008

Delayed leukoencephalopathy after hypoxic-ischemic injury.

Arch Neurol 2008 Jan;65(1):144-5

Department of Neurology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1001/archneurol.2007.7DOI Listing
January 2008

Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation.

Neurology 2007 Mar;68(11):859-61

Department of Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1212/01.wnl.0000256716.04218.5bDOI Listing
March 2007

Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease.

Neurobiol Dis 2006 May 24;22(2):233-41. Epub 2006 Jan 24.

MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital/B114-2000, 114 16th Street, Charlestown, MA 02129-4404, USA.

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http://dx.doi.org/10.1016/j.nbd.2005.11.001DOI Listing
May 2006

Chromatin immunoprecipitation technique for study of transcriptional dysregulation in intact mouse brain.

Methods Mol Biol 2004 ;277:261-76

Mass General Institute for Neurodegenerative Disease and Department of Neurology, Massachusetts General Hospital, Charlestown, USA.

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http://dx.doi.org/10.1385/1-59259-804-8:261DOI Listing
September 2004