Publications by authors named "Alfredo Adán"

100Publications

Tocilizumab for the Treatment of Ocular Inflammatory Disease.

Ocul Immunol Inflamm 2021 Jan 12:1-4. Epub 2021 Jan 12.

Centre for Ophthalmology, University Tuebingen , Tuebingen, Germany.

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January 2021

Multi-Modal Imaging in Diffuse Subretinal Fibrosis With Uveitis Syndrome.

Retin Cases Brief Rep 2020 Dec 18;Publish Ahead of Print. Epub 2020 Dec 18.

Hospital Clínic de Barcelona, Instituto de Oftalmología, Facultad de Medicina, Universidad de Barcelona, 08028, Barcelona (Spain) Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.

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December 2020

Uveitic macular edema response to intravitreal dexamethasone implant is independent of optical coherence tomography findings.

Int Ophthalmol 2020 Nov 12. Epub 2020 Nov 12.

Hospital Clínic, Instituto Clínic de Oftalmologia (ICOF), University of Barcelona, Sabino de Arana 1, 08028, Barcelona, Spain.

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November 2020

Use of ultra-wide field retinal imaging and optical coherence tomography angiography in the diagnosis of incomplete Susac syndrome.

Eur J Ophthalmol 2020 Oct 26:1120672120965482. Epub 2020 Oct 26.

Clinic Institute of Ophthalmology (ICOF), Clinic Hospital of Barcelona, Barcelona, Spain.

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October 2020

Systemic Regulatory T Cells and IL-6 as Prognostic Factors for Anatomical Improvement of Uveitic Macular Edema.

Front Immunol 2020 25;11:579005. Epub 2020 Sep 25.

Group of Ocular Inflammation, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Spain.

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September 2020

Long Term Follow-up and Optimization of Infliximab in Refractory Uveitis Due to Behçet's Disease. National Study of 103 Caucasian Patients.

J Rheumatol 2020 Oct 1. Epub 2020 Oct 1.

Rheumatology, Internal Medicine and Ophthalmology, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, University of Cantabria; Rheumatology, Hospital del Mar, Barcelona; Rheumatology Hospital Universitario Virgen de Valme, Sevilla; Rheumatology and Ophthalmology, Hospital Clinic de Barcelona, Barcelona; Ophthalmology, Hospital General Universitario de Valencia; Rheumatology, Hospital Universitario Doctor Peset, Valencia; Rheumatology Hospital Vall d´Hebron, Barcelona; Autoimmune Diseases, Hospital Universitario San Cecilio, Granada; Rheumatology, Hospital Universitario de Donostia, San Sebastián; Rheumatology, Hospital Universitario Basurto, Bilbao; Rheumatology, Hospital Universitario de Móstoles, Madrid; Rheumatology, Hospital General Universitario de Alicante, Alicante; Rheumatology, Hospital Universitario La Paz, Madrid; Ophthalmology, Hospital Clínico San Carlos, Madrid; Rheumatology, Hospital Sierrallana, Torrelavega; Rheumatology, Hospital Universitario Reina Sofía, Córdoba; Rheumatology, Hospital Universitario 12 de Octubre, Madrid; Rheumatology, Hospital Galdakao-Usansolo, Vizcaya; Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid. This study was presented in part at the 2017 American College of Rheumatology Congress held in San Diego, CA, USA and at the 2018 American College of Rheumatology Congress held in Chicago, IL, USA. This work was also partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from ''Instituto de Salud Carlos III'' (ISCIII) (Spain). Address correspondence to Prof. José Luis Hernández, Internal Medicine, Hospital Universitario Marqués de Valdecilla, IDIVAL. Avda. Valdecilla s/n., ES- 39008, Santander. SPAIN. Email addresses:

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October 2020

Activation of C-reactive protein proinflammatory phenotype in the blood retinal barrier : implications for age-related macular degeneration.

Aging (Albany NY) 2020 07 16;12(14):13905-13923. Epub 2020 Jul 16.

Group of Ocular Inflammation, Clinical and Experimental Studies, Institut d'Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona, Barcelona, Spain.

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July 2020

[Integration of primary care ophthalmology in the hospital: Comparative analysis of results].

Aten Primaria 2020 04 24;52(4):281-282. Epub 2019 Nov 24.

Departamento de Estrategia y Planificación, Hospital Clínic, Barcelona, España.

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April 2020

Angiography and En Face Optical Coherence Tomography Findings in Acute Syphilitic Posterior Placoid Chorioretinopathy.

Case Rep Ophthalmol 2019 May-Aug;10(2):165-171. Epub 2019 May 23.

Uveitis Unit, Hospital Clinic de Barcelona, Instituto de Oftalmología, Facultad de Medicina, Universidad de Barcelona, Barcelona, Spain.

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May 2019

Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

Ocul Immunol Inflamm 2019 Oct 7:1-3. Epub 2019 Oct 7.

Department of Ophthalmology, Hospital Clinic of Barcelona , Barcelona , Spain.

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October 2019

Multimodal image characterization of paravenous atrophy.

GMS Ophthalmol Cases 2019 16;9:Doc27. Epub 2019 Jul 16.

Clinic Institute of Ophthalmology, Clinic Hospital of Barcelona, Spain.

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July 2019

Cytokine production in thyroid eye disease: in vitro effects of dexamethasone and IL-6 blockade with tocilizumab.

Graefes Arch Clin Exp Ophthalmol 2019 Oct 23;257(10):2307-2314. Epub 2019 Jul 23.

Faculty of Medicine. "Medicine and Translational Research" Doctorate Program, University of Barcelona, Barcelona, Spain.

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October 2019

Comparative Study of Infliximab Versus Adalimumab in Refractory Uveitis due to Behçet's Disease: National Multicenter Study of 177 Cases.

Arthritis Rheumatol 2019 12 21;71(12):2081-2089. Epub 2019 Oct 21.

Hospital Universitario Marqués de Valdecilla, Santander, Spain.

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December 2019

Long-Term Intravitreal Dexamethasone Implant Outcomes in Uveitis.

Ocul Immunol Inflamm 2020 17;28(2):228-237. Epub 2019 Apr 17.

Hospital Clinic, Institut Clínicd´Oftalmología (ICOF), Barcelona, Spain.

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January 2021

Bilateral Acute Retinal Necrosis: Clinical Features and Outcomes in a Multicenter Study.

Ocul Immunol Inflamm 2019 30;27(7):1090-1098. Epub 2018 Jul 30.

Department of Ophthalmology, Ospedale San Raffaele Scientific Institute, University Vita-Salute , Milan , Italy.

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April 2020

C-Reactive Protein as a Therapeutic Target in Age-Related Macular Degeneration.

Front Immunol 2018 19;9:808. Epub 2018 Apr 19.

Academic Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom.

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June 2019

Reply.

Med Clin (Barc) 2018 10 7;151(8):336-337. Epub 2018 Mar 7.

Institut Clinic d'Oftalmologia, Hospital Clínic de Barcelona, Barcelona, España.

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October 2018

Safety and Efficacy of Adalimumab in Patients with Noninfectious Uveitis in an Ongoing Open-Label Study: VISUAL III.

Ophthalmology 2018 07 9;125(7):1075-1087. Epub 2018 Feb 9.

University of Bristol, Bristol Eye Hospital, Bristol, United Kingdom, and National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital and University College London, Institute of Ophthalmology, London, United Kingdom.

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July 2018

Targeting interleukin-6 in autoimmune uveitis.

Autoimmun Rev 2017 Oct 2;16(10):1079-1089. Epub 2017 Aug 2.

Uveitis Unit, Institut Clinic d'Oftalmologia, Hospital Clinic de Barcelona, Universitat de Barcelona, Spain.

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October 2017

New imaging techniques in retinal vasculitis.

Med Clin (Barc) 2017 Sep 5;149(6):261-266. Epub 2017 Jul 5.

Institut Clínic d'Oftalmologia, Hospital Clínic de Barcelona, Barcelona, España.

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September 2017

Characterization of isolated retinal vasculitis. Analysis of a cohort from a single center and literature review.

Autoimmun Rev 2017 Mar 27;16(3):237-243. Epub 2017 Jan 27.

Uveitis Unit, Department of Ophthalmology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.

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March 2017

Bacillus Calmette-Guérin Infection and Cytotoxicity in the Retinal Pigment Epithelium.

Ocul Immunol Inflamm 2018 23;26(5):786-792. Epub 2016 Dec 23.

a Clínic Institute of Ophthalmology (ICOF), Hospital Clínic of Barcelona.

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September 2018

C-reactive protein isoforms differentially affect outer blood-retinal barrier integrity and function.

Am J Physiol Cell Physiol 2017 Mar 21;312(3):C244-C253. Epub 2016 Dec 21.

Department of Chemical Engineering and Material Sciences, IQS School of Engineering, Universitat Ramon Llull, Barcelona, Spain.

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March 2017

Evidence for Tocilizumab as a Treatment Option in Refractory Uveitis Associated with Juvenile Idiopathic Arthritis.

J Rheumatol 2016 12 15;43(12):2183-2188. Epub 2016 Sep 15.

From the Department of Ophthalmology, St. Franziskus Hospital, Münster; Department of Ophthalmology and Interdisciplinary Uveitis Center, University of Heidelberg, Heidelberg; University of Duisburg-Essen, Essen, Germany; Department of Ophthalmology, Inselspital, University of Bern, Bern, Switzerland; Institut Clinic d'Oftalmologia, Hospital Clínic de Barcelona, University of Barcelona; Pediatric Rheumatology Unit, and Ophthalmology Department, Hospital Sant Joan de Déu, University of Barcelona, Esplugues, Barcelona, Spain; Department of Paediatric Rheumatology, Bristol Royal Hospital for Children; Clinical Research Unit, Bristol Eye Hospital, Bristol, UK; Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland; Department of Ophthalmology, University Medical Center Utrecht, Utrecht, the Netherlands.

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December 2016

SAFETY AND EFFICACY OF INTRAVITREAL DEXAMETHASONE IMPLANTS IN THE MANAGEMENT OF MACULAR EDEMA SECONDARY TO INFECTIOUS UVEITIS.

Retina 2016 Sep;36(9):1778-85

*Begiker-Ophthalmology Research Group, Ophthalmology Department, BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country, Bilbao, Spain; †Ophthalmology Institute, Hospital Clinic of Barcelona, Barcelona, Spain; ‡Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country, Bilbao, Spain; §Infectious Disease Department, BioCruces Health Research Institute, Cruces Hospital, University of the Basque Country, Bilbao, Spain; and ¶Uveitis Unit, Ophthalmology Department, León Hospital, IBIOMED, León University, León, Spain.

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September 2016

In Response to: "Deuter CM, Zierhut M, Igney-Oertel A, et al. Tocilizumab in Uveitic Macular Edema Refractory to Previous Immunomodulatory Treatment".

Ocul Immunol Inflamm 2017 04 25;25(2):221-222. Epub 2016 Mar 25.

a Institut Clinic d´Oftalmologia, Hospital Clinic de Barcelona, Universitat de Barcelona , Barcelona Spain.

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April 2017

Interleukin-22 serum levels are elevated in active scleritis.

Acta Ophthalmol 2016 Sep 24;94(6):e395-9. Epub 2016 Mar 24.

Massachusetts Eye Research and Surgery Institution (MERSI), Waltham, MA, USA.

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September 2016

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants.

Sci Rep 2016 Mar 10;6:22889. Epub 2016 Mar 10.

Academic Unit of Ophthalmology, School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TH, UK.

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March 2016

Elevated Serum Immune Mediators and Subclinical Inflammation in HLA-A29-associated Birdshot Chorioretinopathy.

Ocul Immunol Inflamm 2016 Dec 8;24(6):647-652. Epub 2015 Dec 8.

a Department of Ophthalmology , Hospital Clinic of Barcelona, University of Barcelona , Barcelona , Spain.

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December 2016

Immunostaining images of vitreous transthyretin amyloid.

Can J Ophthalmol 2015 Oct;50(5):384-7

Department of Pathology, Hospital Clinic of Barcelona, Barcelona, Spain.

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October 2015

Uveitic macular oedema after treatment with vemurafenib.

Acta Ophthalmol 2015 Dec 13;93(8):e686-7. Epub 2015 Feb 13.

Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.

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December 2015

Certolizumab Pegol, a New Anti-TNF-α in the Armamentarium against Ocular Inflammation.

Ocul Immunol Inflamm 2016 17;24(2):167-72. Epub 2014 Oct 17.

a Clínic Institute of Ophthalmology (ICOF), Hospital Clínic of Barcelona , Barcelona , Spain .

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December 2016

An old disease in an atypical place.

Surv Ophthalmol 2014 Nov-Dec;59(6):660-3. Epub 2014 May 28.

Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA, USA.

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July 2015

Long-term effects of tocilizumab therapy for refractory uveitis-related macular edema.

Ophthalmology 2014 Dec 6;121(12):2380-6. Epub 2014 Sep 6.

Institut Clinic d'Oftalmologia, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain. Electronic address:

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December 2014

Anti-TNF-α therapy in patients with refractory uveitis due to Behçet's disease: a 1-year follow-up study of 124 patients.

Rheumatology (Oxford) 2014 Dec 4;53(12):2223-31. Epub 2014 Jul 4.

Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Rheumatology, Hospital General Universitario de Valencia, Valencia, Rheumatology, Hospital de Valme, Sevilla, Ophthalmology and Rheumatology, Hospital Clinic, Barcelona, Ophthalmology, Hospital General Universitario de Valencia, Rheumatology and Ophthalmology, Hospital Peset Valencia, Valencia, Rheumatology Hospital Val d'Hebron, Barcelona, Ophthalmology Division, Hospital de León, Ophthalmology, Hospital Universitario La Fe, Valencia, Ophthalmology and Autoimmune Diseases, Hospital San Cecilio, Granada, Ophthalmology, Hospital Universitario, IOBA, Valladolid, Ophthalmology, Hospital de Cruces, Bilbao, Rheumatology, Hospital de Toledo, Rheumatology and Ophthalmology, Hospital Donosti San Sebastian, Rheumatology, Hospital Basurto, Bilbao, Rheumatology, Hospital Universitario de Móstoles, Rheumatology, Hospital General de Alicante, Rheumatology, Hospital Universitario La Paz Madrid, Rheumatology, Hospital Clínico San Carlos, Madrid, Rheumatology and Ophthalmology, Hospital de Pontevedra, Rheumatology, Hospital Sierrallana, Torrelavega, Rheumatology, Hospital La Princesa, Madrid, Rheumatology, Hospital de Córdoba, Rheumatology, Hospital Universitario de Salamanca, Rheumatology, HUCA La Coruña, Rheumatology, Hospital Doctor Negrín Canarias, Rheumatology, Hospital Universitario Santiago de Compostela, A Coruña, Rheumatology, Hospital Cabueñes, Gijón, Rheumatology, Hospital Lucus Augusti, Lugo, Rheumatology, Hospital San Pedro Alcantara, Caceres, Rheumatology, Hospital Arrixaca, Murcia, Rheumatology, Fundación Jiménez Díaz, Rheumatology, Hospital 12 de Octubre, Madrid, Rheumatology, Hospital Universitario Fundación Alcorcon, Ophthalmology, Hospital Clínico de Zaragoza, Rheumatology, Hospital de Merida, Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Rheumatology, Hospital de Ferrol, A Coruña, Ophthalmology, Rheumatology Hospital Miguel Servet, Zaragoza, and

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December 2014

Proinflammatory cytokines and C-reactive protein in uveitis associated with Behçet's disease.

Mediators Inflamm 2014 8;2014:396204. Epub 2014 Jun 8.

Institut Clínic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain.

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February 2015

Golimumab as rescue therapy for refractory immune-mediated uveitis: a three-center experience.

Mediators Inflamm 2014 28;2014:717598. Epub 2014 May 28.

Uveitis Unit, University Hospital of León, 24071 León, Spain ; Institute of Biomedicine (INBIOMED), University of León, León, Spain ; Department of Immunology, University Hospital of León, 24071 León, Spain.

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February 2015

Use of ultra-wide-field retinal imaging in the management of active Behçet retinal vasculitis.

Retina 2014 Oct;34(10):2121-7

Uveitis Unit, Department of Ophthalmology, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

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October 2014

Tocilizumab for retinal vasoproliferative tumor secondary to juvenile idiopathic arthritis-associated uveitis: a case report.

Graefes Arch Clin Exp Ophthalmol 2014 Jan 24;252(1):163-4. Epub 2013 Sep 24.

Department of Ophthalmology, Hospital Clínic of Barcelona, University of Barcelona, Barcelona, Spain,

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January 2014

Tocilizumab treatment for refractory uveitis-related cystoid macular edema.

Graefes Arch Clin Exp Ophthalmol 2013 Nov 27;251(11):2627-32. Epub 2013 Jul 27.

Department of Ophthalmology, Hospital Clínic of Barcelona, Universitat of Barcelona, Sabino de Arana, 1 08028, Barcelona, Spain,

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November 2013

Cytokine profiling reveals decreased serum levels of CCL2 in active ocular toxoplasmosis.

Br J Ophthalmol 2013 Oct 22;97(10):1338-42. Epub 2013 Jul 22.

Institut Clínic d'Oftalmología, Hospital Clinic de Barcelona, University of Barcelona, , Barcelona, Spain.

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October 2013

Late spectral-domain optical coherence tomography findings in sub-internal limiting membrane hemorrhage.

Retin Cases Brief Rep 2013 ;7(3):276-7

Department of Ophthalmology, Hospital Clinic de Barcelona, Universidad de Barcelona, Barcelona, Spain.

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January 2015

Current and future treatments for Behçet's uveitis: road to remission.

Int Ophthalmol 2014 Apr 1;34(2):365-81. Epub 2013 Jun 1.

Ophthalmology Department, Hospital Clinic of Barcelona, University of Barcelona, Sabino de Arana, 1, 08028, Barcelona, Spain,

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April 2014

Clinical pattern of toxoplasmic retinochoroiditis in a Spanish referral center.

Ophthalmologica 2013 27;229(3):173-8. Epub 2013 Mar 27.

Department of Ophthalmology, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain.

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May 2014

Tocilizumab treatment for recalcitrant uveitic macular edema.

Graefes Arch Clin Exp Ophthalmol 2013 Sep 28;251(9):2249-50. Epub 2012 Dec 28.

Department of Ophthalmology, Hospital Clinic of Barcelona, Calle Sabino de Arana, 1, 08036, Barcelona, Spain,

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September 2013

Behçet disease-associated uveitis successfully treated with golimumab.

Ocul Immunol Inflamm 2013 Apr 19;21(2):160-2. Epub 2012 Dec 19.

Ophthalmology Department, Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain.

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April 2013

Pars plana vitrectomy for vitreoretinal complications of Behçet uveitis.

Eur J Ophthalmol 2013 Jan 26;23(1):119 - 128. Epub 2012 Sep 26.

Department of Ophthalmology, Hospital Clinic de Barcelona, Universitat de Barcelona - Spain.

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January 2013

[Ocular brucellosis].

Med Clin (Barc) 2013 Mar 17;140(6):284. Epub 2012 Sep 17.

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March 2013

Adalimumab for the treatment of Behçet's disease: experience in 19 patients.

Rheumatology (Oxford) 2012 Oct 20;51(10):1825-31. Epub 2012 Jun 20.

Department of Autoimmune Diseases, Hospital Clınic, Barcelona, Catalonia, Spain.

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October 2012