Publications by authors named "Alfredo Falcone"

100Publications

Immune Checkpoint Inhibitors in pMMR Metastatic Colorectal Cancer: A Tough Challenge.

Authors:
Federica Marmorino Alessandra Boccaccino Marco Maria Germani Alfredo Falcone Chiara Cremolini

Cancers (Basel) 2020 Aug 17;12(8). Epub 2020 Aug 17.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, via Risorgimento 36, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/cancers12082317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465130PMC
August 2020

AXL is a predictor of poor survival and of resistance to anti-EGFR therapy in RAS wild-type metastatic colorectal cancer.

Authors:
Claudia Cardone Bernadette Blauensteiner Veronica Moreno-Viedma Giulia Martini Vittorio Simeon Pietro P Vitiello Davide Ciardiello Valentina Belli Nunzia Matrone Teresa Troiani Floriana Morgillo Federica Zito Marino Monica Dentice Annarita Nappi Alessandra Boccaccino Carlotta Antoniotti Chiara Cremolini Filippo Pietrantonio Gerald W Prager Nicola Normanno Evaristo Maiello Guillem Argiles Elena Elez Giuseppe Signoriello Renato Franco Alfredo Falcone Josep Tabernero Maria Sibilia Fortunato Ciardiello Erika Martinelli

Eur J Cancer 2020 Aug 17;138:1-10. Epub 2020 Aug 17.

Department of Precision Medicine, Università Degli Studi Della Campania "Luigi Vanvitelli", Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.07.010DOI Listing
August 2020

Individual Patient Data Meta-Analysis of FOLFOXIRI Plus Bevacizumab Versus Doublets Plus Bevacizumab as Initial Therapy of Unresectable Metastatic Colorectal Cancer.

Authors:
Chiara Cremolini Carlotta Antoniotti Alexander Stein Johanna Bendell Thomas Gruenberger Daniele Rossini Gianluca Masi Elena Ongaro Herbert Hurwitz Alfredo Falcone Hans-Joachim Schmoll Massimo Di Maio

J Clin Oncol 2020 Aug 20:JCO2001225. Epub 2020 Aug 20.

Department of Oncology, University of Turin, Mauriziano Hospital, Turin, Italy.

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http://dx.doi.org/10.1200/JCO.20.01225DOI Listing
August 2020

First-line gemcitabine plus nab-paclitaxel for elderly patients with metastatic pancreatic cancer: Crossing the frontier of age?

Authors:
Caterina Vivaldi Francesca Salani Giulia Rovesti Irene Pecora Silvia Catanese Andrea Casadei-Gardini Valentina Massa Laura Bernardini Laura Riggi Kalliopi Andrikou Giovanni I Rapposelli Vincenzo Formica Monica Lencioni Alfredo Falcone Enrico Vasile Lorenzo Fornaro

Eur J Cancer 2020 Sep 1;137:108-116. Epub 2020 Aug 1.

Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, Pisa, 56126, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.06.031DOI Listing
September 2020

Prognostic and Predictive Biomarkers in Metastatic Colorectal Cancer Patients Receiving Regorafenib.

Authors:
Yingmiao Liu Jing Lyu Kirsten Bell Burdett Alexander B Sibley Ace J Hatch Mark D Starr John C Brady Kelli Hammond Federica Marmorino Daniele Rossini Richard M Goldberg Alfredo Falcone Chiara Cremolini Kouros Owzar Anastasia Ivanova Dominic T Moore Michael S Lee Hanna K Sanoff Federico Innocenti Andrew B Nixon

Mol Cancer Ther 2020 Aug 3. Epub 2020 Aug 3.

Medicine, Duke Medical Center

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http://dx.doi.org/10.1158/1535-7163.MCT-20-0249DOI Listing
August 2020

AtezoTRIBE: a randomised phase II study of FOLFOXIRI plus bevacizumab alone or in combination with atezolizumab as initial therapy for patients with unresectable metastatic colorectal cancer.

Authors:
Carlotta Antoniotti Beatrice Borelli Daniele Rossini Filippo Pietrantonio Federica Morano Lisa Salvatore Sara Lonardi Federica Marmorino Stefano Tamberi Salvatore Corallo Giampaolo Tortora Francesca Bergamo Di Stefano Brunella Alessandra Boccaccino Elisa Grassi Patrizia Racca Emiliano Tamburini Giuseppe Aprile Roberto Moretto Luca Boni Alfredo Falcone Chiara Cremolini

BMC Cancer 2020 Jul 22;20(1):683. Epub 2020 Jul 22.

Department of Oncology, University Hospital of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1186/s12885-020-07169-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376656PMC
July 2020

Single Nucleotide Polymorphisms in MiRNA Binding Sites of Nucleotide Excision Repair-Related Genes Predict Clinical Benefit of Oxaliplatin in FOLFOXIRI Plus Bevacizumab: Analysis of the TRIBE Trial.

Authors:
Mitsukuni Suenaga Marta Schirripa Shu Cao Wu Zhang Dongyun Yang Chiara Cremolini Sabina Murgioni Sara Lonardi Yan Ning Satoshi Okazaki Martin D Berger Yuji Miyamoto Afsaneh Barzi Fotios Loupakis Alfredo Falcone Heinz-Josef Lenz

Cancers (Basel) 2020 Jun 30;12(7). Epub 2020 Jun 30.

Division of Medical Oncology Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.3390/cancers12071742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408001PMC
June 2020

Management of Peritoneal Carcinomatosis With Cytoreductive Surgery Combined With Intraperitoneal Chemohyperthermia at a Novel Italian Center.

Authors:
Pinuccia Faviana Laura Boldrini Barbara Musco Mauro Ferrari Alfonso Greco Lorenzo Fornaro Gianluca Masi Francesco Forfori Sergio Ricci Augusto Brogi Fulvio Basolo Alfredo Falcone Angelo Gadducci Piero Vincenzo Lippolis

In Vivo 2020 Jul-Aug;34(4):2061-2066

Department of General Surgery, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.21873/invivo.12008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439894PMC
March 2020

Prognostic impact of immune-microenvironment in colorectal liver metastases resected after triplets plus a biologic agent: A pooled analysis of five prospective trials.

Authors:
Roberto Moretto Salvatore Corallo Antonino Belfiore Daniele Rossini Alessandra Boccaccino Sara Lonardi Giovanni Centonze Federica Morano Marco Maria Germani Fotios Loupakis Luca Morelli Lucio Urbani Silvia Brich Federica Marmorino Michele Prisciandaro Giuseppe Aprile Matteo Fassan Umberto Cillo Laura Cattaneo Gabriella Fontanini Filippo De Braud Alfredo Falcone Massimo Milione Filippo Pietrantonio Chiara Cremolini

Eur J Cancer 2020 Aug 15;135:78-88. Epub 2020 Jun 15.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2020.04.045DOI Listing
August 2020

Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine.

Authors:
Gregorio Di Franco Alice Usai Niccola Funel Matteo Palmeri Ida Elena Rosamaria Montesanti Matteo Bianchini Desirée Gianardi Niccolò Furbetta Simone Guadagni Enrico Vasile Alfredo Falcone Luca Emanuele Pollina Vittoria Raffa Luca Morelli

World J Gastroenterol 2020 Jun;26(21):2792-2809

General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa 56124, Italy.

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http://dx.doi.org/10.3748/wjg.v26.i21.2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284182PMC
June 2020

TRIBE2 results and toxicity - Authors' reply.

Authors:
Carlotta Antoniotti Chiara Cremolini Daniele Rossini Alfredo Falcone

Lancet Oncol 2020 06;21(6):e300-e301

Department of Oncology, University Hospital of Pisa, Pisa, Italy; Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy; Unit of Medical Oncology, Azienda Ospedaliera-Universitaria Pisana, Pisa 56126, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(20)30288-6DOI Listing
June 2020

Safety, efficacy and patient-reported outcomes with trifluridine/tipiracil in pretreated metastatic colorectal cancer: results of the PRECONNECT study.

Authors:
Jean-Baptiste Bachet Lucjan Wyrwicz Timothy Price Chiara Cremolini Jean-Marc Phelip Fabienne Portales Ahmet Ozet Irfan Cicin Dan Atlan Martin Becquart Loick Vidot Nadjat Mounedji Eric Van Cutsem Julien Taieb Alfredo Falcone

ESMO Open 2020 Jun;5(3)

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Toscana, Italy.

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http://dx.doi.org/10.1136/esmoopen-2020-000698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264999PMC
June 2020

Retreatment With Anti-EGFR Antibodies in Metastatic Colorectal Cancer Patients: A Multi-institutional Analysis.

Authors:
Daniele Rossini Marco Maria Germani Filippo Pagani Antonio Pellino Emanuela Dell'Aquila Maria Bensi Nicole Liscia Roberto Moretto Alessandra Boccaccino Michele Prisciandaro Sara Manglaviti Marta Schirripa Raffaella Vivolo Mario Scartozzi Daniele Santini Lisa Salvatore Filippo Pietrantonio Fotios Loupakis Alfredo Falcone Chiara Cremolini

Clin Colorectal Cancer 2020 Sep 11;19(3):191-199.e6. Epub 2020 Apr 11.

Department of Translational Research and New Technologies in Medicine and Surgery, Unit of Medical Oncology 2, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2020.03.009DOI Listing
September 2020

Real-world treatment patterns, healthcare resource use and clinical outcomes of patients receiving second line therapy for advanced or metastatic gastric cancer.

Authors:
David Gómez-Ulloa Mayur Amonkar Smita Kothari Winson Y Cheung Ian Chau John R Zalcberg Núria Lara Suriñach Alfredo Falcone

BMC Gastroenterol 2020 May 5;20(1):133. Epub 2020 May 5.

University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1186/s12876-020-01232-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201990PMC
May 2020

HER2 Overexpression as a Poor Prognostic Determinant in Resected Biliary Tract Cancer.

Authors:
Caterina Vivaldi Lorenzo Fornaro Clara Ugolini Cristina Niccoli Gianna Musettini Irene Pecora Andrea Cacciato Insilla Francesca Salani Giulia Pasquini Silvia Catanese Monica Lencioni Gianluca Masi Daniela Campani Gabriella Fontantini Alfredo Falcone Enrico Vasile

Oncologist 2020 Apr 30. Epub 2020 Apr 30.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1634/theoncologist.2019-0922DOI Listing
April 2020

The Role of Anti-Angiogenics in Pre-Treated Metastatic -Mutant Colorectal Cancer: A Pooled Analysis.

Authors:
Fabio Gelsomino Andrea Casadei-Gardini Daniele Rossini Alessandra Boccaccino Gianluca Masi Chiara Cremolini Andrea Spallanzani Massimo Giuseppe Viola Ingrid Garajovà Massimiliano Salati Maria Teresa Elia Francesco Caputo Chiara Santini Alfredo Falcone Stefano Cascinu Emiliano Tamburini

Cancers (Basel) 2020 Apr 21;12(4). Epub 2020 Apr 21.

Department of Medical Oncology, Card. G. Panico Hospital of Tricase, 73039 Tricase, Italy.

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http://dx.doi.org/10.3390/cancers12041022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226019PMC
April 2020

A polymorphism within the R-spondin 2 gene predicts outcome in metastatic colorectal cancer patients treated with FOLFIRI/bevacizumab: data from FIRE-3 and TRIBE trials.

Authors:
Martin D Berger Yan Ning Sebastian Stintzing Volker Heinemann Shu Cao Wu Zhang Dongyun Yang Yuji Miyamoto Mitsukuni Suenaga Marta Schirripa Diana L Hanna Shivani Soni Alberto Puccini Ryuma Tokunaga Madiha Naseem Francesca Battaglin Chiara Cremolini Alfredo Falcone Fotios Loupakis Heinz-Josef Lenz

Eur J Cancer 2020 May 16;131:89-97. Epub 2020 Apr 16.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.ejca.2020.02.048DOI Listing
May 2020

Clinical and economic effect of administration of red blood product transfusions in an outpatient supportive care cancer service.

Authors:
Andrea Sbrana Federico Paolieri Francesco Bloise Marco Danova Luca Galli Isa M Brunetti Enrico Vasile Sergio Ricci Alfredo Falcone Andrea Antonuzzo

Biomed Rep 2020 Apr 10;12(4):199-203. Epub 2020 Feb 10.

Medical Oncology Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, I-56126 Pisa, Italy.

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http://dx.doi.org/10.3892/br.2020.1274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054705PMC
April 2020

A Model of a Zebrafish Avatar for Co-Clinical Trials.

Authors:
Alice Usai Gregorio Di Franco Patrizia Colucci Luca Emanuele Pollina Enrico Vasile Niccola Funel Matteo Palmeri Luciana Dente Alfredo Falcone Luca Morelli Vittoria Raffa

Cancers (Basel) 2020 Mar 13;12(3). Epub 2020 Mar 13.

Department of Biology, University di Pisa, S.S. 12 Abetone e Brennero 4, 56127 Pisa, Italy.

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http://dx.doi.org/10.3390/cancers12030677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140063PMC
March 2020

Immune Profiling of Deficient Mismatch Repair Colorectal Cancer Tumor Microenvironment Reveals Different Levels of Immune System Activation.

Authors:
Riccardo Giannini Gemma Zucchelli Mirella Giordano Clara Ugolini Roberto Moretto Katarzyna Ambryszewska Michele Leonardi Elisa Sensi Federica Morano Filippo Pietrantonio Chiara Cremolini Alfredo Falcone Gabriella Fontanini

J Mol Diagn 2020 05 13;22(5):685-698. Epub 2020 Mar 13.

Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2020.02.008DOI Listing
May 2020

Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial.

Authors:
Chiara Cremolini Carlotta Antoniotti Daniele Rossini Sara Lonardi Fotios Loupakis Filippo Pietrantonio Roberto Bordonaro Tiziana Pia Latiano Emiliano Tamburini Daniele Santini Alessandro Passardi Federica Marmorino Roberta Grande Giuseppe Aprile Alberto Zaniboni Sabina Murgioni Cristina Granetto Angela Buonadonna Roberto Moretto Salvatore Corallo Stefano Cordio Lorenzo Antonuzzo Gianluca Tomasello Gianluca Masi Monica Ronzoni Samantha Di Donato Chiara Carlomagno Matteo Clavarezza Giuliana Ritorto Andrea Mambrini Mario Roselli Samanta Cupini Serafina Mammoliti Elisabetta Fenocchio Enrichetta Corgna Vittorina Zagonel Gabriella Fontanini Clara Ugolini Luca Boni Alfredo Falcone

Lancet Oncol 2020 04 9;21(4):497-507. Epub 2020 Mar 9.

Department of Oncology, University Hospital of Pisa, Pisa, Italy; Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30862-9DOI Listing
April 2020

Immune Checkpoint Inhibitors in Esophageal Cancers: are we Finally Finding the Right Path in the Mist?

Authors:
Caterina Vivaldi Silvia Catanese Valentina Massa Irene Pecora Francesca Salani Stefano Santi Monica Lencioni Enrico Vasile Alfredo Falcone Lorenzo Fornaro

Int J Mol Sci 2020 Feb 28;21(5). Epub 2020 Feb 28.

Unit of Medical Oncology, Pisa University Hospital, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/ijms21051658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084692PMC
February 2020

Tumor Regression Grading Assessment in Locally Advanced Pancreatic Cancer After Neoadjuvant FOLFIRINOX: Interobserver Agreement and Prognostic Implications.

Authors:
Andrea Cacciato Insilla Caterina Vivaldi Mirella Giordano Enrico Vasile Carla Cappelli Emanuele Kauffmann Niccolò Napoli Alfredo Falcone Ugo Boggi Daniela Campani

Front Oncol 2020 7;10:64. Epub 2020 Feb 7.

Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.3389/fonc.2020.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025535PMC
February 2020

FLOaTing toward new standards in locally advanced resectable gastroesophageal cancer.

Authors:
Lorenzo Fornaro Caterina Vivaldi Lorenzo Calvetti Alessandro Cappetta Alfredo Falcone Giuseppe Aprile

J Thorac Dis 2019 Dec;11(12):5694-5700

Department of Oncology, San Bortolo General Hospital, Vicenza, Italy.

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http://dx.doi.org/10.21037/jtd.2019.12.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988033PMC
December 2019

Application of the ESR iGuide clinical decision support system to the imaging pathway of patients with hepatocellular carcinoma and cholangiocarcinoma: preliminary findings.

Authors:
Michela Gabelloni Matteo Di Nasso Riccardo Morganti Lorenzo Faggioni Gianluca Masi Alfredo Falcone Emanuele Neri

Radiol Med 2020 Jun 4;125(6):531-537. Epub 2020 Feb 4.

Diagnostic and Interventional Radiology, Department of Translational Research, University of Pisa, Via Roma, 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s11547-020-01142-wDOI Listing
June 2020

Angiogenesis Genotyping and Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib: The ALICE-2 Study.

Authors:
Luca Faloppi Marco Puzzoni Andrea Casadei Gardini Nicola Silvestris Gianluca Masi Giorgia Marisi Caterina Vivaldi Cosmo Damiano Gadaleta Pina Ziranu Maristella Bianconi Cristian Loretelli Laura Demurtas Eleonora Lai Riccardo Giampieri Eva Galizia Paola Ulivi Nicola Battelli Alfredo Falcone Stefano Cascinu Mario Scartozzi

Target Oncol 2020 02;15(1):115-126

Medical Oncology Unit, University Hospital and University of Cagliari, Cagliari, Italy.

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http://dx.doi.org/10.1007/s11523-020-00698-xDOI Listing
February 2020

mutant metastatic colorectal cancers: new arrows in our quiver.

Authors:
Chiara Cremolini Roberto Moretto Gemma Zucchelli Alfredo Falcone

Ann Transl Med 2019 Dec;7(Suppl 8):S367

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.21037/atm.2019.08.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976512PMC
December 2019

Prognostic clinical factors in patients affected by non-small-cell lung cancer receiving Nivolumab.

Authors:
Francesco Pantano Marco Russano Alfredo Berruti Giovanni Mansueto Maria R Migliorino Vincenzo Adamo Giuseppe Aprile Alain Gelibter Corrado Ficorella Alfredo Falcone Antonio Russo Michele Aieta Michele Maio Olga Martelli Sandro Barni Andrea Napolitano Elisa Roca Silvia Quadrini Daniela Iacono Alessandro Russo Lorenzo Calvetti Mario A Occhipinti Alessio Cortellini Enrico Vasile Francesco Passiglia Marco Imperatori Luana Calabrò Anna M Di Giacomo Fausto Petrelli Giulia Pasquini Tindara Franchina Olga Venditti Salvatore Intagliata Antonio Galvano Iacopo Fioroni Bruno Vincenzi Giuseppe Tonini Daniele Santini

Expert Opin Biol Ther 2020 Mar 6;20(3):319-326. Epub 2020 Feb 6.

Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1080/14712598.2020.1724953DOI Listing
March 2020

Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Outcomes with Nivolumab in Pretreated Non-Small Cell Lung Cancer (NSCLC): A Large Retrospective Multicenter Study.

Authors:
Alessandro Russo Marco Russano Tindara Franchina Maria R Migliorino Giuseppe Aprile Giovanni Mansueto Alfredo Berruti Alfredo Falcone Michele Aieta Alain Gelibter Antonio Russo Sandro Barni Michele Maio Olga Martelli Francesco Pantano Daniela Iacono Lorenzo Calvetti Silvia Quadrini Elisa Roca Enrico Vasile Marco Imperatori Mario Occhipinti Antonio Galvano Fausto Petrelli Luana Calabrò Giulia Pasquini Salvatore Intagliata Giuseppina R R Ricciardi Giuseppe Tonini Daniele Santini Vincenzo Adamo

Adv Ther 2020 03 30;37(3):1145-1155. Epub 2020 Jan 30.

Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy.

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http://dx.doi.org/10.1007/s12325-020-01229-wDOI Listing
March 2020

Duration of oxaliplatin-based adjuvant chemotherapy in patients with Stage III or high-risk Stage II resected colon cancer.

Authors:
Roberto Moretto Alfredo Falcone Chiara Cremolini

Int J Cancer 2020 05 29;146(9):2652-2654. Epub 2020 Jan 29.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1002/ijc.32884DOI Listing
May 2020

First-line trifluridine/tipiracil plus bevacizumab for unresectable metastatic colorectal cancer: SOLSTICE study design.

Authors:
Thierry André Mark Saunders Akira Kanehisa Eric Gandossi Ronan Fougeray Nadia Causse Amellal Alfredo Falcone

Future Oncol 2020 Feb 9;16(4):21-29. Epub 2020 Jan 9.

University Hospital of Pisa, Pisa, Italy.

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http://dx.doi.org/10.2217/fon-2019-0786DOI Listing
February 2020

Dedifferentiated liposarcoma: when eribulin can make the difference.

Authors:
Andrea Sbrana Federico Paolieri Francesco Bloise Simona Manacorda Amedeo Nuzzo Enrico Sammarco Luca Galli Alfredo Falcone

Future Oncol 2020 Jan 24;16(1s):21-24. Epub 2019 Dec 24.

Medical Oncology Unit 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.2217/fon-2019-0598DOI Listing
January 2020

Safety and effectiveness of regorafenib in patients with metastatic colorectal cancer in routine clinical practice in the prospective, observational CORRELATE study.

Authors:
Michel Ducreux Lone Nørgård Petersen Leopold Öhler Francesca Bergamo Jean-Philippe Metges Jan Willem de Groot Jaw-Yuan Wang Beatriz García Paredes Emmanuelle Dochy Sabine Fiala-Buskies Andrés Cervantes Juan Manuel O'Connor Alfredo Falcone

Eur J Cancer 2019 12 4;123:146-154. Epub 2019 Nov 4.

Department of Medical Oncology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.ejca.2019.09.015DOI Listing
December 2019

Clinical impact of first-line bevacizumab plus chemotherapy in metastatic colorectal cancer of mucinous histology: a multicenter, retrospective analysis on 685 patients.

Authors:
Vincenzo Catalano Francesca Bergamo Chiara Cremolini Bruno Vincenzi Francesca Negri Paolo Giordani Paolo Alessandroni Rossana Intini Silvia Stragliotto Daniele Rossini Beatrice Borelli Daniele Santini Donatella Sarti Marco B L Rocchi Sara Lonardi Alfredo Falcone Vittorina Zagonel Rodolfo Mattioli Francesco Graziano

J Cancer Res Clin Oncol 2020 Feb 6;146(2):493-501. Epub 2019 Nov 6.

Department of Oncology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Presidio San Salvatore, Via Lombroso 1, 61122, Pesaro, Italy.

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http://dx.doi.org/10.1007/s00432-019-03077-wDOI Listing
February 2020

Health-related Quality of Life in the Phase III LUME-Colon 1 Study: Comparison and Interpretation of Results From EORTC QLQ-C30 Analyses.

Authors:
Heinz-Josef Lenz Guillem Argiles Takayuki Yoshino Sara Lonardi Alfredo Falcone María Luisa Limón Alberto Sobrero Claudia Hastedt Barbara Peil Florian Voss Ingolf Griebsch Eric Van Cutsem

Clin Colorectal Cancer 2019 12 4;18(4):269-279.e5. Epub 2019 Sep 4.

Digestive Oncology, University Hospitals Leuven and KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.clcc.2019.08.005DOI Listing
December 2019

Validated Nomogram Predicting 6-Month Survival in Pancreatic Cancer Patients Receiving First-Line 5-Fluorouracil, Oxaliplatin, and Irinotecan.

Authors:
Lorenzo Fornaro Francesco Leone Angélique Vienot Andrea Casadei-Gardini Caterina Vivaldi Astrid Lièvre Pasquale Lombardi Emmanuele De Luca Dewi Vernerey Elisa Sperti Gianna Musettini Maria Antonietta Satolli Julien Edeline Rosella Spadi Cindy Neuzillet Alfredo Falcone Giulia Pasquini Mario Clerico Alessandro Passardi Paola Buscaglia Aurélia Meurisse Massimo Aglietta Clémence Brac Enrico Vasile Francesco Montagnani

Clin Colorectal Cancer 2019 12 4;18(4):e394-e401. Epub 2019 Sep 4.

S.C. Oncologia, Department of Oncology, ASL BI, Biella, Italy.

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http://dx.doi.org/10.1016/j.clcc.2019.08.004DOI Listing
December 2019

Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer.

Authors:
Tomasz Burzykowski Elisabeth Coart Everardo D Saad Qian Shi Dirkje W Sommeijer Carsten Bokemeyer Eduardo Díaz-Rubio Jean-Yves Douillard Alfredo Falcone Charles S Fuchs Richard M Goldberg J Randolph Hecht Paulo M Hoff Herbert Hurwitz Fairooz F Kabbinavar Miriam Koopman Timothy S Maughan Cornelis J A Punt Leonard Saltz Hans-Joachim Schmoll Matthew T Seymour Niall C Tebbutt Christophe Tournigand Eric Van Cutsem Aimery de Gramont John R Zalcberg Marc Buyse

JAMA Netw Open 2019 09 4;2(9):e1911750. Epub 2019 Sep 4.

Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1001/jamanetworkopen.2019.11750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755539PMC
September 2019

Body Mass Index and Hormone Receptor Status Influence Recurrence Risk in HER2-Positive Early Breast Cancer Patients.

Authors:
Luca Cantini Mirco Pistelli Filippo Merloni Andrea Fontana Ilaria Bertolini Claudia De Angelis Lucia Bastianelli Arianna Della Mora Alfredo Santinelli Agnese Savini Elena Maccaroni Lucrezia Diodati Alfredo Falcone Rossana Berardi

Clin Breast Cancer 2020 02 11;20(1):e89-e98. Epub 2019 Jul 11.

Clinica Oncologica, Università Politecnica delle Marche, AOU Ospedali Riuniti, Ancona, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clbc.2019.06.008DOI Listing
February 2020

Overexpression of TK1 and CDK9 in plasma-derived exosomes is associated with clinical resistance to CDK4/6 inhibitors in metastatic breast cancer patients.

Authors:
Marzia Del Re Ilaria Bertolini Stefania Crucitta Lorenzo Fontanelli Eleonora Rofi Claudia De Angelis Lucrezia Diodati Diletta Cavallero Giulia Gianfilippo Barbara Salvadori Stefano Fogli Alfredo Falcone Cristian Scatena Antonio Giuseppe Naccarato Manuela Roncella Matteo Ghilli Riccardo Morganti Andrea Fontana Romano Danesi

Breast Cancer Res Treat 2019 Nov 26;178(1):57-62. Epub 2019 Jul 26.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, 55, Via Roma, 56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s10549-019-05365-yDOI Listing
November 2019

Early Tumor Shrinkage and Depth of Response Evaluation in Metastatic Pancreatic Cancer Treated with First Line Chemotherapy: An Observational Retrospective Cohort Study.

Authors:
Caterina Vivaldi Lorenzo Fornaro Carla Cappelli Irene Pecora Silvia Catanese Francesca Salani Andrea Cacciato Insilla Emanuele Kauffmann Francescamaria Donati Giulia Pasquini Valentina Massa Niccolò Napoli Monica Lencioni Piero Boraschi Daniela Campani Ugo Boggi Davide Caramella Alfredo Falcone Enrico Vasile

Cancers (Basel) 2019 Jul 4;11(7). Epub 2019 Jul 4.

Division of Medical Oncology, Pisa University Hospital, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/cancers11070939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678367PMC
July 2019

Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial.

Authors:
Filippo Pietrantonio Federica Morano Salvatore Corallo Rosalba Miceli Sara Lonardi Alessandra Raimondi Chiara Cremolini Lorenza Rimassa Francesca Bergamo Andrea Sartore-Bianchi Marco Tampellini Patrizia Racca Matteo Clavarezza Rosa Berenato Marta Caporale Maria Antista Monica Niger Valeria Smiroldo Roberto Murialdo Alberto Zaniboni Vincenzo Adamo Gianluca Tomasello Monica Giordano Fausto Petrelli Raffaella Longarini Saverio Cinieri Alfredo Falcone Vittorina Zagonel Maria Di Bartolomeo Filippo de Braud

JAMA Oncol 2019 Jul 3. Epub 2019 Jul 3.

Oncology and Hemato-oncology Department, University of Milan, Milan, Italy.

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https://jamanetwork.com/journals/jamaoncology/fullarticle/27
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http://dx.doi.org/10.1001/jamaoncol.2019.1467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613306PMC
July 2019

Clinical and molecular determinants of extrahepatic disease progression in patients with metastatic colorectal cancer with liver-limited metastases deemed initially unresectable.

Authors:
Elena Ongaro Chiara Cremolini Daniele Rossini Francesca Corti Filippo Pagani Luca Morelli Lucio Urbani Gianluca Masi Carlo Sposito Beatrice Filippi Beatrice Borelli Gemma Zucchelli Roberto Moretto Alessandra Boccaccino Leonardo Solaini Filippo de Braud Vincenzo Mazzaferro Alfredo Falcone Alessandro Cucchetti Filippo Pietrantonio

ESMO Open 2019 9;4(2):e000496. Epub 2019 May 9.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

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http://dx.doi.org/10.1136/esmoopen-2019-000496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555604PMC
May 2019

Quantitative evidence for early metastatic seeding in colorectal cancer.

Authors:
Zheng Hu Jie Ding Zhicheng Ma Ruping Sun Jose A Seoane J Scott Shaffer Carlos J Suarez Anna S Berghoff Chiara Cremolini Alfredo Falcone Fotios Loupakis Peter Birner Matthias Preusser Heinz-Josef Lenz Christina Curtis

Nat Genet 2019 07 17;51(7):1113-1122. Epub 2019 Jun 17.

Department of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41588-019-0423-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982526PMC
July 2019

Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells.

Authors:
Paola Orlandi Daniela Gentile Marta Banchi Federico Cucchiara Teresa Di Desidero Chiara Cremolini Roberto Moretto Alfredo Falcone Guido Bocci

Invest New Drugs 2020 02 1;38(1):92-98. Epub 2019 Jun 1.

Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Savi 10, I-56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-019-00804-5DOI Listing
February 2020

Bevacizumab as maintenance therapy in mCRC: Interpreting results of the MOMA trial.

Authors:
Federica Marmorino Alfredo Falcone Chiara Cremolini

Oncotarget 2019 Apr 19;10(29):2791-2792. Epub 2019 Apr 19.

Chiara Cremolini: Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.26870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497461PMC
April 2019

AR-V7 and AR-FL expression is associated with clinical outcome: a translational study in patients with castrate resistant prostate cancer.

Authors:
Marzia Del Re Stefania Crucitta Andrea Sbrana Eleonora Rofi Federico Paolieri Giulia Gianfilippo Luca Galli Alfredo Falcone Riccardo Morganti Camillo Porta Eleni Efstathiou Ron van Schaik Guido Jenster Romano Danesi

BJU Int 2019 May 4. Epub 2019 May 4.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1111/bju.14792DOI Listing
May 2019

Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial.

Authors:
Cathy Eng Tae Won Kim Johanna Bendell Guillem Argilés Niall C Tebbutt Maria Di Bartolomeo Alfredo Falcone Marwan Fakih Mark Kozloff Neil H Segal Alberto Sobrero Yibing Yan Ilsung Chang Anne Uyei Louise Roberts Fortunato Ciardiello

Lancet Oncol 2019 06 16;20(6):849-861. Epub 2019 Apr 16.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30027-0DOI Listing
June 2019

Benefit from anti-EGFRs in and wild-type metastatic transverse colon cancer: a clinical and molecular proof of concept study.

Authors:
Chiara Cremolini Matteo Benelli Elisa Fontana Filippo Pagani Daniele Rossini Giovanni Fucà Adele Busico Elena Conca Samantha Di Donato Fotios Loupakis Marta Schirripa Sara Lonardi Beatrice Borelli Elena Ongaro Katherine Eason Federica Morano Mariaelena Casagrande Matteo Fassan Anguraj Sadanandam Filippo de Braud Alfredo Falcone Filippo Pietrantonio

ESMO Open 2019 8;4(2):e000489. Epub 2019 Mar 8.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2019-000
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http://dx.doi.org/10.1136/esmoopen-2019-000489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435314PMC
March 2019

Interprofessional spiritual care in oncology: a literature review.

Authors:
Christina M Puchalski Andrea Sbrana Betty Ferrell Najmeh Jafari Stephen King Tracy Balboni Guido Miccinesi Anna Vandenhoeck Michael Silbermann Lodovico Balducci Julianna Yong Andrea Antonuzzo Alfredo Falcone Carla Ida Ripamonti

ESMO Open 2019 16;4(1):e000465. Epub 2019 Feb 16.

Oncology-Supportive Care Unit, Department of Oncology-Haematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2018-000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435249PMC
February 2019

Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics.

Authors:
Teresa Di Desidero Paola Orlandi Anna Fioravanti Greta Alì Chiara Cremolini Fotios Loupakis Daniela Gentile Marta Banchi Federico Cucchiara Carlotta Antoniotti Gianluca Masi Gabriella Fontanini Alfredo Falcone Guido Bocci

Biochem Pharmacol 2019 06 3;164:94-105. Epub 2019 Apr 3.

Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Savi 10, I-56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.04.001DOI Listing
June 2019

Lack of Benefit From Anti-EGFR Treatment in RAS and BRAF Wild-type Metastatic Colorectal Cancer With Mucinous Histology or Mucinous Component.

Authors:
Roberto Moretto Federica Morano Elena Ongaro Daniele Rossini Filippo Pietrantonio Mariaelena Casagrande Carlotta Antoniotti Salvatore Corallo Federica Marmorino Francesco Cortiula Federico Nichetti Beatrice Borelli Gemma Zucchelli Alessandra Boccaccino Gianluca Masi Filippo de Braud Alfredo Falcone Chiara Cremolini

Clin Colorectal Cancer 2019 06 7;18(2):116-124. Epub 2019 Mar 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.02.007DOI Listing
June 2019

AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3.

Authors:
Ryuma Tokunaga Shu Cao Madiha Naseem Francesca Battaglin Jae Ho Lo Hiroyuki Arai Fotios Loupakis Sebastian Stintzing Alberto Puccini Martin D Berger Shivani Soni Wu Zhang Christoph Mancao Bodour Salhia Shannon M Mumenthaler Daniel J Weisenberger Gangning Liang Chiara Cremolini Volker Heinemann Alfredo Falcone Joshua Millstein Heinz-Josef Lenz

Int J Cancer 2019 10 26;145(8):2082-2090. Epub 2019 Mar 26.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/ijc.32261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7491977PMC
October 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Authors:
Alberto Puccini Fotios Loupakis Sebastian Stintzing Shu Cao Francesca Battaglin Ryuma Togunaka Madiha Naseem Martin D Berger Shivani Soni Wu Zhang Christoph Mancao Bodour Salhia Shannon M Mumenthaler Daniel J Weisenberger Gangning Liang Chiara Cremolini Volker Heinemann Alfredo Falcone Joshua Millstein Heinz-Josef Lenz

Eur J Cancer 2019 04 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

Prognostic impact of ATM mutations in patients with metastatic colorectal cancer.

Authors:
Giovanni Randon Giovanni Fucà Daniele Rossini Alessandra Raimondi Filippo Pagani Federica Perrone Elena Tamborini Adele Busico Giorgia Peverelli Federica Morano Monica Niger Maria Antista Salvatore Corallo Serena Saggio Beatrice Borelli Gemma Zucchelli Massimo Milione Giancarlo Pruneri Maria Di Bartolomeo Alfredo Falcone Filippo de Braud Chiara Cremolini Filippo Pietrantonio

Sci Rep 2019 02 27;9(1):2858. Epub 2019 Feb 27.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via G. Venezian, 1 - 20133, Milan, Italy.

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http://dx.doi.org/10.1038/s41598-019-39525-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393680PMC
February 2019

Robotic-assisted surgery for colorectal liver metastasis: A single-centre experience.

Authors:
Simone Guadagni Niccolò Furbetta Gregorio Di Franco Matteo Palmeri Desirée Gianardi Matteo Bianchini Martina Guadagnucci Luca Pollina Gianluca Masi Chiara Cremolini Alfredo Falcone Franco Mosca Giulio Di Candio Luca Morelli

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Translational and New Technologies in Medicine, General Surgery Unit; EndoCAS (Center for Computer Assisted Surgery), University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.4103/jmas.JMAS_265_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176011PMC
February 2019

Validated clinico-pathologic nomogram in the prediction of HER2 status in gastro-oesophageal cancer.

Authors:
Lorenzo Fornaro Caterina Vivaldi Annamaria Parnofiello Clara Ugolini Giuseppe Aprile Giovanna De Maglio Irene Pecora Donatella Iacono Francesca Crivelli Silvia Catanese Giovanni Gerardo Cardellino Monica Lencioni Enrico Vasile Francesca Salani Mario Clerico Lorenzo Calvetti Alfredo Falcone Gianpiero Fasola Gabriella Fontanini Francesco Montagnani

Br J Cancer 2019 03 12;120(5):522-526. Epub 2019 Feb 12.

Department of Oncology, Azienda Sanitaria Locale di Biella, Ponderano (BI), Italy.

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http://www.nature.com/articles/s41416-019-0399-4
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http://dx.doi.org/10.1038/s41416-019-0399-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461920PMC
March 2019

Total neoadjuvant approach with FOLFOXIRI plus bevacizumab followed by chemoradiotherapy plus bevacizumab in locally advanced rectal cancer: the TRUST trial.

Authors:
Gianluca Masi Caterina Vivaldi Lorenzo Fornaro Sara Lonardi Piero Buccianti Aldo Sainato Lorenzo Marcucci Angelo Martignetti Emanuele Damiano Luca Urso Maura Castagna Gabriella Fontanini Francesca Bergamo Gianna Musettini Lucio Urbani Elisa Sensi Riccardo Balestri Sabrina Montrone Francesco Pasqualetti Chiara Cremolini Antonello Di Paolo Vittorina Zagonel Alfredo Falcone

Eur J Cancer 2019 03 7;110:32-41. Epub 2019 Feb 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.006DOI Listing
March 2019

Phase II randomised study of maintenance treatment with bevacizumab or bevacizumab plus metronomic chemotherapy after first-line induction with FOLFOXIRI plus Bevacizumab for metastatic colorectal cancer patients: the MOMA trial.

Authors:
Chiara Cremolini Federica Marmorino Francesca Bergamo Giuseppe Aprile Lisa Salvatore Gianluca Masi Emanuela Dell'Aquila Carlotta Antoniotti Sabina Murgioni Giacomo Allegrini Beatrice Borelli Donatello Gemma Mariaelena Casagrande Cristina Granetto Sara Delfanti Samantha Di Donato Marta Schirripa Elisa Sensi Giuseppe Tonini Sara Lonardi Gabriella Fontanini Luca Boni Alfredo Falcone

Eur J Cancer 2019 03 5;109:175-182. Epub 2019 Feb 5.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.12.028DOI Listing
March 2019

DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients.

Authors:
Marzia Del Re Saverio Cinieri Angela Michelucci Stefano Salvadori Fotios Loupakis Marta Schirripa Chiara Cremolini Stefania Crucitta Cecilia Barbara Angelo Di Leo Tiziana Pia Latiano Filippo Pietrantonio Samantha Di Donato Paolo Simi Alessandro Passardi Filippo De Braud Giuseppe Altavilla Claudio Zamagni Roberto Bordonaro Alfredo Butera Evaristo Maiello Carmine Pinto Alfredo Falcone Valentina Mazzotti Riccardo Morganti Romano Danesi

Pharmacogenomics J 2019 12 6;19(6):556-563. Epub 2019 Feb 6.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/s41397-019-0077-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6867961PMC
December 2019

Is a pharmacogenomic panel useful to estimate the risk of oxaliplatin-related neurotoxicity in colorectal cancer patients?

Authors:
Federico Nichetti Felicia Stefania Falvella Rosalba Miceli Stefania Cheli Raffaella Gaetano Giovanni Fucà Gabriele Infante Antonia Martinetti Carlotta Antoniotti Alfredo Falcone Maria Di Bartolomeo Chiara Cremolini Filippo de Braud Filippo Pietrantonio

Pharmacogenomics J 2019 10 4;19(5):465-472. Epub 2019 Feb 4.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1038/s41397-019-0078-0DOI Listing
October 2019

Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with regorafenib.

Authors:
Marta Schirripa Beatrice Borelli Romina D'Aurizio Simone Lubrano Chiara Cremolini Gemma Zucchelli Carlotta Antoniotti Federica Marmorino Alessandra Anna Prete Sabina Murgioni Francesca Bergamo Vittorina Zagonel Andrea Tuccoli Andrea Marranci Milena Rizzo Lorena Tedeschi Letizia Magnoni Alfredo Falcone Fotios Loupakis Laura Poliseno

Pharmacogenomics J 2019 10 28;19(5):455-464. Epub 2019 Jan 28.

Institute of Clinical Physiology, CNR, Pisa, Italy.

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http://dx.doi.org/10.1038/s41397-019-0075-3DOI Listing
October 2019

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Authors:
Eleonora Rofi Caterina Vivaldi Marzia Del Re Elena Arrigoni Stefania Crucitta Niccola Funel Stefano Fogli Enrico Vasile Gianna Musettini Lorenzo Fornaro Alfredo Falcone Romano Danesi

Pharmacogenomics 2019 01 6;20(1):49-68. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.2217/pgs-2018-0149DOI Listing
January 2019

Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.

Authors:
Chiara Cremolini Daniele Rossini Emanuela Dell'Aquila Sara Lonardi Elena Conca Marzia Del Re Adele Busico Filippo Pietrantonio Romano Danesi Giuseppe Aprile Emiliano Tamburini Carlo Barone Gianluca Masi Francesco Pantano Francesca Pucci Domenico C Corsi Nicoletta Pella Francesca Bergamo Eleonora Rofi Cecilia Barbara Alfredo Falcone Daniele Santini

JAMA Oncol 2019 03;5(3):343-350

Department of Medical Oncology, Campus Bio-Medico University of Rome, Rome, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2018.5080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439839PMC
March 2019

Optimization of biomarkers-based classification scores as progression-free survival predictors: an intuitive graphical representation.

Authors:
Marian Manciu Sorour Hosseini Teresa Di Desidero Giacomo Allegrini Alfredo Falcone Guido Bocci Robert A Kirken Giulio Francia

Future Sci OA 2018 12 1;4(10):FSO346. Epub 2018 Nov 1.

Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, 79968, USA.

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https://www.future-science.com/doi/10.4155/fsoa-2018-0020
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http://dx.doi.org/10.4155/fsoa-2018-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234460PMC
December 2018

Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy.

Authors:
Ryuma Tokunaga Shu Cao Madiha Naseem Jae Ho Lo Francesca Battaglin Alberto Puccini Martin D Berger Shivani Soni Joshua Millstein Wu Zhang Sebastian Stintzing Fotios Loupakis Chiara Cremolini Volker Heinemann Alfredo Falcone Heinz-Josef Lenz

Clin Colorectal Cancer 2019 03 13;18(1):e8-e19. Epub 2018 Sep 13.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183038
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http://dx.doi.org/10.1016/j.clcc.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416082PMC
March 2019

Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database.

Authors:
Mohamed E Salem Jun Yin Benjamin A Weinberg Lindsay A Renfro Levi D Pederson Timothy S Maughan Richard A Adams Eric Van Cutsem Alfredo Falcone Niall C Tebbutt Matthew T Seymour Eduardo Díaz-Rubio Enrique Aranda Carsten Bokemeyer Volker Heinemann Harpreet Wasan Aimery de Gramont Axel Grothey Qian Shi Daniel J Sargent John L Marshall

Eur J Cancer 2018 11 27;103:205-213. Epub 2018 Sep 27.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.ejca.2018.08.020DOI Listing
November 2018

BRAF V600E Mutation as a Negative Prognostic Determinant in Resected Colorectal Liver Metastases.

Authors:
Roberto Moretto Chiara Cremolini Alfredo Falcone

JAMA Surg 2018 12;153(12):1162-1163

Unit of Medical Oncology 2, Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2018.3334DOI Listing
December 2018

Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single-Arm, Open-Label Phase IIIb CONSIGN Study.

Authors:
Eric Van Cutsem Erika Martinelli Stefano Cascinu Alberto Sobrero Maria Banzi Jean-François Seitz Carlo Barone Marc Ychou Marc Peeters Baruch Brenner Ralf Dieter Hofheinz Evaristo Maiello Thierry André Andrea Spallanzani Rocio Garcia-Carbonero Yull E Arriaga Udit Verma Axel Grothey Christian Kappeler Ashok Miriyala Joachim Kalmus Alfredo Falcone Alberto Zaniboni

Oncologist 2019 02 6;24(2):185-192. Epub 2018 Sep 6.

Department of Oncology, Fondazione Poliambulanza, Brescia, Italy.

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http://dx.doi.org/10.1634/theoncologist.2018-0072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369948PMC
February 2019

The Winding Roadmap of Biomarkers toward Clinic: Lessons from Predictors of Resistance to Anti-EGFRs in Metastatic Colorectal Cancer.

Authors:
Carlotta Antoniotti Elena Ongaro Alfredo Falcone Chiara Cremolini

Int J Mol Sci 2018 Aug 5;19(8). Epub 2018 Aug 5.

Department of Oncology, University Hospital of Pisa, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/ijms19082298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121538PMC
August 2018

TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable and wild-type metastatic colorectal cancer.

Authors:
Beatrice Borelli Roberto Moretto Sara Lonardi Andrea Bonetti Carlotta Antoniotti Filippo Pietrantonio Gianluca Masi Valentina Burgio Federica Marmorino Lisa Salvatore Daniele Rossini Alberto Zaniboni Gemma Zucchelli Angelo Martignetti Monica Di Battista Nicoletta Pella Alessandro Passardi Alessandra Boccaccino Francesco Leone Camilla Colombo Cristina Granetto Francesca Vannini Valentina Angela Marsico Erika Martinelli Lorenzo Antonuzzo Stefano Vitello Laura Delliponti Luca Boni Chiara Cremolini Alfredo Falcone

ESMO Open 2018 9;3(4):e000403. Epub 2018 Jul 9.

Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2018-000
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http://dx.doi.org/10.1136/esmoopen-2018-000403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045747PMC
July 2018

Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions.

Authors:
Lorenzo Fornaro Enrico Vasile Giuseppe Aprile Thorsten Oliver Goetze Caterina Vivaldi Alfredo Falcone Salah-Eddin Al-Batran

Cancer Treat Rev 2018 Sep 18;69:90-100. Epub 2018 Jun 18.

Institute of Clinical Cancer Research, Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.ctrv.2018.06.012DOI Listing
September 2018

Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group.

Authors:
Kaitlyn K H Goey Halfdan Sørbye Bengt Glimelius Richard A Adams Thierry André Dirk Arnold Jordan D Berlin György Bodoky Aimery de Gramont Eduardo Díaz-Rubio Cathy Eng Alfredo Falcone Axel Grothey Volker Heinemann Howard S Hochster Richard S Kaplan Scott Kopetz Roberto Labianca Christopher H Lieu Neal J Meropol Timothy J Price Richard L Schilsky Hans-Joachim Schmoll Einat Shacham-Shmueli Qian Shi Alberto F Sobrero John Souglakos Eric Van Cutsem John Zalcberg Martijn G H van Oijen Cornelis J A Punt Miriam Koopman

Eur J Cancer 2018 09 22;100:35-45. Epub 2018 Jun 22.

Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.05.010DOI Listing
September 2018

Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer.

Authors:
Mitsukuni Suenaga Marta Schirripa Shu Cao Wu Zhang Dongyun Yang Chiara Cremolini Sara Lonardi Francesca Bergamo Yang Ning Noriko Yamamoto Satoshi Okazaki Martin D Berger Yuji Miyamoto Roel Gopez Afsaneh Barzi Toshiharu Yamaguchi Sebastian Stintzing Volker Heinemann Fotios Loupakis Alfredo Falcone Heinz-Josef Lenz

Pharmacogenomics J 2018 09 21;18(5):623-632. Epub 2018 Jun 21.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.

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http://dx.doi.org/10.1038/s41397-018-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151284PMC
September 2018

Trifluridine/Tipiracil (TAS-102) in Refractory Metastatic Colorectal Cancer: A Multicenter Register in the Frame of the Italian Compassionate Use Program.

Authors:
Chiara Cremolini Daniele Rossini Erika Martinelli Filippo Pietrantonio Sara Lonardi Silvia Noventa Emiliano Tamburini Giovanni Luca Frassineti Stefania Mosconi Federico Nichetti Sabina Murgioni Teresa Troiani Beatrice Borelli Gemma Zucchelli Alessandro Dal Maso Vincenzo Sforza Gianluca Masi Carlotta Antoniotti Maria Di Bartolomeo Rosalba Miceli Fortunato Ciardiello Alfredo Falcone

Oncologist 2018 10 8;23(10):1178-1187. Epub 2018 May 8.

Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1634/theoncologist.2017-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263124PMC
October 2018

An Italian cost-effectiveness analysis of paclitaxel albumin (nab-paclitaxel) + gemcitabine vs gemcitabine alone for metastatic pancreatic cancer patients: the APICE study.

Authors:
Carlo Lazzaro Carlo Barone Francesco Caprioni Stefano Cascinu Alfredo Falcone Evaristo Maiello Michele Milella Carmine Pinto Michele Reni Giampaolo Tortora

Expert Rev Pharmacoecon Outcomes Res 2018 Aug 20;18(4):435-446. Epub 2018 Apr 20.

j Azienda Ospedaliera Universitaria Integrata Borgo Roma , Verona , Italy.

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http://dx.doi.org/10.1080/14737167.2018.1464394DOI Listing
August 2018

Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study.

Authors:
Diana L Hanna Fotios Loupakis Dongyun Yang Chiara Cremolini Marta Schirripa Meng Li Satoshi Matsusaka Martin D Berger Yuji Miyamoto Wu Zhang Yan Ning Carlotta Antoniotti Lisa Salvatore Miriana Moran Gary Zeger Stephanie H Astrow Alfredo Falcone Heinz-Josef Lenz

Clin Colorectal Cancer 2018 09 14;17(3):e471-e488. Epub 2018 Mar 14.

Division of Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110978PMC
September 2018

Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Authors:
Mitsukuni Suenaga Marta Schirripa Shu Cao Wu Zhang Dongyun Yang Yan Ning Chiara Cremolini Carlotta Antoniotti Beatrice Borelli Tetsuo Mashima Satoshi Okazaki Martin D Berger Yuji Miyamoto Roel Gopez Afsaneh Barzi Sara Lonardi Toshiharu Yamaguchi Alfredo Falcone Fotios Loupakis Heinz-Josef Lenz

Clin Colorectal Cancer 2018 06 27;17(2):e395-e414. Epub 2018 Feb 27.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493703PMC
June 2018

Current status and perspectives in immunotherapy for metastatic melanoma.

Authors:
Riccardo Marconcini Francesco Spagnolo Luigia Stefania Stucci Simone Ribero Elena Marra Francesco De Rosa Virginia Picasso Lorenza Di Guardo Carolina Cimminiello Stefano Cavalieri Laura Orgiano Enrica Tanda Laura Spano Alfredo Falcone Paola Queirolo

Oncotarget 2018 02 3;9(15):12452-12470. Epub 2018 Jan 3.

Department of Medical Oncology, IRCCS AOU San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

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http://dx.doi.org/10.18632/oncotarget.23746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844761PMC
February 2018

Differential histopathologic parameters in colorectal cancer liver metastases resected after triplets plus bevacizumab or cetuximab: a pooled analysis of five prospective trials.

Authors:
Chiara Cremolini Massimo Milione Federica Marmorino Federica Morano Gemma Zucchelli Alessia Mennitto Michele Prisciandaro Sara Lonardi Alessio Pellegrinelli Daniele Rossini Francesca Bergamo Giuseppe Aprile Lucio Urbani Luca Morelli Marta Schirripa Giovanni Gerardo Cardellino Matteo Fassan Gabriella Fontanini Filippo de Braud Vincenzo Mazzaferro Alfredo Falcone Filippo Pietrantonio

Br J Cancer 2018 04 13;118(7):955-965. Epub 2018 Mar 13.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori - Via Venezian, 1, 20100, Milano, Italy.

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http://dx.doi.org/10.1038/s41416-018-0015-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931102PMC
April 2018

NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients.

Authors:
Marta Schirripa Wu Zhang Dongyun Yang Shu Cao Satoshi Okazaki Fotios Loupakis Martin D Berger Yan Ning Yuji Miyamoto Mitsukuni Suenaga Giulia Alberti Jordan D West Sara Lonardi Taline Khoukaz Francesca Bergamo Francesca Battaglin Carlotta Antoniotti Alfredo Falcone Sebastian Stintzing Volker Heinemann Heinz-Josef Lenz

PLoS One 2018 9;13(3):e0193640. Epub 2018 Mar 9.

Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193640PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844536PMC
June 2018

PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC.

Authors:
Marzia Del Re Riccardo Marconcini Giulia Pasquini Eleonora Rofi Caterina Vivaldi Francesco Bloise Giuliana Restante Elena Arrigoni Chiara Caparello Maria Grazia Bianco Stefania Crucitta Iacopo Petrini Enrico Vasile Alfredo Falcone Romano Danesi

Br J Cancer 2018 03 6;118(6):820-824. Epub 2018 Mar 6.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/bjc.2018.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886129PMC
March 2018

Pharmacokinetic analysis of metronomic capecitabine in refractory metastatic colorectal cancer patients.

Authors:
Teresa Di Desidero Paola Orlandi Anna Fioravanti Chiara Cremolini Fotios Loupakis Federica Marmorino Carlotta Antoniotti Gianluca Masi Sara Lonardi Francesca Bergamo Vittorina Zagonel Alfredo Falcone Guido Bocci

Invest New Drugs 2018 08 27;36(4):709-714. Epub 2018 Feb 27.

Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-018-0579-8DOI Listing
August 2018

and genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer.

Authors:
Chiara Cremolini Marzia Del Re Carlotta Antoniotti Sara Lonardi Francesca Bergamo Fotios Loupakis Beatrice Borelli Federica Marmorino Valentina Citi Enrico Cortesi Roberto Moretto Monica Ronzoni Gianluca Tomasello Alberto Zaniboni Patrizia Racca Angela Buonadonna Giacomo Allegrini Vincenzo Ricci Samantha Di Donato Vittorina Zagonel Luca Boni Alfredo Falcone Romano Danesi

Oncotarget 2018 Jan 21;9(8):7859-7866. Epub 2017 Dec 21.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.23559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814264PMC
January 2018

Activity and Safety of Cetuximab Plus Modified FOLFOXIRI Followed by Maintenance With Cetuximab or Bevacizumab for RAS and BRAF Wild-type Metastatic Colorectal Cancer: A Randomized Phase 2 Clinical Trial.

Authors:
Chiara Cremolini Carlotta Antoniotti Sara Lonardi Giuseppe Aprile Francesca Bergamo Gianluca Masi Roberta Grande Giuseppe Tonini Claudia Mescoli Giovanni Gerardo Cardellino Luigi Coltelli Lisa Salvatore Domenico Cristiano Corsi Cristiana Lupi Donatello Gemma Monica Ronzoni Emanuela Dell'Aquila Federica Marmorino Francesca Di Fabio Maria Laura Mancini Lorenzo Marcucci Gabriella Fontanini Vittorina Zagonel Luca Boni Alfredo Falcone

JAMA Oncol 2018 Apr;4(4):529-536

Unit of Medical Oncology 2, Department of Translational Research and New Technologies in Medicine and Surgery, Azienda Ospedaliera-Universitaria Pisana, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2017.5314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885260PMC
April 2018

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

Authors:
Filippo Pietrantonio Federica Di Nicolantonio Alexa B Schrock Jeeyun Lee Sabine Tejpar Andrea Sartore-Bianchi Jaclyn F Hechtman Jason Christiansen Luca Novara Niall Tebbutt Giovanni Fucà Carlotta Antoniotti Seung Tae Kim Danielle Murphy Rosa Berenato Federica Morano James Sun Bosun Min Philip J Stephens Marissa Chen Luca Lazzari Vincent A Miller Robert Shoemaker Alessio Amatu Massimo Milione Jeffrey S Ross Salvatore Siena Alberto Bardelli Siraj M Ali Alfredo Falcone Filippo de Braud Chiara Cremolini

J Natl Cancer Inst 2017 12;109(12)

Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1093/jnci/djx089DOI Listing
December 2017

EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas.

Authors:
Iacopo Petrini Monica Lencioni Enrico Vasile Lorenzo Fornaro Lorenzo Belluomini Giulia Pasquini Laura Ginocchi Chiara Caparello Gianna Musettini Caterina Vivaldi Sara Caponi Sergio Ricci Agenese Proietti Gabriella Fontanini Antonio Giuseppe Naccarato Vincenzo Nardini Stefano Santi Alfredo Falcone

Cancer Biomark 2018 Feb;21(3):731-741

Medical Oncology, University Hospital of Pisa, 56126 Pisa, Italy.

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http://dx.doi.org/10.3233/CBM-170865DOI Listing
February 2018

Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.

Authors:
Katrin M Sjoquist Lindsay A Renfro R John Simes Niall C Tebbutt Stephen Clarke Matthew T Seymour Richard Adams Timothy S Maughan Leonard Saltz Richard M Goldberg Hans-Joachim Schmoll Eric Van Cutsem Jean-Yves Douillard Paulo M Hoff Joel Randolph Hecht Christophe Tournigand Cornelis J A Punt Miriam Koopman Herbert Hurwitz Volker Heinemann Alfredo Falcone Rainer Porschen Charles Fuchs Eduardo Diaz-Rubio Enrique Aranda Carsten Bokemeyer Ioannis Souglakos Fairooz F Kabbinavar Benoist Chibaudel Jeffrey P Meyers Daniel J Sargent Aimery de Gramont John R Zalcberg

J Natl Cancer Inst 2018 06;110(6):638-648

School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia.

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https://academic.oup.com/jnci/article/110/6/638/4757465
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http://dx.doi.org/10.1093/jnci/djx253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005015PMC
June 2018

Proxies of quality of life in metastatic colorectal cancer: analyses in the RECOURSE trial.

Authors:
Eric Van Cutsem Alfredo Falcone Rocio Garcia-Carbonero Yoshito Komatsu Alessandro Pastorino Marc Peeters Yasuhiro Shimada Kentaro Yamazaki Takayuki Yoshino Alberto Zaniboni Nadia Amellal Akira Kanehisa Robert Winkler Lukas Makris Robert J Mayer Atsushi Ohtsu Josep Tabernero

ESMO Open 2017 23;2(5):e000261. Epub 2017 Nov 23.

Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/esmoopen-2017-000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708320PMC
November 2017

Vinorelbine in BRAF V600E mutated metastatic colorectal cancer: a prospective multicentre phase II clinical study.

Authors:
Chiara Cremolini Filippo Pietrantonio Gianluca Tomasello Vincenzo Dadduzio Roberto Moretto Federica Morano Marta Schirripa Carlotta Antoniotti Giovanni Fucà Francesca Bergamo Daniele Rossini Federico Nichetti Stamatia Ziampiri Michele Ghidini Federica Marmorino Michele Prisciandaro Alfredo Falcone Filippo De Braud Fotios Loupakis Sara Lonardi

ESMO Open 2017 10;2(3):e000241. Epub 2017 Aug 10.

Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IRCCS, Padua, Italy.

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http://dx.doi.org/10.1136/esmoopen-2017-000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703381PMC
August 2017

A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab.

Authors:
Martin D Berger Sebastian Stintzing Volker Heinemann Shu Cao Dongyun Yang Yu Sunakawa Satoshi Matsusaka Yan Ning Satoshi Okazaki Yuji Miyamoto Mitsukuni Suenaga Marta Schirripa Diana L Hanna Shivani Soni Alberto Puccini Wu Zhang Chiara Cremolini Alfredo Falcone Fotios Loupakis Heinz-Josef Lenz

Clin Cancer Res 2018 02 5;24(4):784-793. Epub 2017 Dec 5.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1663DOI Listing
February 2018

Integrated safety summary for trifluridine/tipiracil (TAS-102).

Authors:
Alfredo Falcone Atsushi Ohtsu Eric Van Cutsem Robert J Mayer Michele Buscaglia Johanna C Bendell Scott Kopetz Paul Bebeau Takayuki Yoshino

Anticancer Drugs 2018 01;29(1):89-96

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000554DOI Listing
January 2018

Patients with NSCLC may display a low ratio of p.T790M activating EGFR mutations in plasma at disease progression: implications for personalised treatment.

Authors:
Marzia Del Re Paola Bordi Iacopo Petrini Eleonora Rofi Francesca Mazzoni Lorenzo Belluomini Enrico Vasile Giuliana Restante Francesco Di Costanzo Alfredo Falcone Antonio Frassoldati Ron H N van Schaik Christi M J Steendam Antonio Chella Marcello Tiseo Riccardo Morganti Romano Danesi

Oncotarget 2017 Oct 15;8(49):86056-86065. Epub 2017 Sep 15.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.20947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689667PMC
October 2017

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

Authors:
Riccardo Ricotta Antonella Verrioli Silvia Ghezzi Luca Porcu A Grothey Alfredo Falcone Eric Van Cutsem Guillem Argilés Antoine Adenis Marc Ychou Carlo Barone Olivier Bouché Marc Peeters Yves Humblet Laurent Mineur Alberto F Sobrero Joleen M Hubbard Chiara Cremolini Hans Prenen Josep Tabernero Hajer Jarraya Thibault Mazard Sophie Deguelte-Lardiere Konstantinos Papadimitriou Marc Van den Eynde Alessandro Pastorino Daniela Redaelli Katia Bencardino Chiara Funaioli Alessio Amatu Giulia Carlo-Stella Valter Torri Andrea Sartore-Bianchi Angelo Vanzulli Salvatore Siena

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2016-000111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548980PMC
February 2017

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

Authors:
Lorenzo Fornaro Caterina Vivaldi Dong Lin Hui Xue Alfredo Falcone Yuzhuo Wang Francesco Crea Martin D Bootman

PLoS One 2017 28;12(8):e0182818. Epub 2017 Aug 28.

School of Life, Health & Chemical Sciences, The Open University, Walton Hall, Milton Keynes, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573204PMC
October 2017

Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer.

Authors:
Marzia Del Re Caterina Vivaldi Eleonora Rofi Enrico Vasile Mario Miccoli Chiara Caparello Paolo Davide d'Arienzo Lorenzo Fornaro Alfredo Falcone Romano Danesi

Sci Rep 2017 08 11;7(1):7931. Epub 2017 Aug 11.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/s41598-017-08297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554237PMC
August 2017

Reply to Ugo De Giorgi, Vincenza Conteduca, and Emanuela Scarpi's Letter to the Editor re: Marzia Del Re, Elisa Biasco, Stefania Crucitta, et al. The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients. Eur Urol 2017;71:680-7.

Authors:
Marzia Del Re Elisa Biasco Stefania Crucitta Lisa Derosa Eleonora Rofi Cinzia Orlandini Mario Miccoli Luca Galli Alfredo Falcone Guido W Jenster Ron H van Schaik Romano Danesi

Eur Urol 2018 01 9;73(1):e11-e12. Epub 2017 Aug 9.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.eururo.2017.07.034DOI Listing
January 2018

Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.

Authors:
Satoshi Okazaki Marta Schirripa Fotios Loupakis Shu Cao Wu Zhang Dongyun Yang Yan Ning Martin D Berger Yuji Miyamoto Mitsukuni Suenaga Syma Iqubal Afsaneh Barzi Chiara Cremolini Alfredo Falcone Francesca Battaglin Lisa Salvatore Beatrice Borelli Timothy G Helentjaris Heinz-Josef Lenz

Cancer 2017 Nov 14;123(22):4506-4514. Epub 2017 Jul 14.

Department of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/cncr.30880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673544PMC
November 2017

Adjuvant chemoradiotherapy (gemcitabine-based) in pancreatic adenocarcinoma: the Pisa University experience.

Authors:
Aldo Sainato Sabrina Montrone Francesco Pasqualetti Marianna Coppola Nunzia L V Cernusco Marco Panichi Alessandra Gonnelli Enrico Vasile Riccardo Morganti Alfredo Falcone Ugo Boggi Fabiola Paiar

Tumori 2017 Nov 11;103(6):577-582. Epub 2017 Jul 11.

Department of Radiotherapy, Pisa University, Pisa - Italy.

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http://dx.doi.org/10.5301/tj.5000664DOI Listing
November 2017

The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab.

Authors:
Laura Demurtas Marco Puzzoni Riccardo Giampieri Pina Ziranu Valeria Pusceddu Alessandra Mandolesi Chiara Cremolini Gianluca Masi Fabio Gelsomino Carlotta Antoniotti Cristian Loretelli Fausto Meriggi Alberto Zaniboni Alfredo Falcone Stefano Cascinu Mario Scartozzi

Br J Cancer 2017 Jul 20;117(3):315-321. Epub 2017 Jun 20.

Departments of Medical Oncology, University of Cagliari, University Hospital 'Duilio Casula' S.S. 554, Km 4,500 Bivio per Sestu, Monserrato, Cagliari 09042, Italy.

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http://dx.doi.org/10.1038/bjc.2017.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537494PMC
July 2017

TRIBE-2: a phase III, randomized, open-label, strategy trial in unresectable metastatic colorectal cancer patients by the GONO group.

Authors:
Chiara Cremolini Federica Marmorino Fotios Loupakis Gianluca Masi Carlotta Antoniotti Lisa Salvatore Marta Schirripa Luca Boni Vittorina Zagonel Sara Lonardi Giuseppe Aprile Emiliano Tamburini Vincenzo Ricci Monica Ronzoni Filippo Pietrantonio Chiara Valsuani Gianluca Tomasello Alessandro Passardi Giacomo Allegrini Samantha Di Donato Daniele Santini Alfredo Falcone

BMC Cancer 2017 Jun 9;17(1):408. Epub 2017 Jun 9.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1186/s12885-017-3360-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466800PMC
June 2017