Publications by authors named "Ali Delpisheh"

100 Publications

Prevalence, comorbidity and predictors of anxiety disorders among children and adolescents.

Asian J Psychiatr 2020 Oct 16;53:102059. Epub 2020 May 16.

Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Childhood anxiety may lead to serious health consequences in later life. The present study provides the prevalence, comorbidity, and predictors of anxiety disorders among children and adolescents. This was a cross-sectional national project that was implemented on 28,698 children and adolescents in Iran. Participants entered the study by multistage cluster sampling with an equal number of each gender and three age groups (6-9, 10-14, and 15-18 years) within each cluster. The tools used in this research were the demographic questionnaire and K-SADS-PL. To analyze the data logistic regression and chi-square tests were used in SPSS (ver. 16). The prevalence of anxiety disorder in children and adolescents was 13.2 in boys and 15.1 in girls. Furthermore, gender, age, place of residence and history of psychiatric hospitalization of parents could predict anxiety disorders. Anxiety disorders had comorbidity with behavioral disorders, neurodevelopmental disorders, mood disorders, psychotic disorders, substance abuse disorders, and elimination disorders. According to our findings in this study, anxiety disorders affect the performance, health and life of children and adolescents, identifying the childhood anxiety, as well as finding diseases that are associated with anxiety disorders, can help in the prevention of the disorder.
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http://dx.doi.org/10.1016/j.ajp.2020.102059DOI Listing
October 2020

Prevalence, comorbidity and predictors of anxiety disorders among children and adolescents.

Asian J Psychiatr 2020 Oct 16;53:102059. Epub 2020 May 16.

Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Childhood anxiety may lead to serious health consequences in later life. The present study provides the prevalence, comorbidity, and predictors of anxiety disorders among children and adolescents. This was a cross-sectional national project that was implemented on 28,698 children and adolescents in Iran. Participants entered the study by multistage cluster sampling with an equal number of each gender and three age groups (6-9, 10-14, and 15-18 years) within each cluster. The tools used in this research were the demographic questionnaire and K-SADS-PL. To analyze the data logistic regression and chi-square tests were used in SPSS (ver. 16). The prevalence of anxiety disorder in children and adolescents was 13.2 in boys and 15.1 in girls. Furthermore, gender, age, place of residence and history of psychiatric hospitalization of parents could predict anxiety disorders. Anxiety disorders had comorbidity with behavioral disorders, neurodevelopmental disorders, mood disorders, psychotic disorders, substance abuse disorders, and elimination disorders. According to our findings in this study, anxiety disorders affect the performance, health and life of children and adolescents, identifying the childhood anxiety, as well as finding diseases that are associated with anxiety disorders, can help in the prevention of the disorder.
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http://dx.doi.org/10.1016/j.ajp.2020.102059DOI Listing
October 2020

Prevalence, comorbidity and predictors of anxiety disorders among children and adolescents.

Asian J Psychiatr 2020 Oct 16;53:102059. Epub 2020 May 16.

Industrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Childhood anxiety may lead to serious health consequences in later life. The present study provides the prevalence, comorbidity, and predictors of anxiety disorders among children and adolescents. This was a cross-sectional national project that was implemented on 28,698 children and adolescents in Iran. Participants entered the study by multistage cluster sampling with an equal number of each gender and three age groups (6-9, 10-14, and 15-18 years) within each cluster. The tools used in this research were the demographic questionnaire and K-SADS-PL. To analyze the data logistic regression and chi-square tests were used in SPSS (ver. 16). The prevalence of anxiety disorder in children and adolescents was 13.2 in boys and 15.1 in girls. Furthermore, gender, age, place of residence and history of psychiatric hospitalization of parents could predict anxiety disorders. Anxiety disorders had comorbidity with behavioral disorders, neurodevelopmental disorders, mood disorders, psychotic disorders, substance abuse disorders, and elimination disorders. According to our findings in this study, anxiety disorders affect the performance, health and life of children and adolescents, identifying the childhood anxiety, as well as finding diseases that are associated with anxiety disorders, can help in the prevention of the disorder.
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http://dx.doi.org/10.1016/j.ajp.2020.102059DOI Listing
October 2020

Prevalence, comorbidities, and sociodemographic predictors of conduct disorder: the national epidemiology of Iranian children and adolescents psychiatric disorders (IRCAP).

Eur Child Adolesc Psychiatry 2020 Oct 6;29(10):1385-1399. Epub 2019 Dec 6.

Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

The aim was to evaluate the lifetime prevalence of conduct disorder according to sociodemographic characteristics, determine the sociodemographic predictors of conduct disorder, and estimate the rates of comorbidities of psychiatric disorders in children and adolescents with conduct disorder by age and gender. The National Epidemiology of Iranian Children and Adolescents Psychiatric Disorders was a cross-sectional, general population-based study on 30,532 children and adolescents aged 6-18 years from all provinces of Iran, which was done using multistage cluster sampling. Iranian citizens aged 6-18 years who resided at least 1 year in each province were included, and children and adolescents with severe physical illnesses that prevented them to participate in the study were excluded. The sample weighting adjustment was used, since we had randomly selected the equal number of 1000 participants of each province from the urban and rural areas. Trained psychologists conducted diagnostic interviews with the adolescents and the children's parents using the Persian version of the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL). In this study, 54 children aged 6-9 years (0.58%, CI 0.47-0.77), 64 adolescents aged 10-14 years (0.57%, CI 0.47-0.77), and 117 adolescents aged 15-18 years (1.22%, CI 0.96-1.44) met the criteria of the lifetime conduct disorder. Conduct disorder was significantly more common in boys than in girls, and was significantly less prevalent among those participants whose fathers had no history of psychiatric hospitalization. Of the participants with conduct disorder, 83.4% met the criteria for at least one other psychiatric disorder. Conduct disorder had a high rate of comorbidity with oppositional defiant disorder (54.89%, CI 48.50-61.12), attention-deficit/hyperactivity disorder (32.34%, CI 26.68-38.56), tobacco use (20.43%, CI 15.77-26.04), and depressive disorders (18.30%, CI 13.88-23.74). Because of using the diagnostic instrument, we found a low total rate of prevalence for conduct disorder; however, higher rates of it were observed among boys and adolescents. Further studies are needed to explore the nature of comorbidities of conduct disorder and to consider them in a large clinical population.
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http://dx.doi.org/10.1007/s00787-019-01448-9DOI Listing
October 2020

Prevalence, correlates and comorbidities of feeding and eating disorders in a nationally representative sample of Iranian children and adolescents.

Int J Eat Disord 2020 03 19;53(3):349-361. Epub 2019 Nov 19.

Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objective: This study investigated the prevalence of feeding and eating disorders, and identified their correlates and comorbidities among children and adolescents.

Method: We used the nationally representative sample of the Iranian Children and Adolescents' Psychiatric disorders (IRCAP) survey, with 30,532 participants randomly selected by a multistage cluster sampling method. We employed the kiddie schedule for affective disorders and schizophrenia-present and lifetime version (K-SADS-PL) semi-structured face-to-face interview to screen for any psychiatric disorders, including feeding and eating disorders, and associated factors. We used multivariate binary logistic regression to analyze the data.

Results: Valid data from 27,111 participants were analyzed. The total prevalence of feeding and eating disorders among children and adolescents was 0.89 (0.81-1.10). In all types of feeding and eating disorders, the adjusted odds ratio was higher among girls (except binge-eating disorder) and older adolescents but was lower among rural residents. The most common psychiatric comorbidities observed in children and adolescents with feeding and eating disorders were obsessive-compulsive disorder (20.2%), agoraphobia (20.2%), depressive disorder (16.4%), social phobia (10.1%), oppositional defiant disorder (10.1%), generalized anxiety disorder (9.4%), attention deficit hyperactivity disorder (7.5%), and conduct disorder (5.7%), which were significantly more common compared to their peers without feeding and eating disorders.

Discussion: Older age, female gender and living in an urban area are predisposing factors in feeding and eating disorders (in binge-eating disorder, the male gender is a positive correlate). We suggest that future works pay attention to the role of gender, comorbidities and predisposing factors.
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http://dx.doi.org/10.1002/eat.23197DOI Listing
March 2020

Angiogenic factors and the risk of preeclampsia: A systematic review and meta-analysis.

Int J Reprod Biomed 2019 Jan 3;17(1). Epub 2019 Mar 3.

Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The etiological nature of preeclampsia is heterogeneous. The use of biomarkers indices in early pregnancy helps to have appropriate stratification of pregnancies into high- and low risk for the purpose of choosing timely interventions.

Objective: The aim of this systematic review was to determine the pathogenic role of soluble soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) in the prediction of preeclampsia in women.

Materials And Methods: We performed a systematic search of the international databases including PubMed, Scopus, and Web of Science until August 2017. The quality of included studies was assessed using the Newcastle-Ottawa Scale. The primary outcome in this review was preeclampsia. The statistical heterogeneity was assessed using the X test and quantified by I . Pooled effects size was obtained by random effects model. Subgroup analyses were also carried out.

Results: Totally, 284 records were identified in the initial search and 15 records were finally included in the meta-analysis. The pooled odds ratios (ORs) for the association between the high level of sFlt-1 and low level of PlGF and subsequent development of preeclampsia among women were 5.20 (95% CI: 1.24-9.16) and 2.53 (95% CI: 1.33-3.75), respectively. The mean difference for sFlt-1 and PlGF in women with preeclampsia compared to controls was 1.15 (95% CI: 0.43-1.86) and -0.94 (95% CI: -1.37-0.52), respectively.

Conclusion: According to the results from this meta-analysis, increased levels of sFlt-1 and reduced levels of PlGF predict the subsequent development of preeclampsia.
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http://dx.doi.org/10.18502/ijrm.v17i1.3815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652157PMC
January 2019

The role of socio-economic inequality in the prevalence of hypertension in adults.

J Cardiovasc Thorac Res 2019 30;11(2):116-120. Epub 2019 Jun 30.

Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.

The large portion of burden of diseases, especially in the developing countries is attributed to hypertension. Identification of the potential risk factors of hypertension is essential for disease management. In this study we investigated the role of socio-economic inequality in the prevalence of hypertension in Ilam Province. Totally, 690 individuals aged over 15 were enrolled in this cross-sectional study, through systematic random sampling from March 1 to October 30, 2017. Socio-economic status (SES) score was calculated by 7 variables including; age, sex, job, marital status, educational level, and economic status, residency, then, it was divided to five levels. Concentration index was used to estimate the inequality in hypertension. To estimate the percentage contribution in final step elasticity divided to concentration index for each contributor and contributions to inequality is estimated. The concentration index for hypertension was -0.154 95% CI (-0.02, -0.23), therefore hypertension was more prevalent in lower socioeconomic groups. The important socioeconomic contributors in inequality were job (=0.008), educational level (=0.005), and SES (=0.003). According to concentration index decomposition, the main sources of inequality in hypertension were job (15%), educational level (18%), and SES (21%), respectively. Hypertension is more prevalent in lower SES groups and the job, education, and SES are important contributory factors of inequality. One substantial key point to achieve an effectiveness approach to deal with chronic diseases might be building partnership with disadvantaged populations.
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http://dx.doi.org/10.15171/jcvtr.2019.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669432PMC
June 2019

Investigation of Risk Factors Associated with Leptospirosis in the North of Iran (2011-2017).

J Res Health Sci 2019 Jun 22;19(2):e00449. Epub 2019 Jun 22.

Mashhad University of Medical Sciences, Mashhad, Iran.

Background: The risk factors for infection with leptospirosis in Iran have never been studied. We aimed to determine the risk factors of leptospirosis and the epidemiological pattern of this disease in Golestan Province, Iran during 2011-2017.

Study Design: A case-control study.

Methods: This case-control study was performed on the population of patients diagnosed with leptospirosis. Controls were selected from the residents of Golestan province, northern Iran and were matched with the cases for gender, age group, and place of residence. After coding the data collected in checklists, the analysis was performed in SPSS using independent t-test, logistic regression, contingency tables, and Fisher exact test.

Results: Eighty-seven cases were diagnosed infected with leptospirosis. Most patients were male (69.0%) and residents of rural areas (82.7%). The three leading risk factors for leptospirosis were exposure to stagnant rice paddy water while having a skin scratch/injury (OR=11.21, 95% CI: 3.02, 43.06), washing the face with stagnant rice paddy water (OR=11.33, 95% CI: 5.12, 25.01), and sighting of rats or rat nest in rice paddies (OR=3.30, 95% CI: 1.01, 11.62).

Conclusion: For farmers working in stagnant and muddy waters of rice paddies, occupational protection measures such as wearing waterproof boots, gloves, support, and socks can reduce the chance of infection with leptospirosis. Health education of the people with susceptible occupations about the transmission and prevention methods can also play a key role in controlling this disease.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183546PMC
June 2019

Risk factors of knee osteoarthritis: A case-control study.

Pak J Med Sci 2019 ;35(3):636-640

Abdorrahim Afkhamzadeh (MD, MPH). Associate Professor of Community Medicine, Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Background And Objective: Knee osteoarthritis is one of the most common rheumatologic problems. To investigate risk factors related to the knee osteoarthritis a case-control study was performed using cases diagnosed in the Community Oriented Program for Control of Rheumatic Diseases (COPCORD) study, stage I.

Methods: Using data from the 2012 COPCORD study, stage-I that was conducted in Sanandaj, northwestern of Iran, we runned a case-control study in 2014-2015. Cases were 700 knee osteoarthritis using American College of Rheumatology (ACR) criteria, frequency matched with 700 healthy controls that were randomly selected from the general population.

Results: In multivariate analysis, statistical significant relation was observed between knee OA and some studied factors such as body mass index (P <0.001), lodging (living in highland vs. plain) (P <0.001), type of used toilet (regular vs. toilet) (P <0.001), history of using high-heeled shoes (>3 cm) (P = 0.005), history of knee Injury (P = 0.04), history of lower limb fracture (P = 0.02), Number of pregnancies (P <0.001) and history of pain and swelling (lasting for one months) (P = 0.04).

Conclusions: Living in highland area, using regular toilet, having knee injury and lower limb fracture in the past were most significant associated factors with occurrence of knee osteoarthritis.
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http://dx.doi.org/10.12669/pjms.35.3.277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572946PMC
January 2019

Prevalence and Correlates of Psychiatric Disorders in a National Survey of Iranian Children and Adolescents.

Iran J Psychiatry 2019 Jan;14(1):1-15

Department of Psychiatry, Oregon Health and Science University, Portland, United States of America.

Considering the impact of rapid sociocultural, political, and economical changes on societies and families, population-based surveys of mental disorders in different communities are needed to describe the magnitude of mental health problems and their disabling effects at the individual, familial, and societal levels. A population-based cross sectional survey (IRCAP project) of 30 532 children and adolescents between 6 and 18 years was conducted in all provinces of Iran using a multistage cluster sampling method. Data were collected by 250 clinical psychologists trained to use the validated Persian version of the semi-structured diagnostic interview Kiddie-Schedule for Affective Disorders and Schizophrenia-PL (K-SADS-PL). In this national epidemiological survey, 6209 out of 30 532 (22.31%) were diagnosed with at least one psychiatric disorder. The anxiety disorders (14.13%) and behavioral disorders (8.3%) had the highest prevalence, while eating disorders (0.13%) and psychotic symptoms (0.26%) had the lowest. The prevalence of psychiatric disorders was significantly lower in girls (OR = 0.85; 95% CI: 0.80-0.90), in those living in the rural area (OR = 0.80; 95% CI: 0.73-0.87), in those aged 15-18 years (OR = 0.92; 95% CI: 0.86-0.99), as well as that was significantly higher in those who had a parent suffering from mental disorders (OR = 1.96; 95% CI: 1.63-2.36 for mother and OR = 1.33; 95% CI: 1.07-1.66 for father) or physical illness (OR = 1.26; 95% CI: 1.17-1.35 for mother and OR = 1.19; 95% CI: 1.10-1.28 for father). About one fifth of Iranian children and adolescents suffer from at least one psychiatric disorder. Therefore, we should give a greater priority to promoting mental health and public health, provide more accessible services and trainings, and reduce barriers to accessing existing services.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505051PMC
January 2019

Diabetes Mortality and Morbidity Trends and Related Risk Factors in Iranian Adults: An Appraisal via Current Data.

J Tehran Heart Cent 2018 Oct;13(4):195-197

Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran. 69311-63545. Tel: +98 9121307577. E-mail:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450814PMC
October 2018

Estimated Incidence Rate of Multiple Sclerosis and Its Relationship with Geographical Factors in Isfahan Province between the Years 2001 and 2014.

Int J Prev Med 2018 21;9:103. Epub 2018 Nov 21.

Department of Epidemiology, Medical University of Ilam, Ilam, Iran.

Background: Multiple sclerosis (MS) is an autoimmune disease associated with inflammation of the central nervous system in humans. This disease is the most common neurological disease, especially in young people. Various factors, including biological, genetic, and environmental factors, are effective on the prevalence of MS disease. This study intends to determine the relationship between geographical factors, and the prevalence of MS disease was performed.

Methods: This ecological study was carried out on 2000 patients with diagnosis of MS during the years 2001-2014 in Isfahan province. All patients' data including age, sex, marital status, year, and location of patients were extracted from the files. Arc geographic information systems version 10.3 software was used for geographical maps, and for statistical analysis of data, SPSS.16 software ANOVA tests, independent -test, and Kruskal-Wallis were used.

Results: Based on recorded cases of MS, the highest and lowest cumulative incidence of diseases was related to the city of Isfahan (75.92 in one hundred thousand) and Aran Bidgol (1.16 in one hundred thousand), respectively. A significant relationship was observed between the incidence and height above sea level ( = 0.001), the average annual rainfall ( = 0.001), and land use ( = 0.001). With increase in the height above sea level and the average annual precipitation, the incidence of disease decreased.

Conclusions: MS disease incidence is high in Isfahan province. The distribution of the disease is not the same in the cities of this province, and some cities have a higher incidence. Furthermore, the incidence of the disease is influenced by geographical factors such as height above sea level, average annual rainfall, and land use. Therefore, it is recommended that relevant authorities by the implementation of screening programs in high-risk areas take action to identify and treat patients in the early stages.
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http://dx.doi.org/10.4103/ijpvm.IJPVM_317_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282481PMC
November 2018

5-year survival rates based on the type of leukemia in Iran, a Meta-analysis.

Caspian J Intern Med 2018 ;9(4):316-324

Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.

Background: According to epidemiological studies, leukemia is among the five most common cancers in Iran. Keeping efforts to estimate survival is critical to monitoring and improving patients' quality of life with leukemia. The purpose of this study was to evaluate the 5-year survival rate of leukemia patients in Iran using meta-analysis method.

Methods: This meta-analysis was carried out according to studies that adhere to inclusion and exclusion criteria during enrolment. The valid Iranian databases included: Medex, Magiran, SID, and Medlib, along with international data bases, namely, Scopus, Pubmed, and ISI were searched to find relevant articles. After determining the heterogeneity between studies, the random effects models were used to estimate pooled survival in leukemia patients.

Results: In total, 18 studies involving 2517 participants were included in this meta-analysis. The pooled 5-year survival rate was 0.56 % (95% CI, 0.54 to 0.58). According to types AML and ALL, the 5-year survival rates in Iran were 35.0 % (95% CI: 32.0-38.0) and 57.0 % (95% CI: 54.0-60.0), respectively.

Conclusion: Based on our findings, slightly less than 50% of leukemia deaths happened in the first 5 years after diagnosis, which is lower than the global average.
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http://dx.doi.org/10.22088/cjim.9.4.316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230465PMC
January 2018

The Relationship Between Human Development Index and Its Components with Thyroid Cancer Incidence and Mortality: Using the Decomposition Approach.

Int J Endocrinol Metab 2018 Oct 20;16(4):e65078. Epub 2018 Oct 20.

Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Background: The link between age specific-rates of thyroid cancer (TC) and human development index (HDI) and also its components can be a new direction for planning by policy makers.

Objectives: This study aimed at identifying the relationship between TC rates by gender, and HDI and its components in different regions of the world.

Methods: An ecological study was conducted; the data was obtained from the GLOBOCAN project in 2012. Inequality in TC estimates (age-specific incidence and mortality rates), according to the HDI and its components was calculated. Concentration index (CI) was used to estimate inequality and CI was decomposed to determine contribution of HDI and its components in inequality.

Results: The inequality index (CI) was 0.29 (95% CI: 0.21 - 0.38) and -0.15 (95% CI: -0.23 - 0.06) for incidence and mortality of TC by HDI, respectively. The important contributors in inequality for incidence rates of TC were life expectancy at birth (0.30), mean years of schooling (0.26), and expected years of schooling (0.18). The important contributors in inequality of mortality rates were mean years of schooling (0.19), expected years of schooling (0.17), and urbanization (0.17).

Conclusions: According to the findings of this study, global inequalities exist in the TC incidence and mortality rates; incidence rates of TC are more concentrated in countries with high HDI, yet inequality index showed that deaths occurred more in disadvantaged countries.
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http://dx.doi.org/10.5812/ijem.65078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218660PMC
October 2018

Spatio-Temporal Study of Gastric Cancer Incidence in Kermanshah Province, Iran During the Years 2009-2014

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2871-2876. Epub 2018 Oct 26.

Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:

Background and objective: Stomach cancer is the second common and the most deadly type of cancer in Iranian populations. The pattern of this cancer varies in different populations; demonstrating association with environmental, racial, and geographical factors. The focus of this study was to identify the clustering and the high-risk and low-risk regions for stomach cancer by using spatio-temporal analysis in Kermanshah province during 2009-2014. Method: All new cases of stomach cancer were studied by census method in 2009 to end 2014 in Kermanshah province. The required information and statistics (address, age, and sex) of patients were extracted from the cancer registry system of Vice-Chancellor in health affairs, Kermanshah University of Medical Sciences. Also, with having the location, diagnosis time, and counting information of all age groups of stomach cancer patients, the spatially and temporally abnormal places of clustering were identified with the use of saTScan and GIS. Results: the total number of stomach cancer subjects during the period of study was 1040, with a mean age of 66.5± 1. in addition, 11 regions (located in 1st, 2nd, and 3rd municipal districts) demonstrated abnormal Spatio-temporal pattern of stomach cancer incidence (hot spots) and clustered disease, with 5 regions (in 4th and 5th districts) representing lower chance of clustering (cold spots, p value˂0.05). Conclusion: Given the growing rate of stomach cancer incidence in specific geographical areas and, its high potential of mortality, and the possible relationship with environmental variables (e.g. climate variables); the efforts need to be focused on the identification of hot/cold spots, the predisposing factors, and the possible clusters in the affected areas.
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291030PMC
October 2018

Spatio-Temporal Study of Gastric Cancer Incidence in Kermanshah Province, Iran During the Years 2009-2014

Asian Pac J Cancer Prev 2018 Oct 26;19(10):2871-2876. Epub 2018 Oct 26.

Faculty of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Email:

Background and objective: Stomach cancer is the second common and the most deadly type of cancer in Iranian populations. The pattern of this cancer varies in different populations; demonstrating association with environmental, racial, and geographical factors. The focus of this study was to identify the clustering and the high-risk and low-risk regions for stomach cancer by using spatio-temporal analysis in Kermanshah province during 2009-2014. Method: All new cases of stomach cancer were studied by census method in 2009 to end 2014 in Kermanshah province. The required information and statistics (address, age, and sex) of patients were extracted from the cancer registry system of Vice-Chancellor in health affairs, Kermanshah University of Medical Sciences. Also, with having the location, diagnosis time, and counting information of all age groups of stomach cancer patients, the spatially and temporally abnormal places of clustering were identified with the use of saTScan and GIS. Results: the total number of stomach cancer subjects during the period of study was 1040, with a mean age of 66.5± 1. in addition, 11 regions (located in 1st, 2nd, and 3rd municipal districts) demonstrated abnormal Spatio-temporal pattern of stomach cancer incidence (hot spots) and clustered disease, with 5 regions (in 4th and 5th districts) representing lower chance of clustering (cold spots, p value˂0.05). Conclusion: Given the growing rate of stomach cancer incidence in specific geographical areas and, its high potential of mortality, and the possible relationship with environmental variables (e.g. climate variables); the efforts need to be focused on the identification of hot/cold spots, the predisposing factors, and the possible clusters in the affected areas.
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291030PMC
October 2018

Total Calcium (Dietary and Supplementary) Intake and Prostate Cancer: a Systematic Review and Meta-Analysis

Asian Pac J Cancer Prev 2018 Jun 25;19(6):1449-1456. Epub 2018 Jun 25.

Faculty of Public Health, Ilam University of Medical Sciences, Ilam,

Background: Controversial results have been reported concerning the influence of calcium intake on prostate cancer risk. The aim of this study was to determine any association between total calcium (in the diet and in supplements) intake and prostate cancer. Materials and Methods: The present systematic review and meta-analysis study was carried out following a PRISMA guidelines. Two reviewers independently using MeSH keywords searched international databases including PubMed, Science Direct, Cochrane, EMBASE, Web of Science, CINAHL, EBSCO and search engines such as Google Scholar. The searches were performed without any time limit until May 2016. The results were pooled using a random effects model and homogeneity was confirmed using the Q test and I2 index. Subgroup analyses was performed according to continents and study designs. The data were analyzed using STATA software version 3.2, with p<0.05 considered significant. Result: Overall, 12 studies with a total sample size of 905,046 were entered into the final meta-analysis. The main age range of the participants was 50 to 70 years. The relative risks (RR) for total calcium with total prostate cancer, localized prostate cancer, and advance prostate cancer were estimated to be 1.15 (95% CI: 1.04-3.46), 1.05 (95% CI: 0.96-1.14), and 1.15 (95% CI: 0.89-1.50), respectively. Only the relationship between total calcium and total prostate cancer was significant (P<0.05). Conclusions: High calcium intake can be considered as a risk factor for total prostate cancer. Therefore, calcium intake might be a target for prevention.
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http://dx.doi.org/10.22034/APJCP.2018.19.6.1449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103569PMC
June 2018

Total Calcium (Dietary and Supplementary) Intake and Prostate Cancer: a Systematic Review and Meta-Analysis

Asian Pac J Cancer Prev 2018 Jun 25;19(6):1449-1456. Epub 2018 Jun 25.

Faculty of Public Health, Ilam University of Medical Sciences, Ilam,

Background: Controversial results have been reported concerning the influence of calcium intake on prostate cancer risk. The aim of this study was to determine any association between total calcium (in the diet and in supplements) intake and prostate cancer. Materials and Methods: The present systematic review and meta-analysis study was carried out following a PRISMA guidelines. Two reviewers independently using MeSH keywords searched international databases including PubMed, Science Direct, Cochrane, EMBASE, Web of Science, CINAHL, EBSCO and search engines such as Google Scholar. The searches were performed without any time limit until May 2016. The results were pooled using a random effects model and homogeneity was confirmed using the Q test and I2 index. Subgroup analyses was performed according to continents and study designs. The data were analyzed using STATA software version 3.2, with p<0.05 considered significant. Result: Overall, 12 studies with a total sample size of 905,046 were entered into the final meta-analysis. The main age range of the participants was 50 to 70 years. The relative risks (RR) for total calcium with total prostate cancer, localized prostate cancer, and advance prostate cancer were estimated to be 1.15 (95% CI: 1.04-3.46), 1.05 (95% CI: 0.96-1.14), and 1.15 (95% CI: 0.89-1.50), respectively. Only the relationship between total calcium and total prostate cancer was significant (P<0.05). Conclusions: High calcium intake can be considered as a risk factor for total prostate cancer. Therefore, calcium intake might be a target for prevention.
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http://dx.doi.org/10.22034/APJCP.2018.19.6.1449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103569PMC
June 2018

Effect of childhood BMI on asthma: a systematic review and meta-analysis of case-control studies.

BMC Pediatr 2018 04 26;18(1):143. Epub 2018 Apr 26.

Department of Pediatrics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Background: Asthma is a multifactorial syndrome that threatens the health of children. Body mass index (BMI) might be one of the potential factors but the evidence is controversial. The aim of this study is to perform a comprehensive meta-analysis to investigate the association between asthma and BMI.

Methods: Electronic databases including, Web of Science, Pubmed, Scopus, Science Direct, ProQuest, up to April 2017, were searched by two researchers independently. The keywords "asthma, body mass index, obesity, overweight, childhood and adolescence" were used. Random and fixed effects models were applied to obtain the overall odds ratios (ORs) and standardized mean difference (SMD). Heterogeneity between the studies was examined using I and Cochrane Q statistics.

Results: After reviewing 2511 articles, 16 studies were eligible for meta-analysis according to inclusion/exclusion criteria. A meta-analysis from 11 case-control studies revealed OR of asthma and overweight as OR = 1.64; (95% Confidence Interval (CI): 1.13-2.38) and from 14 case-control studies, OR for asthma and obesity was OR = 1.92 (95% CI: 1.39-2.65), which indicated that risk of asthma in overweight and obese children and adolescence was significantly higher (1.64 and 1.92 times) than that of individuals with (p-value < 0.01 for underweight/normal weight in both cases). Furthermore, there was a significant relationship between asthma and BMI > 85 percentile according to SMD SMD = 0.21; (95%CI: 0.03-0.38; p-value = 0.021).

Conclusions: The results showed a significant relationship between BMI (obesity/overweight) and asthma among children and adolescents. It is important to study the confounding factors that affect the relationship between asthma and BMI in future epidemiological researches.
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http://dx.doi.org/10.1186/s12887-018-1093-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922016PMC
April 2018

Economic Status Inequality Is a Predictor for Screening and Health Utilization.

Korean J Fam Med 2018 Jan 23;39(1):62-63. Epub 2018 Jan 23.

Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.

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http://dx.doi.org/10.4082/kjfm.2018.39.1.62DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788849PMC
January 2018

Interventional study plan to investigate the training effects on physical and psychological outcomes awareness of smoking in teenagers.

J Educ Health Promot 2017 4;6:99. Epub 2017 Dec 4.

Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Background: Studies have found that nearly 90% of the first use of tobacco takes place before high school graduation (teenagers) and training discussion due to prevention can be useful, therefore, here, we aimed to determine the effects of training on awareness of cigarette outcomes (physical and psychological) in male teenagers.

Materials And Methods: We conducted an interventional study using Solomon's four-group plan, which used a two-stage cluster sampling in four groups (two experimental groups and two control groups). The three sessions of at least 2 h of education intervention including visual displaying using photo, film, and short scientific texts were held for the interventional group. After 1 month, all four groups took posttest, and research groups were followed up after 8 months of intervention. All data were analyzed using one-way analysis of variance and covariance in SPSS.

Results: According to the results, the mean of posttest scores had increased rather than pretest scores, and generally, a significant difference was observed ( ≤ 0.001). These results were significant in the aspect of both physical and psychological outcomes awareness. The difference between the mean of scores in follow-up period and posttest was not statistically significant, and it shows training retention after 8 months ( < 0.666).

Conclusions: It can be concluded that through the training, it is possible to increase the awareness of teenagers about physical and psychological outcomes of cigarette smoking that this can have an important role in smoking prevention.
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http://dx.doi.org/10.4103/jehp.jehp_160_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747224PMC
December 2017

Hearing loss in Iranian thalassemia major patients treated with deferoxamine: A systematic review and meta-analysis.

Caspian J Intern Med 2017 ;8(4):239-249

Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background: Hearing disorders are reported in thalassemia patients treated with deferoxamine. This study aimed to assess hearing loss in Iranian thalassemia major patients treated with deferoxamine.

Methods: This review article was designed based on PRISMA guidelines. To review the literature, two researchers studied national and international databases including Iranmedex, Magiran, Medlib, SID, Scopus, PubMed, Science Direct, Web of Science and Google Scholar without time limit until May 2017. Cochran's Q test and I index were used to assess the heterogeneity of the studies. The data were analyzed using Comprehensive Meta-Analysis software version 2 and p<0.05 was considered significant.

Results: A total of 17 articles involving 1,835 Iranian thalassemia major patients treated with deferoxamine were included in the meta-analysis. The overall prevalence of hearing loss was estimated 27.3% (95% confidence intervals (CI): 19-37.6). The prevalence of sensorineural, conductive and mixed hearing loss was estimated 10.6% (95% CI: 5.7-18.8), 14.6% (95% CI: 10.5-20.6) and 9.1% (95% CI: 5.6-14.6), respectively. No significant differences were noted regarding the relationship hearing loss and mean serum ferritin (P=0.29) and average daily deferoxamine (P=0.30). Meta-regression model showed an increased significance in the prevalence of hearing loss based on the year of studies (p<0.0001).

Conclusions: There is a high prevalence of hearing loss in Iranian thalassemia major patients treated with deferoxamine. Therefore, periodic hearing assessments and regular check-ups after the initiation of chelation therapy are necessary.
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http://dx.doi.org/10.22088/cjim.8.4.239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686301PMC
January 2017

Hearing loss in Iranian thalassemia major patients treated with deferoxamine: A systematic review and meta-analysis.

Caspian J Intern Med 2017 ;8(4):239-249

Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background: Hearing disorders are reported in thalassemia patients treated with deferoxamine. This study aimed to assess hearing loss in Iranian thalassemia major patients treated with deferoxamine.

Methods: This review article was designed based on PRISMA guidelines. To review the literature, two researchers studied national and international databases including Iranmedex, Magiran, Medlib, SID, Scopus, PubMed, Science Direct, Web of Science and Google Scholar without time limit until May 2017. Cochran's Q test and I index were used to assess the heterogeneity of the studies. The data were analyzed using Comprehensive Meta-Analysis software version 2 and p<0.05 was considered significant.

Results: A total of 17 articles involving 1,835 Iranian thalassemia major patients treated with deferoxamine were included in the meta-analysis. The overall prevalence of hearing loss was estimated 27.3% (95% confidence intervals (CI): 19-37.6). The prevalence of sensorineural, conductive and mixed hearing loss was estimated 10.6% (95% CI: 5.7-18.8), 14.6% (95% CI: 10.5-20.6) and 9.1% (95% CI: 5.6-14.6), respectively. No significant differences were noted regarding the relationship hearing loss and mean serum ferritin (P=0.29) and average daily deferoxamine (P=0.30). Meta-regression model showed an increased significance in the prevalence of hearing loss based on the year of studies (p<0.0001).

Conclusions: There is a high prevalence of hearing loss in Iranian thalassemia major patients treated with deferoxamine. Therefore, periodic hearing assessments and regular check-ups after the initiation of chelation therapy are necessary.
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http://dx.doi.org/10.22088/cjim.8.4.239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686301PMC
January 2017

Hearing loss in Iranian thalassemia major patients treated with deferoxamine: A systematic review and meta-analysis.

Caspian J Intern Med 2017 ;8(4):239-249

Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background: Hearing disorders are reported in thalassemia patients treated with deferoxamine. This study aimed to assess hearing loss in Iranian thalassemia major patients treated with deferoxamine.

Methods: This review article was designed based on PRISMA guidelines. To review the literature, two researchers studied national and international databases including Iranmedex, Magiran, Medlib, SID, Scopus, PubMed, Science Direct, Web of Science and Google Scholar without time limit until May 2017. Cochran's Q test and I index were used to assess the heterogeneity of the studies. The data were analyzed using Comprehensive Meta-Analysis software version 2 and p<0.05 was considered significant.

Results: A total of 17 articles involving 1,835 Iranian thalassemia major patients treated with deferoxamine were included in the meta-analysis. The overall prevalence of hearing loss was estimated 27.3% (95% confidence intervals (CI): 19-37.6). The prevalence of sensorineural, conductive and mixed hearing loss was estimated 10.6% (95% CI: 5.7-18.8), 14.6% (95% CI: 10.5-20.6) and 9.1% (95% CI: 5.6-14.6), respectively. No significant differences were noted regarding the relationship hearing loss and mean serum ferritin (P=0.29) and average daily deferoxamine (P=0.30). Meta-regression model showed an increased significance in the prevalence of hearing loss based on the year of studies (p<0.0001).

Conclusions: There is a high prevalence of hearing loss in Iranian thalassemia major patients treated with deferoxamine. Therefore, periodic hearing assessments and regular check-ups after the initiation of chelation therapy are necessary.
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http://dx.doi.org/10.22088/cjim.8.4.239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686301PMC
January 2017

Prevalence of low back pain in Iranian nurses: a systematic review and meta-analysis.

BMC Nurs 2017 11;16:50. Epub 2017 Sep 11.

Department of Biostatistics, Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Background: Low back pain (LBP) as a musculoskeletal disorder is one of the most common occupational injuries in nurses but there isn't any valid measure of the prevalence of LBP in Iranian nursing. In order to increase the power and improve the estimates of the prevalence of LBP in Iranian nurses, a comprehensive meta-analysis was carried out. A summary measure of all studies conducted in this field was found and distributions of LBP were evaluated based on different variables.

Methods: Inclusion criteria included articles with prevalence of LBP in Iranian nurses, who had at least six months of work experience without any trauma, injuries to spine, or any underlying disease. The keywords"prevalence, low back pain, nurses", and "Iran" were used as part of this search. Databases such as Pubmed, Web of Science, Science direct, Scopus, IranMedex, Irandoc, Magiran, SID, CIVILICA, IMEMR and Google scholar were searched up to and including 15 June 2016. For data extraction a form was designed that included the following variables: Author names, province, sample size, age, gender, marital status, work experience, body mass index, job type, smoking status, work schedule, year of publication, type of standard questionnaire, prevalence of LBP, studies' quality score and climate classifications. Data analysis was carried out using fixed and random effects model. Heterogeneity between studies was assessed by using the I and Q tests.

Results: In all 1250 articles were identified and 22 articles with 9347 participants met the inclusion criteria for meta-analyses after filtering. The prevalence of low back pain during their working life and during the last year, was estimated at 63% (95% Confidence Interval (CI): 57.4-68.5) and 61.2% (95% CI: 55.7-66.7) respectively. The prevalence rate of this disorder was 58.7% (95% CI: 35.8-81.7) and 60.4% (95% CI: 52.2-68.6) among men and women respectively. Furthermore, prevalence's of LBP were 59.5% in wards nurses, 50.3% in operating room technicians, and 39.4% in aid nurses.

Conclusions: The results showed the high prevalence of LBP injury in nurses, especially female nurses. The effect of musculoskeletal disorders such as LBP may be reduced by considering proper observation of the principles of ergonomics in the workplace, performing physical examinations on a regular basis, identifying risk factors in the advancement of musculoskeletal disorders and then trying to fix them.
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http://dx.doi.org/10.1186/s12912-017-0243-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594574PMC
September 2017

Effect of prenatal smoking cessation interventions on birth weight: meta-analysis.

J Matern Fetal Neonatal Med 2019 Jan 19;32(2):332-338. Epub 2017 Sep 19.

d Department of Epidemiology , School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , Hamadan , Iran.

Background: Smoking is preventable factor for pregnancy outcomes such as low birth weight (LBW). In this study, we assessed the effects of smoking cessation in pregnancy period on the birth weight in Randomized Controlled Trial studies (RCTs).

Methods: International databases of Pub Med, Scopus, and Web of Science, by the MeSH heading and/or additional terms, were searched to assess relevant studies in systematic possess. I statistics was used to assess of heterogeneity. Pooled effects size was obtained by random effects model. Meta-regression was used to explore of heterogeneity using Stata software version 12 (Stata Corp, College Station, TX).

Results: A total 16 RCTs, 6192 women were enrolled to assess of smoking cessation in pregnancy period on the birth weight. Relative risk (RR) of not smoking at the end of pregnancy in intervention group was 2.47 (95% CI: 1.73-3.20). The odds ratio (OR) for effect of smoking cessation on LBW was 0.65 (95% CI: 0.42-0.88) and standardized mean difference (SMD) was significantly increased in the intervention group, 0.28 (95% CI: 0.05-0.50).

Conclusions: Results of this study approve results of previous RCTs that smoking cessation in pregnancy is a good practical action to prevention of LBW in infants.
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http://dx.doi.org/10.1080/14767058.2017.1378335DOI Listing
January 2019

Effect of prenatal smoking cessation interventions on birth weight: meta-analysis.

J Matern Fetal Neonatal Med 2019 Jan 19;32(2):332-338. Epub 2017 Sep 19.

d Department of Epidemiology , School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , Hamadan , Iran.

Background: Smoking is preventable factor for pregnancy outcomes such as low birth weight (LBW). In this study, we assessed the effects of smoking cessation in pregnancy period on the birth weight in Randomized Controlled Trial studies (RCTs).

Methods: International databases of Pub Med, Scopus, and Web of Science, by the MeSH heading and/or additional terms, were searched to assess relevant studies in systematic possess. I statistics was used to assess of heterogeneity. Pooled effects size was obtained by random effects model. Meta-regression was used to explore of heterogeneity using Stata software version 12 (Stata Corp, College Station, TX).

Results: A total 16 RCTs, 6192 women were enrolled to assess of smoking cessation in pregnancy period on the birth weight. Relative risk (RR) of not smoking at the end of pregnancy in intervention group was 2.47 (95% CI: 1.73-3.20). The odds ratio (OR) for effect of smoking cessation on LBW was 0.65 (95% CI: 0.42-0.88) and standardized mean difference (SMD) was significantly increased in the intervention group, 0.28 (95% CI: 0.05-0.50).

Conclusions: Results of this study approve results of previous RCTs that smoking cessation in pregnancy is a good practical action to prevention of LBW in infants.
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http://dx.doi.org/10.1080/14767058.2017.1378335DOI Listing
January 2019

Effect of prenatal smoking cessation interventions on birth weight: meta-analysis.

J Matern Fetal Neonatal Med 2019 Jan 19;32(2):332-338. Epub 2017 Sep 19.

d Department of Epidemiology , School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , Hamadan , Iran.

Background: Smoking is preventable factor for pregnancy outcomes such as low birth weight (LBW). In this study, we assessed the effects of smoking cessation in pregnancy period on the birth weight in Randomized Controlled Trial studies (RCTs).

Methods: International databases of Pub Med, Scopus, and Web of Science, by the MeSH heading and/or additional terms, were searched to assess relevant studies in systematic possess. I statistics was used to assess of heterogeneity. Pooled effects size was obtained by random effects model. Meta-regression was used to explore of heterogeneity using Stata software version 12 (Stata Corp, College Station, TX).

Results: A total 16 RCTs, 6192 women were enrolled to assess of smoking cessation in pregnancy period on the birth weight. Relative risk (RR) of not smoking at the end of pregnancy in intervention group was 2.47 (95% CI: 1.73-3.20). The odds ratio (OR) for effect of smoking cessation on LBW was 0.65 (95% CI: 0.42-0.88) and standardized mean difference (SMD) was significantly increased in the intervention group, 0.28 (95% CI: 0.05-0.50).

Conclusions: Results of this study approve results of previous RCTs that smoking cessation in pregnancy is a good practical action to prevention of LBW in infants.
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http://dx.doi.org/10.1080/14767058.2017.1378335DOI Listing
January 2019

Effect of prenatal smoking cessation interventions on birth weight: meta-analysis.

J Matern Fetal Neonatal Med 2019 Jan 19;32(2):332-338. Epub 2017 Sep 19.

d Department of Epidemiology , School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran , Hamadan , Iran.

Background: Smoking is preventable factor for pregnancy outcomes such as low birth weight (LBW). In this study, we assessed the effects of smoking cessation in pregnancy period on the birth weight in Randomized Controlled Trial studies (RCTs).

Methods: International databases of Pub Med, Scopus, and Web of Science, by the MeSH heading and/or additional terms, were searched to assess relevant studies in systematic possess. I statistics was used to assess of heterogeneity. Pooled effects size was obtained by random effects model. Meta-regression was used to explore of heterogeneity using Stata software version 12 (Stata Corp, College Station, TX).

Results: A total 16 RCTs, 6192 women were enrolled to assess of smoking cessation in pregnancy period on the birth weight. Relative risk (RR) of not smoking at the end of pregnancy in intervention group was 2.47 (95% CI: 1.73-3.20). The odds ratio (OR) for effect of smoking cessation on LBW was 0.65 (95% CI: 0.42-0.88) and standardized mean difference (SMD) was significantly increased in the intervention group, 0.28 (95% CI: 0.05-0.50).

Conclusions: Results of this study approve results of previous RCTs that smoking cessation in pregnancy is a good practical action to prevention of LBW in infants.
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http://dx.doi.org/10.1080/14767058.2017.1378335DOI Listing
January 2019

Effects of Socio-economic Status Inequality on Health Outcomes.

Arch Iran Med 2017 05;20(5):329

Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.

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May 2017