Alfredo Cagnotto

IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Milan University, Via Balzaretti 9, 20133 Milan, Italy. Electronic address:

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May 2016

The hunt for brain Aβ oligomers by peripherally circulating multi-functional nanoparticles: Potential therapeutic approach for Alzheimer disease.

Authors:

Simona Mancini Stefania Minniti Maria Gregori Giulio Sancini Alfredo Cagnotto Pierre-Olivier Couraud Lara Ordóñez-Gutiérrez Francisco Wandosell Mario Salmona Francesca Re

Nanomedicine 2016 Jan 26;12(1):43-52. Epub 2015 Sep 26.

Department of Health Sciences, University of Milano-Bicocca, Monza MB, Italy. Electronic address:

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January 2016

Investigation of Functionalized Poly(N,N-dimethylacrylamide)-block-polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier In Vitro.

Authors:

Maria Gregori Daniela Bertani Emanuela Cazzaniga Antonina Orlando Michele Mauri Alberto Bianchi Francesca Re Silvia Sesana Stefania Minniti Maura Francolini Alfredo Cagnotto Mario Salmona Luca Nardo Domenico Salerno Francesco Mantegazza Massimo Masserini Roberto Simonutti

Macromol Biosci 2015 Dec 21;15(12):1687-97. Epub 2015 Jul 21.

Department of Materials Science, University of Milano-Bicocca, Via Roberto Cozzi 55, 20125, Milano, Italy.

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December 2015

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.

Authors:

Maria N Modica Sebastiano Intagliata Valeria Pittalà Loredana Salerno Maria A Siracusa Alfredo Cagnotto Mario Salmona Giuseppe Romeo

Bioorg Med Chem Lett 2015 Apr 25;25(7):1427-30. Epub 2015 Feb 25.

Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, Catania 95125, Italy.

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April 2015

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.

Authors:

Margherita Brindisi Stefania Butini Silvia Franceschini Simone Brogi Francesco Trotta Sindu Ros Alfredo Cagnotto Mario Salmona Alice Casagni Marco Andreassi Simona Saponara Beatrice Gorelli Pia Weikop Jens D Mikkelsen Jorgen Scheel-Kruger Karin Sandager-Nielsen Ettore Novellino Giuseppe Campiani Sandra Gemma

J Med Chem 2014 Nov 7;57(22):9578-97. Epub 2014 Nov 7.

European Research Centre for Drug Discovery and Development, and ‡Dipartimento di Biotecnologie, Chimica e Farmacia, Università degli Studi di Siena , via Aldo Moro 2, 53100 Siena, Italy.

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November 2014

Multifunctional liposomes reduce brain β-amyloid burden and ameliorate memory impairment in Alzheimer's disease mouse models.

Authors:

Claudia Balducci Simona Mancini Stefania Minniti Pietro La Vitola Margherita Zotti Giulio Sancini Mario Mauri Alfredo Cagnotto Laura Colombo Fabio Fiordaliso Emanuele Grigoli Mario Salmona Anniina Snellman Merja Haaparanta-Solin Gianluigi Forloni Massimo Masserini Francesca Re

J Neurosci 2014 Oct;34(42):14022-31

Department of Health Sciences, University of Milano-Bicocca, 20900 Monza, Italy, and.

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October 2014

Synthesis and endothelin receptors binding affinity of new 1,3,5- substituted pyrrole-2-carboxylic acid derivatives.

Authors:

Loredana Salerno Maria N Modica Giuseppe Romeo Valeria Pittala Alfredo Cagnotto Maria A Siracusa

Med Chem 2015 ;11(2):109-17

Dipartimento di Scienze del Farmaco, Universita degli Studi di Catania, Viale A. Doria, 6, 95125 - Catania, Italy.

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October 2015

Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.

Authors:

Loredana Salerno Valeria Pittalà Maria N Modica Maria A Siracusa Sebastiano Intagliata Alfredo Cagnotto Mario Salmona Rafał Kurczab Andrzej J Bojarski Giuseppe Romeo

Eur J Med Chem 2014 Oct 7;85:716-26. Epub 2014 Aug 7.

Dipartimento di Scienze del Farmaco, Università di Catania, Viale A. Doria 6, 95125 Catania, Italy.

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October 2014

The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly.

Authors:

Massimo Messa Laura Colombo Elena del Favero Laura Cantù Tatiana Stoilova Alfredo Cagnotto Alessandro Rossi Michela Morbin Giuseppe Di Fede Fabrizio Tagliavini Mario Salmona

J Biol Chem 2014 Aug 18;289(35):24143-52. Epub 2014 Jul 18.

From the Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy,

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August 2014

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease.

Authors:

Laura Bana Stefania Minniti Elisa Salvati Silvia Sesana Vanessa Zambelli Alfredo Cagnotto Antonina Orlando Emanuela Cazzaniga Rob Zwart Wiep Scheper Massimo Masserini Francesca Re

Nanomedicine 2014 Oct 10;10(7):1583-90. Epub 2013 Dec 10.

Department of Health Sciences, University of Milano-Bicocca, Monza, Italy.

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October 2014

Tetrahydro-β-carboline-based spirocyclic lactam as type II' β-turn: application to the synthesis and biological evaluation of somatostatine mimetics.

Authors:

Giordano Lesma Roberto Cecchi Alfredo Cagnotto Marco Gobbi Fiorella Meneghetti Manuele Musolino Alessandro Sacchetti Alessandra Silvani

J Org Chem 2013 Mar 21;78(6):2600-10. Epub 2013 Feb 21.

Dipartimento di Chimica, Università degli Studi di Milano, via C. Golgi 19, 20133 Milano, Italy.

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March 2013

Specific recognition of biologically active amyloid-β oligomers by a new surface plasmon resonance-based immunoassay and an in vivo assay in Caenorhabditis elegans.

Authors:

Matteo Stravalaci Antonio Bastone Marten Beeg Alfredo Cagnotto Laura Colombo Giuseppe Di Fede Fabrizio Tagliavini Laura Cantù Elena Del Favero Michele Mazzanti Roberto Chiesa Mario Salmona Luisa Diomede Marco Gobbi

J Biol Chem 2012 Aug 26;287(33):27796-805. Epub 2012 Jun 26.

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy.

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August 2012

Good gene, bad gene: new APP variant may be both.

Authors:

Giuseppe Di Fede Marcella Catania Michela Morbin Giorgio Giaccone Maria Luisa Moro Roberta Ghidoni Laura Colombo Massimo Messa Alfredo Cagnotto Margherita Romeo Matteo Stravalaci Luisa Diomede Marco Gobbi Mario Salmona Fabrizio Tagliavini

Prog Neurobiol 2012 Dec 19;99(3):281-92. Epub 2012 Jun 19.

Neurology V & Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

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December 2012

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.

Authors:

Claudia Manzoni Laura Colombo Paolo Bigini Valentina Diana Alfredo Cagnotto Massimo Messa Monica Lupi Valentina Bonetto Mauro Pignataro Cristina Airoldi Erika Sironi Alun Williams Mario Salmona

PLoS One 2011 23;6(9):e24909. Epub 2011 Sep 23.

Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

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March 2012

Synthesis and molecular modeling of 1H-pyrrolopyrimidine-2,4-dione derivatives as ligands for the α1-adrenoceptors.

Authors:

Valeria Pittalà Maria A Siracusa Maria N Modica Loredana Salerno Alessandro Pedretti Giulio Vistoli Alfredo Cagnotto Tiziana Mennini Giuseppe Romeo

Bioorg Med Chem 2011 Sep 21;19(17):5260-76. Epub 2011 Jun 21.

Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Catania, Italy.

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September 2011

Functionalization with ApoE-derived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide.

Authors:

Francesca Re Ilaria Cambianica Silvia Sesana Elisa Salvati Alfredo Cagnotto Mario Salmona Pierre-Olivier Couraud S Moein Moghimi Massimo Masserini Giulio Sancini

J Biotechnol 2011 Dec 6;156(4):341-6. Epub 2011 Jul 6.

Department of Experimental Medicine, University of Milano-Bicocca, via Cadore 48, Monza, Italy.

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December 2011

Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model.

Authors:

Francesca Re Ilaria Cambianica Cristiano Zona Silvia Sesana Maria Gregori Roberta Rigolio Barbara La Ferla Francesco Nicotra Gianluigi Forloni Alfredo Cagnotto Mario Salmona Massimo Masserini Giulio Sancini

Nanomedicine 2011 Oct 20;7(5):551-9. Epub 2011 May 20.

Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy.

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October 2011

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity.

Authors:

Angelisa Frasca Marlien Aalbers Federica Frigerio Fabio Fiordaliso Monica Salio Marco Gobbi Alfredo Cagnotto Fabrizio Gardoni Giorgio S Battaglia Govert Hoogland Monica Di Luca Annamaria Vezzani

Neurobiol Dis 2011 Aug 6;43(2):507-15. Epub 2011 May 6.

Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy.

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August 2011

Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation.

Authors:

Torun Melø Paolo Bigini Ursula Sonnewald Silvia Balosso Alfredo Cagnotto Sara Barbera Sarah Uboldi Annamaria Vezzani Tiziana Mennini

J Neurochem 2010 Dec 19;115(6):1445-54. Epub 2010 Nov 19.

Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

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December 2010

Interactions of the prion peptide (PrP 106-126) with brain capillary endothelial cells: coordinated cell killing and remodeling of intercellular junctions.

Authors:

Itzik Cooper Katayun Cohen-Kashi Malina Alfredo Cagnotto Gianfranco Bazzoni Mario Salmona Vivian I Teichberg

J Neurochem 2011 Feb;116(4):467-75

Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.

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February 2011

Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.

Authors:

Valentina Diana Arianna Ottolina Francesca Botti Elena Fumagalli Eleonora Calcagno Massimiliano De Paola Alfredo Cagnotto Gloria Invernici Eugenio Parati Daniela Curti Tiziana Mennini

Exp Neurol 2010 Sep 15;225(1):163-72. Epub 2010 Jun 15.

Department of Molecular Biochemistry and Pharmacology; Laboratory of Receptor Pharmacology Mario Negri Institute for Pharmacological Research, via La Masa, 19-20156 Milan, Italy.

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September 2010

Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.

Authors:

Stefania Butini Roberta Budriesi Michel Hamon Elena Morelli Sandra Gemma Margherita Brindisi Giuseppe Borrelli Ettore Novellino Isabella Fiorini Pierfranco Ioan Alberto Chiarini Alfredo Cagnotto Tiziana Mennini Claudia Fracasso Silvio Caccia Giuseppe Campiani

J Med Chem 2009 Nov;52(21):6946-50

European Research Centre for Drug Discovery and Development, 53100 Siena, Italy.

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November 2009

Proteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the wobbler mouse, a model of motor neuron degeneration.

Authors:

Antonio Bastone Elena Fumagalli Paolo Bigini Pietro Perini Davide Bernardinello Alfredo Cagnotto Ilario Mereghetti Daniela Curti Mario Salmona Tiziana Mennini

J Proteome Res 2009 Nov;8(11):5229-40

Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy.

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November 2009

Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.

J Med Chem 2009 Jun;52(11):3548-62

European Research Centre for Drug Discovery and Development, Siena, Italy.

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June 2009

Overcoming synthetic Abeta peptide aging: a new approach to an age-old problem.

Authors:

Claudia Manzoni Laura Colombo Massimo Messa Alfredo Cagnotto Laura Cantù Elena Del Favero Mario Salmona

Amyloid 2009 ;16(2):71-80

Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

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September 2010

Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior.

J Med Chem 2009 Jan;52(1):151-69

European Research Centre for Drug Discovery and Development, University of Siena, Siena, Italy.

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January 2009

Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands.

Authors:

Maria A Siracusa Loredana Salerno Maria N Modica Valeria Pittalà Giuseppe Romeo Maria E Amato Mateusz Nowak Andrzej J Bojarski Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini

J Med Chem 2008 Aug 4;51(15):4529-38. Epub 2008 Jul 4.

Dipartimento di Scienze Farmaceutiche, Università di Catania, Catania, Italy.

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August 2008

Synthesis and receptor binding of new thieno[2,3-d]-pyrimidines as selective ligands of 5-HT(3) receptors.

Authors:

Maria N Modica Giuseppe Romeo Loredana Salerno Valeria Pittalà Maria A Siracusa Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini Róbert Gáspár Adrienn Gál George Falkay Márta Palkó Gábor Maksay Ferenc Fülöp

Arch Pharm (Weinheim) 2008 Jun;341(6):333-43

Dipartimento di Scienze Farmaceutiche, Università di Catania, Catania, Italy.

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June 2008

Synthesis and endothelin receptor binding affinity of a novel class of 2-substituted-4-aryl-3-quinolinecarboxylic acid derivatives.

Authors:

Valeria Pittalà Maria Modica Loredana Salerno Maria Angela Siracusa Francesco Guerrera Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini Giuseppe Romeo

Med Chem 2008 Mar;4(2):129-37

Dipartimento di Scienze Farmaceutiche, Università di Catania, Catania, Italy.

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March 2008

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse.

Authors:

Paolo Bigini Mariaelena Repici Giuseppina Cantarella Elena Fumagalli Sara Barbera Alfredo Cagnotto Ada De Luigi Rossella Tonelli Renato Bernardini Tiziana Borsello Tiziana Mennini

Neurobiol Dis 2008 Mar 12;29(3):465-76. Epub 2007 Nov 12.

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy.

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March 2008

Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.

Authors:

Nicola Micale Simona Colleoni Giovanna Postorino Alessia Pellicanò Maria Zappalà John Lazzaro Valentina Diana Alfredo Cagnotto Tiziana Mennini Silvana Grasso

Bioorg Med Chem 2008 Mar 5;16(5):2200-11. Epub 2007 Dec 5.

Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Messina, Italy.

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March 2008

Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse.

Authors:

Paolo Bigini Cristiana Atzori Elena Fumagalli Alfredo Cagnotto Sara Barbera Antonio Migheli Tiziana Mennini

Neurosci Lett 2007 Oct 4;426(2):106-10. Epub 2007 Sep 4.

Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy.

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October 2007

Novel sigma receptor ligands: synthesis and biological profile.

Authors:

Orazio Prezzavento Agata Campisi Simone Ronsisvalle Giovanni Li Volti Agostino Marrazzo Vincenzo Bramanti Giuseppe Cannavò Luca Vanella Alfredo Cagnotto Tiziana Mennini Riccardo Ientile Giuseppe Ronsisvalle

J Med Chem 2007 Mar 13;50(5):951-61. Epub 2007 Feb 13.

Department of Pharmaceutical Sciences, University of Catania, Viale A. Doria 6, 95125 Catania, Italy.

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March 2007

Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice.

Authors:

Paolo Bigini Fabrizio Gardoni Sara Barbera Alfredo Cagnotto Elena Fumagalli Annalisa Longhi Massimiliano M Corsi Monica Di Luca Tiziana Mennini

BMC Neurosci 2006 Oct 26;7:71. Epub 2006 Oct 26.

Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy.

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October 2006

Dimethyl sulfoxide: an antagonist in scintillation proximity assay [(35)S]-GTPgammaS binding to rat 5-HT(6) receptor cloned in HEK-293 cells?

Authors:

Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini

J Neurosci Methods 2007 Mar 17;160(2):251-5. Epub 2006 Oct 17.

"Mario Negri" Institute for Pharmacological Research, via Eritrea 62, 20157 Milan, Italy.

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March 2007

Chiral resolution and binding study of 1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino[2,1-d]pyrrolo[1,2-b] [1,2,5]benzotriazepine (10-methyl-10-azaaptazepine) and 2-methyl-1,3,4,14b-tetrahydro-2H-pyrazino[2,1-d]pyrrolo[1,2-b] [1,2,5]benzothiadiazepine 10,10-dioxide (tiaaptazepine).

Authors:

Gabriella De Martino Giuseppe La Regina Francesco La Torre Roberto Cirilli Ilario Mereghetti Alfredo Cagnotto Marino Artico Romano Silvestri

Farmaco 2005 Nov-Dec;60(11-12):931-7. Epub 2005 Oct 11.

Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Piazzale A. Moro 5, I-00185 Roma, Italy.

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February 2006

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

Authors:

Valeria Pittalà Giuseppe Romeo Loredana Salerno Maria Angela Siracusa Maria Modica Luisa Materia Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini Gabriella Marucci Piero Angeli Filippo Russo

Bioorg Med Chem Lett 2006 Jan 10;16(1):150-3. Epub 2005 Oct 10.

Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125 Catania, Italy.

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January 2006

Novel (E)-alpha-[(1H-indol-3-yl)methylene]benzeneacetic acids as endothelin receptor ligands.

Authors:

Valeria Pittalà Giuseppe Romeo Luisa Materia Loredana Salerno Maria Angela Siracusa Maria Modica Ilario Mereghetti Alfredo Cagnotto Filippo Russo

Farmaco 2005 Sep;60(9):731-8

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria 6, 95125 Catania, Italy.

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September 2005

A facile synthesis of new 2-carboxamido-3-carboxythiophene and 4,5,6,7-tetrahydro-2-carboxamido-3-carboxythieno[2,3-c]pyridine derivatives as potential endothelin receptors ligands.

Authors:

Valeria Pittalà Maria Modica Giuseppe Romeo Luisa Materia Loredana Salerno Mariangela Siracusa Alfredo Cagnotto Ilario Mereghetti Filippo Russo

Farmaco 2005 Sep;60(9):711-20

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria 6, 95125 Catania, Italy.

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September 2005

Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia.

Authors:

Angela Garau Riccardo Bertini Francesco Colotta Federica Casilli Paolo Bigini Alfredo Cagnotto Tiziana Mennini Pietro Ghezzi Pia Villa

Cytokine 2005 May;30(3):125-31

Mario Negri Institute for Pharmacological Research, Milan, Italy.

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May 2005

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

Authors:

Emanuele Patanè Valeria Pittalà Francesco Guerrera Loredana Salerno Giuseppe Romeo Maria Angela Siracusa Filippo Russo Fabrizio Manetti Maurizio Botta Ilario Mereghetti Alfredo Cagnotto Tiziana Mennini

J Med Chem 2005 Apr;48(7):2420-31

Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125 Catania, Italy.

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April 2005

Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies.

Authors:

Giuseppe Campiani Stefania Butini Caterina Fattorusso Francesco Trotta Sandra Gemma Bruno Catalanotti Vito Nacci Isabella Fiorini Alfredo Cagnotto Ilario Mereghetti Tiziana Mennini Patrizia Minetti M Assunta Di Cesare M Antonietta Stasi Stefano Di Serio Orlando Ghirardi Ornella Tinti Paolo Carminati

J Med Chem 2005 Mar;48(6):1705-8

Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development, Università di Siena, 53100 Siena, Italy.

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March 2005

Synthesis and binding properties of novel selective 5-HT3 receptor ligands.

Authors:

Maria Modica Giuseppe Romeo Luisa Materia Filippo Russo Alfredo Cagnotto Tiziana Mennini Róbert Gáspár George Falkay Ferenc Fülöp

Bioorg Med Chem 2004 Jul;12(14):3891-901

Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125 Catania, Italy.

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July 2004

Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice.

Authors:

Tiziana Mennini Paolo Bigini Alfredo Cagnotto Lucia Carvelli Patrizia Di Nunno Elena Fumagalli Massimo Tortarolo Wim A Buurman Pietro Ghezzi Caterina Bendotti

Cytokine 2004 Feb;25(3):127-35

Department Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157, Milan, Italy.

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February 2004

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

J Med Chem 2004 Jan;47(1):143-57

Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro and European Research Centre for Drug Discovery and Development, Universitá degli Studi di Siena, 53100 Siena, Italy.

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January 2004

Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.

Authors:

Delphine Moison Philippe De Deurwaerdère Alfredo Cagnotto Agostino Marrazzo Orazio Prezzavento Giuseppe Ronsisvalle Tiziana Mennini Umberto Spampinato

Neuropharmacology 2003 Dec;45(7):945-53

Laboratoire de Neuropsychobiologie des Désadaptations, Unité Mixte de Recherche-Centre National de la Recherche Scientifique 5541, Université Victor Segalen Bordeaux 2, Bordeaux, France.

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December 2003