Publications by authors named "Alfredo Cagnotto"

62Publications

Super Resolution Microscopy of SUMO Proteins in Neurons.

Front Cell Neurosci 2019 1;13:486. Epub 2019 Nov 1.

Department of Neuroscience, Dulbecco Telethon Institute, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.

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November 2019

Identification of amino acid residues critical for the B cell growth-promoting activity of HIV-1 matrix protein p17 variants.

Biochim Biophys Acta Gen Subj 2019 01 21;1863(1):13-24. Epub 2018 Sep 21.

Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy. Electronic address:

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January 2019

Humanin Specifically Interacts with Amyloid-β Oligomers and Counteracts Their in vivo Toxicity.

J Alzheimers Dis 2017 ;57(3):857-871

Department of Molecular Biochemistry and Pharmacology, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.

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August 2017

Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.

Bioorg Med Chem Lett 2016 08 28;26(16):4052-6. Epub 2016 Jun 28.

Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, Catania 95125, Italy.

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August 2016

Clusterin Binds to Aβ1-42 Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation.

J Biol Chem 2016 Mar 16;291(13):6958-66. Epub 2016 Feb 16.

From the Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, 20156 Milan, Italy

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March 2016

The new β amyloid-derived peptide Aβ1-6A2V-TAT(D) prevents Aβ oligomer formation and protects transgenic C. elegans from Aβ toxicity.

Neurobiol Dis 2016 Apr 11;88:75-84. Epub 2016 Jan 11.

Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy.

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April 2016

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.

Neurobiol Dis 2016 May 22;89:101-11. Epub 2015 Dec 22.

IRCCS Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy; Department of Pharmacological and Biomolecular Sciences, Milan University, Via Balzaretti 9, 20133 Milan, Italy. Electronic address:

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May 2016

Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.

Bioorg Med Chem Lett 2015 Apr 25;25(7):1427-30. Epub 2015 Feb 25.

Dipartimento di Scienze del Farmaco, Università di Catania, viale A. Doria 6, Catania 95125, Italy.

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April 2015

Synthesis and endothelin receptors binding affinity of new 1,3,5- substituted pyrrole-2-carboxylic acid derivatives.

Med Chem 2015 ;11(2):109-17

Dipartimento di Scienze del Farmaco, Universita degli Studi di Catania, Viale A. Doria, 6, 95125 - Catania, Italy.

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October 2015

The peculiar role of the A2V mutation in amyloid-β (Aβ) 1-42 molecular assembly.

J Biol Chem 2014 Aug 18;289(35):24143-52. Epub 2014 Jul 18.

From the Department of Molecular Biochemistry and Pharmacology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy,

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August 2014

Good gene, bad gene: new APP variant may be both.

Prog Neurobiol 2012 Dec 19;99(3):281-92. Epub 2012 Jun 19.

Neurology V & Neuropathology, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

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December 2012

Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.

Exp Neurol 2010 Sep 15;225(1):163-72. Epub 2010 Jun 15.

Department of Molecular Biochemistry and Pharmacology; Laboratory of Receptor Pharmacology Mario Negri Institute for Pharmacological Research, via La Masa, 19-20156 Milan, Italy.

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September 2010

Overcoming synthetic Abeta peptide aging: a new approach to an age-old problem.

Amyloid 2009 ;16(2):71-80

Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy.

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September 2010

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse.

Neurobiol Dis 2008 Mar 12;29(3):465-76. Epub 2007 Nov 12.

Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy.

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March 2008

Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse.

Neurosci Lett 2007 Oct 4;426(2):106-10. Epub 2007 Sep 4.

Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy.

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October 2007

Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice.

BMC Neurosci 2006 Oct 26;7:71. Epub 2006 Oct 26.

Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy.

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October 2006

Dimethyl sulfoxide: an antagonist in scintillation proximity assay [(35)S]-GTPgammaS binding to rat 5-HT(6) receptor cloned in HEK-293 cells?

J Neurosci Methods 2007 Mar 17;160(2):251-5. Epub 2006 Oct 17.

"Mario Negri" Institute for Pharmacological Research, via Eritrea 62, 20157 Milan, Italy.

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March 2007

Novel (E)-alpha-[(1H-indol-3-yl)methylene]benzeneacetic acids as endothelin receptor ligands.

Farmaco 2005 Sep;60(9):731-8

Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria 6, 95125 Catania, Italy.

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September 2005

Synthesis and binding properties of novel selective 5-HT3 receptor ligands.

Bioorg Med Chem 2004 Jul;12(14):3891-901

Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125 Catania, Italy.

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July 2004

Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice.

Cytokine 2004 Feb;25(3):127-35

Department Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157, Milan, Italy.

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February 2004

Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.

Neuropharmacology 2003 Dec;45(7):945-53

Laboratoire de Neuropsychobiologie des Désadaptations, Unité Mixte de Recherche-Centre National de la Recherche Scientifique 5541, Université Victor Segalen Bordeaux 2, Bordeaux, France.

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December 2003

New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.

J Med Chem 2003 Jul;46(14):2877-94

Dipartimento di Scienze Farmaceutiche, Università di Catania, Viale A Doria 6, 95125 Catania, Italy.

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July 2003

[1,2,4]Triazole derivatives as 5-HT(1A) serotonin receptor ligands.

Bioorg Med Chem 2002 Feb;10(2):313-23

Dipartimento di Scienze Farmaceutiche, Università di Catania, viale A. Doria 6, 95125, Catania, Italy.

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February 2002