Alfredo Budillon

Alfredo Budillon

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Alfredo Budillon

Alfredo Budillon

Publications by authors named "Alfredo Budillon"

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Large extracellular vesicles: Size matters in tumor progression.

Cytokine Growth Factor Rev 2020 Feb 31;51:69-74. Epub 2019 Dec 31.

Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cytogfr.2019.12.007DOI Listing
February 2020

Vorinostat Potentiates 5-Fluorouracil/Cisplatin Combination by Inhibiting Chemotherapy-Induced EGFR Nuclear Translocation and Increasing Cisplatin Uptake.

Mol Cancer Ther 2019 08 12;18(8):1405-1417. Epub 2019 Jun 12.

Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS-Fondazione G. Pascale, Napoli, Italy.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1117DOI Listing
August 2019

Novel pathways involved in cisplatin resistance identified by a proteomics approach in non-small-cell lung cancer cells.

J Cell Physiol 2019 Jun 26;234(6):9077-9092. Epub 2018 Oct 26.

Experimental Pharmacology Unit, Laboratori di Mercogliano, Istituto Nazionale Tumori, IRCCS-Fondazione G. Pascale, Napoli, Italy.

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http://doi.wiley.com/10.1002/jcp.27585
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http://dx.doi.org/10.1002/jcp.27585DOI Listing
June 2019

Implication for Cancer Stem Cells in Solid Cancer Chemo-Resistance: Promising Therapeutic Strategies Based on the Use of HDAC Inhibitors.

J Clin Med 2019 Jun 26;8(7). Epub 2019 Jun 26.

ExperimentalPharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, 80131, Naples, Italy.

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http://dx.doi.org/10.3390/jcm8070912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678716PMC
June 2019

Identification and Targeting of Stem Cell-Activated Pathways in Cancer Therapy.

Stem Cells Int 2019 4;2019:8549020. Epub 2019 Jun 4.

Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.

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http://dx.doi.org/10.1155/2019/8549020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589219PMC
June 2019

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Cancer Cell 2019 05 25;35(5):798-815.e5. Epub 2019 Apr 25.

Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, via Adamello 16, 20139 Milan, Italy; Department of Biosciences, University of Milan, 20100 Milan, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108193015
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http://dx.doi.org/10.1016/j.ccell.2019.03.007DOI Listing
May 2019

The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles.

Stem Cells Int 2018 5;2018:6392198. Epub 2018 Nov 5.

Experimental Pharmacology Unit, Istituto Nazionale Tumori-IRCCS-Fondazione G. Pascale, Naples, Italy.

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https://www.hindawi.com/journals/sci/2018/6392198/
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http://dx.doi.org/10.1155/2018/6392198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247433PMC
November 2018

Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins.

Recent Pat Anticancer Drug Discov 2018 ;13(2):184-200

Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazione Giovanni Pascale - IRCCS, 80131 Naples, Italy.

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http://dx.doi.org/10.2174/1574892812666171129141211DOI Listing
October 2018

Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line.

Toxins (Basel) 2018 Oct 28;10(11). Epub 2018 Oct 28.

Unità di Farmacologia e Tossicologia-Dipartimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli "Federico II", 80138 Napoli, Italy.

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http://www.mdpi.com/2072-6651/10/11/436
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http://dx.doi.org/10.3390/toxins10110436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265880PMC
October 2018

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers.

Sci Rep 2018 Jul 10;8(1):10395. Epub 2018 Jul 10.

Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS - Fondazione G. Pascale, Napoli, Italy.

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http://dx.doi.org/10.1038/s41598-018-28739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039466PMC
July 2018

Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.

Oxid Med Cell Longev 2017 9;2017:2597581. Epub 2017 Jul 9.

Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, Naples, Italy.

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http://dx.doi.org/10.1155/2017/2597581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523271PMC
April 2018

Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach.

Metabolomics 2018 02 14;14(3):33. Epub 2018 Feb 14.

Unità di Farmacologia e Tossicologia - Dipatimento di Medicina Veterinaria e Produzioni Animali, Università degli Studi di Napoli "Federico II", Naples, Italy.

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http://dx.doi.org/10.1007/s11306-018-1330-3DOI Listing
February 2018

Conformational analysis of the human chemokine receptor CXCR3.

Mol Immunol 2017 12 17;92:76-86. Epub 2017 Oct 17.

Istituto Nazionale Tumori "Fondazione G. Pascale", IRCCS, Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2017.10.010DOI Listing
December 2017

Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53.

J Exp Clin Cancer Res 2017 Dec 6;36(1):177. Epub 2017 Dec 6.

Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Via Mariano Semmola, 13, 80131, Naples, NA, Italy.

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http://dx.doi.org/10.1186/s13046-017-0647-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719792PMC
December 2017

HDAC inhibition potentiates immunotherapy in triple negative breast cancer.

Oncotarget 2017 Dec 12;8(69):114156-114172. Epub 2017 Dec 12.

Division of Hematology and Oncology, University of California, San Francisco, California, USA.

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http://dx.doi.org/10.18632/oncotarget.23169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768393PMC
December 2017

Environment and bladder cancer: molecular analysis by interaction networks.

Oncotarget 2017 Sep 26;8(39):65240-65252. Epub 2017 May 26.

Experimental Pharmacology Unit, Istituto Nazionale Tumori "Fondazione G. Pascale", IRCCS, Napoli, Italia.

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http://dx.doi.org/10.18632/oncotarget.18222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630327PMC
September 2017

Tissue transglutaminase (TG2) is involved in the resistance of cancer cells to the histone deacetylase (HDAC) inhibitor vorinostat.

Amino Acids 2017 03 19;49(3):517-528. Epub 2016 Oct 19.

Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale-IRCCS, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/s00726-016-2338-5DOI Listing
March 2017

Proteomic characterization of peroxisome proliferator-activated receptor-γ (PPARγ) overexpressing or silenced colorectal cancer cells unveils a novel protein network associated with an aggressive phenotype.

Mol Oncol 2016 10 25;10(8):1344-62. Epub 2016 Jul 25.

Centro Ricerche Oncologiche Mercogliano, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy; Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423198PMC
October 2016

Biotin-targeted Pluronic(®) P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells.

Int J Pharm 2016 Sep 29;511(1):127-139. Epub 2016 Jun 29.

Laboratory of Drug Delivery, Department of Pharmacy, University of Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy.

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http://dx.doi.org/10.1016/j.ijpharm.2016.06.118DOI Listing
September 2016

Management of non-small cell lung cancer in the era of personalized medicine.

Int J Biochem Cell Biol 2016 09 15;78:173-179. Epub 2016 Jul 15.

Experimental Pharmacology, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione Giovanni Pascale' - IRCCS, Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.07.011DOI Listing
September 2016

Impact of Subsequent Therapies on Outcome of the FIRE-3/AIO KRK0306 Trial.

J Clin Oncol 2016 05 7;34(13):1564. Epub 2016 Mar 7.

Istituto Nazionale Tumori - Istituto di Ricovero e Cura a Carattere Scientifico "Fondazione G. Pascale", Naples, Italy.

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http://dx.doi.org/10.1200/JCO.2015.66.1512DOI Listing
May 2016

A perspective on the current treatment strategies for locally advanced rectal cancer.

Int J Biochem Cell Biol 2015 Aug 6;65:192-6. Epub 2015 Jun 6.

Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione Giovanni Pascale' - IRCCS, Napoli, Italy.

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http://dx.doi.org/10.1016/j.biocel.2015.06.002DOI Listing
August 2015

Pathophysiologically relevant in vitro tumor models for drug screening.

Drug Discov Today 2015 Jul 20;20(7):848-55. Epub 2015 Apr 20.

Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hněvotínská 5, 779 00 Olomouc, Czech Republic; EATRIS Headquarters, Giovanni Migliaccio, De Boelelaan 1118, 1081 HZ Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2015.04.004DOI Listing
July 2015

Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma.

Cell Cycle 2014 17;13(4):652-65. Epub 2013 Dec 17.

Oncology Research Center of Mercogliano (CROM); Istituto Nazionale Per Lo Studio E La Cura Dei Tumori "Fondazione Giovanni Pascale"; IRCCS; Italy.

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http://dx.doi.org/10.4161/cc.27546DOI Listing
April 2015

New perspective for an old antidiabetic drug: metformin as anticancer agent.

Cancer Treat Res 2014 ;159:355-76

Experimental Pharmacology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori Fondazioni Giovanni Pascale - IRCCS, 80131, Naples, Italy.

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http://dx.doi.org/10.1007/978-3-642-38007-5_21DOI Listing
April 2014

Targeting thymidylate synthase in colorectal cancer: critical re-evaluation and emerging therapeutic role of raltitrexed.

Expert Opin Drug Saf 2014 Jan 5;13(1):113-29. Epub 2013 Oct 5.

Gastrointestinal Medical Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori 'Fondazione Giovanni Pascale' - IRCCS , Via M. Semmola - 80131 Napoli , Italy +39 081 5903629 ; +39 081 5903813 ;

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http://dx.doi.org/10.1517/14740338.2014.845167DOI Listing
January 2014

Multidisciplinary approach to rectal cancer: are we ready for selective treatment strategies?

Anticancer Agents Med Chem 2013 Jul;13(6):852-60

Gastrointestinal Medical Oncology, National Cancer Institute G.Pascale, Via M. Semmola, Naples, Italy.

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http://dx.doi.org/10.2174/18715206113139990123DOI Listing
July 2013

Tissue transglutaminase: a new target to reverse cancer drug resistance.

Amino Acids 2013 Jan 1;44(1):63-72. Epub 2011 Dec 1.

Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, National Cancer Institute G. Pascale, Via M. Semmola, 80131 Naples, Italy.

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http://link.springer.com/10.1007/s00726-011-1167-9
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http://dx.doi.org/10.1007/s00726-011-1167-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535412PMC
January 2013

Early FDG PET response assessment of preoperative radiochemotherapy in locally advanced rectal cancer: correlation with long-term outcome.

Eur J Nucl Med Mol Imaging 2012 Dec 5;39(12):1848-57. Epub 2012 Oct 5.

Department of Gastrointestinal Medical Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione "G. Pascale", Naples, Italy.

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http://dx.doi.org/10.1007/s00259-012-2229-2DOI Listing
December 2012

A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome.

J Clin Endocrinol Metab 2012 Jul 16;97(7):2333-40. Epub 2012 Apr 16.

Department of Medicine and Surgery, University of Salerno, Via Allende 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1210/jc.2011-3106DOI Listing
July 2012

Pancreatic cancer: between bench and bedside.

Curr Drug Targets 2012 Jun;13(6):729-30

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http://dx.doi.org/10.2174/138945012800564130DOI Listing
June 2012

The primary occurrence of BRAF(V600E) is a rare clonal event in papillary thyroid carcinoma.

J Clin Endocrinol Metab 2012 Feb 14;97(2):517-24. Epub 2011 Dec 14.

Department of Medicine and Surgery, University of Salerno, Via Allende 84081, Baronissi, Salerno, Italy.

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http://dx.doi.org/10.1210/jc.2011-0618DOI Listing
February 2012

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1.

J Natl Cancer Inst 2011 Aug 8;103(15):1190-204. Epub 2011 Jul 8.

Experimental Pharmacology Unit, Istituto Nazionale per lo studio e la cura dei Tumori-Fondazione G. Pascale, Naples, Italy.

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http://dx.doi.org/10.1093/jnci/djr243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149044PMC
August 2011

Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis.

Recent Pat Anticancer Drug Discov 2010 Jan;5(1):1-13

Experimental Pharmacology Unit, National Cancer Institute of Naples 'G Pascale' Naples 80131, Italy.

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http://dx.doi.org/10.2174/157489210789702172DOI Listing
January 2010

Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.

Cancer Biol Ther 2009 May 9;8(9):782-91. Epub 2009 May 9.

Experimental Pharmacology Unit, Department of Research, Istituto Nazionale Tumori, Via M. Semmola, Naples, Italy.

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http://dx.doi.org/10.4161/cbt.8.9.8118DOI Listing
May 2009

Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.

Anticancer Drugs 2007 Aug;18(7):781-91

National Tumour Institute, Federico II University Medical School, Via M. Semmola, 80131 Naples, Italy.

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http://dx.doi.org/10.1097/CAD.0b013e32809ef9b7DOI Listing
August 2007

Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.

Biochim Biophys Acta 2007 Jul 22;1773(7):1095-106. Epub 2007 May 22.

Department of Morphological and Biomedical Sciences, Section of Biochemistry, University of Verona, Verona, Italy.

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http://dx.doi.org/10.1016/j.bbamcr.2007.05.002DOI Listing
July 2007

Concomitant occurrence of facial cutaneous and parotid gland metastases from rectal cancer after preoperative chemoradiotherapy.

Onkologie 2007 Jun 29;30(6):324-6. Epub 2007 May 29.

B Medical Oncology, National Institute of Tumours Fondazione G. Pascale, Naples, Italy.

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http://dx.doi.org/10.1159/000102538DOI Listing
June 2007

Histone deacetylase inhibitors: a new wave of molecular targeted anticancer agents.

Recent Pat Anticancer Drug Discov 2007 Jun;2(2):119-34

Experimental Pharmacology Unit, Department of Experimental Oncology, National Cancer Institute Fondazione G. Pascale, Naples, Italy.

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http://dx.doi.org/10.2174/157489207780832450DOI Listing
June 2007

Cetuximab is an active treatment of metastatic and chemorefractory thymoma.

Front Biosci 2007 Jan 1;12:757-61. Epub 2007 Jan 1.

Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy.

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http://dx.doi.org/10.2741/2098DOI Listing
January 2007

Molecular dynamics simulation and automated docking of the pro-apoptotic Bax protein and its complex with a peptide designed from the Bax-binding domain of anti-apoptotic Ku70.

J Cell Biochem 2006 Sep;99(1):305-18

Department of Biochemistry and Biophysics, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.

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http://dx.doi.org/10.1002/jcb.20893DOI Listing
September 2006

Mechanisms of disease: Preclinical reports of antineoplastic synergistic action of bisphosphonates.

Nat Clin Pract Oncol 2006 Jun;3(6):325-38

Department of Medical Oncology, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1038/ncponc0520DOI Listing
June 2006

EGF-R small inhibitors and anti-EGF-R antibodies: advantages and limits of a new avenue in anticancer therapy.

Recent Pat Anticancer Drug Discov 2006 Jun;1(2):209-22

Department of Experimental Oncology, Experimental Pharmacology Unit, National Institute of Tumors Fondaz. G. Pascale of Naples, Italy.

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http://dx.doi.org/10.2174/157489206777442250DOI Listing
June 2006

Emerging anti-cancer molecular mechanisms of aminobisphosphonates.

Endocr Relat Cancer 2006 Mar;13(1):7-26

Department of Experimental Oncology, Experimental Pharmacology Unit, National Institute of Tumours, Fondazione G. Pascale, Via Mariano Semmola, 80131 Naples, Italy.

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https://erc.bioscientifica.com/view/journals/erc/13/1/013000
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http://dx.doi.org/10.1677/erc.1.01094DOI Listing
March 2006

Targeted therapies and non-small cell lung cancer: methodological and conceptual challenge for clinical trials.

Curr Opin Oncol 2005 Mar;17(2):123-9

Clinical Trials Unit, National Cancer Institute of Naples, Italy.

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http://dx.doi.org/10.1097/01.cco.0000155048.51919.ebDOI Listing
March 2005