Alfredo Falcone

Alfredo Falcone

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Alfredo Falcone

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Lack of Benefit From Anti-EGFR Treatment in RAS and BRAF Wild-type Metastatic Colorectal Cancer With Mucinous Histology or Mucinous Component.

Authors:
Roberto Moretto Federica Morano Elena Ongaro Daniele Rossini Filippo Pietrantonio Mariaelena Casagrande Carlotta Antoniotti Salvatore Corallo Federica Marmorino Francesco Cortiula Federico Nichetti Beatrice Borelli Gemma Zucchelli Alessandra Boccaccino Gianluca Masi Filippo de Braud Alfredo Falcone Chiara Cremolini

Clin Colorectal Cancer 2019 Jun 7;18(2):116-124. Epub 2019 Mar 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy; Department of Translational Research and New Technology in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2019.02.007DOI Listing
June 2019

Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics.

Authors:
Teresa Di Desidero Paola Orlandi Anna Fioravanti Greta Alì Chiara Cremolini Fotios Loupakis Daniela Gentile Marta Banchi Federico Cucchiara Carlotta Antoniotti Gianluca Masi Gabriella Fontanini Alfredo Falcone Guido Bocci

Biochem Pharmacol 2019 Jun 3;164:94-105. Epub 2019 Apr 3.

Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Savi 10, I-56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.04.001DOI Listing
June 2019

Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial.

Authors:
Cathy Eng Tae Won Kim Johanna Bendell Guillem Argilés Niall C Tebbutt Maria Di Bartolomeo Alfredo Falcone Marwan Fakih Mark Kozloff Neil H Segal Alberto Sobrero Yibing Yan Ilsung Chang Anne Uyei Louise Roberts Fortunato Ciardiello

Lancet Oncol 2019 Jun 16;20(6):849-861. Epub 2019 Apr 16.

Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30027-0DOI Listing
June 2019

Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells.

Authors:
Paola Orlandi Daniela Gentile Marta Banchi Federico Cucchiara Teresa Di Desidero Chiara Cremolini Roberto Moretto Alfredo Falcone Guido Bocci

Invest New Drugs 2019 Jun 1. Epub 2019 Jun 1.

Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Via Savi 10, I-56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-019-00804-5DOI Listing
June 2019

AR-V7 and AR-FL expression is associated with clinical outcome: a translational study in patients with castrate resistant prostate cancer.

Authors:
Marzia Del Re Stefania Crucitta Andrea Sbrana Eleonora Rofi Federico Paolieri Giulia Gianfilippo Luca Galli Alfredo Falcone Riccardo Morganti Camillo Porta Eleni Efstathiou Ron van Schaik Guido Jenster Romano Danesi

BJU Int 2019 May 4. Epub 2019 May 4.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1111/bju.14792DOI Listing
May 2019

Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.

Authors:
Alberto Puccini Fotios Loupakis Sebastian Stintzing Shu Cao Francesca Battaglin Ryuma Togunaka Madiha Naseem Martin D Berger Shivani Soni Wu Zhang Christoph Mancao Bodour Salhia Shannon M Mumenthaler Daniel J Weisenberger Gangning Liang Chiara Cremolini Volker Heinemann Alfredo Falcone Joshua Millstein Heinz-Josef Lenz

Eur J Cancer 2019 Apr 7;111:138-147. Epub 2019 Mar 7.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436973PMC
April 2019

Bevacizumab as maintenance therapy in mCRC: Interpreting results of the MOMA trial.

Authors:
Federica Marmorino Alfredo Falcone Chiara Cremolini

Oncotarget 2019 Apr 19;10(29):2791-2792. Epub 2019 Apr 19.

Chiara Cremolini: Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.26870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497461PMC
April 2019

Prognostic Effect of Adenosine-related Genetic Variants in Metastatic Colorectal Cancer Treated With Bevacizumab-based Chemotherapy.

Authors:
Ryuma Tokunaga Shu Cao Madiha Naseem Jae Ho Lo Francesca Battaglin Alberto Puccini Martin D Berger Shivani Soni Joshua Millstein Wu Zhang Sebastian Stintzing Fotios Loupakis Chiara Cremolini Volker Heinemann Alfredo Falcone Heinz-Josef Lenz

Clin Colorectal Cancer 2019 03 13;18(1):e8-e19. Epub 2018 Sep 13.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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https://linkinghub.elsevier.com/retrieve/pii/S15330028183038
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http://dx.doi.org/10.1016/j.clcc.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416082PMC
March 2019

Phase II randomised study of maintenance treatment with bevacizumab or bevacizumab plus metronomic chemotherapy after first-line induction with FOLFOXIRI plus Bevacizumab for metastatic colorectal cancer patients: the MOMA trial.

Authors:
Chiara Cremolini Federica Marmorino Francesca Bergamo Giuseppe Aprile Lisa Salvatore Gianluca Masi Emanuela Dell'Aquila Carlotta Antoniotti Sabina Murgioni Giacomo Allegrini Beatrice Borelli Donatello Gemma Mariaelena Casagrande Cristina Granetto Sara Delfanti Samantha Di Donato Marta Schirripa Elisa Sensi Giuseppe Tonini Sara Lonardi Gabriella Fontanini Luca Boni Alfredo Falcone

Eur J Cancer 2019 Mar 5;109:175-182. Epub 2019 Feb 5.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.12.028DOI Listing
March 2019

Total neoadjuvant approach with FOLFOXIRI plus bevacizumab followed by chemoradiotherapy plus bevacizumab in locally advanced rectal cancer: the TRUST trial.

Authors:
Gianluca Masi Caterina Vivaldi Lorenzo Fornaro Sara Lonardi Piero Buccianti Aldo Sainato Lorenzo Marcucci Angelo Martignetti Emanuele Damiano Luca Urso Maura Castagna Gabriella Fontanini Francesca Bergamo Gianna Musettini Lucio Urbani Elisa Sensi Riccardo Balestri Sabrina Montrone Francesco Pasqualetti Chiara Cremolini Antonello Di Paolo Vittorina Zagonel Alfredo Falcone

Eur J Cancer 2019 Mar 7;110:32-41. Epub 2019 Feb 7.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2019.01.006DOI Listing
March 2019

Validated clinico-pathologic nomogram in the prediction of HER2 status in gastro-oesophageal cancer.

Authors:
Lorenzo Fornaro Caterina Vivaldi Annamaria Parnofiello Clara Ugolini Giuseppe Aprile Giovanna De Maglio Irene Pecora Donatella Iacono Francesca Crivelli Silvia Catanese Giovanni Gerardo Cardellino Monica Lencioni Enrico Vasile Francesca Salani Mario Clerico Lorenzo Calvetti Alfredo Falcone Gianpiero Fasola Gabriella Fontanini Francesco Montagnani

Br J Cancer 2019 Mar 12;120(5):522-526. Epub 2019 Feb 12.

Department of Oncology, Azienda Sanitaria Locale di Biella, Ponderano (BI), Italy.

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http://www.nature.com/articles/s41416-019-0399-4
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http://dx.doi.org/10.1038/s41416-019-0399-4DOI Listing
March 2019

AMPK variant, a candidate of novel predictor for chemotherapy in metastatic colorectal cancer: A meta-analysis using TRIBE, MAVERICC and FIRE3.

Authors:
Ryuma Tokunaga Shu Cao Madiha Naseem Francesca Battaglin Jae Ho Lo Hiroyuki Arai Fotios Loupakis Sebastian Stintzing Alberto Puccini Martin D Berger Shivani Soni Wu Zhang Christoph Mancao Bodour Salhia Shannon M Mumenthaler Daniel J Weisenberger Gangning Liang Chiara Cremolini Volker Heinemann Alfredo Falcone Joshua Millstein Heinz-Josef Lenz

Int J Cancer 2019 Mar 11. Epub 2019 Mar 11.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1002/ijc.32261DOI Listing
March 2019

Benefit from anti-EGFRs in and wild-type metastatic transverse colon cancer: a clinical and molecular proof of concept study.

Authors:
Chiara Cremolini Matteo Benelli Elisa Fontana Filippo Pagani Daniele Rossini Giovanni Fucà Adele Busico Elena Conca Samantha Di Donato Fotios Loupakis Marta Schirripa Sara Lonardi Beatrice Borelli Elena Ongaro Katherine Eason Federica Morano Mariaelena Casagrande Matteo Fassan Anguraj Sadanandam Filippo de Braud Alfredo Falcone Filippo Pietrantonio

ESMO Open 2019 8;4(2):e000489. Epub 2019 Mar 8.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2019-000
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http://dx.doi.org/10.1136/esmoopen-2019-000489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435314PMC
March 2019

Regorafenib for Patients with Metastatic Colorectal Cancer Who Progressed After Standard Therapy: Results of the Large, Single-Arm, Open-Label Phase IIIb CONSIGN Study.

Authors:
Eric Van Cutsem Erika Martinelli Stefano Cascinu Alberto Sobrero Maria Banzi Jean-François Seitz Carlo Barone Marc Ychou Marc Peeters Baruch Brenner Ralf Dieter Hofheinz Evaristo Maiello Thierry André Andrea Spallanzani Rocio Garcia-Carbonero Yull E Arriaga Udit Verma Axel Grothey Christian Kappeler Ashok Miriyala Joachim Kalmus Alfredo Falcone Alberto Zaniboni

Oncologist 2019 Feb 6;24(2):185-192. Epub 2018 Sep 6.

Department of Oncology, Fondazione Poliambulanza, Brescia, Italy.

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http://dx.doi.org/10.1634/theoncologist.2018-0072DOI Listing
February 2019

Is a pharmacogenomic panel useful to estimate the risk of oxaliplatin-related neurotoxicity in colorectal cancer patients?

Authors:
Federico Nichetti Felicia Stefania Falvella Rosalba Miceli Stefania Cheli Raffaella Gaetano Giovanni Fucà Gabriele Infante Antonia Martinetti Carlotta Antoniotti Alfredo Falcone Maria Di Bartolomeo Chiara Cremolini Filippo de Braud Filippo Pietrantonio

Pharmacogenomics J 2019 Feb 4. Epub 2019 Feb 4.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1038/s41397-019-0078-0DOI Listing
February 2019

DPYD*6 plays an important role in fluoropyrimidine toxicity in addition to DPYD*2A and c.2846A>T: a comprehensive analysis in 1254 patients.

Authors:
Marzia Del Re Saverio Cinieri Angela Michelucci Stefano Salvadori Fotios Loupakis Marta Schirripa Chiara Cremolini Stefania Crucitta Cecilia Barbara Angelo Di Leo Tiziana Pia Latiano Filippo Pietrantonio Samantha Di Donato Paolo Simi Alessandro Passardi Filippo De Braud Giuseppe Altavilla Claudio Zamagni Roberto Bordonaro Alfredo Butera Evaristo Maiello Carmine Pinto Alfredo Falcone Valentina Mazzotti Riccardo Morganti Romano Danesi

Pharmacogenomics J 2019 Feb 6. Epub 2019 Feb 6.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/s41397-019-0077-1DOI Listing
February 2019

Robotic-assisted surgery for colorectal liver metastasis: A single-centre experience.

Authors:
Simone Guadagni Niccolò Furbetta Gregorio Di Franco Matteo Palmeri Desirée Gianardi Matteo Bianchini Martina Guadagnucci Luca Pollina Gianluca Masi Chiara Cremolini Alfredo Falcone Franco Mosca Giulio Di Candio Luca Morelli

J Minim Access Surg 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Translational and New Technologies in Medicine, General Surgery Unit; EndoCAS (Center for Computer Assisted Surgery), University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.4103/jmas.JMAS_265_18DOI Listing
February 2019

Prognostic impact of ATM mutations in patients with metastatic colorectal cancer.

Authors:
Giovanni Randon Giovanni Fucà Daniele Rossini Alessandra Raimondi Filippo Pagani Federica Perrone Elena Tamborini Adele Busico Giorgia Peverelli Federica Morano Monica Niger Maria Antista Salvatore Corallo Serena Saggio Beatrice Borelli Gemma Zucchelli Massimo Milione Giancarlo Pruneri Maria Di Bartolomeo Alfredo Falcone Filippo de Braud Chiara Cremolini Filippo Pietrantonio

Sci Rep 2019 Feb 27;9(1):2858. Epub 2019 Feb 27.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via G. Venezian, 1 - 20133, Milan, Italy.

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http://dx.doi.org/10.1038/s41598-019-39525-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393680PMC
February 2019

Interprofessional spiritual care in oncology: a literature review.

Authors:
Christina M Puchalski Andrea Sbrana Betty Ferrell Najmeh Jafari Stephen King Tracy Balboni Guido Miccinesi Anna Vandenhoeck Michael Silbermann Lodovico Balducci Julianna Yong Andrea Antonuzzo Alfredo Falcone Carla Ida Ripamonti

ESMO Open 2019 16;4(1):e000465. Epub 2019 Feb 16.

Oncology-Supportive Care Unit, Department of Oncology-Haematology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2018-000465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435249PMC
February 2019

The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer.

Authors:
Eleonora Rofi Caterina Vivaldi Marzia Del Re Elena Arrigoni Stefania Crucitta Niccola Funel Stefano Fogli Enrico Vasile Gianna Musettini Lorenzo Fornaro Alfredo Falcone Romano Danesi

Pharmacogenomics 2019 Jan 6;20(1):49-68. Epub 2018 Dec 6.

Unit of Clinical Pharmacology & Pharmacogenetics, Department of Clinical & Experimental Medicine, University of Pisa, Italy.

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http://dx.doi.org/10.2217/pgs-2018-0149DOI Listing
January 2019

Early modifications of circulating microRNAs levels in metastatic colorectal cancer patients treated with regorafenib.

Authors:
Marta Schirripa Beatrice Borelli Romina D'Aurizio Simone Lubrano Chiara Cremolini Gemma Zucchelli Carlotta Antoniotti Federica Marmorino Alessandra Anna Prete Sabina Murgioni Francesca Bergamo Vittorina Zagonel Andrea Tuccoli Andrea Marranci Milena Rizzo Lorena Tedeschi Letizia Magnoni Alfredo Falcone Fotios Loupakis Laura Poliseno

Pharmacogenomics J 2019 Jan 28. Epub 2019 Jan 28.

Institute of Clinical Physiology, CNR, Pisa, Italy.

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http://dx.doi.org/10.1038/s41397-019-0075-3DOI Listing
January 2019

Optimization of biomarkers-based classification scores as progression-free survival predictors: an intuitive graphical representation.

Authors:
Marian Manciu Sorour Hosseini Teresa Di Desidero Giacomo Allegrini Alfredo Falcone Guido Bocci Robert A Kirken Giulio Francia

Future Sci OA 2018 12 1;4(10):FSO346. Epub 2018 Nov 1.

Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX, 79968, USA.

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https://www.future-science.com/doi/10.4155/fsoa-2018-0020
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http://dx.doi.org/10.4155/fsoa-2018-0020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234460PMC
December 2018

Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database.

Authors:
Mohamed E Salem Jun Yin Benjamin A Weinberg Lindsay A Renfro Levi D Pederson Timothy S Maughan Richard A Adams Eric Van Cutsem Alfredo Falcone Niall C Tebbutt Matthew T Seymour Eduardo Díaz-Rubio Enrique Aranda Carsten Bokemeyer Volker Heinemann Harpreet Wasan Aimery de Gramont Axel Grothey Qian Shi Daniel J Sargent John L Marshall

Eur J Cancer 2018 11 27;103:205-213. Epub 2018 Sep 27.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1016/j.ejca.2018.08.020DOI Listing
November 2018

Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.

Authors:
Chiara Cremolini Daniele Rossini Emanuela Dell'Aquila Sara Lonardi Elena Conca Marzia Del Re Adele Busico Filippo Pietrantonio Romano Danesi Giuseppe Aprile Emiliano Tamburini Carlo Barone Gianluca Masi Francesco Pantano Francesca Pucci Domenico C Corsi Nicoletta Pella Francesca Bergamo Eleonora Rofi Cecilia Barbara Alfredo Falcone Daniele Santini

JAMA Oncol 2018 Nov 21. Epub 2018 Nov 21.

Department of Medical Oncology, Campus Bio-Medico University of Rome, Rome, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2018.5080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439839PMC
November 2018

Trifluridine/Tipiracil (TAS-102) in Refractory Metastatic Colorectal Cancer: A Multicenter Register in the Frame of the Italian Compassionate Use Program.

Authors:
Chiara Cremolini Daniele Rossini Erika Martinelli Filippo Pietrantonio Sara Lonardi Silvia Noventa Emiliano Tamburini Giovanni Luca Frassineti Stefania Mosconi Federico Nichetti Sabina Murgioni Teresa Troiani Beatrice Borelli Gemma Zucchelli Alessandro Dal Maso Vincenzo Sforza Gianluca Masi Carlotta Antoniotti Maria Di Bartolomeo Rosalba Miceli Fortunato Ciardiello Alfredo Falcone

Oncologist 2018 Oct 8;23(10):1178-1187. Epub 2018 May 8.

Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1634/theoncologist.2017-0573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263124PMC
October 2018

Prognostic Value of ACVRL1 Expression in Metastatic Colorectal Cancer Patients Receiving First-line Chemotherapy With Bevacizumab: Results From the Triplet Plus Bevacizumab (TRIBE) Study.

Authors:
Diana L Hanna Fotios Loupakis Dongyun Yang Chiara Cremolini Marta Schirripa Meng Li Satoshi Matsusaka Martin D Berger Yuji Miyamoto Wu Zhang Yan Ning Carlotta Antoniotti Lisa Salvatore Miriana Moran Gary Zeger Stephanie H Astrow Alfredo Falcone Heinz-Josef Lenz

Clin Colorectal Cancer 2018 09 14;17(3):e471-e488. Epub 2018 Mar 14.

Division of Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110978PMC
September 2018

Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer.

Authors:
Mitsukuni Suenaga Marta Schirripa Shu Cao Wu Zhang Dongyun Yang Chiara Cremolini Sara Lonardi Francesca Bergamo Yang Ning Noriko Yamamoto Satoshi Okazaki Martin D Berger Yuji Miyamoto Roel Gopez Afsaneh Barzi Toshiharu Yamaguchi Sebastian Stintzing Volker Heinemann Fotios Loupakis Alfredo Falcone Heinz-Josef Lenz

Pharmacogenomics J 2018 09 21;18(5):623-632. Epub 2018 Jun 21.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, USA.

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http://dx.doi.org/10.1038/s41397-018-0030-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151284PMC
September 2018

Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group.

Authors:
Kaitlyn K H Goey Halfdan Sørbye Bengt Glimelius Richard A Adams Thierry André Dirk Arnold Jordan D Berlin György Bodoky Aimery de Gramont Eduardo Díaz-Rubio Cathy Eng Alfredo Falcone Axel Grothey Volker Heinemann Howard S Hochster Richard S Kaplan Scott Kopetz Roberto Labianca Christopher H Lieu Neal J Meropol Timothy J Price Richard L Schilsky Hans-Joachim Schmoll Einat Shacham-Shmueli Qian Shi Alberto F Sobrero John Souglakos Eric Van Cutsem John Zalcberg Martijn G H van Oijen Cornelis J A Punt Miriam Koopman

Eur J Cancer 2018 09 22;100:35-45. Epub 2018 Jun 22.

Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.05.010DOI Listing
September 2018

Locally advanced gastro-oesophageal cancer: Recent therapeutic advances and research directions.

Authors:
Lorenzo Fornaro Enrico Vasile Giuseppe Aprile Thorsten Oliver Goetze Caterina Vivaldi Alfredo Falcone Salah-Eddin Al-Batran

Cancer Treat Rev 2018 Sep 18;69:90-100. Epub 2018 Jun 18.

Institute of Clinical Cancer Research, Krankenhaus Nordwest, University Cancer Center, Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.ctrv.2018.06.012DOI Listing
September 2018

BRAF V600E Mutation as a Negative Prognostic Determinant in Resected Colorectal Liver Metastases.

Authors:
Roberto Moretto Chiara Cremolini Alfredo Falcone

JAMA Surg 2018 Sep 12. Epub 2018 Sep 12.

Unit of Medical Oncology 2, Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamasurg.2018.3334DOI Listing
September 2018

Pharmacokinetic analysis of metronomic capecitabine in refractory metastatic colorectal cancer patients.

Authors:
Teresa Di Desidero Paola Orlandi Anna Fioravanti Chiara Cremolini Fotios Loupakis Federica Marmorino Carlotta Antoniotti Gianluca Masi Sara Lonardi Francesca Bergamo Vittorina Zagonel Alfredo Falcone Guido Bocci

Invest New Drugs 2018 08 27;36(4):709-714. Epub 2018 Feb 27.

Divisione di Farmacologia, Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-018-0579-8DOI Listing
August 2018

An Italian cost-effectiveness analysis of paclitaxel albumin (nab-paclitaxel) + gemcitabine vs gemcitabine alone for metastatic pancreatic cancer patients: the APICE study.

Authors:
Carlo Lazzaro Carlo Barone Francesco Caprioni Stefano Cascinu Alfredo Falcone Evaristo Maiello Michele Milella Carmine Pinto Michele Reni Giampaolo Tortora

Expert Rev Pharmacoecon Outcomes Res 2018 Aug 20;18(4):435-446. Epub 2018 Apr 20.

j Azienda Ospedaliera Universitaria Integrata Borgo Roma , Verona , Italy.

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http://dx.doi.org/10.1080/14737167.2018.1464394DOI Listing
August 2018

The Winding Roadmap of Biomarkers toward Clinic: Lessons from Predictors of Resistance to Anti-EGFRs in Metastatic Colorectal Cancer.

Authors:
Carlotta Antoniotti Elena Ongaro Alfredo Falcone Chiara Cremolini

Int J Mol Sci 2018 Aug 5;19(8). Epub 2018 Aug 5.

Department of Oncology, University Hospital of Pisa, 56126 Pisa, Italy.

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http://dx.doi.org/10.3390/ijms19082298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121538PMC
August 2018

TRIPLETE: a randomised phase III study of modified FOLFOXIRI plus panitumumab versus mFOLFOX6 plus panitumumab as initial therapy for patients with unresectable and wild-type metastatic colorectal cancer.

Authors:
Beatrice Borelli Roberto Moretto Sara Lonardi Andrea Bonetti Carlotta Antoniotti Filippo Pietrantonio Gianluca Masi Valentina Burgio Federica Marmorino Lisa Salvatore Daniele Rossini Alberto Zaniboni Gemma Zucchelli Angelo Martignetti Monica Di Battista Nicoletta Pella Alessandro Passardi Alessandra Boccaccino Francesco Leone Camilla Colombo Cristina Granetto Francesca Vannini Valentina Angela Marsico Erika Martinelli Lorenzo Antonuzzo Stefano Vitello Laura Delliponti Luca Boni Chiara Cremolini Alfredo Falcone

ESMO Open 2018 9;3(4):e000403. Epub 2018 Jul 9.

Unit of Medical Oncology, Azienda Ospedaliero-Universitaria Pisana, Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.

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http://esmoopen.bmj.com/lookup/doi/10.1136/esmoopen-2018-000
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http://dx.doi.org/10.1136/esmoopen-2018-000403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045747PMC
July 2018

Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project.

Authors:
Katrin M Sjoquist Lindsay A Renfro R John Simes Niall C Tebbutt Stephen Clarke Matthew T Seymour Richard Adams Timothy S Maughan Leonard Saltz Richard M Goldberg Hans-Joachim Schmoll Eric Van Cutsem Jean-Yves Douillard Paulo M Hoff Joel Randolph Hecht Christophe Tournigand Cornelis J A Punt Miriam Koopman Herbert Hurwitz Volker Heinemann Alfredo Falcone Rainer Porschen Charles Fuchs Eduardo Diaz-Rubio Enrique Aranda Carsten Bokemeyer Ioannis Souglakos Fairooz F Kabbinavar Benoist Chibaudel Jeffrey P Meyers Daniel J Sargent Aimery de Gramont John R Zalcberg

J Natl Cancer Inst 2018 06;110(6):638-648

School of Public Health and Preventative Medicine, Monash University, Melbourne, Australia.

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https://academic.oup.com/jnci/article/110/6/638/4757465
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http://dx.doi.org/10.1093/jnci/djx253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005015PMC
June 2018

NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients.

Authors:
Marta Schirripa Wu Zhang Dongyun Yang Shu Cao Satoshi Okazaki Fotios Loupakis Martin D Berger Yan Ning Yuji Miyamoto Mitsukuni Suenaga Giulia Alberti Jordan D West Sara Lonardi Taline Khoukaz Francesca Bergamo Francesca Battaglin Carlotta Antoniotti Alfredo Falcone Sebastian Stintzing Volker Heinemann Heinz-Josef Lenz

PLoS One 2018 9;13(3):e0193640. Epub 2018 Mar 9.

Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193640PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844536PMC
June 2018

Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib.

Authors:
Mitsukuni Suenaga Marta Schirripa Shu Cao Wu Zhang Dongyun Yang Yan Ning Chiara Cremolini Carlotta Antoniotti Beatrice Borelli Tetsuo Mashima Satoshi Okazaki Martin D Berger Yuji Miyamoto Roel Gopez Afsaneh Barzi Sara Lonardi Toshiharu Yamaguchi Alfredo Falcone Fotios Loupakis Heinz-Josef Lenz

Clin Colorectal Cancer 2018 06 27;17(2):e395-e414. Epub 2018 Feb 27.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2018.02.010DOI Listing
June 2018

Activity and Safety of Cetuximab Plus Modified FOLFOXIRI Followed by Maintenance With Cetuximab or Bevacizumab for RAS and BRAF Wild-type Metastatic Colorectal Cancer: A Randomized Phase 2 Clinical Trial.

Authors:
Chiara Cremolini Carlotta Antoniotti Sara Lonardi Giuseppe Aprile Francesca Bergamo Gianluca Masi Roberta Grande Giuseppe Tonini Claudia Mescoli Giovanni Gerardo Cardellino Luigi Coltelli Lisa Salvatore Domenico Cristiano Corsi Cristiana Lupi Donatello Gemma Monica Ronzoni Emanuela Dell'Aquila Federica Marmorino Francesca Di Fabio Maria Laura Mancini Lorenzo Marcucci Gabriella Fontanini Vittorina Zagonel Luca Boni Alfredo Falcone

JAMA Oncol 2018 Apr;4(4):529-536

Unit of Medical Oncology 2, Department of Translational Research and New Technologies in Medicine and Surgery, Azienda Ospedaliera-Universitaria Pisana, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1001/jamaoncol.2017.5314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885260PMC
April 2018

Differential histopathologic parameters in colorectal cancer liver metastases resected after triplets plus bevacizumab or cetuximab: a pooled analysis of five prospective trials.

Authors:
Chiara Cremolini Massimo Milione Federica Marmorino Federica Morano Gemma Zucchelli Alessia Mennitto Michele Prisciandaro Sara Lonardi Alessio Pellegrinelli Daniele Rossini Francesca Bergamo Giuseppe Aprile Lucio Urbani Luca Morelli Marta Schirripa Giovanni Gerardo Cardellino Matteo Fassan Gabriella Fontanini Filippo de Braud Vincenzo Mazzaferro Alfredo Falcone Filippo Pietrantonio

Br J Cancer 2018 04 13;118(7):955-965. Epub 2018 Mar 13.

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori - Via Venezian, 1, 20100, Milano, Italy.

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http://dx.doi.org/10.1038/s41416-018-0015-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931102PMC
April 2018

PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC.

Authors:
Marzia Del Re Riccardo Marconcini Giulia Pasquini Eleonora Rofi Caterina Vivaldi Francesco Bloise Giuliana Restante Elena Arrigoni Chiara Caparello Maria Grazia Bianco Stefania Crucitta Iacopo Petrini Enrico Vasile Alfredo Falcone Romano Danesi

Br J Cancer 2018 03 6;118(6):820-824. Epub 2018 Mar 6.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/bjc.2018.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886129PMC
March 2018

A Polymorphism within the Vitamin D Transporter Gene Predicts Outcome in Metastatic Colorectal Cancer Patients Treated with FOLFIRI/Bevacizumab or FOLFIRI/Cetuximab.

Authors:
Martin D Berger Sebastian Stintzing Volker Heinemann Shu Cao Dongyun Yang Yu Sunakawa Satoshi Matsusaka Yan Ning Satoshi Okazaki Yuji Miyamoto Mitsukuni Suenaga Marta Schirripa Diana L Hanna Shivani Soni Alberto Puccini Wu Zhang Chiara Cremolini Alfredo Falcone Fotios Loupakis Heinz-Josef Lenz

Clin Cancer Res 2018 02 5;24(4):784-793. Epub 2017 Dec 5.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1663DOI Listing
February 2018

EGFR and AKT1 overexpression are mutually exclusive and associated with a poor survival in resected gastric adenocarcinomas.

Authors:
Iacopo Petrini Monica Lencioni Enrico Vasile Lorenzo Fornaro Lorenzo Belluomini Giulia Pasquini Laura Ginocchi Chiara Caparello Gianna Musettini Caterina Vivaldi Sara Caponi Sergio Ricci Agenese Proietti Gabriella Fontanini Antonio Giuseppe Naccarato Vincenzo Nardini Stefano Santi Alfredo Falcone

Cancer Biomark 2018 Feb;21(3):731-741

Medical Oncology, University Hospital of Pisa, 56126 Pisa, Italy.

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http://dx.doi.org/10.3233/CBM-170865DOI Listing
February 2018

Current status and perspectives in immunotherapy for metastatic melanoma.

Authors:
Riccardo Marconcini Francesco Spagnolo Luigia Stefania Stucci Simone Ribero Elena Marra Francesco De Rosa Virginia Picasso Lorenza Di Guardo Carolina Cimminiello Stefano Cavalieri Laura Orgiano Enrica Tanda Laura Spano Alfredo Falcone Paola Queirolo

Oncotarget 2018 02 3;9(15):12452-12470. Epub 2018 Jan 3.

Department of Medical Oncology, IRCCS AOU San Martino-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

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http://dx.doi.org/10.18632/oncotarget.23746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844761PMC
February 2018

Reply to Ugo De Giorgi, Vincenza Conteduca, and Emanuela Scarpi's Letter to the Editor re: Marzia Del Re, Elisa Biasco, Stefania Crucitta, et al. The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients. Eur Urol 2017;71:680-7.

Authors:
Marzia Del Re Elisa Biasco Stefania Crucitta Lisa Derosa Eleonora Rofi Cinzia Orlandini Mario Miccoli Luca Galli Alfredo Falcone Guido W Jenster Ron H van Schaik Romano Danesi

Eur Urol 2018 01 9;73(1):e11-e12. Epub 2017 Aug 9.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.eururo.2017.07.034DOI Listing
January 2018

Integrated safety summary for trifluridine/tipiracil (TAS-102).

Authors:
Alfredo Falcone Atsushi Ohtsu Eric Van Cutsem Robert J Mayer Michele Buscaglia Johanna C Bendell Scott Kopetz Paul Bebeau Takayuki Yoshino

Anticancer Drugs 2018 01;29(1):89-96

Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan.

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http://dx.doi.org/10.1097/CAD.0000000000000554DOI Listing
January 2018

and genotyping to predict adverse events during first-line FOLFIRI or FOLFOXIRI plus bevacizumab in metastatic colorectal cancer.

Authors:
Chiara Cremolini Marzia Del Re Carlotta Antoniotti Sara Lonardi Francesca Bergamo Fotios Loupakis Beatrice Borelli Federica Marmorino Valentina Citi Enrico Cortesi Roberto Moretto Monica Ronzoni Gianluca Tomasello Alberto Zaniboni Patrizia Racca Angela Buonadonna Giacomo Allegrini Vincenzo Ricci Samantha Di Donato Vittorina Zagonel Luca Boni Alfredo Falcone Romano Danesi

Oncotarget 2018 Jan 21;9(8):7859-7866. Epub 2017 Dec 21.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.23559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814264PMC
January 2018

ALK, ROS1, and NTRK Rearrangements in Metastatic Colorectal Cancer.

Authors:
Filippo Pietrantonio Federica Di Nicolantonio Alexa B Schrock Jeeyun Lee Sabine Tejpar Andrea Sartore-Bianchi Jaclyn F Hechtman Jason Christiansen Luca Novara Niall Tebbutt Giovanni Fucà Carlotta Antoniotti Seung Tae Kim Danielle Murphy Rosa Berenato Federica Morano James Sun Bosun Min Philip J Stephens Marissa Chen Luca Lazzari Vincent A Miller Robert Shoemaker Alessio Amatu Massimo Milione Jeffrey S Ross Salvatore Siena Alberto Bardelli Siraj M Ali Alfredo Falcone Filippo de Braud Chiara Cremolini

J Natl Cancer Inst 2017 12;109(12)

Azienda Ospedaliero, Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1093/jnci/djx089DOI Listing
December 2017

Adjuvant chemoradiotherapy (gemcitabine-based) in pancreatic adenocarcinoma: the Pisa University experience.

Authors:
Aldo Sainato Sabrina Montrone Francesco Pasqualetti Marianna Coppola Nunzia L V Cernusco Marco Panichi Alessandra Gonnelli Enrico Vasile Riccardo Morganti Alfredo Falcone Ugo Boggi Fabiola Paiar

Tumori 2017 Nov 11;103(6):577-582. Epub 2017 Jul 11.

Department of Radiotherapy, Pisa University, Pisa - Italy.

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http://dx.doi.org/10.5301/tj.5000664DOI Listing
November 2017

Tandem repeat variation near the HIC1 (hypermethylated in cancer 1) promoter predicts outcome of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.

Authors:
Satoshi Okazaki Marta Schirripa Fotios Loupakis Shu Cao Wu Zhang Dongyun Yang Yan Ning Martin D Berger Yuji Miyamoto Mitsukuni Suenaga Syma Iqubal Afsaneh Barzi Chiara Cremolini Alfredo Falcone Francesca Battaglin Lisa Salvatore Beatrice Borelli Timothy G Helentjaris Heinz-Josef Lenz

Cancer 2017 Nov 14;123(22):4506-4514. Epub 2017 Jul 14.

Department of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1002/cncr.30880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673544PMC
November 2017

Proxies of quality of life in metastatic colorectal cancer: analyses in the RECOURSE trial.

Authors:
Eric Van Cutsem Alfredo Falcone Rocio Garcia-Carbonero Yoshito Komatsu Alessandro Pastorino Marc Peeters Yasuhiro Shimada Kentaro Yamazaki Takayuki Yoshino Alberto Zaniboni Nadia Amellal Akira Kanehisa Robert Winkler Lukas Makris Robert J Mayer Atsushi Ohtsu Josep Tabernero

ESMO Open 2017 23;2(5):e000261. Epub 2017 Nov 23.

Department of Medical Oncology, Vall d'Hebron University Hospital and Institute of Oncology (VHIO), Universitat Autònoma de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/esmoopen-2017-000261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708320PMC
November 2017

Prognostic relevance of a T-type calcium channels gene signature in solid tumours: A correlation ready for clinical validation.

Authors:
Lorenzo Fornaro Caterina Vivaldi Dong Lin Hui Xue Alfredo Falcone Yuzhuo Wang Francesco Crea Martin D Bootman

PLoS One 2017 28;12(8):e0182818. Epub 2017 Aug 28.

School of Life, Health & Chemical Sciences, The Open University, Walton Hall, Milton Keynes, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573204PMC
October 2017

Patients with NSCLC may display a low ratio of p.T790M activating EGFR mutations in plasma at disease progression: implications for personalised treatment.

Authors:
Marzia Del Re Paola Bordi Iacopo Petrini Eleonora Rofi Francesca Mazzoni Lorenzo Belluomini Enrico Vasile Giuliana Restante Francesco Di Costanzo Alfredo Falcone Antonio Frassoldati Ron H N van Schaik Christi M J Steendam Antonio Chella Marcello Tiseo Riccardo Morganti Romano Danesi

Oncotarget 2017 Oct 15;8(49):86056-86065. Epub 2017 Sep 15.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.20947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689667PMC
October 2017

Early changes in plasma DNA levels of mutant KRAS as a sensitive marker of response to chemotherapy in pancreatic cancer.

Authors:
Marzia Del Re Caterina Vivaldi Eleonora Rofi Enrico Vasile Mario Miccoli Chiara Caparello Paolo Davide d'Arienzo Lorenzo Fornaro Alfredo Falcone Romano Danesi

Sci Rep 2017 08 11;7(1):7931. Epub 2017 Aug 11.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1038/s41598-017-08297-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554237PMC
August 2017

Vinorelbine in BRAF V600E mutated metastatic colorectal cancer: a prospective multicentre phase II clinical study.

Authors:
Chiara Cremolini Filippo Pietrantonio Gianluca Tomasello Vincenzo Dadduzio Roberto Moretto Federica Morano Marta Schirripa Carlotta Antoniotti Giovanni Fucà Francesca Bergamo Daniele Rossini Federico Nichetti Stamatia Ziampiri Michele Ghidini Federica Marmorino Michele Prisciandaro Alfredo Falcone Filippo De Braud Fotios Loupakis Sara Lonardi

ESMO Open 2017 10;2(3):e000241. Epub 2017 Aug 10.

Unit of Medical Oncology 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto IRCCS, Padua, Italy.

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http://dx.doi.org/10.1136/esmoopen-2017-000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703381PMC
August 2017

Surrogate Endpoints in Second-Line Trials of Targeted Agents in Metastatic Colorectal Cancer: A Literature-Based Systematic Review and Meta-Analysis.

Authors:
Chiara Cremolini Carlotta Antoniotti Filippo Pietrantonio Rosa Berenato Marco Tampellini Chiara Baratelli Lisa Salvatore Federica Marmorino Beatrice Borelli Federico Nichetti Paolo Bironzo Cristina Sonetto Maria Di Bartolomeo Filippo de Braud Fotios Loupakis Alfredo Falcone M Di Maio

Cancer Res Treat 2017 07 15;49(3):834-845. Epub 2016 Nov 15.

Department of Oncology, University of Turin, A.O. Ordine Mauriziano, Turin, Italy.

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http://dx.doi.org/10.4143/crt.2016.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512363PMC
July 2017

Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial.

Authors:
Marta Schirripa Wu Zhang Volker Heinemann Shu Cao Satoshi Okazaki Dongyun Yang Fotios Loupakis Martin D Berger Yan Ning Yuji Miyamoto Mitsukuni Suenaga Roel F Gopez Jordan D West Diana Hanna Afsaneh Barzi Alfredo Falcone Sebastian Stintzing Heinz-Josef Lenz

Int J Cancer 2017 07 10;141(2):383-392. Epub 2017 May 10.

Medical Oncology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90033.

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http://dx.doi.org/10.1002/ijc.30715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510747PMC
July 2017

The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab.

Authors:
Laura Demurtas Marco Puzzoni Riccardo Giampieri Pina Ziranu Valeria Pusceddu Alessandra Mandolesi Chiara Cremolini Gianluca Masi Fabio Gelsomino Carlotta Antoniotti Cristian Loretelli Fausto Meriggi Alberto Zaniboni Alfredo Falcone Stefano Cascinu Mario Scartozzi

Br J Cancer 2017 Jul 20;117(3):315-321. Epub 2017 Jun 20.

Departments of Medical Oncology, University of Cagliari, University Hospital 'Duilio Casula' S.S. 554, Km 4,500 Bivio per Sestu, Monserrato, Cagliari 09042, Italy.

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http://dx.doi.org/10.1038/bjc.2017.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537494PMC
July 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

Authors:
Lindsay A Renfro Richard M Goldberg Axel Grothey Alberto Sobrero Richard Adams Matthew T Seymour Volker Heinemann Hans-Joachim Schmoll Jean-Yves Douillard Herbert Hurwitz Charles S Fuchs Eduardo Diaz-Rubio Rainer Porschen Christophe Tournigand Benoist Chibaudel Paulo M Hoff Fairooz F Kabbinavar Alfredo Falcone Niall C Tebbutt Cornelis J A Punt J Randolph Hecht John Souglakos Carsten Bokemeyer Eric Van Cutsem Leonard Saltz Aimery de Gramont Daniel J Sargent

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.5771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466009PMC
June 2017

Multimodality treatment of locally advanced squamous cell carcinoma of the oesophagus: A comprehensive review and network meta-analysis.

Authors:
Francesco Montagnani Lorenzo Fornaro Paolo Frumento Caterina Vivaldi Alfredo Falcone Luisa Fioretto

Crit Rev Oncol Hematol 2017 Jun 23;114:24-32. Epub 2017 Mar 23.

SC Oncologia Medica 1, Dipartimento Oncologico, Azienda USL Toscana Centro, Istituto Toscano Tumori, Piazza Santa Maria Nuova 1, 50100, Firenze, Italy.

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http://dx.doi.org/10.1016/j.critrevonc.2017.03.024DOI Listing
June 2017

TRIBE-2: a phase III, randomized, open-label, strategy trial in unresectable metastatic colorectal cancer patients by the GONO group.

Authors:
Chiara Cremolini Federica Marmorino Fotios Loupakis Gianluca Masi Carlotta Antoniotti Lisa Salvatore Marta Schirripa Luca Boni Vittorina Zagonel Sara Lonardi Giuseppe Aprile Emiliano Tamburini Vincenzo Ricci Monica Ronzoni Filippo Pietrantonio Chiara Valsuani Gianluca Tomasello Alessandro Passardi Giacomo Allegrini Samantha Di Donato Daniele Santini Alfredo Falcone

BMC Cancer 2017 Jun 9;17(1):408. Epub 2017 Jun 9.

Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, Oncologia Medica 2 Universitaria, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1186/s12885-017-3360-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466800PMC
June 2017

Autophagy-related polymorphisms predict hypertension in patients with metastatic colorectal cancer treated with FOLFIRI and bevacizumab: Results from TRIBE and FIRE-3 trials.

Authors:
Martin D Berger Shinichi Yamauchi Shu Cao Diana L Hanna Yu Sunakawa Marta Schirripa Satoshi Matsusaka Dongyun Yang Susan Groshen Wu Zhang Yan Ning Satoshi Okazaki Yuji Miyamoto Mitsukuni Suenaga Sara Lonardi Chiara Cremolini Alfredo Falcone Volker Heinemann Fotios Loupakis Sebastian Stintzing Heinz-Josef Lenz

Eur J Cancer 2017 05 26;77:13-20. Epub 2017 Mar 26.

Division of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA; Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.02.020DOI Listing
May 2017

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients.

Authors:
Marzia Del Re Elisa Biasco Stefania Crucitta Lisa Derosa Eleonora Rofi Cinzia Orlandini Mario Miccoli Luca Galli Alfredo Falcone Guido W Jenster Ron H van Schaik Romano Danesi

Eur Urol 2017 04 10;71(4):680-687. Epub 2016 Oct 10.

Clinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.eururo.2016.08.012DOI Listing
April 2017

Efficacy of FOLFOXIRI plus bevacizumab in liver-limited metastatic colorectal cancer: A pooled analysis of clinical studies by Gruppo Oncologico del Nord Ovest.

Authors:
Chiara Cremolini Mariaelena Casagrande Fotios Loupakis Giuseppe Aprile Francesca Bergamo Gianluca Masi Roberto Moretto R Filippo Pietrantonio Federica Marmorino Gemma Zucchelli Gianluca Tomasello Giuseppe Tonini Giacomo Allegrini Cristina Granetto Laura Ferrari Lucio Urbani Umberto Cillo Pierluigi Pilati Elisa Sensi Alessio Pellegrinelli Massimo Milione Gabriella Fontanini Alfredo Falcone

Eur J Cancer 2017 03 13;73:74-84. Epub 2016 Dec 13.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Via Roma 67, 56126 Pisa, Italy; University of Pisa, Via Roma 67, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.10.028DOI Listing
March 2017

Metastatic BRAF K601E-mutated melanoma reaches complete response to MEK inhibitor trametinib administered for over 36 months.

Authors:
Riccardo Marconcini Luca Galli Andrea Antonuzzo Simona Bursi Claudia Roncella Gabriella Fontanini Elisa Sensi Alfredo Falcone

Exp Hematol Oncol 2017 21;6. Epub 2017 Mar 21.

Department of Oncology, Azienda Ospedaliero-Universitaria Pisana and University of Pisa, Istituto Toscano Tumori, Santa Chiara Hospital, Via Roma 67, 56100 Pisa, Italy.

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http://ehoonline.biomedcentral.com/articles/10.1186/s40164-0
Publisher Site
http://dx.doi.org/10.1186/s40164-017-0067-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361706PMC
March 2017

Contribution of KRAS mutations and c.2369C > T (p.T790M) EGFR to acquired resistance to EGFR-TKIs in EGFR mutant NSCLC: a study on circulating tumor DNA.

Authors:
Marzia Del Re Marcello Tiseo Paola Bordi Armida D'Incecco Andrea Camerini Iacopo Petrini Maurizio Lucchesi Alessandro Inno Daniele Spada Enrico Vasile Valentina Citi Giorgio Malpeli Enrica Testa Stefania Gori Alfredo Falcone Domenico Amoroso Antonio Chella Federico Cappuzzo Andrea Ardizzoni Aldo Scarpa Romano Danesi

Oncotarget 2017 Feb;8(8):13611-13619

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.6957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355124PMC
February 2017

Cardiac safety of adjuvant non-pegylated liposomal doxorubicin combined with cyclophosphamide and followed by paclitaxel in older breast cancer patients.

Authors:
Luigi Coltelli Andrea Fontana Sara Lucchesi Laura Ginocchi Guido Bocci Mario Filidei Marco Scalese Giada Arrighi Chiara Finale Lorenzo Marcucci Orlando Goletti Barbara Salvadori Ilaria Ferrarini Eleonora Bona Alfredo Falcone Giacomo Allegrini

Breast 2017 Feb 23;31:186-191. Epub 2016 Nov 23.

Division of Medical Oncology, Pontedera Hospital, Azienda Toscana Nord Ovest, via Roma 151, 56025 PI, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09609776163023
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http://dx.doi.org/10.1016/j.breast.2016.11.006DOI Listing
February 2017

First-line therapy for mCRC - the influence of primary tumour location on the therapeutic algorithm.

Authors:
Chiara Cremolini Carlotta Antoniotti Roberto Moretto Gianluca Masi Alfredo Falcone

Nat Rev Clin Oncol 2017 02 17;14(2):113. Epub 2017 Jan 17.

Unit of Medical Oncology 2, Azienda Ospedaliera-Universitaria Pisana; and at the Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2016.219DOI Listing
February 2017

Regorafenib: lights and shadows of antiangiogenic therapies in gastric cancer.

Authors:
Caterina Vivaldi Alfredo Falcone Lorenzo Fornaro

Transl Gastroenterol Hepatol 2017 23;2:11. Epub 2017 Feb 23.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.21037/tgh.2017.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5334553PMC
February 2017

Radiological imaging markers predicting clinical outcome in patients with metastatic colorectal carcinoma treated with regorafenib: post hoc analysis of the CORRECT phase III trial (RadioCORRECT study).

Authors:
Riccardo Ricotta Antonella Verrioli Silvia Ghezzi Luca Porcu A Grothey Alfredo Falcone Eric Van Cutsem Guillem Argilés Antoine Adenis Marc Ychou Carlo Barone Olivier Bouché Marc Peeters Yves Humblet Laurent Mineur Alberto F Sobrero Joleen M Hubbard Chiara Cremolini Hans Prenen Josep Tabernero Hajer Jarraya Thibault Mazard Sophie Deguelte-Lardiere Konstantinos Papadimitriou Marc Van den Eynde Alessandro Pastorino Daniela Redaelli Katia Bencardino Chiara Funaioli Alessio Amatu Giulia Carlo-Stella Valter Torri Andrea Sartore-Bianchi Angelo Vanzulli Salvatore Siena

ESMO Open 2016 13;1(6):e000111. Epub 2017 Feb 13.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.

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http://dx.doi.org/10.1136/esmoopen-2016-000111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548980PMC
February 2017

Topoisomerase 1 Promoter Variants and Benefit from Irinotecan in Metastatic Colorectal Cancer Patients.

Authors:
Elisa Paolicchi Caterina Vivaldi Veronica De Gregorio Francesco Crea Lorenzo Fornaro Gianluca Masi Fotios Loupakis Francesco Graziano Monica Ronzoni Vincenzo Ricci Alfredo Falcone Romano Danesi

Oncology 2016 31;91(5):283-288. Epub 2016 Aug 31.

Unit of Clinical Pharmacology and Pharmacogenetics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1159/000448004DOI Listing
January 2017

Third-Line Chemotherapy with Irinotecan plus 5-Fluorouracil in Caucasian Metastatic Gastric Cancer Patients.

Authors:
Giulia Pasquini Enrico Vasile Chiara Caparello Caterina Vivaldi Gianna Musettini Monica Lencioni Iacopo Petrini Lorenzo Fornaro Alfredo Falcone

Oncology 2016 6;91(6):311-316. Epub 2016 Oct 6.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1159/000443962DOI Listing
January 2017

Stereotactic Body Radiotherapy in Patients with Lung Oligometastases from Colorectal Cancer.

Authors:
Francesco Pasqualetti Sabrina Montrone Caterina Vivaldi Margherita Zani David Fedele Lorenzo Fornaro Giuseppe Pasqualetti Lisa Salvatore Bruno Manfredi Concetta Laliscia Gabriele Coraggio Alessandra Gonnelli Fotios Loupakis Gianluca Masi Aldo Sainato Fabio Monzani Alfredo Falcone Fabiola Paiar

Anticancer Res 2017 01;37(1):315-319

Department of Clinical and Translational Sciences, Division of Radiation Oncology, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.21873/anticanres.11323DOI Listing
January 2017

Serum LDH predicts benefit from bevacizumab beyond progression in metastatic colorectal cancer.

Authors:
Federica Marmorino Lisa Salvatore Cecilia Barbara Giacomo Allegrini Lorenzo Antonuzzo Gianluca Masi Fotios Loupakis Beatrice Borelli Silvana Chiara Maria Chiara Banzi Emanuela Miraglio Domenico Amoroso Francesco Dargenio Andrea Bonetti Angelo Martignetti Myriam Paris Daniela Tomcikova Luca Boni Alfredo Falcone Chiara Cremolini

Br J Cancer 2017 01 12;116(3):318-323. Epub 2017 Jan 12.

Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Istituto Toscano Tumori, Via Roma, 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/bjc.2016.413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294477PMC
January 2017

Clinical, pharmacodynamic and pharmacokinetic results of a prospective phase II study on oral metronomic vinorelbine and dexamethasone in castration-resistant prostate cancer patients.

Authors:
Teresa Di Desidero Lisa Derosa Luca Galli Paola Orlandi Andrea Fontana Anna Fioravanti Riccardo Marconcini Mario Giorgi Beatrice Campi Alessandro Saba Sara Lucchesi Renato Felipetto Romano Danesi Giulio Francia Giacomo Allegrini Alfredo Falcone Guido Bocci

Invest New Drugs 2016 12 24;34(6):760-770. Epub 2016 Aug 24.

Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma, 55, I-56126, Pisa, Italy.

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http://dx.doi.org/10.1007/s10637-016-0385-0DOI Listing
December 2016

Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database.

Authors:
Jan Franko Qian Shi Jeffrey P Meyers Timothy S Maughan Richard A Adams Matthew T Seymour Leonard Saltz Cornelis J A Punt Miriam Koopman Christophe Tournigand Niall C Tebbutt Eduardo Diaz-Rubio John Souglakos Alfredo Falcone Benoist Chibaudel Volker Heinemann Joseph Moen Aimery De Gramont Daniel J Sargent Axel Grothey

Lancet Oncol 2016 Dec 12;17(12):1709-1719. Epub 2016 Oct 12.

Department of Oncology, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/S1470-2045(16)30500-9DOI Listing
December 2016

A still missing piece of the FIRE-3 puzzle.

Authors:
Carlotta Antoniotti Roberto Moretto Daniele Rossini Alfredo Falcone Chiara Cremolini

Lancet Oncol 2016 12;17(12):e515

Department of Oncology, University Hospital of Pisa, Via Roma 67, 56126 Pisa, Italy; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 67, 56126 Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(16)30568-XDOI Listing
December 2016

Apatinib in Advanced Gastric Cancer: A Doubtful Step Forward.

Authors:
Lorenzo Fornaro Enrico Vasile Alfredo Falcone

J Clin Oncol 2016 11;34(31):3822-3823

Lorenzo Fornaro, Enrico Vasile, and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisa, Pisa, Italy.

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http://dx.doi.org/10.1200/JCO.2016.68.6931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477932PMC
November 2016

An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer.

Authors:
Alfredo Falcone Lisa Salvatore

Future Oncol 2016 Sep 7;12(18):2065-9. Epub 2016 Jun 7.

University of Pisa, Azienda Ospedaliero Universitaria Pisana, Istituto Toscano Tumori (ITT), Via Roma, 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.2217/fon-2016-0249DOI Listing
September 2016

First-line treatment with FOLFOXIRI for advanced pancreatic cancer in clinical practice: Patients' outcome and analysis of prognostic factors.

Authors:
Caterina Vivaldi Chiara Caparello Gianna Musettini Giulia Pasquini Silvia Catanese Lorenzo Fornaro Monica Lencioni Alfredo Falcone Enrico Vasile

Int J Cancer 2016 Aug 18;139(4):938-45. Epub 2016 Apr 18.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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http://dx.doi.org/10.1002/ijc.30125DOI Listing
August 2016

Location of Primary Tumor and Benefit From Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies in Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer.

Authors:
Roberto Moretto Chiara Cremolini Daniele Rossini Filippo Pietrantonio Francesca Battaglin Alessia Mennitto Francesca Bergamo Fotios Loupakis Federica Marmorino Rosa Berenato Valentina Angela Marsico Marta Caporale Carlotta Antoniotti Gianluca Masi Lisa Salvatore Beatrice Borelli Gabriella Fontanini Sara Lonardi Filippo De Braud Alfredo Falcone

Oncologist 2016 08 5;21(8):988-94. Epub 2016 Jul 5.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy University of Pisa, Pisa, Italy

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http://dx.doi.org/10.1634/theoncologist.2016-0084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978565PMC
August 2016

FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer.

Authors:
Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti

World J Gastroenterol 2016 Aug;22(31):6987-7005

Chiara Caparello, Alfredo Falcone, Niccola Funel, Enrico Vasile, Elisa Giovannetti, University Hospital of Pisa, 56124 Pisa, Italy.

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http://dx.doi.org/10.3748/wjg.v22.i31.6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988311PMC
August 2016

Clinical Significance of TLR1 I602S Polymorphism for Patients with Metastatic Colorectal Cancer Treated with FOLFIRI plus Bevacizumab.

Authors:
Satoshi Okazaki Fotios Loupakis Sebastian Stintzing Shu Cao Wu Zhang Dongyun Yang Yan Ning Yu Sunakawa Stefan Stremitzer Satoshi Matsusaka Martin D Berger Anish Parekh Jordan D West Yuji Miyamoto Mitsukuni Suenaga Marta Schirripa Chiara Cremolini Alfredo Falcone Volker Heinemann R William DePaolo Heinz-Josef Lenz

Mol Cancer Ther 2016 07 11;15(7):1740-5. Epub 2016 May 11.

Department of Medical Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936942PMC
July 2016

TAS-102 for the treatment of metastatic colorectal cancer.

Authors:
Lisa Salvatore Daniele Rossini Roberto Moretto Chiara Cremolini Marta Schirripa Carlotta Antoniotti Federica Marmorino Fotios Loupakis Alfredo Falcone Gianluca Masi

Expert Rev Anticancer Ther 2015 28;15(11):1283-92. Epub 2015 Oct 28.

a Division of Medical Oncology , Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori , Pisa , Italy.

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http://dx.doi.org/10.1586/14737140.2015.1105746DOI Listing
June 2016

Comment on: 'Nab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective multicentre cohort'.

Authors:
Caterina Vivaldi Lorenzo Fornaro Chiara Caparello Alfredo Falcone Enrico Vasile

Br J Cancer 2016 05 28;114(11):e8. Epub 2016 Apr 28.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/bjc.2016.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891507PMC
May 2016

Second-line therapy for advanced pancreatic cancer: evaluation of prognostic factors and review of current literature.

Authors:
Chiara Caparello Caterina Vivaldi Lorenzo Fornaro Gianna Musettini Giulia Pasquini Silvia Catanese Gianluca Masi Monica Lencioni Alfredo Falcone Enrico Vasile

Future Oncol 2016 Apr 17;12(7):901-8. Epub 2016 Feb 17.

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy.

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http://dx.doi.org/10.2217/fon.16.16DOI Listing
April 2016

Corrigendum: Natural History of Non-Small-Cell Lung Cancer with Bone Metastases.

Authors:
Daniele Santini Sandro Barni Salvatore Intagliata Alfredo Falcone Francesco Ferraù Domenico Galetta Luca Moscetti Nicla La Verde Toni Ibrahim Fausto Petrelli Enrico Vasile Laura Ginocchi Davide Ottaviani Flavia Longo Cinzia Ortega Antonio Russo Giuseppe Badalamenti Elena Collovà Gaetano Lanzetta Giovanni Mansueto Vincenzo Adamo Filippo De Marinis Maria Antonietta Satolli Flavia Cantile Andrea Mancuso Francesca Maria Tanca Raffaele Addeo Marco Russano Michelle Sterpi Francesco Pantano Bruno Vincenzi Giuseppe Tonini

Sci Rep 2016 Apr 15;6:22205. Epub 2016 Apr 15.

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http://dx.doi.org/10.1038/srep22205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832177PMC
April 2016

Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.

Authors:
Riccardo Giampieri Lisa Salvatore Michela Del Prete Tiziana Prochilo Marco D'Anzeo Cristian Loretelli Fotios Loupakis Giuseppe Aprile Elena Maccaroni Kalliopi Andrikou Maristella Bianconi Alessandro Bittoni Luca Faloppi Laura Demurtas Rodolfo Montironi Marina Scarpelli Alfredo Falcone Alberto Zaniboni Mario Scartozzi Stefano Cascinu

Sci Rep 2016 04 27;6:25195. Epub 2016 Apr 27.

Medical Oncology, Translational Research Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

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http://dx.doi.org/10.1038/srep25195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846860PMC
April 2016

Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database.

Authors:
Lindsay A Renfro Fotios Loupakis Richard A Adams Matthew T Seymour Volker Heinemann Hans-Joachim Schmoll Jean-Yves Douillard Herbert Hurwitz Charles S Fuchs Eduardo Diaz-Rubio Rainer Porschen Christophe Tournigand Benoist Chibaudel Alfredo Falcone Niall C Tebbutt Cornelis J A Punt J Randolph Hecht Carsten Bokemeyer Eric Van Cutsem Richard M Goldberg Leonard B Saltz Aimery de Gramont Daniel J Sargent Heinz-Josef Lenz

J Clin Oncol 2016 Jan 26;34(2):144-50. Epub 2015 Oct 26.

Lindsay A. Renfro and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Fotios Loupakis and Alfredo Falcone, Azienda Ospedaliero-Universitaria Pisana and Università di Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital Cancer Center, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Institut de Cancerologie, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil, Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs, Dana-Farber Cancer Institute Boston, MA; Eduardo Diaz-Rubio, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; J. Randolph Hecht, David Geffen School of Medicine at the University of California at Los Angeles; Heinz-Josef Lenz, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, Los Angeles, CA; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; Richard M. Goldberg, Ohio State University, Columbus, OH; and Leonard B. Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2015.61.6441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070548PMC
January 2016

Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer.

Authors:
Fotios Loupakis Roberto Moretto Giuseppe Aprile Marta Muntoni Chiara Cremolini Donatella Iacono Mariaelena Casagrande Laura Ferrari Lisa Salvatore Marta Schirripa Daniele Rossini Giovanna De Maglio Gianpiero Fasola Lorenzo Calvetti Sara Pilotto Luisa Carbognin Gabriella Fontanini Giampaolo Tortora Alfredo Falcone Isabella Sperduti Emilio Bria

Br J Cancer 2016 Jan 17;114(1):30-6. Epub 2015 Nov 17.

Dipartimento di Medicina, Oncologia Medica, University of Verona, Azienda Ospedaliera Universitaria Integrata, Piazzale Aristide Stefani 1, 37126 Verona, Italy.

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http://dx.doi.org/10.1038/bjc.2015.399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716533PMC
January 2016

Pharmacoepigenetics in gastrointestinal tumors: MGMT methylation and beyond.

Authors:
Lorenzo Fornaro Caterina Vivaldi Chiara Caparello Gianna Musettini Editta Baldini Gianluca Masi Alfredo Falcone

Front Biosci (Elite Ed) 2016 Jan 1;8:170-80. Epub 2016 Jan 1.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

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January 2016

MRI tumor volume reduction rate vs tumor regression grade in the pre-operative re-staging of locally advanced rectal cancer after chemo-radiotherapy.

Authors:
Emanuele Neri Elisa Guidi Francesca Pancrazi Maura Castagna Elisa Castelluccio Riccardo Balestri Piero Buccianti Luca Masi Alfredo Falcone Bruno Manfredi Lorenzo Faggioni Carlo Bartolozzi

Eur J Radiol 2015 Dec 20;84(12):2438-43. Epub 2015 Aug 20.

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Unit of Diagnostic and Interventional Radiology, Pisa University Hospital, Italy.

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http://dx.doi.org/10.1016/j.ejrad.2015.08.008DOI Listing
December 2015

TRIBE study: are all three cytotoxic drugs crucial? - Authors' reply.

Authors:
Fotios Loupakis Chiara Cremolini Daniele Rossini Alfredo Falcone

Lancet Oncol 2015 Dec;16(16):e578-9

Polo Oncologico, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy; Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina, Università di Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00416-7DOI Listing
December 2015

Natural History of Non-Small-Cell Lung Cancer with Bone Metastases.

Authors:
Daniele Santini Santini Daniele Sandro Barni Barni Sandro Salvatore Intagliata Intagliata Salvatore Alfredo Falcone Falcone Alfredo Francesco Ferraù Ferraù Francesco Domenico Galetta Galetta Domenico Luca Moscetti Moscetti Luca Nicla La Verde La Verde Nicla Toni Ibrahim Ibrahim Toni Fausto Petrelli Petrelli Fausto Enrico Vasile Vasile Enrico Laura Ginocchi Ginocchi Laura Davide Ottaviani Ottaviani Davide Flavia Longo Longo Flavia Cinzia Ortega Ortega Cinzia Antonio Russo Russo Antonio Giuseppe Badalamenti Badalamenti Giuseppe Elena Collovà Collovà Elena Gaetano Lanzetta Lanzetta Gaetano Giovanni Mansueto Mansueto Giovanni Vincenzo Adamo Adamo Vincenzo Filippo De Marinis De Marinis Filippo Maria Antonietta Satolli Flavia Cantile Cantile Flavia Andrea Mancuso Mancuso Andrea Francesca Maria Tanca Raffaele Addeo Addeo Raffaele Marco Russano Russano Marco Michelle Sterpi M Sterpi Francesco Pantano Pantano Francesco Bruno Vincenzi Vincenzi Bruno Giuseppe Tonini Tonini Giuseppe

Sci Rep 2015 Dec 22;5:18670. Epub 2015 Dec 22.

Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1038/srep18670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687045PMC
December 2015

Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data.

Authors:
Lorenzo Fornaro Caterina Vivaldi Stefano Cereda Francesco Leone Giuseppe Aprile Sara Lonardi Nicola Silvestris Daniele Santini Michele Milella Chiara Caparello Gianna Musettini Giulia Pasquini Alfredo Falcone Giovanni Brandi Isabella Sperduti Enrico Vasile

J Exp Clin Cancer Res 2015 Dec 23;34:156. Epub 2015 Dec 23.

Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Via Roma 67, 56126, Pisa, Italy.

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http://dx.doi.org/10.1186/s13046-015-0267-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689003PMC
December 2015

Molecular and pathological characterization of the EZH2 rs3757441 single nucleotide polymorphism in colorectal cancer.

Authors:
Lorenzo Fornaro Pinuccia Faviana Veronica De Gregorio Caterina Vivaldi Elisa Paolicchi Gianluca Masi Fotios Loupakis Elisa Sensi Cristiana Lupi Gabriella Fontanini Yuzhuo Wang Romano Danesi Alfredo Falcone Francesco Crea

BMC Cancer 2015 Nov 9;15:874. Epub 2015 Nov 9.

Experimental Therapeutics, BCCA Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/s12885-015-1889-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640238PMC
November 2015

First-line chemotherapy for mCRC—a review and evidence-based algorithm.

Authors:
Chiara Cremolini Marta Schirripa Carlotta Antoniotti Roberto Moretto Lisa Salvatore Gianluca Masi Alfredo Falcone Fotios Loupakis

Nat Rev Clin Oncol 2015 Oct 28;12(10):607-19. Epub 2015 Jul 28.

Unit of Medical Oncology 2, Azienda Ospedaliera-Universitaria Pisana, Via Roma 67, 56126 Pisa, Italy.

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http://dx.doi.org/10.1038/nrclinonc.2015.129DOI Listing
October 2015

Prognostic clinical factors in pretreated colorectal cancer patients receiving regorafenib: implications for clinical management.

Authors:
Michela Del Prete Riccardo Giampieri Fotios Loupakis Tiziana Prochilo Lisa Salvatore Luca Faloppi Maristella Bianconi Alessandro Bittoni Giuseppe Aprile Alberto Zaniboni Alfredo Falcone Mario Scartozzi Stefano Cascinu

Oncotarget 2015 Oct;6(32):33982-92

Medical Oncology, AO Ospedali Riuniti-Università Politecnica delle Marche, Ancona, Italy.

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http://www.oncotarget.com/fulltext/5053
Publisher Site
http://dx.doi.org/10.18632/oncotarget.5053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741819PMC
October 2015

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients.

Authors:
Anna Solini Vittorio Simeon Lisa Derosa Paola Orlandi Chiara Rossi Andrea Fontana Luca Galli Teresa Di Desidero Anna Fioravanti Sara Lucchesi Luigi Coltelli Laura Ginocchi Giacomo Allegrini Romano Danesi Alfredo Falcone Guido Bocci

Oncotarget 2015 Oct;6(30):28743-54

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

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http://dx.doi.org/10.18632/oncotarget.4926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745689PMC
October 2015

FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study.

Authors:
Chiara Cremolini Fotios Loupakis Carlotta Antoniotti Cristiana Lupi Elisa Sensi Sara Lonardi Silvia Mezi Gianluca Tomasello Monica Ronzoni Alberto Zaniboni Giuseppe Tonini Chiara Carlomagno Giacomo Allegrini Silvana Chiara Mauro D'Amico Cristina Granetto Marina Cazzaniga Luca Boni Gabriella Fontanini Alfredo Falcone

Lancet Oncol 2015 Oct 31;16(13):1306-15. Epub 2015 Aug 31.

Department of Oncology, University Hospital of Pisa, Pisa, Italy; Department of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(15)00122-9DOI Listing
October 2015

Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.

Authors:
Bruno Vincenzi Chiara Cremolini Andrea Sartore-Bianchi Antonio Russo Francesco Mannavola Giuseppe Perrone Francesco Pantano Fotios Loupakis Daniele Rossini Elena Ongaro Erica Bonazzina Emanuela Dell'Aquila Marco Imperatori Alice Zoccoli Giuseppe Bronte Giovanna De Maglio Gabriella Fontanini Clara Natoli Alfredo Falcone Daniele Santini Andrea Onetti-Muda Salvatore Siena Giuseppe Tonini Giuseppe Aprile

Oncotarget 2015 Oct;6(31):31604-12

Department of Medical Oncology, Azienda Ospedaliero-Universitaria, Udine, Italy.

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http://dx.doi.org/10.18632/oncotarget.5231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741627PMC
October 2015