Publications by authors named "Ali Asadollahi-Amin"

14 Publications

  • Page 1 of 1

Sociodemographic Characteristics, HIV-Related Risk Behaviors and HIV preva-lence of Vulnerable Men in Tehran, Iran.

Curr HIV Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Health Informatics, Graduate School of Medicine, Kyoto University, Kyoto. Japan.

Background: Sexual minorities, such as men who have sex with men (MSM), are dis-proportionately impacted by HIV/AIDS compared to heterosexual men . The increased prevalence of HIV/AIDs among this group of individuals is associated with increased participation in HIV-related risk behavior, such as multiple sexual partnerships and in-jection drug use. However, very little is known about the prevalence of HIV and the risk behaviors related to HIV infection among MSM in Iran. This absence of data is due to the increased discrimination and stigmatization MSM, and other vulnerable popula-tions, face in Iran. This study was conducted to identify HIV-related risks, HIV preva-lence and sociodemographic characteristics of the MSM population in Iran.

Method: A cross-sectional study was conducted among MSM attending the Sexual Health Clinic at Imam Khomeini Hospital in 2018. A sexual health screening question-naire was used to aid in identifying HIV-related risk behaviors. HIV status was deter-mined using an HIV rapid test and confirmed by an ELISA.

Results: One hundred MSM enrolled in this study, from whom 41% aged 18-25 years old. The majorities were single; almost one-third had a diploma degree. Only a fifth were employed, and about a quarter (25%) reported substance abuse. Among eighty-three people (83%) reported having sex during the past three months, and only 27 (27.3%) of participants always used condoms for sex. Among 80 participants tested for HIV, two positive results were detected (2.5%).

Conclusion: Data collected through a sexual health questionnaire indicate that the prevalence of HIV is increased among MSM in Iran. This finding sheds light on the urgent need for the implemenation of social programs providing counseling and healthcare to vulnerable populations in Iran.
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http://dx.doi.org/10.2174/1570162X19666210412114627DOI Listing
April 2021

Infectious Mononucleosis Complicated with Bilateral Peritonsillar Abscess and Splenic Infarction.

Case Rep Infect Dis 2021 12;2021:6623834. Epub 2021 Mar 12.

Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Infectious mononucleosis (IM) due to Epstein-Barr virus (EBV) infection is usually self-limited. It presents with fever, pharyngitis, fatigue, and cervical lymph node enlargement. It is common among adolescents and young adults. Although most patients recovered without any sequelae, rare complications have been reported. We described a 28-year-old man with fever, sore throat, dysphagia, and a positive IgM viral capsid Ag (VCA Ag) for EBV infection. He was admitted and received dexamethasone. He developed bilateral peritonsillar abscess (PTA) and splenic infarction, rare complications of acute EBV infection, two days after discharge. Although early reports noted PTA might occur following dexamethasone administration, recently, no obvious evidence supports it. However, high erythrocyte sedimentation rate level in our patient might indicate bacterial superinfection, which could exacerbate with dexamethasone administration. Several mechanisms such as transient hypercoagulable state and insufficient blood supply due to splenomegaly were proposed for splenic infarction due to EBV infection. Since our patient remained asymptomatic during the disease, IM-associated splenic complications, including splenic infarction, should be kept in mind. Our patient underwent bilateral tonsillectomy and received conservative management for the splenic infarction. These two rare complications of acute EBV infection have not been reported simultaneously yet.
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http://dx.doi.org/10.1155/2021/6623834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979303PMC
March 2021

COVID-19 and Alcohol Misuse: A Case Report.

Infect Disord Drug Targets 2021 Feb 3. Epub 2021 Feb 3.

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences. 0.

In the beginning of 2020, a newly emerged virus, now named SARS-CoV-2, began to spread in China. After four months, it has reached all over the globe, infecting more than 2.5 million people. Currently, there are no proved treatments available. However, in social media, false information about alcohol consumption and its role against the virus is spreading. We described a victim of these false facts who presented with reduced eyesight due to alcohol drinking, a few days later showed symptoms of COVID-19 and, even though treated, lost his eyesight partially. Alcohol taking has no preventive or curing effect on COVID-19 and negatively impacts the body and immune system, which, therefore, should not be considered a treatment for COVID-19 disease.
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http://dx.doi.org/10.2174/1871526521666210203214533DOI Listing
February 2021

Possible role of hypothyroidism in the prognosis of COVID-19.

Intern Med J 2020 11;50(11):1410-1412

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.

In patients with COVID-19, certain medical conditions could result in poorer clinical outcomes. However, the prognostic role of hypothyroidism in COVID-19 is still unknown. In the present retrospective study, we estimated the prevalence of hypothyroidism in COVID-19 admitted patients in Tehran, Iran. Among 390 COVID-19 admitted patients, 21 hypothyroid cases (5.4%) were found, in which nearly 90% were aged 50 years and older. Regarding the effect of hypothyroidism on COVID-19 mortality, 60 (15.3%) of total patients and 4 (19%) of hypothyroid patients died, and no significant difference was found between the two groups.
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http://dx.doi.org/10.1111/imj.15000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753499PMC
November 2020

Postoperative COVID-19 pneumonia in an asymptomatic patient: a case report.

Infect Disord Drug Targets 2020 Nov 11. Epub 2020 Nov 11.

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Postal Code:1419733141, Tehran,. Iran.

The recent outbreak of the coronavirus disease (COVID-19) in China has rapidly spread throughout the world and there are many reports of symptoms ranging from malaise to acute respiratory distress syndrome (ARDS) caused by this in-fection. However, few reports have been discussed surgical outcomes in COVID-19 patients. In this report, we described a case of an elderly female developed with postoperative pulmonary complications after uneventful elective minor surgery. The patient was asymptomatic before the operation with no history of cough or fever. After surgery, the patient developed respiratory distress and chest radiological imaging revealed bilateral ground-glass opacities. It seems any type of surgeries requiring local anesthesia or general anesthesia may contribute to worsening outcomes in patients with covid19.
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http://dx.doi.org/10.2174/1871526520999201111195845DOI Listing
November 2020

An Update to Enterococcal Bacteremia: Epidemiology, Resistance, and Outcome.

Infect Disord Drug Targets 2020 Nov 3. Epub 2020 Nov 3.

Department of Infectious Diseases, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sci-ences, Tehran,. Iran.

Background: An increase in resistant gram-positive cocci, especially enterococci, requires an epidemiologic re-assay and its results may affect empirical treatments for these infections.

Objective: In this study, we investigated the microbial epidemiology and resistance pattern of enterococcal bacteremia.

Methods: This study was a cross-sectional study that investigates all cases of positive blood cultures with Enterococcus spp. at a tertiary referral colligates hospital in Tehran in 2018.

Results: Enterococcus spp. was isolated from blood cultures of a total of 73 patients. The most patients were male 42 (57.7%). The mean age of the patients was 58.8 (±18.8) years. Hospital-acquired infection was the most type of infection involving enterococcal bacteremia (80.8%) comparing with community-acquired (6.7%) and health care-associated (12.3%). Renal failure and cancer were the most underlying disease in E. faecalis and E. faecium, respectively. Mortality for Vanco-mycin-resistant enterococci (VRE) was approximately two times more than the sensitive ones. Between the dead/alive groups, the following items were different significantly (P.Value<0.05): Vancomycin resistance for enterococcus isolated, immunodeficiency as underlying disease, Mechanical ventilation, hospitalization period, and the empiric regimen.

Conclusion: Increased antibiotic-resistant strains, especially Vancomycin-resistant enterococci (VRE), pose a serious threat to the general public, especially hospitalized patients, and increase mortality. Surveillance of microorganisms and antimi-crobial resistance is a crucial part of an efficient health care system.
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http://dx.doi.org/10.2174/1871526520999201103191829DOI Listing
November 2020

Lung Involvement Found on Chest CT Scan in a Pre-Symptomatic Person with SARS-CoV-2 Infection: A Case Report.

Trop Med Infect Dis 2020 Apr 7;5(2). Epub 2020 Apr 7.

Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran 1419733141, Iran.

The novel coronavirus SARS-CoV-2 infection is spreading worldwide, and there are many reports of acute respiratory distress syndrome caused by this infection. However, asymptomatic lung involvement has not been reported. We hereby present the case of a 44-year-old health-care worker, who was found to be infected with the SARS-CoV-2 virus after a CT-scan performed for an unrelated condition revealed a lesion in the lung field compatible with COVID-19 infection. His condition deteriorated initially, but eventually improved with supportive treatment and the compassionate use of antivirals and antimalarials and is now in a stable condition.
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http://dx.doi.org/10.3390/tropicalmed5020056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344491PMC
April 2020

A Lateral Neck Myeloid Sarcoma Presenting as Acute Otitis Externa.

Arch Iran Med 2018 11 1;21(11):544-546. Epub 2018 Nov 1.

Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.

Myeloid sarcoma (MS) is a solid extra-medullary tumor of immature myeloid cells which could occur before, during or after remission of acute leukemia at any site on the body. Owing to variation in differential diagnosis, pathologic evaluation and immunohistochemical staining are essential for definitive diagnosis. Rarely, MS has been shown as an isolated extramedullary relapse (iEMR) after allogeneic stem cell transplantation (allo-SCT), which often does not necessarily result in bone marrow involvement. It seems that despite chemotherapy and graft-versus-leukemia (GVL) effects on bone marrow, leukemic cells could remain alive in the extra-medullary region. However, in order to achieve longer survival, timely diagnosis as well as combined systemic, local, and cellular therapeutic modalities should be considered in any patient with iEMR after allo-SCT. We report a left lateral neck isolated MS presented as acute otitis externa in a patient with prior allo-SCT due to acute myeloid leukemia (AML). Therefore, MS should be considered in patients with any history of acute leukemia even if the patient presents with signs and symptoms of an infectious disease.
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November 2018

Well-tolerated oral cyclosporine in a case of hypersensitivity to parenteral cyclosporine in postallogeneic bone marrow transplantation.

Indian J Pharmacol 2018 Mar-Apr;50(2):94-96

Department of Hematology, Oncology, and Bone Marrow Transplantation, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Cyclosporine is one of the main drugs used for the prophylaxis of graft versus host disease in bone marrow transplanted patients. Hypersensitivity reaction to intravenous cyclosporine is rare and might be due to its vehicle polyoxyethylated castor oil, Cremophor EL. The exact mechanism is unknown, but IgE and IgG antibodies, complement, and histamine release have been considered to play a role in the development of this reaction. Here, we describe a case of anaphylaxis to intravenous cyclosporine, which was developed in a 19-year-old Iranian female with acute myeloid leukemia who underwent allogeneic bone marrow transplantation from her sister. The corn oil-based soft gelatin capsule (Sandimmune) was substituted with no reaction. Our observation along with the previous reports confirms the role of Cremophor EL in hypersensitivity reaction to cyclosporine, according to which, modifying the formulation of the intravenous (IV) form could be the solution for this problem.
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http://dx.doi.org/10.4103/ijp.IJP_99_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044130PMC
December 2018

Photoclinic.

Arch Iran Med 2018 05 1;21(5):226-227. Epub 2018 May 1.

Iranian Research Center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran.

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May 2018

Spontaneous Complete Remission in a Patient with Acute Myeloid Leukemia and Severe Sepsis.

Case Rep Hematol 2017 24;2017:9593750. Epub 2017 Jul 24.

Department of Infectious Disease, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Without treatment, acute myeloid leukemia (AML) is almost always fatal. Spontaneous remission of AML is a rare phenomenon and usually with a short duration. The exact mechanisms are unknown. However, its association with infection and blood transfusions has been described. We report a 53-year-old male who presented with severe sepsis and who was diagnosed with AML (M4). He has experienced complete spontaneous remission with relatively long duration. To the best of our knowledge, it is the first case of spontaneous remission described in Iran.
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http://dx.doi.org/10.1155/2017/9593750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546120PMC
July 2017

Photoclinic.

Arch Iran Med 2017 07;20(7):459-460

Department of Infectious Disease, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

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July 2017

Therapeutic effects of minocycline on mild-to-moderate depression in HIV patients: a double-blind, placebo-controlled, randomized trial.

Int Clin Psychopharmacol 2016 Jan;31(1):20-6

aDepartment of Infectious Diseases, Imam Hospital bPsychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Patients with the HIV infection are at high risk for developing depression. The aim of this study was to investigate the safety and efficacy of antidepressant effects of minocycline on HIV patients with depression. Forty-six HIV patients, with mild-to-moderate depression and a Hamilton Depression Rating Scale (HDRS) up to 18, participated in a parallel, randomized, double-blind, placebo-controlled trial and underwent 6 weeks of treatment with either minocycline (100 mg twice daily) or placebo in the same manner. Patients were assessed using HDRS at baseline and at weeks 3 and 6. The primary outcome measure was to evaluate the efficacy of minocycline in improving depressive symptoms. General linear model repeated measures showed significant effect for time × treatment interaction on the HDRS score during the trial course [F(2, 88)=7.50, P=0.001]. There was no significant difference between the two groups regarding adverse events. No serious adverse event was reported. The administration of 100 mg minocycline twice daily seems to be safe and effective in improving depressive symptoms in HIV/AIDS patients with mild-to-moderate depression.
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http://dx.doi.org/10.1097/YIC.0000000000000098DOI Listing
January 2016