Publications by authors named "Ali Maleki"

96 Publications

White blood cell count and clustered components of metabolic syndrome: A study in western Iran.

Caspian J Intern Med 2021 ;12(1):59-64

Sarem Fertility and Infertility Research Center (SAFIR), Sarem Women's Hospital, Tehran, Iran.

Background: White blood cell count (WBC) is one of the objective parameters of systemic inflammation. The aim of present study was to evaluate the relationship between WBC count and metabolic syndrome.

Methods: In this study on Lor population in Borujerd province (West of Iran), from 2011 to 2013, 800 persons were enrolled. MetS was defined based on ATP III criteria. Differences among the quartiles of WBC were examined by one-way analysis of variance.

Results: Only 14.7% did not have any of the five components and 43% of all subjects had metabolic syndrome. The means of WBC count in MetS group were significantly higher than the control group (p<0.0001). In subjects without any MetS components, the means of WBC was 5.321 /µL, and it was 5.664, 5.714, 5.961, 6.302, and 6.572 /µL in subjects with 1, 2, 3, 4, and 5 components, respectively. These differences show a significant increasing trend (p<0.0001).

Conclusion: WBC count was associated with clustered components of metabolic syndrome. It seems that WBC counts could be considered as a predictive factor for metabolic syndrome in preventive medicine.
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http://dx.doi.org/10.22088/cjim.12.1.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7919179PMC
January 2021

Chitosan hydrogel/silk fibroin/Mg(OH) nanobiocomposite as a novel scaffold with antimicrobial activity and improved mechanical properties.

Sci Rep 2021 Jan 12;11(1):650. Epub 2021 Jan 12.

Department of Biotechnology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran.

Herein, a novel nanobiocomposite scaffold based on modifying synthesized cross-linked terephthaloyl thiourea-chitosan hydrogel (CTT-CS hydrogel) substrate using the extracted silk fibroin (SF) biopolymer and prepared Mg(OH) nanoparticles was designed and synthesized. The biological capacity of this nanobiocomposite scaffold was evaluated by cell viability method, red blood cells hemolytic and anti-biofilm assays. According to the obtained results from 3 and 7 days, the cell viability of CTT-CS/SF/Mg(OH) nanobiocomposite scaffold was accompanied by a considerable increment from 62.5 to 89.6% respectively. Furthermore, its low hemolytic effect (4.5%), and as well, the high anti-biofilm activity and prevention of the P. aeruginosa biofilm formation confirmed its promising hemocompatibility and antibacterial activity. Apart from the cell viability, blood biocompatibility, and antibacterial activity of CTT-CS/SF/Mg(OH) nanobiocomposite scaffold, its structural features were characterized using spectral and analytical techniques (FT-IR, EDX, FE-SEM and TG). As well as, given the mechanical tests, it was indicated that the addition of SF and Mg(OH) nanoparticles to the CTT-CS hydrogel could improve its compressive strength from 65.42 to 649.56 kPa.
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http://dx.doi.org/10.1038/s41598-020-80133-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7804245PMC
January 2021

Oxytocin Prevents the Development of 3-NP-Induced Anxiety and Depression in Male and Female Rats: Possible Interaction of OXTR and mGluR2.

Cell Mol Neurobiol 2020 Nov 17. Epub 2020 Nov 17.

Neurobiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Huntington disease (HD) is a progressive neurological disorder with dominant motor symptoms. It also has psychiatric manifestations, like anxiety and depression, that can emerge themselves before motor symptoms and impose a major burden on patients. Oxytocin (OXT) is a newly emerged treatment for disorders like autism and schizophrenia and recently is using to alleviate depression and anxiety. In the current study, we investigated the behavioral and molecular effects of OXT on the development of anxiety and depression in 3-nitropropionic acid (3-NP)-induced model of HD. Anxiety- and depression-like behaviors as well as the levels of oxytocin receptor (OXTR), metabotropic glutamate receptor (mGluR) 2, mGluR5, and glutathione (GSH) were measured in striatum, hippocampus, prefrontal cortex, and amygdala. Also, we questioned if sex had any modulatory effect. We found that 3-NP increased anxiety and depression compared to controls. It also reduced the levels of OXTR and mGluR2, increased mGluR5, and reduced GSH in studied brain regions. Pretreatment with OXT before the injection of 3-NP ameliorated anxiety and depression. Additionally, it protected the brain from developing low levels of OXTR, mGluR2, and GSH and high levels of mGluR5 in studied regions. The protective effects of OXT were similar between male and female animals. These data suggest that OXTR, mGluR2, mGluR5, and GSH may contribute to psychiatric manifestations of HD. In addition, pretreatment with OXT could prevent the mood changes in male and female rats.
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http://dx.doi.org/10.1007/s10571-020-01003-0DOI Listing
November 2020

Neural decoding of continuous upper limb movements: a meta-analysis.

Disabil Rehabil Assist Technol 2020 Nov 13:1-7. Epub 2020 Nov 13.

Semnan University, Semnan, Iran.

Objective: EEG-based motion trajectory decoding makes a promising approach for neurotechnology which can be used for neural control of motion reconstruction and neurorehabilitation tools. However, the feasibility and validity of continuous motion decoding by non-invasive brain activity are not clear. The main aim of this study was to perform a meta-analysis across studies that examined the ability of EEG-based continuous motion decoding of upper limb movements.

Approach: Pearson's correlation coefficient (CC) was used to evaluate the model performance of the studies and considered as an effect size. To estimate the overall effect size of neural decoding of motion trajectory across studies, characteristics of included studies were addressed and the random effect model was applied to the heterogeneous studies which estimated overall effect size distribution. Furthermore, the significant difference between the two subgroups of imagined and executed movements was analysed.

Main Results: The mean of the overall effect size was computed 0.46 across the nonhomogeneous studies. The results showed no significant difference between imagined and executed movements (Chi=0.28, df = 1,  = 0.60).

Significance: Meta-analysis results confirm that imagination like execution movements can be used for neural decoding of motion trajectory in neural motor control systems. Also, nonlinear compare with linear model statistically confirmed to be more beneficial for complex movements. Furthermore, a new approach of synergy-based motion decoding can be significantly effective to increase model performance and more research needs to evaluate this method for different levels of complexity of movements. IMPLICATIONS FOR REHABILITATION Neural decoding methods base on EEG as a non-invasive brain activity, are more user friendly for neurorehabilitation than invasive methods that developing of it makes it more applicable for reconstructing activities of daily living. Neurotechnology for neural control of motion reconstruction, makes the rehabilitation tools to be more synchrony with human intentional movement that can be used to improve the brain neuroplastisity in stroke or other paralysed people. The feasibility and validity of imagined movements equal with executed movements show that amputee people also can benefit EEG-based motion decoding for controling rehabilitation tools just by imagination of their intentional movements. For neurorehabilitation tools, comparing the study outcomes illucidate that the approach of synergy-based motor control in brain activities concluded significantly high performance that highlighted the need it to more investigated in future research.
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http://dx.doi.org/10.1080/17483107.2020.1842919DOI Listing
November 2020

Author Correction: Synthesis of nickel nanoparticles by a green and convenient method as a magnetic mirror with antibacterial activities.

Sci Rep 2020 Oct 30;10(1):19100. Epub 2020 Oct 30.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846‑13114, Iran.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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http://dx.doi.org/10.1038/s41598-020-76399-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599323PMC
October 2020

A historical overview of the activation and porosity of metal-organic frameworks.

Chem Soc Rev 2020 Oct;49(20):7406-7427

Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, USA. and Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.

Since the first reports of metal-organic frameworks (MOFs), this unique class of crystalline, porous materials has garnered increasing attention in a wide variety of applications such as gas storage and separation, catalysis, enzyme immobilization, drug delivery, water capture, and sensing. A fundamental feature of MOFs is their porosity which provides space on the micro- and meso-scale for confining and exposing their functionalities. Therefore, designing MOFs with high porosity and developing suitable activation methods for preserving and accessing their pore space have been a common theme in MOF research. Reticular chemistry allows for the facile design of MOFs from highly tunable metal nodes and organic linkers in order to realize different pore structures, topologies, and functionalities. With the hope of shedding light on future research endeavors in MOF porosity, it is worthwhile to examine the development of MOFs, with an emphasis on their porosity and how to properly access their pore space. In this review, we will provide an overview of the historic evolution of porosity and activation of MOFs, followed by a synopsis of the strategies to design and preserve permanent porosity in MOFs.
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http://dx.doi.org/10.1039/d0cs00997kDOI Listing
October 2020

Multi-Stimuli Nanocomposite Therapeutic: Docetaxel Targeted Delivery and Synergies in Treatment of Human Breast Cancer Tumor.

Small 2020 10 18;16(41):e2002733. Epub 2020 Sep 18.

Department of Chemistry and Biochemistry, Wilfrid Laurier University, 75 University Ave. W., Waterloo, Ontario, N2L 3C5, Canada.

A versatile breast cancer-targeting nanocomposite therapeutic combining docetaxel (DXL), polyvinyl alcohol (PVA) network for controlled release, and silica-protected magnetic iron oxide nanoparticles (Fe O NPs) for targeted delivery and gold nanoparticles (AuNPs) for plasmonic photothermal therapy (PPTT) is presented in this work. First, the designed nanocomposite is magnetically directed for cancer-targeted therapy confirmed by computerized tomography (CT) scans. Second, 10% DXL by mass is loaded into PVA, a pH and temperature responsive gel, for controlled release. Third, PPTT is confirmed with Au/Fe O /PVA-10%DXL using a prototype circulation system and then for tumor treatment in vivo; Au/Fe O /PVA-10%DXL is conveniently directed and the entrapped DXL is selectively released (≈96%) via the interaction of green and near-infrared (NIR) light with the localized surface plasmon resonance of AuNPs. A 75% cell death is reported from in vitro studies with DXL doses as low as 20 µg mL of Au/Fe O /PVA-10%DXL, and a 70% tumor growth inhibition is demonstrated by in vivo experiments with the biosafety studies confirming minimal side effects to other organs. Overall, the developed Au/Fe O /PVA-10%DXL has a strong potential to simultaneously enhance CT imaging contrast together with the targeted delivery of DXL.
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http://dx.doi.org/10.1002/smll.202002733DOI Listing
October 2020

Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties.

Carbohydr Polym 2020 Nov 24;248:116802. Epub 2020 Jul 24.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran. Electronic address:

For biomedical applications, the design and synthesis of biocompatible nanostructures, are considered as critical challenges. In this study, graphene oxide (GO) was covalently modified by natural sodium alginate (Alg) polymer. By adding silk fibroin (SF) to this nanostructure, a hybrid nanobiocomposite (GO/Alg/SF) was resulted and its unique features were determined using FT-IR, EDX, FE-SEM, XRD and TG analyses. Because of using less toxic and high biocompatible materials, specific biological results were achieved. The cell viability of this novel nanostructure was 89.2 % and its hemolytic effect was less than 6% while the highest concentration (1000 μg/mL) of this nanostructure was chosen for these purposes. Also, high mechanical properties including the compressive strength (0.87 ± 0.034 (MPa)) and the compressive modulus (2.25 ± 0.091 (MPa)) were exposed. This nanostructure can be considered as a scaffold for wound dressing applications due to the mentioned properties.
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http://dx.doi.org/10.1016/j.carbpol.2020.116802DOI Listing
November 2020

Metal-based nanoparticles for bone tissue engineering.

J Tissue Eng Regen Med 2020 12 30;14(12):1687-1714. Epub 2020 Sep 30.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal-based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle-based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.
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http://dx.doi.org/10.1002/term.3131DOI Listing
December 2020

Green and efficient three-component synthesis of 4H-pyran catalysed by CuFeO@starch as a magnetically recyclable bionanocatalyst.

R Soc Open Sci 2020 Jul 1;7(7):200385. Epub 2020 Jul 1.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.

The development of simple, practical and inexpensive catalysis systems using natural materials is one of the main goals of pharmaceutical chemistry as well as green chemistry. Owing to the ability of easy separation of nanocatalyst, those goals could be approached by applying heterogeneous bionanocatalyst in combination with magnetic nanoparticles. Starch is one of the most abundant natural polymers; therefore, preparing bionanocatalyst from starch is very valuable as starch is largely available and inexpensive. An ecologically benign and efficacious heterogeneous nanocatalyst was prepared based on a biopolymer, and its attributes and morphology were specified by using Fourier transform infrared spectra, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), thermal analysis and vibrating sample magnetometer measurements; followed by studying catalytic behaviour of bionanocomposite in a multicomponent reaction to synthesize of 4H-pyran derivatives. 4H-pyran is extremely valuable in pharmaceutical chemistry, and the development of methods for synthesis of different derivatives of 4H-pyran is momentous. Revealing environmentally benign nature, mild condition, easy work-up, low cost and non-toxicity are some of the advantages of this protocol. Besides, the bionanocomposite was recovered using an external magnetic bar and could be re-used at least six times with no further decrease in its catalytic activity.
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http://dx.doi.org/10.1098/rsos.200385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428224PMC
July 2020

Fabrication of FeO@PVA-Cu Nanocomposite and Its Application for Facile and Selective Oxidation of Alcohols.

Front Chem 2020 21;8:615. Epub 2020 Jul 21.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.

FeO@PVA-Cu nanocomposite was introduced as an affordable catalyst for selective oxidation of alcohols into various aldehydes and ketones. The synthesized nanocomposite was characterized by applying essential analyses. The peaks that are appeared in FT-IR spectroscopy confirmed the production of the FeO@PVA-Cu nanocomposite. In addition, EDX analysis proved the presence of oxygen, carbon, iron, and copper elements in the catalyst. Further, TGA analysis showed high thermal stability of the nanocomposite. VSM technique was applied to examine the magnetic property of the nanocomposite. The results demonstrated a high magnetic property in the catalyst, which enables easy separation of it from the reaction solution. TEM and SEM imaging showed the nanoscale size of the particles (~20 nm) in the catalyst. Additionally, XRD data was compatible with that of FeO nanoparticles. The application of the nanocomposite has been studied in the selective oxidation of alcohols in the presence of acetonitrile as solvent, and hydrogen peroxide as a supplementary oxidizing agent. This technique is remarkably facile and inexpensive. Further, the products showed high yields. In addition, the calculated TON and TOF values indicated the phenomenal efficiency of the nanocomposite in preparation of targeted products.
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http://dx.doi.org/10.3389/fchem.2020.00615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396633PMC
July 2020

Alginate hydrogel-polyvinyl alcohol/silk fibroin/magnesium hydroxide nanorods: A novel scaffold with biological and antibacterial activity and improved mechanical properties.

Int J Biol Macromol 2020 Nov 16;162:1959-1971. Epub 2020 Aug 16.

Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.

In this study, a nanobiocomposite scaffold was fabricated by combining sodium alginate, polyvinyl alcohol, silk fibroin and magnesium hydroxide nanorods. The structural characteristics and properties of the scaffold were identified by field emission scanning electron microscope (FE-SEM), thermogravimetric analysis (TGA), Fourier-transformed infrared (FT-IR) and energy dispersive X-Ray (EDX) analyses. To introduce the application, biocompatibility, mechanical properties and biological activity of the scaffold were obtained. The composite was found to have high porosity, no cytotoxicity, excellent cellular adaptation, and most importantly Mg(OH) nanorod had antibacterial activity and inhibited the growth of bacteria. In addition, silk fibroin and alginate increased the scaffold strength due to mechanical tests. Hemolytic assay and cell metabolic activity of this novel nanobiocomposite showed that the hemolytic effect was less than 8% and about 92% of cells survived. Due to considerable biological activities and acceptable mechanical properties, the mentioned nanobiocomposite can be considered as a scaffold for possible use in wound dressing, tissue engineering and drug delivery systems.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.090DOI Listing
November 2020

Experimental study on classical and metaheuristics algorithms for optimal nano-chitosan concentration selection in surface coating and food packaging.

Food Chem 2021 Jan 28;335:127681. Epub 2020 Jul 28.

Department of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

In this study the Lagrange interpolation optimization algorithm based on two variables with respect to all experimental replicates (POA), was compared with two other heuristics methods (WOA and GOA). Modification of the apple surface by an edible nano coating solution in food packaging was used as case study. The experiment was performed as a factorial test based on completely randomized design by 100 permutations data sets. Results showed a significant difference between the three optimization methods (POA, WOA and GOA) which indicates the necessity of optimization and also efficiency of the present POA. The optimum result by POA, similar to a rose petal property, could rise 72% in surface contact angle (CA). The scanning electron microscopy (SEM) images of the derived surfaces showed almost a uniform spherical nanoparticles morphology. Remarkable advantages of this new approach are no additional material requirement, healthful, easy, inexpensive, fast and affordable technique for surface improvement.
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http://dx.doi.org/10.1016/j.foodchem.2020.127681DOI Listing
January 2021

Antimicrobial therapeutic enhancement of levofloxacin via conjugation to a cell-penetrating peptide: An efficient sonochemical catalytic process.

J Pept Sci 2020 Oct 29;26(10):e3277. Epub 2020 Jul 29.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, Iran.

Herein, we make an effort to enhance the antimicrobial activity of levofloxacin (LVX) antibiotic via conjugation to a cell-penetrating peptide (CPP) including Cys-Gly-Ala-Phe-Pro-His-Arg. For this purpose, cysteine is used as a linker between the LVX and CPP chain, and two heterogeneous nanoscale catalytic systems are employed as the substantial alternatives for traditional peptide coupling reagents like N,N,N',N'-tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate (TBTU). Briefly, it has been found out that the antimicrobial potency of the synthesized CPP-LVX conjugate (on the gram-positive and gram-negative bacteria) is noticeably enhanced (~20% more). It has been revealed via zone of inhibition (ZOI) and optical density (OD) evaluations. As a convenient method for making this type of the effective conjugations, ultrasound waves (with a specific frequency and power density) activate the catalytic sites of the heterogeneous nanoparticles. Through this synergistic effect, peptide/amide bond is formed during a short time (10 min), and high reaction yield (>90%) is obtained under mild conditions. Moreover, as a simple purification process, the catalyst nanoparticles are collected and separated through their high magnetic property.
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http://dx.doi.org/10.1002/psc.3277DOI Listing
October 2020

Synthesis of nickel nanoparticles by a green and convenient method as a magnetic mirror with antibacterial activities.

Sci Rep 2020 07 28;10(1):12627. Epub 2020 Jul 28.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

In this work, a simple protocol was described for the synthesis of nickel magnetic mirror nanoparticles (NMMNPs) including antibacterial activities. The identification of NMNPs was carried out by field-emission scanning electron microscopy (FESEM) images, energy-dispersive X-ray (EDX) analysis, X-ray diffraction (XRD) pattern, transmission electron microscopy (TEM) images and vibrating sample magnetometer (VSM) curve. The antibacterial activities are investigated against S. aureus and E. coli as the Gram-positive and Gram-negative bacteria, respectively. The UV-Vis absorption was also studied in the present of NMMNPs at different time intervals that disclosed decreasing of the bacterial concentration. More than 80% of the bacteria were disappeared after treating in the presence of NMMNPs for 18 h. The Ni-NPs revealed an excellent mirror attribute with a well-controlled transmission (7%). A better light-reflectivity over conventional glass or a mercury mirror proved their utility for domestic uses in comparison with conventional mirrors as rather toxic materials like mercury. Owing to its magnetic properties, this kind of mirror can be easily made onto glass by using an external magnet. An ordered crystalline structure, admissible magnetic properties, substantial antibacterial activities, tunable mirror properties, mild reaction conditions, and overall, the facile synthesis are the specific features of the present protocol for the possible uses of NMMNPs in diverse applications.
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http://dx.doi.org/10.1038/s41598-020-69679-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387540PMC
July 2020

Ultrafast modulation of the spectral filtering properties of a THz metasurface.

Opt Express 2020 Jul;28(14):20296-20304

We demonstrate ultrafast tuning of a plasmonic spectral filter at terahertz (THz) frequencies. The device is made of periodically spaced gold crosses deposited on the surface of an undoped silicon wafer in which transient free carriers can be optically injected with a femtosecond resonant pulse. We demonstrate the concept by measuring the transmission spectrum of a notch filter using time-domain THz spectroscopy. Proper synchronization of the THz probe and visible excitation pulses leads to an enhanced transmission at the resonance by more than two orders of magnitude. Finite-difference time-domain simulations, which are in agreement with the experimental results, show that the underlying mechanisms responsible for the resonance blueshift and linewidth broadening can be attributed to the photoinduced change in dielectric properties of the substrate. This is supported by the numerically simulated field distribution and reflection/transmission coefficients. The device can be used in future pulse shaping and ultrafast switching experiments.
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http://dx.doi.org/10.1364/OE.395508DOI Listing
July 2020

Development of novel and green NiFeO/geopolymer nanocatalyst based on bentonite for synthesis of imidazole heterocycles by ultrasonic irradiations.

Sci Rep 2020 07 15;10(1):11671. Epub 2020 Jul 15.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, 16846-13114, Tehran, Iran.

Geopolymers as aluminosilicate inorganic polymers and eco-friendly building materials which can be used as substrate for different kinds of composite. In this research, according to the fabrication of geopolymer based on bentonite as a substrate and embedment of NiFeO nanoparticles in the construction of this polymer, the synthesis of a new magnetic nanocomposite (NiFeO/geopolymer) was investigated for the first time. In order to describe its chemistry and morphology features, different analyses such as Fourier transform infrared spectroscopy, field-emission scanning electron microscopy and transmission electron microscopy images, Brunauer-Emmet-Teller adsorption-desorption isotherm, X-ray diffraction pattern, energy-dispersive X-ray analysis, thermogravimetric analysis, and vibrating-sample magnetometer analysis were used. The application of this novel nanocatalyst was studied for one-pot three-component condensation reaction of substituted imidazole derivatives by accelerated ultrasonic irradiations. Compared to the other conventional catalysts which were used for the synthesis of imidazole derivatives, the green synthesis method for fabrication of this heterogeneous and magnetic nanocatalyst, its high thermal stability, being eco-friendly, noticeable efficiency and easy reusability have become privileges to be superior.
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http://dx.doi.org/10.1038/s41598-020-68426-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363903PMC
July 2020

Synthesis of Core-Shell Magnetic Supramolecular Nanocatalysts based on Amino-Functionalized Calix[4]arenes for the Synthesis of -Chromenes by Ultrasonic Waves.

ChemistryOpen 2020 Jul 24;9(7):735-742. Epub 2020 Mar 24.

School of Mechanical Engineering Iran University of Science and Technology Tehran Iran.

One of the most common phenol-formaldehyde cyclic oligomers from hydroxyalkylation reactions that exhibit supramolecular chemistry are calixarenes. These macrocyclic compounds are qualified to act as synthetic catalysts due to their specific features including being able to form host-guest complexes, having unique structural scaffolds and their relative ease of chemical modifications with a variety of functions on their upper rim and lower rim. Here, a functional magnetic nanocatalyst was designed and synthesized by using a synthetic amino-functionalized calix[4]arene. Its catalytic activity was evaluated in a one-pot synthesis of 2-amino--chromene derivatives. Besides, this novel magnetic nanocatalyst was characterized by spectroscopic and analytical techniques such as FT-IR, EDX, FE-SEM, TEM VSM, XRD analysis.
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http://dx.doi.org/10.1002/open.202000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327476PMC
July 2020

Elbow angle generation during activities of daily living using a submovement prediction model.

Biol Cybern 2020 06 9;114(3):389-402. Epub 2020 Jun 9.

Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran.

The present study aimed to develop a realistic model for the generation of human activities of daily living (ADL) movements. The angular profiles of the elbow joint during functional ADL tasks such as eating and drinking were generated by a submovement-based closed-loop model. First, the ADL movements recorded from three human participants were broken down into logical phases, and each phase was decomposed into submovement components. Three separate artificial neural networks were trained to learn the submovement parameters and were then incorporated into a closed-loop model with error correction ability. The model was able to predict angular trajectories of human ADL movements with target access rate = 100%, VAF = 98.9%, and NRMSE = 4.7% relative to the actual trajectories. In addition, the model can be used to provide the desired target for practical trajectory planning in rehabilitation systems such as functional electrical stimulation, robot therapy, brain-computer interface, and prosthetic devices.
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http://dx.doi.org/10.1007/s00422-020-00834-wDOI Listing
June 2020

Stress detection using ECG and EMG signals: A comprehensive study.

Comput Methods Programs Biomed 2020 Sep 5;193:105482. Epub 2020 May 5.

Biomedical Engineering Department, Semnan University, Semnan, Iran. Electronic address:

Background And Objective: In recent years, stress and mental health have been considered as important worldwide concerns. Stress detection using physiological signals such as electrocardiogram (ECG), skin conductance (SC), electromyogram (EMG) and electroencephalogram (EEG) is a traditional approach. However, the effect of stress on the EMG signal of different muscles and the efficacy of combination of the EMG and other biological signals for stress detection have not been taken into account yet. This paper presents a comprehensive review of the EMG signal of the right and left trapezius and right and left erector spinae muscles for multi-level stress recognition. Also, the ECG signal was employed to evaluate the efficacy of EMG signals for stress detection.

Methods: Both EMG and ECG signals were acquired simultaneously from 34 healthy students (23 females and 11 males, aged 20-37 years). Mental arithmetic, Stroop color-word test, time pressure, and stressful environment were employed to induce stress in the laboratory.

Results: The accuracies of stress recognition in two, three and four levels were 100%, 97.6%, and 96.2%, respectively, obtained from the distinct combination of feature selection and machine learning algorithms.

Conclusions: The comparison of stress detection accuracies resulted from EMG and ECG indicators demonstrated the strong ability and the effectiveness of EMG signal for multi-level stress detection.
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http://dx.doi.org/10.1016/j.cmpb.2020.105482DOI Listing
September 2020

Magnetic dextrin nanobiomaterial: An organic-inorganic hybrid catalyst for the synthesis of biologically active polyhydroquinoline derivatives by asymmetric Hantzsch reaction.

Mater Sci Eng C Mater Biol Appl 2020 Apr 2;109:110502. Epub 2019 Dec 2.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.

Dextrin is a low molecular weight polysaccharide obtained from natural resources. Due to exceptional properties such as chemical structure, having extreme reactive functional groups, low cost, commercial availability, non-toxicity and biocompatibility, it can be introduced as a green organocatalyst. The fabrication of hybrid materials from natural polymers and synthetic inorganic materials constructs compounds with new features, abilities and applications. Therefore, magnetic dextrin nanobiocomposite was prepared using a simple chemical co-precipitation. Then, it was characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray (EDX) analysis, vibrating sample magnetometer (VSM) curve, scanning electron microscopy (SEM) image, X-ray diffraction (XRD) pattern, thermogravimetric analysis (TGA) and inductively-coupled plasma atomic emission spectroscopy (ICP-AES) analysis. Subsequently, to evaluate the catalytic performance of the synthetic hybrid catalyst, it was tested for the synthesis of biologically active polyhydroquinoline derivatives by four-component condensation reactions of aromatic aldehyde, ethyl acetoacetate, dimedone, ammonium acetate in ethanol under refluxing conditions. Experimental observations indicated some advantages of the present method, such as the use of green and biopolymer-based catalyst, simple procedure, mild reaction conditions, short reaction times (15-45 min), appropriate yield of products (70-95%) and catalyst reusability after five consecutive runs without considerable catalytic performance decrease.
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http://dx.doi.org/10.1016/j.msec.2019.110502DOI Listing
April 2020

Cellulose-Supported Sulfonated Magnetic Nanoparticles: Utilized for One-pot Synthesis of α-Iminonitrile Derivatives.

Curr Org Synth 2020 ;17(4):288-294

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.

ntroduction: An instrumental strategy for α-iminonitrile derivatives preparation by Fe3O4@cellulose-OSO3H (MCSA) as an eco-friendly nanocatalyst and oxidative agent in aerobic condition, is presented.

Materials And Methods: Through this method, a one-pot three-component condensation reaction of various aldehydes, primary amines and trimethylsilylcyanide (TMSCN) were applied to synthesize the desired products. It was performed in absolute ethanol and under a mild condition by using the presented nanocatalyst. High reaction yields were obtained through using the presented magnetic agent, as well. Moreover, the threecomponent reactions were executed using accessible and economical precursors. The convenient separation and recyclability of the used nanocatalyst were also precisely investigated.

Results And Discussion: In this research, we identified novel α-iminonitrile derivatives using 1H NMR, 13C NMR, CHN, and FT-IR analyses, as well. In order to determine the well-known derivatives, we used FT-IR method as well as comparing their melting points with those of reported.

Conclusion: In summary, an extremely efficient method was used for the environmentally-friendly synthesis of α-iminonitrile derivatives that are important bioactive substances. The catalytic oxidative coupling reaction afforded the products via a one-pot three-component condensation reaction of various aldehydes, primary amines and TMSCN with great reaction yields, in ethanol under mild conditions.
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http://dx.doi.org/10.2174/1570179417666200324184936DOI Listing
November 2020

Fuzzy ensemble system for SSVEP stimulation frequency detection using the MLR and MsetCCA.

J Neurosci Methods 2020 05 12;338:108686. Epub 2020 Mar 12.

Biomedical Engineering Department, Semnan University, Semnan, Iran. Electronic address:

Background: BCI systems based on steady-state visual evoked potentials (SSVEP) have formed an immense contribution to practical applications, due to their high recognition accuracy and ease of use. The MLR method has a better frequency recognition accuracy for short-term windows, and the MsetCCA method works more accurately in long-term windows.

New Method: The proposed fuzzy ensemble system can analyze the relevant SSVEP signals of each subject from 0.5 to 4 s windows with 0.5 s incremental steps. It is capable of taking decisions to improve the accuracy of SSVEP stimulation frequency recognition using the MLR and MsetCCA methods.

Results: Our fuzzy system provides high-accuracy results for the stimulation frequency recognition in signals with the length of 1 s and more. Specifically, the average accuracy of 2 s windows has improved to 100 percent.

Comparison With Existing Methods: The recognition accuracy of the presented system is always better than both MLR and MsetCCA methods.

Conclusion: One of the capabilities of fuzzy systems is that they can use human information and knowledge to build engineering systems. The fuzzy ensemble system can utilize various methods or classifiers simultaneously. The new system has proposed to combine multiple methods using the fuzzy ensemble, which encompasses the benefits of all the subsystems.
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http://dx.doi.org/10.1016/j.jneumeth.2020.108686DOI Listing
May 2020

Design and Fabrication of a Magnetite-based Polymer-supported Hybrid Nanocomposite: A Promising Heterogeneous Catalytic System Utilized in Known Palladium-assisted Coupling Reactions.

Comb Chem High Throughput Screen 2020 ;23(2):119-125

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.

Objective: Herein, a novel heterogeneous catalytic system constructed of iron oxide and palladium nanoparticles is presented. Firstly, a convenient synthetic pathway for the preparation of this catalytic system is introduced, then the application of the fabricated nanocomposite in the Pd-catalyzed C─C coupling reactions is monitored. High reaction yields (98%) have been obtained in short reaction time, by using this catalytic system.

Materials And Methods: Fe3O4/P4VP-Pd catalytic system was fabricated via an in situ method by 4- vinylpyridine (4-VP). In this regard, all the essential structural analyses such as FT-IR, EDX, VSM, and TGA have been performed on the Fe3O4/P4VP-Pd catalytic system to investigate its properties. The spherical morphology of the NPs and their uniform size have also been studied by the SEM method. Further, the reaction progress was controlled by thin-layer chromatography. Finally, NMR analysis was used to identify the synthesized biphenyl pharmaceutical derivatives.

Results: High efficiency of this catalytic system has been precisely investigated and the optimal conditions were determined. The catalytic process is carried out in 20 min, under mild conditions (room temperature). Then, the purification process is easily performed via magnetic separation of the catalyst NPs. After completion of the synthesis reaction, the NPs were collected, washed, and reused several times.

Conclusion: Among recently reported heterogeneous catalytic systems, Fe3O4/P4VP-Pd is recommended due to its high catalytic performance, convenience of the preparation process, excellent biocompatibility, economic benefits, and well reusability. Overall, in order to save time in the complex synthetic processes and also prevent using so many chemical reagents and solvents for the purification process, the presented catalytic system could be suitable for scaling up and applying for the industrial applications.
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http://dx.doi.org/10.2174/1386207323666200128152136DOI Listing
January 2020

Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide.

Nanoscale 2020 Feb 30;12(6):3855-3870. Epub 2020 Jan 30.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd section of South Renmin Road, Chengdu 610041, P.R. China.

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to a cell-penetrating peptide (CPP). Silica-coated iron oxide NPs were produced via a co-deposition method, and coated by a polyvinyl alcohol (PVA) polymeric network via physicochemical binding. Vancomycin (VAN) was then entrapped into this PVA network. A hexapeptide sequence Gly-Ala-Phe-Pro-His-Arg, was synthesized in the solid phase and then conjugated onto the surface of the magnetic NPs. The drug ratio incorporation into the carrier system and drug release were monitored through precise analysis. Confocal microscopy showed that the NPs could be internalized into Staphylococcus aureus and Escherichia coli bacterial cells. The antimicrobial effects of VAN were significantly enhanced by this system with a low dosage of VAN. Advantages include rapid targeted-drug delivery process, drug dose reduction, and equal effects on both Gram-positive and Gram-negative bacteria.
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http://dx.doi.org/10.1039/c9nr09687fDOI Listing
February 2020

Preparation of Carbon-14 Labeled 2-(2-mercaptoacetamido)-3-phenylpropanoic Acid as Metallo-beta-lactamases Inhibitor (MBLI), for Coadministration with Beta-lactam Antibiotics.

Curr Org Synth 2019 ;16(5):765-771

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Aim And Objective: Bacteria could become resistant to β-lactam antibiotics through production of β- lactamase enzymes like metallo-β-lactamase. 2-(2-mercaptoacetamido)-3-phenylpropanoic acid was reported as a model inhibitor for this enzyme. In order to elucidate the mechanism of action in the body's internal environment, preparation of a labeled version of 2-(2-mercaptoacetamido)-3-phenylpropanoic acid finds importance. In this regard, we report a convenient synthetic pathway for preparation of carbon-14 labeled 2-(2- mercaptoacetamido)-3-phenylpropanoic acid.

Materials And Methods: This study was initiated by using non-radioactive materials. Then, necessary characterization was performed after each of the reactions. Finally, the synthesis steps were continued to produce the target labeled product. For labeled products, the process was started from benzoic acid-[carboxyl- 14C] which has been prepared from barium 14C-carbonate. Chromatography column and NMR spectroscopy were used for purifications and identification of desired products, respectively. Barium [14C]carbonate was purchased from Amersham Pharmacia Biotech and was converted to [14C]benzyl bromide. Radioactivity was determined using liquid scintillation spectrometer.

Results: We used [14C]PhCH2Br which was previously prepared from [14C]BaCO3, H2SO4, PhMgI, LAH and HBr, respectively. To neutralize the [14C]phenylalanine in acidic condition and to reach an isoelectric point of phenylalanine (pH = 5.48), Pb(OH)2 was used. Next, thioacetic acid and bromo acetic acid were used to prepare (acetylthio) acetic acid. A peptide coupling reagent was used in this stage to facilitating amide bond formation reaction between [14C]methyl-2-amino-3-phenyl propanoate hydrochloride and (acetylthio) acetic acid.

Conclusion: Carbon-14 labeled 2-(2-mercaptoacetamido)-3-phenylpropanoic acid via radioactive phenylalanine was obtained with overall chemical yield 73% and radioactivity 65.3 nCi. The labeled target product will be used for in vivo pharmacological studies.
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http://dx.doi.org/10.2174/1570179416666190423114704DOI Listing
July 2020

Preparation of a novel magnetic bionanocomposite based on factionalized chitosan by creatine and its application in the synthesis of polyhydroquinoline, 1,4-dyhdropyridine and 1,8-dioxo-decahydroacridine derivatives.

Int J Biol Macromol 2020 Feb 10;144:29-46. Epub 2019 Dec 10.

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran. Electronic address:

In this research, for the first time, novel magnetic chitosan-terephthaloyl-creatine bionanocomposite was successfully designed and synthesized. For this purpose, chitosan bio-polymeric chains were functionalized by synthetic creatine-terephthaloyl chloride ligands. Then, the functionalized polymeric substrate was magnetized by in-situ preparation of FeO magnetic nanoparticles. The characterization of the magnetic bionanocomposite was well accomplished by various spectral and analytical techniques such as FT-IR, EDX, FE-SEM, TEM, XRD, TGA and VSM analysis. Apart from characterizing its specific and unique features, the catalytic efficiency and performance of this new magnetic bionanocomposite were evaluated in symmetric and unsymmetrical Hantzsch condensation reactions. In comparison of conventional catalysts and previous studies, this heterogeneous nanocatalyst with high potential magnetic property and eco-friendly nature can be efficiently applied for one-pot synthesis of polyhydroquinoline, 1,4-dyhdropyridine and 1,8-dioxo-decahydroacridine derivatives in high yields of the product within short reaction times in accordance with green chemistry principals.
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http://dx.doi.org/10.1016/j.ijbiomac.2019.12.059DOI Listing
February 2020

The Effects of Upper Limb Motor Recovery on Submovement Characteristics among the Patients with Stroke: A Meta-Analysis.

PM R 2020 06 27;12(6):589-601. Epub 2020 Jan 27.

Biomedical Engineering Department, Amirkabir University of Technology, Tehran, Iran.

Objective: To evaluate the evidence related to the effect of upper limb motor recovery on submovement characteristics, including duration, amplitude, overlap, interpeak distance, and the number of submovements in stroke patients using a meta-analysis.

Type Of Study: Meta-analysis.

Literature Survey: The literature search was restricted to articles written in English published from inception to October 2018 in Web of Science, PubMed, Science Direct, IEEE Explore, MEDLINE, CDSR, Scopus, Compendex, Wiley Online Library, Springer Link, and REHABDATA.

Methodology: Studies were included if they encompassed adult participants with a clinical diagnosis of stroke who underwent upper limb rehabilitation and if they assessed and reported submovement characteristics as the outcome measures in pre- and posttreatment stages. Changes in submovement characteristics between pre- and postinterventions were compared using the standardized mean difference (SMD). Finally, a test for heterogeneity and publication bias was implemented for all meta-analyses.

Synthesis: Among the 188 retrieved articles, seven of them (one randomized controlled trial, six pre-post) involving 259 patients were selected for meta-analysis. Based on the results, the overall observed changes in all meta-analyses were statistically significant. In total, submovement amplitude (SMD 0.624, 95% confidence interval [CI] [0.356, 0.893]), duration (SMD 0.61, 95% CI [0.332, 0.888]), and overlap (SMD 0.928, 95% CI [0.768, 1.088]) increased whereas interpeak distance (SMD -0.278, 95% CI [-0.42, -0.137]), and the total number of submovements (SMD -0.804, 95% CI [-1.069, -0.538]) decreased.

Conclusions: The submovements appeared to become longer, fewer, and more overlapped with motor recovery. Based on the results, the ability of the neural system to blend submovements increased in both acute/subacute and chronic patients during recovery. Therefore, assessing the submovements during recovery can be a new quantitative measure of motor improvement, providing another means of comparing rehabilitation interventions and individualizing therapy for stroke patients.
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http://dx.doi.org/10.1002/pmrj.12294DOI Listing
June 2020

Recent advances in the application of mesoporous silica-based nanomaterials for bone tissue engineering.

Mater Sci Eng C Mater Biol Appl 2020 Feb 15;107:110267. Epub 2019 Oct 15.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA, 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA. Electronic address:

Silica nanomaterials (SNMs) and their composites have recently been investigated as scaffolds for bone tissue engineering. SNM scaffolds possess the ability to encourage bone cell growth and also allow the simultaneous delivery of biologically active biomolecules that are encapsulated in the mesopores. Their high mechanical strength, low cytotoxicity, ability to stimulate both the proliferation and osteogenic differentiation of progenitor cells make the SNMs appropriate scaffolds. Their physiochemical properties facilitate the cell spreading process, allow easy access to nutrients and help the cell-cell communication process during bone tissue engineering. The ability to deliver small biomolecules, such as dexamethasone, different growth factors, vitamins and mineral ions depends on the morphology, porosity, and crystallinity of SNMs and their composites with other polymeric materials. In this review, the abilities of SNMs to perform as suitable scaffolds for bone tissue engineering are comprehensively discussed.
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http://dx.doi.org/10.1016/j.msec.2019.110267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907012PMC
February 2020

A brief survey on the advanced brain drug administration by nanoscale carriers: With a particular focus on AChE reactivators.

Life Sci 2020 Jan 21;240:117099. Epub 2019 Nov 21.

Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran. Electronic address:

Obviously, delivery of the medications to the brain is more difficult than other tissues due to the existence of a strong obstacle, which is called blood-brain barrier (BBB). Because of the lipophilic nature of this barrier, it would be a complex (and in many cases impossible) process to cross the medications with hydrophilic behavior from BBB and deliver them to the brain. Thus, novel intricate drug-carriers in nano scales have been recently developed and suitably applied for this purpose. One of the most important categories of these hydrophilic medications, are reactivators for acetyl cholinesterase (AChE) enzyme that facilitates the breakdown of acetylcholine (as a neurotransmitter). The AChE function is inhibited by organophosphorus (OP) nerve agents that are extremely used in military conflicts. In this review, the abilities of the nanosized drug delivery systems to perform as suitable vehicles for AChE reactivators are comprehensively discussed.
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http://dx.doi.org/10.1016/j.lfs.2019.117099DOI Listing
January 2020