Alfredo Falcone

Alfredo Falcone

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Alfredo Falcone

Publications by authors named "Alfredo Falcone"

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Lack of Benefit From Anti-EGFR Treatment in RAS and BRAF Wild-type Metastatic Colorectal Cancer With Mucinous Histology or Mucinous Component.

Clin Colorectal Cancer 2019 Jun 7;18(2):116-124. Epub 2019 Mar 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.02.007DOI Listing
June 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Eur J Cancer 2019 Apr 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

Bevacizumab as maintenance therapy in mCRC: Interpreting results of the MOMA trial.

Oncotarget 2019 Apr 19;10(29):2791-2792. Epub 2019 Apr 19.

Chiara Cremolini: Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.26870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497461PMC
April 2019

Total neoadjuvant approach with FOLFOXIRI plus bevacizumab followed by chemoradiotherapy plus bevacizumab in locally advanced rectal cancer: the TRUST trial.

Eur J Cancer 2019 Mar 7;110:32-41. Epub 2019 Feb 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.006DOI Listing
March 2019

Robotic-assisted surgery for colorectal liver metastasis: A single-centre experience.

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Translational and New Technologies in Medicine, General Surgery Unit; EndoCAS (Center for Computer Assisted Surgery), University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.4103/jmas.JMAS_265_18DOI Listing
February 2019

Interprofessional spiritual care in oncology: a literature review.

ESMO Open 2019 16;4(1):e000465. Epub 2019 Feb 16.

Oncology-Supportive Care Unit, Department of Oncology-Haematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2018-000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435249PMC
February 2019

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Pharmacogenomics 2019 Jan 6;20(1):49-68. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.2217/pgs-2018-0149DOI Listing
January 2019

Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions.

Cancer Treat Rev 2018 Sep 18;69:90-100. Epub 2018 Jun 18.

Institute of Clinical Cancer Research, Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.ctrv.2018.06.012DOI Listing
September 2018

BRAF V600E Mutation as a Negative Prognostic Determinant in Resected Colorectal Liver Metastases.

JAMA Surg 2018 Sep 12. Epub 2018 Sep 12.

Unit of Medical Oncology 2, Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2018.3334DOI Listing
September 2018

Pharmacokinetic analysis of metronomic capecitabine in refractory metastatic colorectal cancer patients.

Invest New Drugs 2018 08 27;36(4):709-714. Epub 2018 Feb 27.

Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-018-0579-8DOI Listing
August 2018

Integrated safety summary for trifluridine/tipiracil (TAS-102).

Anticancer Drugs 2018 01;29(1):89-96

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000554DOI Listing
January 2018

Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer.

Sci Rep 2017 08 11;7(1):7931. Epub 2017 Aug 11.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/s41598-017-08297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554237PMC
August 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.5771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466009PMC
June 2017

Multimodality treatment of locally advanced squamous cell carcinoma of the oesophagus: A comprehensive review and network meta-analysis.

Crit Rev Oncol Hematol 2017 Jun 23;114:24-32. Epub 2017 Mar 23.

SC Oncologia Medica 1, Dipartimento Oncologico, Azienda USL Toscana Centro, Istituto Toscano Tumori, Piazza Santa Maria Nuova 1, 50100, Firenze, Italy.

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http://dx.doi.org/10.1016/j.critrevonc.2017.03.024DOI Listing
June 2017

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.

Eur J Cancer 2017 05 26;77:13-20. Epub 2017 Mar 26.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.020DOI Listing
May 2017

Metastatic BRAF K601E-mutated melanoma reaches complete response to MEK inhibitor trametinib administered for over 36 months.

Exp Hematol Oncol 2017 21;6. Epub 2017 Mar 21.

Department of Oncology, Azienda Ospedaliero-Universitaria Pisana and University of Pisa, Istituto Toscano Tumori, Santa Chiara Hospital, Via Roma 67, 56100 Pisa, Italy.

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http://ehoonline.biomedcentral.com/articles/10.1186/s40164-0
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http://dx.doi.org/10.1186/s40164-017-0067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361706PMC
March 2017

First-line therapy for mCRC - the influence of primary tumour location on the therapeutic algorithm.

Nat Rev Clin Oncol 2017 02 17;14(2):113. Epub 2017 Jan 17.

Unit of Medical Oncology 2, Azienda Ospedaliera-Universitaria Pisana; and at the Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2016.219DOI Listing
February 2017

Regorafenib: lights and shadows of antiangiogenic therapies in gastric cancer.

Transl Gastroenterol Hepatol 2017 23;2:11. Epub 2017 Feb 23.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.21037/tgh.2017.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334553PMC
February 2017

Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients.

Oncology 2016 31;91(5):283-288. Epub 2016 Aug 31.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1159/000448004DOI Listing
January 2017

Third-Line Chemotherapy with Irinotecan plus 5-Fluorouracil in Caucasian Metastatic Gastric Cancer Patients.

Oncology 2016 6;91(6):311-316. Epub 2016 Oct 6.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1159/000443962DOI Listing
January 2017

A still missing piece of the FIRE-3 puzzle.

Lancet Oncol 2016 12;17(12):e515

Department of Oncology, University Hospital of Pisa, Via Roma 67, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30568-XDOI Listing
December 2016

Apatinib in Advanced Gastric Cancer: A Doubtful Step Forward.

J Clin Oncol 2016 11;34(31):3822-3823

Lorenzo Fornaro, Enrico Vasile, and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisa, Pisa, Italy.

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http://dx.doi.org/10.1200/JCO.2016.68.6931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477932PMC
November 2016

An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer.

Future Oncol 2016 Sep 7;12(18):2065-9. Epub 2016 Jun 7.

University of Pisa, Azienda Ospedaliero Universitaria Pisana, Istituto Toscano Tumori (ITT), Via Roma, 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.2217/fon-2016-0249DOI Listing
September 2016

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer.

World J Gastroenterol 2016 Aug;22(31):6987-7005

Chiara Caparello, Alfredo Falcone, Niccola Funel, Enrico Vasile, Elisa Giovannetti, University Hospital of Pisa, 56124 Pisa, Italy.

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http://dx.doi.org/10.3748/wjg.v22.i31.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988311PMC
August 2016

TAS-102 for the treatment of metastatic colorectal cancer.

Expert Rev Anticancer Ther 2015 28;15(11):1283-92. Epub 2015 Oct 28.

a Division of Medical Oncology , Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori , Pisa , Italy.

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http://dx.doi.org/10.1586/14737140.2015.1105746DOI Listing
June 2016

Second-line therapy for advanced pancreatic cancer: evaluation of prognostic factors and review of current literature.

Future Oncol 2016 Apr 17;12(7):901-8. Epub 2016 Feb 17.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy.

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http://dx.doi.org/10.2217/fon.16.16DOI Listing
April 2016

Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database.

J Clin Oncol 2016 Jan 26;34(2):144-50. Epub 2015 Oct 26.

Lindsay A. Renfro and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Fotios Loupakis and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisana and Università di Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital Cancer Center, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Institut de Cancerologie, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil, Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs, Dana-Farber Cancer Institute Boston, MA; Eduardo Diaz-Rubio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; J. Randolph Hecht, David Geffen School of Medicine at the University of California at Los Angeles; Heinz-Josef Lenz, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; Richard M. Goldberg, Ohio State University, Columbus, OH; and Leonard B. Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.61.6441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070548PMC
January 2016

Pharmacoepigenetics in gastrointestinal tumors: MGMT methylation and beyond.

Front Biosci (Elite Ed) 2016 Jan 1;8:170-80. Epub 2016 Jan 1.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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January 2016

MRI tumor volume reduction rate vs tumor regression grade in the pre-operative re-staging of locally advanced rectal cancer after chemo-radiotherapy.

Eur J Radiol 2015 Dec 20;84(12):2438-43. Epub 2015 Aug 20.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Unit of Diagnostic and Interventional Radiology, Pisa University Hospital, Italy.

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http://dx.doi.org/10.1016/j.ejrad.2015.08.008DOI Listing
December 2015

TRIBE study: are all three cytotoxic drugs crucial? - Authors' reply.

Lancet Oncol 2015 Dec;16(16):e578-9

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina, Università di Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00416-7DOI Listing
December 2015

First-line chemotherapy for mCRC—a review and evidence-based algorithm.

Nat Rev Clin Oncol 2015 Oct 28;12(10):607-19. Epub 2015 Jul 28.

Unit of Medical Oncology 2, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2015.129DOI Listing
October 2015