Publications by authors named "Ali Almasi"

17 Publications

  • Page 1 of 1

Survey on the indexes of health equity in the physical environment and infrastructures of Kermanshah province, Iran.

J Egypt Public Health Assoc 2021 Apr 1;96(1). Epub 2021 Apr 1.

Social Development & Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Health equity is directly associated with the proper distribution of resources, the existence of infrastructures, and the balanced physical environment. The present study aimed to survey the indexes of health equity in the physical environment and infrastructures of Kermanshah province based on the national indexes.

Results: The results revealed that access to transportation, health centers, solid waste management, and green and sports per capita had the least distance from the negative ideal whereas the noise pollution index had the greatest distance. However, house hygiene and air pollution indexes were within the negative and positive ideal ranges.

Conclusions: The health equity indexes were not distributed equitably across counties and geographical regions of Kermanshah province.
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http://dx.doi.org/10.1186/s42506-021-00068-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8017071PMC
April 2021

Spatial modeling of mortality from acute lower respiratory infections in children under 5 years of age in 2000-2017: a global study.

Clin Exp Pediatr 2021 Mar 19. Epub 2021 Mar 19.

Social Development & Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Over the past few decades, various goals have been defined to reduce the mortality of children caused by acute lower respiratory infections (ALRI) worldwide. However, few spatial studies to date have reported on ALRI deaths.

Purpose: We aimed to assess the spatial modeling of mortality from ALRI in children under 5 years of age during 2000-2017 using a global data.

Methods: The data on the mortality of children under 5 years old caused by ALRI were initially obtained from the official website of the World Health Organization. The income status of their home countries was also gathered from the Country Income Groups (World Bank Classification) website and divided into five categories. After that, in the ArcGIS 10.6 environment, a database was created and the statistical tests and related maps were extracted. The Global Moran's I Statistic, Getis-Ord Gi statistic, and geographically weighted regression were used for the analyses. In this study, higher Z-scores indicated the hot spots, while lower Z-scores indicated the cold spots.

Results: In 2000-2017, child mortality showed a downward trend from 17.6 per 100000 children to 8.1 and had a clustered pattern. Hot spots were concentrated in Asia in 2000 but shifted toward African countries by 2017. A cold spot that formed in Europe in 2007 showed an ascending trend by 2017. Based on the results of geographically weighted regression test, the regions identified as the hot spots of mortality from ALRI in children under 5 years old were among the middle-income countries (R2 = 0.01, adjusted R2 = 8.77).

Conclusion: While the total number of child deaths in 2000-2017 has decreased, the number of hot spots has increased among countries. This study also concluded that, during the study period, Central and Western Africa countries became the main new hot spots of deaths from ALRI.
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http://dx.doi.org/10.3345/cep.2020.01438DOI Listing
March 2021

Learning receptive field properties of complex cells in V1.

PLoS Comput Biol 2021 Mar 2;17(3):e1007957. Epub 2021 Mar 2.

Department of Biomedical Engineering, The University of Melbourne, Melbourne, Australia.

There are two distinct classes of cells in the primary visual cortex (V1): simple cells and complex cells. One defining feature of complex cells is their spatial phase invariance; they respond strongly to oriented grating stimuli with a preferred orientation but with a wide range of spatial phases. A classical model of complete spatial phase invariance in complex cells is the energy model, in which the responses are the sum of the squared outputs of two linear spatially phase-shifted filters. However, recent experimental studies have shown that complex cells have a diverse range of spatial phase invariance and only a subset can be characterized by the energy model. While several models have been proposed to explain how complex cells could learn to be selective to orientation but invariant to spatial phase, most existing models overlook many biologically important details. We propose a biologically plausible model for complex cells that learns to pool inputs from simple cells based on the presentation of natural scene stimuli. The model is a three-layer network with rate-based neurons that describes the activities of LGN cells (layer 1), V1 simple cells (layer 2), and V1 complex cells (layer 3). The first two layers implement a recently proposed simple cell model that is biologically plausible and accounts for many experimental phenomena. The neural dynamics of the complex cells is modeled as the integration of simple cells inputs along with response normalization. Connections between LGN and simple cells are learned using Hebbian and anti-Hebbian plasticity. Connections between simple and complex cells are learned using a modified version of the Bienenstock, Cooper, and Munro (BCM) rule. Our results demonstrate that the learning rule can describe a diversity of complex cells, similar to those observed experimentally.
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http://dx.doi.org/10.1371/journal.pcbi.1007957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954310PMC
March 2021

Quality of life of HIV-infected individuals: insights from a study of patients in Kermanshah, Iran.

BMC Infect Dis 2021 Feb 23;21(1):203. Epub 2021 Feb 23.

Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Quality of life (QOL) is one of the major factors to assessing the health and wellbeing of People living with HIV (PLWH). Likewise, improved QOL is among the prominent goals of patient treatment. This study was conducted to investigate the QOL of PLWH in Kermanshah, Iran.

Methods: This cross-sectional study was conducted on 364 PLWH of Kermanshah between 2016 and 2017. Outpatients were selected as the sample through the convenience sampling method from HIV Positive Clients of Kermanshah Behavioral Diseases Counseling Center. The reasons for the selection of outpatients include: (a) some patients were substance users, homeless or did not have a fixed address to follow-up; (b) addresses and personal details that were registered on the first admission were incorrect or incomplete; (c) due to financial issues, some were forced to relocate frequently and were difficult to track; (d) some patients were convicts or prisoners, making it hard to find them after their release; (e) some of them were from other provinces, where managing access was not easy/possible. Data was collected using WHOQOL-HIV BREF questionnaire (Persian Version). Data also analyzed with STATA 14, and SPSS 23 using T-test and multiple regression.

Results: This study showed that mean (SD) age of PLWH was 40.21 (10.45) years. Females had better QOL than males except for spirituality, religion and personal beliefs. The gender differences disappeared in multivariate results. A significant association was observed between education and the independence, environment, and spirituality domains of QOL. In addition, being married was correlated with overall QOL, psychological and social relationships domains of QOL of PLWH. Drug use was a behavioral factor with negative influence on the QOL.

Conclusion: This study found that marital status and drug use were the main predictors of various domains of QOL. Drug use was a behavioral factor with a negative influence on the QOL. Hence, it is recommended that health professionals, planners, and policymakers take effective measures to improve the status quo.
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http://dx.doi.org/10.1186/s12879-021-05908-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903600PMC
February 2021

Analysis of extracellular spike waveforms and associated receptive fields of neurons in cat primary visual cortex.

J Physiol 2021 04 2;599(8):2211-2238. Epub 2021 Mar 2.

National Vision Research Institute, Australian College of Optometry, Carlton, Victoria, 3053, Australia.

Key Points: Extracellular spikes recorded in the visual cortex (Area 17/18, V1) are commonly classified into either regular-spiking (RS) or fast-spiking (FS). Using multi-electrode arrays positioned in cat V1 and a broadband stimulus, we show that there is also a distinct class with positive-spiking (PS) waveforms. PS units were associated mainly with non-oriented receptive fields while RS and FS units had orientation-selective receptive fields. We suggest that PS units are recordings of axons originating from the thalamus. This conclusion was reinforced by our finding that we could record PS units after cortical silencing, but not record RS and FS units. The importance of our findings is that we were able to correlate spike shapes with receptive field characteristics with high precision using multi-electrode extracellular recording techniques. This allows considerable increases in the amount of information that can be extracted from future cortical experiments.

Abstract: Extracellular spike waveforms from recordings in the visual cortex have been classified into either regular-spiking (RS) or fast-spiking (FS) units. While both these types of spike waveforms are negative-dominant, we show that there are also distinct classes of spike waveforms in visual Area 17/18 (V1) of anaesthetised cats with positive-dominant waveforms, which are not regularly reported. The spatial receptive fields (RFs) of these different spike waveform types were estimated, which objectively revealed the existence of oriented and non-oriented RFs. We found that units with positive-dominant spikes, which have been associated with recordings from axons in the literature, had mostly non-oriented RFs (84%), which are similar to the centre-surround RFs observed in the dorsal lateral geniculate nucleus (dLGN). Thus, we hypothesise that these positive-dominant waveforms may be recordings from dLGN afferents. We recorded from V1 before and after the application of muscimol (a cortical silencer) and found that the positive-dominant spikes (PS) remained while the RS and FS cells did not. We also noted that the PS units had spiking characteristics normally associated with dLGN units (i.e. higher response spike rates, lower response latencies and higher proportion of burst spikes). Our findings show quantitatively that it is possible to correlate the RF properties of cortical neurons with particular spike waveforms. This has implications for how extracellular recordings should be interpreted and complex experiments can now be contemplated that would have been very challenging previously, such as assessing the feedforward connectivity between brain areas in the same location of cortical tissue.
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http://dx.doi.org/10.1113/JP280844DOI Listing
April 2021

A study of 0-14-year-old children's access to health centers in rural areas using a buffer model (a case study of villages based in Kermanshah province, Iran).

J Educ Health Promot 2020 26;9:324. Epub 2020 Nov 26.

Department of Nursing, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.

Introduction: Children are among the most vulnerable groups in society, whose health is of prominent significance. Moreover, as a group of clients with special needs in the health care system, they require special attention. Therefore, the present study aimed to investigate the 0-14-year-old children's access to health centers in rural areas of Kermanshah Province, Iran.

Materials And Methods: In the present cross-sectional study, both the latest published demographic statistics related to the Population and Housing Census, announced by the Statistical Center of Iran in 2011, and the information about the public and private hospitals in the province, collected by Kermanshah University of Medical Sciences, were used as the basis for the analyses. In addition, given the importance of the spatial nature of the research, geographic information system was used for data analysis, and a buffer model was also applied.

Results: The results revealed that out of the total population of 0-14-year-old children residing in rural areas within 15,000 and 30,000-km radii of Kermanshah Province, 87.94% and 75.11% of girls versus 88.15% and 75.38% of boys lacked access to health centers, respectively.

Conclusion: It was found out that the 0-14-year-old children's access to health centers was in poor condition in rural areas of Kermanshah Province, which would endanger the health of this age group.
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http://dx.doi.org/10.4103/jehp.jehp_547_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774620PMC
November 2020

Photocatalytic degradation of cephalexin by UV activated persulfate and Fenton in synthetic wastewater: optimization, kinetic study, reaction pathway and intermediate products.

J Environ Health Sci Eng 2020 Dec 12;18(2):1359-1373. Epub 2020 Oct 12.

Department of Environmental Health Engineering, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

We used Low pressure mercury vapor lamp activated of Sodium Persulfate (UV/SPS) and Fenton processes in two separate reactors to comparison of cephalexin (CPX) degradation in aqueous solution. The effect of pH, initial concentration of SPS, concentration of CPX, concentration of HO and concentration of Fe on the degradation of CPX were investigated. The residue of CPX and metabolites were determined by HPLC and GC/MS. The Total Organic Carbon (TOC) analysis was utilized for surveying the mineralization of CPX. Biodegradability of CPX in both advanced oxidation processes was evaluated by BOD5/COD in optimum condition. The results indicated that the maximum CPX removal was obtained at pH 3, HO 3 mM, concentration of initial CPX 10 mg/L and by increasing the doses of SPS from 0.1 to 0.2 mM, the degradation of CPX was enhanced. In this study, the most important factors for AOP efficiency was concentration of initial CPX; and then pH in UV/SPS and HO in Fenton processes. The TOC measurements indicate that the UV/SPS and Fenton can efficiently mineralize CPX. CPX removed enough to achieve suitable biodegradability for a further biological process. Too, analysis of generated intermediates during the degradation of CPX was conducted by GC/MS method and a degradation pathway was proposed.
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http://dx.doi.org/10.1007/s40201-020-00553-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721770PMC
December 2020

Geographical Access of the Elderly to Health Care Centers During a 20-Year Period (1996-2016): a Case Study of Kermanshah, Iran.

J Gen Intern Med 2020 Oct 19. Epub 2020 Oct 19.

Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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http://dx.doi.org/10.1007/s11606-020-06289-wDOI Listing
October 2020

Mechanisms of Feature Selectivity and Invariance in Primary Visual Cortex.

Cereb Cortex 2020 Jul;30(9):5067-5087

National Vision Research Institute, Australian College of Optometry, Carlton VIC 3053, Australia.

Visual object identification requires both selectivity for specific visual features that are important to the object's identity and invariance to feature manipulations. For example, a hand can be shifted in position, rotated, or contracted but still be recognized as a hand. How are the competing requirements of selectivity and invariance built into the early stages of visual processing? Typically, cells in the primary visual cortex are classified as either simple or complex. They both show selectivity for edge-orientation but complex cells develop invariance to edge position within the receptive field (spatial phase). Using a data-driven model that extracts the spatial structures and nonlinearities associated with neuronal computation, we quantitatively describe the balance between selectivity and invariance in complex cells. Phase invariance is frequently partial, while invariance to orientation and spatial frequency are more extensive than expected. The invariance arises due to two independent factors: (1) the structure and number of filters and (2) the form of nonlinearities that act upon the filter outputs. Both vary more than previously considered, so primary visual cortex forms an elaborate set of generic feature sensitivities, providing the foundation for more sophisticated object processing.
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http://dx.doi.org/10.1093/cercor/bhaa102DOI Listing
July 2020

Hybrid diamond/ carbon fiber microelectrodes enable multimodal electrical/chemical neural interfacing.

Biomaterials 2020 02 22;230:119648. Epub 2019 Nov 22.

School of Physics, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Implantable medical devices are now in regular use to treat or ameliorate medical conditions, including movement disorders, chronic pain, cardiac arrhythmias, and hearing or vision loss. Aside from offering alternatives to pharmaceuticals, one major advantage of device therapy is the potential to monitor treatment efficacy, disease progression, and perhaps begin to uncover elusive mechanisms of diseases pathology. In an ideal system, neural stimulation, neural recording, and electrochemical sensing would be conducted by the same electrode in the same anatomical region. Carbon fiber (CF) microelectrodes are the appropriate size to achieve this goal and have shown excellent performance, in vivo. Their electrochemical properties, however, are not suitable for neural stimulation and electrochemical sensing. Here, we present a method to deposit high surface area conducting diamond on CF microelectrodes. This unique hybrid microelectrode is capable of recording single-neuron action potentials, delivering effective electrical stimulation pulses, and exhibits excellent electrochemical dopamine detection. Such electrodes are needed for the next generation of miniaturized, closed-loop implants that can self-tune therapies by monitoring both electrophysiological and biochemical biomarkers.
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http://dx.doi.org/10.1016/j.biomaterials.2019.119648DOI Listing
February 2020

Dataset on adsorption of methylene blue from aqueous solution onto activated carbon obtained from low cost wastes by chemical-thermal activation - modelling using response surface methodology.

Data Brief 2019 Aug 23;25:104036. Epub 2019 May 23.

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The aim of this study was to produce activated carbon derived from corn stalk (AC-CS) with suitable characteristics as inexpensive, nontoxic adsorbent with good efficiency for elimination of Methylene Blue (MB) as cationic dye from aqueous solution in batch adsorption process. The morphology and functional groups of adsorbent were characterized by SEM and FTIR in this dataset. In addition, the influence of MB concentration, pH, adsorbent dosage, and contact time on the removal of dye using AC-CS was tested by central composite design (CCD) under response surface methodology (RSM). Based on results, the parameters adsorbent dose and initial dye concentration for this investigation play an important role in the adsorption studies of methylene blue. The experimental values were in good agreement with the model predicted values also the results of the study showed that maximum absorbance efficiency at initial concentration of 10 mg/l, absorbent dose of 1.4 g, contact time of 50 min and pH 11 was 90%.
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http://dx.doi.org/10.1016/j.dib.2019.104036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6565604PMC
August 2019

Using high frequency and low-intensity ultrasound to enhance activated sludge characteristics.

Ultrason Sonochem 2019 Jun 22;54:274-280. Epub 2019 Jan 22.

Research Center for Environmental Determinants of Health, Department of Environmental Health Engineering, School of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

In this study, high-frequency ultrasound wave (1.8 MHz) at low intensity was applied to improve activated sludge settleability at high MLSS concentration. The effect of irradiation intensity, sonication mode, MLSS concentration and sample volume on the physical characteristics of sludge in a pilot scale settling column were investigated for optimizing the conditions. The obtained results showed that high-frequency ultrasound decreased the height of sludge (44%) and effluent turbidity (82.2%) and increased sludge settling velocity about 3 times at high biomass concentration. Irradiation intensity of 0.4 w/cm and sonication mode with interval times of 10 s showed the best results on the performance of the system at MLSS concentration of 8000 mg/L with a sample volume of 3 L.
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http://dx.doi.org/10.1016/j.ultsonch.2019.01.030DOI Listing
June 2019

Isolation and characterization of probiotics from dairies.

Iran J Microbiol 2017 Aug;9(4):234-243

Biotechnology Research Center, Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Background And Objectives: Probiotics are live microorganisms, which show beneficial health effects on hosts once consumed in sufficient amounts. LAB group can be isolated and characterized from traditional dairy sources. This study aimed at isolating, identifying, and characterizing (low pH/high bile salt tolerance, antibacterial activity, and antibiotic susceptibility) LAB strains from traditional Iranian dairy products.

Materials And Methods: Isolated strains were identified by Gram staining, catalase assay, and 3 molecular identification methods; namely, (GTG) 5-PCR fingerprinting, ARDRA, and 16S rDNA gene sequencing.

Results: A total of 19 LAB strains belonging to 4 genera ( and ) were identified.

Conclusion: The experiments revealed that 15HN, subsp. 44L and 50H strains, which were isolated from shiraz, cheese and shiraz, respectively, displayed a desirable tolerance to low pH and high bile salts, favorable anti-pathogen activity, and acceptable antibiotic susceptibility; hence, they could be considered as novel probiotic candidates and applied in the food industry.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723976PMC
August 2017

Removal of Penicillin G by combination of sonolysis and Photocatalytic (sonophotocatalytic) process from aqueous solution: process optimization using RSM (Response Surface Methodology).

Electron Physician 2016 Sep 20;8(9):2878-2887. Epub 2016 Sep 20.

M.Sc. of Biostatistics, Department of Biostatistics, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.

Introduction: Penicillin G (PG) is used in a variety of infectious diseases, extensively. Generally, when antibiotics are introduced into the food chain, they pose a threat to the environment and can risk health outcomes. The aim of the present study was the removal of Penicillin G from an aqueous solution through an integrated system of UV/ZnO and UV/WO with Ultrasound pretreatment.

Methods: In this descriptive-analytical work dealing with the removal of Penicillin G from an aqueous solution, four significant variables, contact time (60-120 min), Penicillin G concentration (50-150 mg/L), ZnO dose (200-400 mg/L), and WO dose (100-200 mg/L) were investigated. Experiments were performed in a Pyrex reactor (batch, 1 Lit) with an artificial UV 100-Watt medium pressure mercury lamp, coupled with ultrasound (100 W, 40 KHz) for PG pre-treatment. Chemical Oxygen Demand (COD) was selected to follow the performance of the photo-catalytic process and sonolysis. The experiments were based on a Central Composite Design (CCD) and analyzed by Response Surface Methodology (RSM). A mathematical model of the process was designed according to the proposed degradation scheme.

Results: The results showed that the maximum removal of PG occurred in ultrasonic/UV/WO in the presence of 50 mg/L WO and contact time of 120 minutes. In addition, an increase in the PG concentration caused a decrease in COD removal. As the initial concentration of the catalyst increased, the COD removal also increased. The maximum COD removal (91.3%) achieved by 200 mg/L WO and 400 mg/l ZnO, a contact time of 120 minutes, and an antibiotic concentration of 50 mg/L. All of the variables in the process efficiency were found to be significant (p < 0.05). Catalyst dose and contact time were shown to have a positive effect on the response (p < 0.05).

Conclusion: The research data supported the conclusion that the combination of advanced oxidation process of sonolysis and photocatalytic (sonophotocatalytic) were applicable and environmentally friendly processes, which preferably can be applied extensively.
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http://dx.doi.org/10.19082/XXDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074745PMC
September 2016

Verification of Frequency in Species of Nontuberculous Mycobacteria in Kermanshah Drinking Water Supplies Using the PCR-Sequencing Method.

Microb Drug Resist 2017 Apr 26;23(3):359-364. Epub 2016 Sep 26.

6 Department of Biostatistics, Faculty of Medicine, Kermanshah University of Medical Sciences , Kermanshah, Iran .

Background: Nontuberculous mycobacteria are habitants of environment, especially in aquatic systems. Some of them cause problems in immunodeficient patients. Over the last decade, 16S rRNA gene sequencing was established in 45 novel species of nontuberculous mycobacteria. Experiences revealed that this method underestimates the diversity, but does not distinguish between some of mycobacterium subsp. To recognize emerging rapidly growing mycobacteria and identify their subsp, rpoB gene sequencing has been developed.

Objectives: To better understand the transmission of nontuberculous mycobacterial species from drinking water and preventing the spread of illness with these bacteria, the aim of this study was to detect the presence of bacteria by PCR-sequencing techniques.

Materials And Methods: Drinking water samples were collected from different areas of Kermanshah city in west of IRAN. After decontamination with cetylpyridinium chloride, samples were filtered with 0.45-micron filters, the filter transferred directly on growth medium waiting to appear in colonies, then DNA extraction and PCR were performed, and products were sent to sequencing.

Results: We found 35/110 (32%) nontuberculous mycobacterial species in drinking water samples, isolates included Mycobacterium goodii, Mycobacterium aurum, and Mycobacterium gastri with the most abundance (11.5%), followed by Mycobacterium smegmatis, Mycobacterium porcinum, Mycobacterium peregrinum, Mycobacterium mucogenicum, and Mycobacterium chelonae (8%).

Conclusions: In this study, we recognized the evidence of contamination by nontuberculous mycobacteria in corroded water pipes. As a result of the high prevalence of these bacteria in drinking water in Kermanshah, this is important evidence of transmission through drinking water. This finding can also help public health policy makers control these isolates in drinking water supplies in Kermanshah.
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http://dx.doi.org/10.1089/mdr.2016.0064DOI Listing
April 2017

Systemic sclerosis: comparison of efficacy of oral cyclophosphamide and azathioprine on skin score and pulmonary involvement-a retrospective study.

Rheumatol Int 2014 Dec 7;34(12):1691-9. Epub 2014 May 7.

Rheumatology Research Center, Firoozgar Hospital, Tehran University of Medical Sciences, Tehran, Iran,

The aim of this study was to evaluate efficacy of azathioprine (AZA) and cyclophosphamide (CYC) as a therapeutic regimen for interstitial lung disease associated with systemic sclerosis (SSc). Thirty-six selected patients included in this retrospective cohort and received one of the two drugs; the first group consists of 15 patients who were treated with AZA (1.5-2 mg/kg/day) and the second group with 21 patients received oral CYC (up to 2 mg/kg/day). Both groups received additional low dose of prednisolone (≤10 mg) for 6 months. Forced vital capacity (FVC), diffusion lung capacity for carbon monoxide (DLCO) and skin score were assessed as outcome measures. Modified Rodnan skin score (mRSS), pulmonary function test and DLCO were evaluated at entry and at the end of study after 12 months. The mean (SD) FVC percentages obtained at baseline and post-treatment in AZA-treated patients were 62.8 ± 9.8 and 71.1 ± 20.9 with mean difference of FVC% +7.6 ± 13.1, p = 0.05, and in CYC-treated patients 59.5 ± 10.7, 63.1 ± 16.2 and +2.9 ± 11.5, respectively, p = 0.19. Baseline and post-treatment DLCO% in AZA-treated patients were 61.4 ± 25.8 and 76.7 ± 24.0 with mean difference of +15.0 ± 14.5, respectively, p = 0.01. In CYC-treated patients, those measures were 67.7 ± 27.5 and 60.0 ± 22.9 with mean difference of -8.0 ± 23.7 (p = 0.12). Following 12 months of treatment in AZA-treated patients, mean difference of changes in mRSS was -2.9 ± 3.7 and -1.4 ± 4.5 in CYC-treated patients. Our results indicated that AZA can be effective in ameliorating or stabilizing lung function in selected SSc patient groups.
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http://dx.doi.org/10.1007/s00296-014-3026-yDOI Listing
December 2014

A dynamical model for generating synthetic Phonocardiogram signals.

Annu Int Conf IEEE Eng Med Biol Soc 2011 ;2011:5686-9

Biomedical Signal and Image Processing Laboratory, School of Electrical Engineering, Sharif University of Technology, Tehran, Iran.

In this paper we introduce a dynamical model for Phonocardiogram (PCG) signal which is capable of generating realistic synthetic PCG signals. This model is based on PCG morphology and consists of three ordinary differential equations and can represent various morphologies of normal PCG signals. Beat-to-beat variation in PCG morphology is significant so model parameters vary from beat to beat. This model is inspired of Electrocardiogram (ECG) dynamical model proposed by McSharry et al. and can be employed to assess biomedical signal processing techniques.
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http://dx.doi.org/10.1109/IEMBS.2011.6091376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390312PMC
June 2012