Publications by authors named "Ali Amiri"

45 Publications

mRNA expression of toll-like receptors 3, 7, 8, and 9 in the nasopharyngeal epithelial cells of coronavirus disease 2019 patients.

BMC Infect Dis 2022 May 10;22(1):448. Epub 2022 May 10.

Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Background: The etiopathogenesis of coronavirus disease 2019 (COVID-19) stem partially from the abnormal activation of the innate and adaptive immune systems. Here in the current investigation, the mRNA expression levels of toll-like receptors (TLRs) were evaluated in the nasopharyngeal epithelial cells from COVID-19 patients.

Methods: Epithelial cells were obtained using nasopharyngeal swab samples from 90 COVID-19 patients and 50 controls. COVID-19 cases were classified into those without symptoms, with symptoms but not hospitalized, and with symptoms and hospitalized. To determine the mRNA expression levels of TLRs, first RNA was extracted and cDNA was synthesized, and finally Real-time PCR was exerted.

Results: It was seen that the transcript levels of TLR3, TLR7, TLR8, and TLR9 were overexpressed in the COVID-19 patients with clinical symptoms needing hospitalization as well as in those with clinical symptoms without needing for hospitalization compared to controls. Upregulation of TLRs was associated with clinical presentations of the patients.

Conclusions: Modulation of TLR3, TLR7, TLR8, TLR9 in the epithelial cells of COVID-19 cases may estimate the disease severity and requirement for hospitalization.
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http://dx.doi.org/10.1186/s12879-022-07437-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086663PMC
May 2022

Evaluating the efficacy of extracted squalene from seed oil in the form of microemulsion for the treatment of COVID-19: A clinical study.

J Med Virol 2022 01 26;94(1):119-130. Epub 2021 Aug 26.

Emergency Medicine Department, Birjand University of Medical Sciences, Birjand, Iran.

This study investigates the effect of the nanostructure of squalene in the form of microemulsion on COVID-19 patients. In this blinded clinical trial, a comparison was made between the efficacy of squalene treatment and controls. A total of 30 COVID-19 patients admitted to the emergency department, and the infection ward was equally allocated to case (n = 15) and control (n = 15) groups according to their age and underlying diseases. The baseline characteristics of subjects, including age, gender, time of treatment onset, underlying condition, white blood cells count, and lymphocyte count were similar (p < 0.05). Baseline laboratory tests and computed tomography (CT) scans were performed for the study groups. The treatment group received 5 mg of intravenous squalene twice a day and standard treatment for 6 days, while controls received only standard treatment. After 6 days of treatment, clinical and CT scan changes were evaluated and compared in intervention and control groups. The need for oxygen therapy (p = 0.020), 2 days of no fever (p = 0.025), cough alleviation (p = 0.010), and lung high-resolution computed tomography improvement (p = 0.033) were significantly different between cases and controls within 7 days of admission. No adverse effects were observed in the treatment group. Our data suggest that squalene could be considered as a potential treatment for COVID-19, and further studies are required to confirm the results.
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http://dx.doi.org/10.1002/jmv.27273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427120PMC
January 2022

Evaluation of antimicrobial properties of nano-silver particles used in orthodontics fixed retainer composites: an experimental in-vitro study.

J Dent Res Dent Clin Dent Prospects 2021 5;15(2):87-93. Epub 2021 May 5.

Department of Orthodontics, Dentistry Faculty, Tehran university of Medical Sciences, Tehran, Iran.

The present study evaluated the antimicrobial efficacy of composite resins containing nano-silver (NAg) particles used in fixed orthodontic retainers. Nano-composite resin samples with 1%, 2%, and 5% concentrations of NAg were prepared. The antimicrobial effectiveness of NAg was assessed against , , and by the biofilm inhibition test (three-day-old biofilms), eluted components test (on days 3, 15, and 30), and disk-diffusion agar test after 48 hours. Measures of central tendency and index of dispersion were used to determine colony-forming units. Kruskal-Wallis test and Mann-Whitney U test were also used. The biofilm inhibition test showed a significant decrease in the colonies of (87.64%, 96.47%, and 99.76% decrease), (98.13%, 99.47%, and 99.93% decrease), and (81.59%, 90.90%, and 99.61% decrease) at 1%, 2%, and 5% concentrations of Nag, respectively, compared to the control groups. The colony-forming unit (CFU)/mL of tested microorganisms continuously decreased with increased NAg concentration. In the eluted component test, no significant differences were noted in the 3rd, 15th, and 30th days between the different concentrations of Nag-containing composite resin disks and control samples. According to the disk-diffusion agar test, there was no growth inhibition zone for the composite resin disks containing 1% and 2% concentrations of Nag. However, the growth inhibition zone was seen with a 5% concentration, with a diameter of 9.5±0.71 mm for , 8.5±0.71 mm for , and 8±1.41 for . The incorporation of NAg into composite resins has antibacterial effects, possibly preventing dental caries around fixed orthodontic retainers.
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http://dx.doi.org/10.34172/joddd.2021.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346710PMC
May 2021

Chemotherapy-induced toxicity in patients with testicular germ cell tumors: The impact of physical fitness and regular exercise.

Andrology 2021 11 19;9(6):1879-1892. Epub 2021 Jul 19.

Department of Metabolic Disease Research & Center of Physical Activity Research, Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.

Background: Testicular germ cell tumors (TGCTs) represent ∼95% of testicular malignancies and are the most common type of malignancy in young male adults. While the incidence of TGCTs has increased during the last decades, the advances in treatment, namely introducing cisplatin into the chemotherapy regimen, have made TGCTs highly curable with the 10-year survival rate exceeding 95%. However, in parallel with increased cure rates, survivors may experience acute and late adverse effects of treatment, which increase morbidity, reduce the quality of life, and can be potentially life-threatening. Chemotherapy-related toxicities include cardiovascular and metabolic diseases, secondary cancer, avascular necrosis, cognitive impairment, cancer-related fatigue, poor mental health-related quality of life, nephrotoxicity, hypogonadism, neurotoxicity, pulmonary toxicity, anxiety, and depression. These treatment-related adverse effects have emerged as important survivorship dilemmas in TGCT cancer survivors. Recently, regular physical exercise has increasingly attracted research and clinical attention as an adjunct therapy for cancer patients.

Purpose: Herein, we review the most common chemotherapy-related adverse effects in TGCT survivors and clinical relevance of exercise and increased cardio-respiratory fitness in modulating chemotherapy-related toxicity and quality of life in this population.

Results And Conclusion: Exercise has positive effects on a spectrum of physical and psychosocial outcomes during and after cancer treatment, and current guidelines on exercise prescription in chronic diseases define the recommended dose (volume and intensity) of regular exercise for cancer survivors, highlighting regular, sufficiently intensive physical activity as an essential part of patients' care.
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http://dx.doi.org/10.1111/andr.13078DOI Listing
November 2021

Short-term memory impairment in patients undergoing general anesthesia and its contributing factors.

Saudi J Anaesth 2020 Oct-Dec;14(4):454-458. Epub 2020 Sep 24.

Department of Anesthesiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Background: Short-term memory disorder following surgery and anesthesia is a common complication of anesthesia and a common complaint of the patients.

Aims: This study was designed to assess memory impairment in patients undergoing elective surgery, investigate the effect of general anesthesia (GA) on memory, and identify the factors contributing to it, as well as the specific effect of anesthesia on each of the memory domains.

Setting And Design: This cross-sectional study was performed in a university hospital.

Methods And Materials: Patients with the American Society of Anesthesiologists (ASA) Class I, II, and III who were candidates for elective abdominal surgery were enrolled. Patients answered several questions based on the Wechsler Memory Scale-Revised V (WMS-R-V), a standardized questionnaire, minutes before entering the operating room (OR) and again after 24 h postoperation, and the differences were recorded.

Statistical Analysis: Analysis was performed using T-independent and Chi-square tests with Pearson's coefficient and Fischer's exact test and Man-Whitney test. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) software.

Results: Four hundred patients (198 females and 202 males) with a mean age of 50.75 years were enrolled in our study. Our study results showed that short-term memory after GA was significantly decreased compared with preanesthesia ( < 0.05). There was no significant relationship between memory disorder following GA and gender ( = 0.18) or comorbidities ( = 0.138). However, older age was found to be a contributing factor to memory loss following GA ( < 0.001). The highest and lowest effect of GA were found on the number repeat (45.2%) and personal information (16.2%) domain of the memory.

Conclusion: GA significantly reduces the patient's short-term memory after the surgery.
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http://dx.doi.org/10.4103/sja.SJA_651_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796728PMC
September 2020

Atomic force microscopy studies of enamel, inner enamel, dentin, and cementum in canine teeth.

Microsc Res Tech 2021 Jun 6;84(6):1098-1105. Epub 2021 Jan 6.

Institute of Continuous Media Mechanics UB RAS, Perm, Russia.

The main goal of the present work is to explore the three dimensional (3-D) atomic force microscopy (AFM) images of human teeth and investigating their micromorphology. For this purpose, 10 fresh and permanent canine teeth were selected from a group of 40-year-old men who were candidate for the experimental processes. Afterward, they were all applied for studying the morphology of their hard tissues. The tapping mode of AFM was used to characterize the surface micromorphology on the square areas of 1 μm × 1 μm (512 × 512 pts). AFM results and surface stereometric analysis indicate the relationships between the micromorphology of the surface and the structural properties of these tissues across the length scales. As can be seen, the surface of cementum has the most irregular topography (D = 2.87 ± 0.01) while the most regular topography (D = 2.43 ± 0.01) is found in dentin. Furthermore, the more and less regularity of the surface have been found in inner enamel (Sq = 26.26 nm) and dentin (Sq = 41.28 nm), respectively. Stereometric and fractal analyses give valuable information about human canine teeth via 3-D micromorphology.
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http://dx.doi.org/10.1002/jemt.23668DOI Listing
June 2021

The Effect of Ergonomic Latex Pillow on Head and Neck Posture and Muscle Endurance in Patients With Cervical Spondylosis: A Randomized Controlled Trial.

J Chiropr Med 2019 Sep 21;18(3):155-162. Epub 2020 Aug 21.

Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Tehran, Iran.

Objectives: Cervical pillows have frequently been reported to attenuate the symptoms of pain and disability. Although the main role of pillows is to optimize head and neck posture and relax the neck muscles, limited studies have examined the effectiveness of pillows from aspects beyond subjective outcome measures, especially their effect on head and neck posture and muscle performance. This study examines the effect of ergonomic latex pillow on the craniovertebral (CV) angle and cervical flexor and extensor muscle endurance in patients with cervical spondylosis.

Methods: This parallel-group, randomized, controlled trial was conducted from January to June 2017. The patients with cervical spondylosis were randomly allocated to the experimental and control groups, who both received identical standard physiotherapy 3 × a week for 4 weeks. The experimental group received an ergonomic latex pillow, but the control group was asked to continue sleeping on their usual pillow. The CV angle and flexor and extensor muscle endurance were measured before and after the intervention. The independent-sample test was used to compare changes in the CV angle, whereas the Mann-Whitney test was used to compare changes in flexor and extensor muscle endurance between the groups, respectively.

Results: The experimental group showed significant changes in the CV angle and extensor muscle endurance. A significant increase was observed in extensor muscle endurance in the experimental group compared with the control group.

Conclusion: The ergonomic latex pillow may affect neck extensor muscle endurance and CV angle in patients with cervical spondylosis, although further studies are needed before any recommendations.
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http://dx.doi.org/10.1016/j.jcm.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452254PMC
September 2019

Fatigue effects on the viscoelastic behavior of men and women in a landing task: a Mass-Spring-Damper modeling approach.

Comput Methods Biomech Biomed Engin 2020 Aug 17;23(10):564-570. Epub 2020 Jun 17.

Department of Physiotherapy and Iranian Center of Excellence in Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

The aim of this study was to compare the fatigue effect on the viscoelastic behavior of the musculoskeletal system between the two sexes in a landing task. Stiffness and shock absorption capacity were studied from ground reaction force data using a mass-spring-damper model. A parametric simulation was also performed to demonstrate the effect of different values of model parameters on the vertical ground reaction force. Following fatigue, the shock absorption capacity reduced in men. According to the parametric simulation, this reduction can result in lower rate of force development which may make men less susceptible to impact injuries than women.
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http://dx.doi.org/10.1080/10255842.2020.1749271DOI Listing
August 2020

Comparative study of muscle energy technique, craniosacral therapy, and sensorimotor training effects on postural control in patients with nonspecific chronic low back pain.

J Family Med Prim Care 2020 Feb 28;9(2):978-984. Epub 2020 Feb 28.

Department of Health Psychology, University of Leuven, Leuven, Belgium.

Background: Malalignment in the pelvic and spinal column disturbs the balance and decreases the postural control ability. Malalignment is known as one of the main causes of back pain particularly the nonspecific chronic low back pain (NSCLBP). The aim of the study is to compare the effect of muscle energy technique (MET), craniosacral therapy (CST), and sensorimotor training (SMT) on postural control in patients with NSCLBP.

Materials And Methods: In this randomized clinical trial study, 45 NSCLBP patients were accidentally allocated in three groups including CST ( = 15), MET ( = 15), and SMT ( = 15). Clinical interventions including CST, MET, and SMT were performed in 10 sessions in 5 weeks (2 sessions per week). The parameters of center of pressure (COP) were assessed in 8 positions such as standing position on double or single leg with open or closed eyes or half squat position on double or single leg with open or closed eyes.

Results: The results of this study showed that all three methods of CST, MET, and SMT are effective in postural control in patients with NSCLBP, although it seems that CST is effective on more balance factors. CST has a greater effect on balance in standing position on a single leg with closed eye. It was also found that the effect of CST was continuous after follow-up.

Conclusion: Moreover, MET and SMT methods were effective in balance control in NSCLBP patients and postural control was more affected by CST.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_849_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113991PMC
February 2020

The effect of soft tissue manipulation and rest on knee extensor muscles fatigue: Do torque parameters and induced perception following muscle fatigue have enough reliability?

J Family Med Prim Care 2020 Feb 28;9(2):950-956. Epub 2020 Feb 28.

Department of Physiotherapy, School of Rehabilitation, Iran University of Medical Sciences, Tehran, Iran.

Background: Muscle fatigue affects the precision of the subjects' performance and limits the range of physical and sports activities. There is limited scientific evidence to support the use of soft tissue manipulation for enhancing muscle performance and its recovery. The aim of this study is to compare the effects of soft tissue manipulation and rest on the knee extensor muscle fatigue after maximal isokinetic contractions.

Methods: Fifteen healthy females 20-30 years of age were selected for this research. This study implemented a semi-experimental test-retest measurement method. The subjects then either rested or received soft tissue manipulation on the knee extensors for a duration of 15 min. After intervention (soft tissue manipulation or rest), the parameters were evaluated for the third time.

Results: The stability of the average of peak torque (APT), average power (AP), and visual analog scale (VAS) before performing fatigue protocol was 85%, 83%, and 31.9%, respectively. The stability after fatigue was 43%, 50%, and 93%, respectively. After maximal fatigue and a decrease in torque output to below 50% maximal torque, 15 min of soft tissue manipulation could change the APT after fatigue from a mean of 58.3 (nm) to 91.5 (nm), the AP from 39.4 to 63.6 (nm/s), and the VAS, from 90.0 to 12 (mm). But 15 min of rest could change the APT from 52.5 to 68.1 (nm), the AP from 37.6 to 48 (nm/s), and the VAS from 90.0 to 27.3 (mm).

Conclusion: The study showed that soft tissue manipulation was more effective than rest as a strategy to return muscles to a normal state and caused more relief in perceived fatigue.
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http://dx.doi.org/10.4103/jfmpc.jfmpc_838_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114034PMC
February 2020

Inflammatory Microenvironment of Acute Myocardial Infarction Prevents Regeneration of Heart with Stem Cells Therapy.

Cell Physiol Biochem 2019 ;53(5):887-909

International Stem Cell Academy, Cologne/Düsseldorf, Germany,

Over the past years, the benefits of stem cell therapy approach for treatment of the cardiovascular diseases have been shown through the rebuilding of new cardiomyocytes and blood vessels. while a successful regeneration of the myocardium has been proven on the animal models of acute myocardial injuries resulted from the stem cells transplantation, no significant long-term regenerative with autologous stem cell therapy in patients with acute myocardial infarction have been reported based on recent meta-analyses. It seems that the inflammatory microenvironment of acute myocardial infarction has an inhibitory effect on the stem cells potential for regenerating the injured myocardium. Secretion of critical cytokines with pro-inflammatory properties including tumor necrosis factor-α, interleukin-1β, and interleukin-6 as well as induction of hypoxic condition and finally formation of cytotoxic elements cause the cellular death and hinder the stem cells proliferation and differentiation. Based on the evidence, application of some approaches like co-delivery of mesenchymal stem cells with the other useful cells, using the stem cells derived productions, administration of preconditioned and modified cells, and also using the anti-inflammatory agents besides the cell therapy are hypothesized as the primary developed safe and practical approaches for decreasing destructive effects of the inflammation on the implanted stem/progenitor cells. In this review, we critically discuss the quiddity of the inflammatory microenvironment and its promoted mechanisms as the main elements to hinder the efficacy of stem cell therapy in the cases of acute myocardial infarction. Also, we finally propose some applied solutions to the problem of cardiac regeneration with stem cells therapy.
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http://dx.doi.org/10.33594/000000180DOI Listing
November 2019

The Correlation between Trabecular Bone Score and Lumbar Spine Bone Mineral Density in Patients with Normal and High Body Mass Index.

Iran J Med Sci 2019 Sep;44(5):374-381

Department of Radiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Trabecular bone score (TBS) measures the underlying quality of bone texture using dual-energy X-ray absorptiometry (DXA) images. The present study aimed to investigate the correlation between lumbar spine bone mineral density (BMD) and TBS, and subsequently determine whether the association varies with the body mass index (BMI).

Methods: Data from 548 patients were collected and categorized into three groups according to the relationship between BMD and age. BMD of the lumbar spine (LS) using DXA and TBS from DXA images were measured. Pearson's correlation coefficient (SPSS software, version 24.0) was used to investigate the association between LS-BMD and TBS, as well as the effect of BMI and age on these parameters. P<0.05 was considered statistically significant.

Results: The total mean TBS was 1.31±0.12. LS-BMD and TBS values significantly decreased with age in both sexes. A statistically significant correlation was found between TBS and LS-BMD (r=0.601). An increase in BMI was associated with a higher LS-BMD score and a lower TBS level. The correlation coefficient between LS-BMD and TBS reduced as the BMI increased. By comparing TBS with BMD, the majority of the patients with osteopenia and osteoporosis had fully degraded and partially degraded TBS, respectively.

Conclusion: TBS was positively correlated with LS-BMD and decreased with age. Moreover, the extent of the correlation varied with respect to BMI.
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http://dx.doi.org/10.30476/IJMS.2019.45413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754535PMC
September 2019

Proprioception in stress urinary incontinence: A narrative review.

Med J Islam Repub Iran 2019 25;33:60. Epub 2019 Jun 25.

Department of Basic Rehabilitation Sciences, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Urinary incontinence (UI) is more common than any other chronic disease. Stress urinary incontinence (SUI), among the various forms of urinary incontinence, is the most prevalent (50%) type of this condition. Female urinary continence is maintained through an integrated function of pelvic floor muscles (PFMs), fascial structures, nerves, supporting ligaments, and the vagina. In women with SUI, the postural activity of the PFMs is delayed and the balance ability is decreased. Many women, by learning the correct timing of a pelvic floor contraction during a cough, are able to eliminate consequent SUI. Timing is an important function of motor coordination and could be affected by proprioception. This study was conducted to review and outline the literature on proprioception as a contributory factor in SUI. PubMed, Scopus, and Google Scholar databases were systematically searched from 1998 to 2017 for articles on the topic of pathophysiology, motor control alterations, and proprioception role in women with SUI. A total of 6 articles addressed the importance of proprioception in motor control and its alterations in women with SUI. There were also publications on postural control, balance, and timing alterations in women with SUI in the literature. However, there was no research on measuring proprioception in the pelvic floor in this group. Both the strength of the PFMs and the contraction timing and proprioception are important factors in maintaining continence. Thus, conducting research on PFMs proprioception in women with SUI, as a cause of incontinence, is encouraged.
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http://dx.doi.org/10.34171/mjiri.33.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708112PMC
June 2019

Effects of Different Frequencies of Whole Body Vibration on Repositioning Error in Patients With Chronic Low Back Pain in Different Angles of Lumbar Flexion.

J Manipulative Physiol Ther 2019 05 26;42(4):227-236. Epub 2019 Jun 26.

Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences and Health Services, Tehran, Iran.

Objective: This study aimed to evaluate the effect of high and low frequency of whole body vibration (WBV) on repositioning error in 3 different angles of lumbar flexion in patients with chronic low back pain.

Methods: Twenty-four participants with chronic low back pain, aged between 20 and 35 years, were included in this randomized crossover trial study. Participants were randomly assigned into 2 groups as follows: (1) low frequency/high frequency, and (2) high frequency/low frequency. Participants received high-frequency (50 Hz) and low-frequency (30 Hz) WBV in a semi-squat position for 5 minutes in 2 sessions, with 2 weeks of rest. Before and after the WBV, lumbar repositioning error in 30% and 60% of lumbar full flexion and neutral position with eyes closed when standing was evaluated using an electrogoniometer.

Results: The repositioning error was decreased in neutral, 30%, and 60% of lumbar flexion after the low-frequency and high-frequency WBV. Post hoc testing revealed that the effect of angle was not significant in repositioning error changes between high-frequency and low-frequency WBV (P > .05). However, the effect of low-frequency WBV on the repositioning error was significantly higher compared with high-frequency WBV (P < .05).

Conclusion: Low-frequency WBV might induce more improvement in the accuracy of lumbopelvic repositioning compared with high-frequency WBV with the method of WBV used in this study.
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http://dx.doi.org/10.1016/j.jmpt.2018.11.006DOI Listing
May 2019

Short-term leachability of salts from Atriplex-derived biochars.

Sci Total Environ 2019 Oct 19;688:701-707. Epub 2019 Jun 19.

Chemical & Materials Engineering, New Mexico State University, PO Box 30001 MSC 3805, Las Cruces, NM 88003, USA. Electronic address:

Disposal of concentrate from brackish water desalination is limited by concerns of salt leaching into fresh water sources. Prevention of salt from leaching can greatly increase desalination concentrate management costs, as there are few options to recover those costs. An option for concentrate disposal is to grow halophyte crops using the concentrate as irrigation water. The purpose of this study was to determine how much of the Ca, Mg, Na, and K taken up by Atriplex species during growth can be stabilized by pyrolysis, thus preventing those cations from returning into the soil solution after harvest. Results show that salts in the biomass are concentrated into the biochars and that pyrolysis conditions affect the amount of salt that can be leached with water. Ca was the most retained of the cations: 100% and 94% were retained in A. canescens biochars and A. lentiformis 600 °C biochar, respectively. Mg retention was similar: 100% and 93% retained for A. canescens and A. lentiformis 600 °C biochars, respectively. Increasing pyrolysis temperature increased the retention of Ca and Mg; trends for K and Na were inconsistent. Soil application of these biochars will still be problematic due to low retention of Na against short-term leaching, thus limiting the potential for on-site sequestration to enable land utilization for crop production. With more understanding of the salt formation and retention mechanisms within biomass, higher amounts of salt might be sequestered longer, while taking advantage of the carbon sequestration and soil quality benefits of biochars.
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http://dx.doi.org/10.1016/j.scitotenv.2019.06.273DOI Listing
October 2019

Association and in silico investigations of miR-302c insertion/deletion variant as a novel biomarker with susceptibility to gastric cancer.

J Cell Biochem 2019 11 20;120(11):18946-18955. Epub 2019 Jun 20.

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Gastric cancer (GC) is the fifth most prevalent malignant tumor and the third most frequent cause of cancer mortality worldwide. rs199971565 is an insertion/deletion (INDEL) located in microRNA-302c (miR-302c) seed site, which may affect its function and biogenesis. There is no genetic association study investigating this INDEL with any disease till now. Thus, the current study was conducted to investigate the association of rs199971565 with susceptibility to GC in an Iranian population. In addition, in silico studies were performed to reveal the possible functional significance of this INDEL. A total of 378 subjects were genotyped through amplification refractory mutation system PCR (ARMS-PCR) after DNA extraction from peripheral blood by the salting out procedure. Also, in silico analyses were performed through databases and web tools including MiRNASNP V2.0, miRWalk V2.0, miRTarBase, DAVID V6.8, RNAfold, PHDcleave, miRmap, and STarMir. Results revealed that there was an association between rs199971565 and the incidence risk of GC under a recessive (P = .04, odds ratio [OR] = 18.73; 95% confidence interval [CI] = 1.07-326.95) model of inheritance. Also, compared to the Ins allele, the Del allele significantly increased the risk of GC (P = .01, OR = 2.02; 95% CI = 1.11-3.66). Further analyses showed no significant association in age and sex between two study groups (P = .216 and P = .798, respectively). In conclusion, for the first time, this study indicated the association and in silico investigations of rs199971565 and suggested it as a novel INDEL biomarker located in the seed site of miR-302c, which may have crucial roles in the susceptibility to GC and its incidence risk.
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http://dx.doi.org/10.1002/jcb.29215DOI Listing
November 2019

The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian People

Asian Pac J Cancer Prev 2019 May 25;20(5):1503-1509. Epub 2019 May 25.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: The GSTP1 gene, which is located on chromosome 11q13, consists of 7 exons and 6 introns. There are two polymorphisms in GSTP1 that have been exposed to a transposition for codon 105 (Ile/Val) and 114 (Ala/Val) in exons 5 and 6, which have been studied previously in relation to lung cancer. Since the level of GSTP1 expression in lung tissues and other human epithelial tissues is high, GSTP1Val-105 polymorphism is recognized as a sensitive factor for tobacco-related cancers, especially lung cancer. Methods: One hundred and twenty tissue block samples of patients with lung cancers and 120 peripheral blood samples of the control group were obtained from two referral cancer centers in Tehran, Iran, from 2011 to 2016. Genomic DNA was extracted from tissue blocks and buffy coat of study cases to detect SNP of GSTP1 gene using Tetra-primer ARMS-PCR. Results: There was a notable correlation between the incidence of lung cancer and variant Val105 (P-value=0.001; OR=2/6; 95% CI=1.49-4.53) and Ile105 (P-value=0.003; OR=0.41; 95% CI=0.23-0.73). The odds ratio for lung cancer in the homozygous Ile105/Ile105 genotype was 3.56 times higher than that of individual with heterozygous Ile105/Val105 (P-value<0.001; OR=3/56; 95% CI=1.826-6.934) genotype, that was statistically significant. Furthermore, the results showed that there was no significant correlation between Ala114/Val114 genotypes and lung cancer. The BC (P-value=0.007; OR=0.16; 95% CI=0.04-0.61) and AA (P=0.001) genotypes were statistically significant (P-value <0.05); and for those who had AA genotype, the odds ratio was almost six times higher than those with BC genotype. Conclusions: The study of GSTP1 polymorphisms indicated that unlike the polymorphism in exon 5, the GSTP1 exon 6 polymorphism correlated with the lung cancer risk in the select group of Iranian people. Likewise, the potential use of this genetic polymorphism as a lung cancer predictor is confirmed.
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http://dx.doi.org/10.31557/APJCP.2019.20.5.1503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857866PMC
May 2019

A Comparison between the Ability of Revised Trauma Score and Kampala Trauma Score in Predicting Mortality; a Meta-Analysis.

Arch Acad Emerg Med 2019 15;7(1):e6. Epub 2019 Jan 15.

Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Introduction: Describing injury severity in trauma patients is vital. In some recent articles the Revised Trauma Score (RTS) and Kampala Trauma Score (KTS) have been suggested as easily performed and feasible triage tools which can be used in resource-limited settings. The present meta-analysis was performed to evaluate and compare the accuracy of the RTS and KTS in predicting mortality in low-and middle income countries (LMICs).

Methods: Two investigators searched the Web of Science, Embase, and Medline databases and the articles which their exact number of true-positive, true-negative, false-positive, and false-negative results could be extracted were selected. Sensitivity and subgroup analysis were performed using Stata software version 14 to determine the factor(s) affecting the accuracy of the RTS and KTS in predicting mortality and source(s) of heterogeneity.

Results: The heterogeneity was high (I2 > 80%) among 11 relevant studies (total n = 20,631). While the sensitivity of the KTS (0.88) was slightly higher than RTS (0.82), the specificity, diagnostic odds ratio, negative likelihood ratio, and positive likelihood ratio of the KTS (0.73, 20, 0.16, 3.30, respectively) were lower than those of the RTS (0.91, 45, 0.20, 8.90, respectively). The area under the summary-receiver operator characteristic curve for KTS and RTS was 0.88 and 0.93, respectively.

Conclusion: However, regarding accuracy and performance, RTS was better than KTS for distinguishing between mortality and survival; both of them are beneficial trauma scoring tools which can be used in LMICs. Further studies are required to specify the appropriate choice of the RTS or KTS regarding the type of injury and different conditions of the patient.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377219PMC
January 2019

Ergonomic Latex Pillows as a Part of a Multimodal Intervention or as an Adjunct to Rehabilitation Programs in Cervical Spondylosis: Are They Useful?: A Randomized Controlled Trial.

Am J Phys Med Rehabil 2019 07;98(7):600-607

From the Department of Orthotics and Prosthetics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran (FF, BF, FA); and Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran (AA).

Objective: This study evaluated the effectiveness of ergonomic latex pillows in terms of clinical and biomechanical (cervical range of motion) outcome measures in patients with cervical spondylosis.

Design: This parallel-group randomized controlled trial randomly assigned 42 patients with cervical spondylosis to the experimental and control groups. Both groups received 12 sessions of routine physical therapy for 4 wks. While the experimental group received an ergonomic latex pillow, the control group slept on their own usual pillow during the mentioned 4-wk period. Pain intensity, functional disability, medication use, and cervical range of motion were measured before and after 4 wks of intervention.

Results: After 4 wks of intervention, the experimental group showed pain relief, decreased disability, and significantly increased range of motion in all directions. The simultaneous use of an ergonomic latex pillow and physical therapy could more successfully decrease pain intensity compared with routine physical therapy alone. In addition, extension and right lateral flexion variables significantly increased in the experimental group compared with the control group.

Conclusions: The administration of an ergonomic latex pillow can ameliorate treatment outcome in patients with cervical spondylosis.
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http://dx.doi.org/10.1097/PHM.0000000000001157DOI Listing
July 2019

A preliminary study: The effect of ergonomic latex pillow on pain and disability in patients with cervical spondylosis.

Med J Islam Repub Iran 2018 5;32:81. Epub 2018 Sep 5.

Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Cervical pillows are considered to be part of the therapeutic strategy in cervical spondylosis, but there is little or no convincing scientific evidence on the effectiveness of these pillows in relieving pain and disability in these patients. Hence, this study investigated the effects of ergonomic latex pillow in conjunction with routine physiotherapy versus routine physiotherapy alone on disability and pain intensity in patients with cervical spondylosis. 22 patients with cervical spondylosis in a single-blinded pilot study with a pre/post-test design were randomly assigned to experimental and control groups. Both groups received 12 sessions of physiotherapy for four weeks. In the experimental group, participants were given an ergonomic latex pillow to sleep it for four weeks. Participants in the control group slept on their own usual pillow. All the participants filled out the Neck Disability Index questionnaire, and scored their neck pain intensity on the Numerical Pain Rating Scale before and after the intervention. Changes of variables (pain and disability) within and between groups were compared by Paired T-test and the Independent Sample T-test, respectively via SPSS v.20 (p<0.05). Numerical Pain Rating Scale and Neck Disability Index scores were decreased statistically significant within groups. In the experimental group, neck disability scores were significantly lower than those in the control group (p=0.038). However, pain intensity scores were not significantly different between groups. Ergonomic latex pillows can significantly decrease disability related to neck pain in patients with cervical spondylosis after four weeks.
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http://dx.doi.org/10.14196/mjiri.32.81DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325275PMC
September 2018

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) Polymorphisms and Lung Cancer Risk among a Select Group of Iranian People

Asian Pac J Cancer Prev 2018 10 26;19(10):2921-2927. Epub 2018 Oct 26.

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective(s): Lung cancer, caused primarily by smoking, is one of the leading determinants of mortality throughout the world. Here we investigated the effects of polymorphisms in two enzymes, i.e., GSTT1 and GSTM1, related to the antioxidant defense line against carcinogens associated with lung cancer among a select group of Iranian people. Materials and Methods: One hundred and twenty lung cancer patients from two referral centers in Tehran, Iran, were recruited for comparison with 120 healthy controls. Genomic DNA was extracted from the FFPE tumor tissues of the select cases and peripheral blood buffy coats of healthy controls. The polymorphisms of GSTT1 and GSTM1 were investigated by multiplex polymerase chain reaction. Results: With the 240 samples studied, no specific relationship with lung cancer was discerned for the GSTM1 (P=0.35; OR=1/33; 95% CI=0.79-2.25) polymorphism, but the GSTT1 (P=0.005; OR=2.4; CI=1.32-4.35) gene polymorphism revealed a notable association on logistic regression, taking into account age and sex factors. Furthermore, the GSTT1 genotype distribution in patients with LSCC was different from that of healthy cases (P=0.006; OR=3.11; CI=1.38-7.04). The risk of developing lung cancer with the T0M1 genotype was 3.46 times higher than with T1M1 genotype (P=0.002; OR=3.46; CI=1.61-7.46). Moreover, the risk of developing LSCC cancer in people with T0M1 genotypes was significantly elevated (P=0.004; OR=4.5; CI=1.62-12.52). Conclusion: Unlike GSTM1, the GSTT1 genotype distribution is associated with the incidence of lung cancer in Iranian people. Different types of lung cancer appear to show various correlations with GST polymorphisms in this regard.
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http://dx.doi.org/10.22034/APJCP.2018.19.10.2921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291040PMC
October 2018

Prevalence of Mycoplasma Pneumoniae Infection in Patients with COPD Exacerbation; a Letter to the Editor.

Emerg (Tehran) 2018 15;6(1):e18. Epub 2018 Mar 15.

Emergency Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036525PMC
March 2018

Metabolic Syndrome and the Iodine-Dose/Creatinine Clearance Ratio as Determinants of Contrast-Induced Acute Kidney Injury.

Cardiorenal Med 2018 15;8(3):217-227. Epub 2018 Jun 15.

Department of Cardiovascular Medicine, Rasoul-e-Akram General Hospital, IUMS, Tehran, Iran.

Background: Finding patients at risk of developing contrast-induced acute kidney injury (CI-AKI) is important because of its associated complications. In the present study, the contribution of different variables, such as the presence of metabolic syndrome (MetS), the volume creatinine clearance (V/CrCl) ratio, the iodine-dose (I-dose)/CrCl ratio, or hypertension, to CI-AKI was evaluated.

Methods: A total of 255 patients undergoing elective coronary angiography with or without intervention were enrolled and divided into a MetS and a control group. All patients were assessed for the development of CI-AKI after the procedures.

Results: CI-AKI occurred in 39.23% (51 of 130) of the MetS patients and 14.4% (18 of 125) of the control group (p < 0.001). The multivariable regression model showed that male sex and the use of statins decreased the risk of CI-AKI, and high triglyceride levels, I-dose/CrCl > 0.52, MetS, CrCl ≤60 mL/min, and age ≥70 years increased the risk of CI-AKI, independent of confounding factors. The difference in the mean V/CrCl ratio was statistically significant between patients who developed CI-AKI and those who did not show renal impairment (2.36 ± 1.35 vs. 1.43 ± 0.89, respectively; p < 0.001). The ROC curve analysis of I-dose/CrCl determined the best cutoff value for patients with and those without MetS as 0.51 and 0.63, with a sensitivity value of 68 and 72% and a specificity value of 73 and 74%, respectively.

Conclusions: We showed that MetS is a strong risk factor for CI-AKI in nondiabetic patients undergoing elective coronary interventions; and the I-dose/CrCl ratio is a strong predictor of CI-AKI in these patients. We suggest that clinicians identify MetS patients and calculate their I-dose/CrCl ratio before coronary interventions.
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http://dx.doi.org/10.1159/000488374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170904PMC
March 2019

Effect of ankle taping on postural control measures during grasp and release task in patients with chronic ankle instability.

J Back Musculoskelet Rehabil 2018 ;31(5):881-887

Physical Therapy Department, Rehabilitation Faculty, Tehran University of Medical Sciences, Tehran, Iran.

Objective: The aim of this study was to examine the effect of Mulligan ankle taping on center of pressure (COP) parameters during performance of a functional upper limb task in patients with chronic ankle instability (CAI).

Methods: A clinical controlled trial study designed between 4 ankle conditions: untaped and taped, CAI and healthy subjects. Fifteen subjects with CAI and 15 healthy controls were asked to grasp an object at their waist level and release it above shoulder level in an oblique pattern during performance of single-leg stance balance test. All the subjects performed 3 trials of single-leg stance with eyes opened before and after Mulligan taping on a force plate during performance of functional upper limb task. The mean displacement (mdCOP), range of COP excursion (rangeCOP) and average speed of COP (velCOP) in anteroposterior (AP) and mediolateral (ML) directions were analysed for differences between groups.

Results: mdCOP and rangeCOP in AP direction were significantly increased (P= 0.04 and 0.03, respectively) in the CAI group. Mulligan taping significantly reduced velCOP in AP and ML directions (P= 0.02).

Conclusion: In CAI patients Mulligan ankle taping can improve postural control by decreasing velCOP, therefore Mulligan taping can have immediate positive effects on postural parameters and maintenance of dynamic postural control.
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http://dx.doi.org/10.3233/BMR-171067DOI Listing
January 2019

Effectiveness of mobilization with movement (Mulligan concept techniques) on low back pain: a systematic review.

Clin Rehabil 2018 Oct 30;32(10):1289-1298. Epub 2018 May 30.

1 Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.

Objective: To evaluate evidence on the effectiveness of Mulligan techniques on low back pain.

Data Sources: PubMed/Medline, Scopus, Ovid, CINAHL, Embase, PEDro, Google Scholar, and Cochrane Library were searched from inception to 31 March 2018 for randomized clinical trials reporting outcomes of pain or disability in adult patients (⩾18 years) with low back pain.

Review Methods: Two authors screened the results and extracted data for use in this review. The risk of bias was evaluated using the Cochrane criteria. Basic information and treatment protocols were also extracted. In addition, the level of evidence of each study and strength of conclusion for pain and disability were determined.

Results: A total of 20 studies with 693 patients were included. Nine trials focused on sustained natural apophyseal glide, three on spinal mobilization with limb movement and seven on bent leg raise. The results showed that Mulligan techniques can decrease pain and disability and increase range of motion in patients with low back pain; however, the strength of conclusion for pain and disability was moderate. Furthermore, inconclusive results were observed for the effectiveness of Mulligan techniques on movement speed. In this review, eight studies were categorized as low risk of bias, while 12 studies had high risk of bias. Level of evidence analysis revealed that 17 studies were classified as level of evidence B, while three studies were classified as level of evidence A2.

Conclusion: Current evidence is insufficient in supporting the benefits of Mulligan techniques on pain, disability, and range of motion in low back pain patients.
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http://dx.doi.org/10.1177/0269215518778321DOI Listing
October 2018

Successful Treatment of a Catheter-Induced Superior Vena Cava Syndrome through Catheter-Directed Thrombolysis: A Case Report.

J Tehran Heart Cent 2017 Oct;12(4):188-191

Department of Cardiovascular Medicine, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Superior vena cava (SVC) syndrome is a medical condition resulting from the obstruction of the blood flow through the large central veins. Recently, central venous catheters have been reported as the increasingly common cause of this syndrome. We describe a 56-year-old woman with previous history of metastatic colon cancer, who had recently undergone central venous catheter insertion for her second chemotherapy course. Eight days following port insertion, she presented with signs and symptoms suggestive of acute SVC syndrome, which was successfully managed with catheter-directed thrombolysis. The pre-discharge transesophageal echocardiography and conventional angiography showed a patent SVC. The patient was discharged and remained asymptomatic over a 6-month follow-up. This case shows that catheter-directed thrombolysis may be used as a safe treatment for catheter-induced acute SVC syndrome in patients who have undergone catheter insertion in the central vein.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849593PMC
October 2017

Nailfold capillaroscopy in 430 patients with rheumatoid arthritis.

Caspian J Intern Med 2017 ;8(4):269-274

Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Microvascular changes are one of the first obvious steps in numerous inflammatory diseases such as rheumatoid arthritis (RA). Nailfold video capillaroscopy (NFC) is an easy, reliable and safe method for evaluating peripheral microangiopathy. The objective of this study was to examine nailfold microcirculation in RA patients, assess morphological and structural changes quantitatively and qualitatively, and recognize useful changes.

Methods: A total of 430 patients diagnosed with RA were examined in a period of 4 years. NFC was performed on all fingers of both hands in each patient. Different parameters indicating microvascular changes were detected and analyzed; such as microvascular architecture, capillary distribution disturbances, capillary morphology, capillary density, efferent/afferent limb ratio, subpapillary venular plexus and morphological abnormalities. The obtained results were categorized into normal pattern, nonspecific morphological abnormality and scleroderma pattern.

Results: The mean age of participants was 51.03±14.54 (19-87 years) that consisted of 359 females and 71 males. Based on the findings, angiogenesis (74.7%) was the most pathological condition observed after tortuosity (99.5%). 7.2% and 20.9% of patients were categorized into normal and scleroderma pattern group, respectively. Among morphological abnormalities, angiogenesis, isolated enlarged loop, irregular enlarged loop and architectural derangement were significantly more frequent in scleroderma than normal pattern (p<0.001).

Conclusion: NFC may play an important role in monitoring RA disease and patients' follow-up. Therefore, in our opinion it could be considered in the course and follow-up of rheumatoid arthritis.
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http://dx.doi.org/10.22088/cjim.8.4.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686305PMC
January 2017

Carbon and Phosphorus Removal from Primary Municipal Wastewater Using Recovered Aluminum.

Environ Sci Technol 2017 Nov 30;51(21):12302-12309. Epub 2017 Oct 30.

Department of Chemical and Biochemical Engineering, University of Western Ontario , London, Ontario Canada.

In this work, recovery of aluminum from coagulated primary sludge and its reuse potential as secondary coagulant were investigated. The recovery process consisted of releasing the particle-bound aluminum from primary sludge by acidification (HCl or HSO), followed by separation using centrifugation for dissolved coagulant recovery. The recovered coagulant was then reused for treating primary wastewater and overall coagulation efficiency was determined. While with fresh alum, the removal efficiencies of total suspended solids, chemical oxygen demand, total phosphorus, and total nitrogen were 85%, 65%, 80% and 33%, respectively, a drop in removal efficiency of total suspended solids and chemical oxygen demand was observed for recovered aluminum (85-60% and 65-50%, respectively). Nitrogen concentration remained almost constant with each cycle, while phosphorus in the effluent increased by 1 mg/L and 3 mg/L in the first and second cycle, respectively. Precipitation of various aluminum species was modeled for determining the recovery potential of aluminum at low pH. Preliminary cost analysis indicates that optimum recovery of aluminum occurred at a pH of 1.5 for both acids. Struvite precipitation effectively removed increased phosphorus solubilized by acidification at the end of second cycle, however, it also decreased the amount of aluminum available for recycle.
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http://dx.doi.org/10.1021/acs.est.7b03405DOI Listing
November 2017

Mannose-Binding Lectin () gene polymorphisms in susceptibility to pulmonary tuberculosis among the Lur population of Lorestan Province of Iran.

Genom Data 2017 Jun 4;12:146-150. Epub 2017 May 4.

Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.

Objective: Tuberculosis (TB) is caused by infection of Mycobacterium tuberculosis. Host genetic variability is an important determinant of the risk of developing TB in humans. Although the association between polymorphisms and TB has been studied in various populations, the results are controversial. The aim of this study was to investigate mannose-binding lectin () gene polymorphisms with susceptibility to pulmonary tuberculosis (PTB) in a Lur population of Iran.

Methods: In this case-control study, four functional gene polymorphisms (, , and ) were genotyped by using PCR Single Strand Conformation Polymorphism (SSCP) technique in a Lur population living in Lorestan Province, consisting of 100 patients with pulmonary tuberculosis (PTB) age and sex matched 100 healthy controls (HCs). Association analyses were performed with the SPSS 21 statistical software.

Results: We found that () genotype polymorphism significantly was associated with increased susceptibility to TB (35% in patients vs. 22% in controls, P = 0.0417, OR = 1.909, %95 CI = 1.020-3.573). Additionally, allele showed a significant association with increased risk of TB (56.5% in patients vs. 46% in controls, P = 0.0357, OR = 1.525, %95 CI = 1.028-2.262). Also, the distribution of allele in patients was significantly lower frequency in TB patients compared to controls (43.5% vs. 54%, P = 0.0357, OR = 0.656, %95 CI = 0.442-0.973). However, the allelic and genotypic frequencies of , and polymorphisms were not significantly different between the patients and the controls. We couldn't detect any significant differences between haplotypes among TB patients and healthy controls.

Conclusions: Our findings demonstrated that genotype and allele may increase the susceptibility to pulmonary TB in the Lur population of Iran, although allele may decrease the susceptibility to pulmonary TB in this population. We suggest that it is necessary to further more studies with larger sample size and other ethnic population.
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http://dx.doi.org/10.1016/j.gdata.2017.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432655PMC
June 2017

Effect of Gastrocnemius Kinesio Taping on Countermovement Jump Performance and Vertical Stiffness Following Muscle Fatigue.

J Sport Rehabil 2018 Jul 22;27(4):306-311. Epub 2018 Jun 22.

Context: Kinesio tape (KT) is a widely used intervention in the fields of sports and rehabilitation. However, its effects on lower-extremity behavior during functional activities are not entirely known.

Objective: To test the hypothesis that application of KT can change performance and vertical stiffness (VS) during the countermovement jump (CMJ) before and after a fatigue protocol.

Design: A predesign and postdesign to study the effect of KT in 2 situations, prefatigue and postfatigue. In each fatiguing condition, there were 2 conditions with and without KT application on the gastrocnemius muscle.

Setting: Biomechanics laboratory.

Participants: Fifty healthy, nonathlete participants (26 females and 24 males).

Interventions: KT application on the gastrocnemius muscle and a fatigue protocol to induce fatigue in plantar flexor muscles.

Main Outcome Measures: Various jumping parameters, including jump height, maximum force, maximum power, rate of force development, eccentric lower-limb stiffness, and VS, were calculated using the vertical ground reaction force data. Eccentric lower-limb stiffness and VS were calculated using a mass-spring model. The studied variables can present lower-extremity elastic behavior and performance during CMJ.

Results: The results of a 2-way repeated-measures analysis of variance showed no significant effect for KT application. Fatigue resulted in lower values of jump height, maximum power, and VS. Moreover, male subjects showed greater values of jump height, maximum force, and maximum power than did females.

Conclusions: The main finding of this study was that gastrocnemius KT has no effect on performance or elastic behavior of the lower-extremity during CMJ. Moreover, KT cannot reduce the adverse effect of fatigue in a functional activity such as CMJ. It seems that gastrocnemius KT is not effective for demanding activities.
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http://dx.doi.org/10.1123/jsr.2017-0009DOI Listing
July 2018
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