Publications by authors named "Ali Zaied"

2 Publications

  • Page 1 of 1

Complete lung collapse as a rare complication of sarcoidosis-associated mediastinal lymphadenopathy.

Respirol Case Rep 2021 Apr 10;9(4):e00739. Epub 2021 Mar 10.

Department of Pulmonology, Critical Care, and Sleep Medicine Mayo Clinic health System Eau Claire WI USA.

Complete lung collapse associated with sarcoidosis is exceedingly rare. Although lymphoma should be ruled out when patients with mediastinal lymphadenopathy develop lung collapse, sarcoidosis should be considered in the differential, especially when associated with fibrosing mediastinitis.
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http://dx.doi.org/10.1002/rcr2.739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946853PMC
April 2021

New-onset insulin-dependent diabetes due to nivolumab.

Endocrinol Diabetes Metab Case Rep 2018 28;2018. Epub 2018 Mar 28.

Divisions of Pulmonary and Critical Care Medicine, Mayo Clinic, Jacksonville, Florida, USA.

Nivolumab, a monoclonal antibody against programmed cell death-1 receptor, is increasingly used in advanced cancers. While nivolumab use enhances cancer therapy, it is associated with increased immune-related adverse events. We describe an elderly man who presented in ketoacidosis after receiving nivolumab for metastatic renal cell carcinoma. On presentation, he was hyperpneic and laboratory analyses showed hyperglycemia and anion-gapped metabolic acidosis consistent with diabetic ketoacidosis. No other precipitating factors, besides nivolumab, were identified. Pre-nivolumab blood glucose levels were normal. The patient responded to treatment with intravenous fluids, insulin and electrolyte replacement. He was diagnosed with insulin-dependent autoimmune diabetes mellitus secondary to nivolumab. Although nivolumab was stopped, he continued to require multiple insulin injection therapy till his last follow-up 7 months after presentation. Clinicians need to be alerted to the development of diabetes mellitus and diabetic ketoacidosis in patients receiving nivolumab.

Learning Points: Diabetic ketoacidosis should be considered in the differential of patients presenting with metabolic acidosis following treatment with antibodies to programmed cell death-1 receptor (anti-PD-1).Autoimmune islet cell damage is the presumed mechanism for how insulin requiring diabetes mellitus can develop following administration of anti-PD-1.Because anti-PD-1 works by the activation of T-cells and reduction of 'self-tolerance', other autoimmune disorders are likely to be increasingly recognized with increased use of these agents.
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http://dx.doi.org/10.1530/EDM-17-0174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881429PMC
March 2018