Alfred L Goldberg

Alfred L Goldberg

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Alfred L Goldberg

Alfred L Goldberg

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SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation.

Authors:
Tian-Xia Jiang Jiang-Bo Zou Qian-Qian Zhu Cui Hua Liu Guang-Fei Wang Ting-Ting Du Zi-Yu Luo Fang Guo Lu-Ming Zhou Juan-Juan Liu Wensheng Zhang You-Sheng Shu Li Yu Peng Li Ze'ev A Ronai Shu-Ichi Matsuzawa Alfred L Goldberg Xiao-Bo Qiu

Proc Natl Acad Sci U S A 2019 Jul 18;116(27):13404-13413. Epub 2019 Jun 18.

State Key Laboratory of Cognitive Neuroscience & Learning and Ministry of Education Key Laboratory of Cell Proliferation & Regulation Biology, College of Life Sciences, Beijing Normal University, 100875 Beijing, China;

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http://dx.doi.org/10.1073/pnas.1901039116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613085PMC
July 2019

Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies.

Authors:
Zhe Sha Tamara Blyszcz Román González-Prieto Alfred C O Vertegaal Alfred L Goldberg

J Biol Chem 2019 Jul 8. Epub 2019 Jul 8.

Harvard Medical School, United States.

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA119.009147
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http://dx.doi.org/10.1074/jbc.RA119.009147DOI Listing
July 2019

Measuring the Overall Rate of Protein Breakdown in Cells and the Contributions of the Ubiquitin-Proteasome and Autophagy-Lysosomal Pathways.

Authors:
Zhe Sha Jinghui Zhao Alfred L Goldberg

Methods Mol Biol 2018 ;1844:261-276

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8706-1_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441977PMC
May 2019

Methods to Rapidly Prepare Mammalian 26S Proteasomes for Biochemical Analysis.

Authors:
Chueh-Ling Kuo Galen Andrew Collins Alfred L Goldberg

Methods Mol Biol 2018 ;1844:277-288

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8706-1_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427908PMC
May 2019

Measurement of the Multiple Activities of 26S Proteasomes.

Authors:
Hyoung Tae Kim Galen Andrew Collins Alfred L Goldberg

Methods Mol Biol 2018 ;1844:289-308

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8706-1_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441976PMC
May 2019

Exploring the Regulation of Proteasome Function by Subunit Phosphorylation.

Authors:
Jordan J S VerPlank Alfred L Goldberg

Methods Mol Biol 2018 ;1844:309-319

Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-8706-1_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382073PMC
May 2019

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.

Authors:
Hanming Zhang Bo Pan Penglong Wu Nirmal Parajuli Mark D Rekhter Alfred L Goldberg Xuejun Wang

Sci Adv 2019 May 22;5(5):eaaw5870. Epub 2019 May 22.

Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA.

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http://dx.doi.org/10.1126/sciadv.aaw5870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531002PMC
May 2019

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.

Authors:
Jordan J S VerPlank Sudarsanareddy Lokireddy Jinghui Zhao Alfred L Goldberg

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1809254116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410790PMC
February 2019

UBL domain of Usp14 and other proteins stimulates proteasome activities and protein degradation in cells.

Authors:
Hyoung Tae Kim Alfred L Goldberg

Proc Natl Acad Sci U S A 2018 12 28;115(50):E11642-E11650. Epub 2018 Nov 28.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1808731115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294929PMC
December 2018

ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation.

Authors:
Donghoon Lee Shinichi Takayama Alfred L Goldberg

Proc Natl Acad Sci U S A 2018 10 25;115(41):E9550-E9559. Epub 2018 Sep 25.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1809934115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187164PMC
October 2018

Impairment of protein degradation and proteasome function in hereditary neuropathies.

Authors:
Jordan J S VerPlank Sudarsanareddy Lokireddy M Laura Feltri Alfred L Goldberg Lawrence Wrabetz

Glia 2018 02 27;66(2):379-395. Epub 2017 Oct 27.

Hunter James Kelly Research Institute and Departments of, Biochemistry and Neurology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York.

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http://dx.doi.org/10.1002/glia.23251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5821146PMC
February 2018

Regulating protein breakdown through proteasome phosphorylation.

Authors:
Jordan J S VerPlank Alfred L Goldberg

Biochem J 2017 09 24;474(19):3355-3371. Epub 2017 Sep 24.

Harvard Medical School, Boston, MA 02115, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831125PMC
September 2017

The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis.

Authors:
Hyoung Tae Kim Alfred L Goldberg

J Biol Chem 2017 06 17;292(23):9830-9839. Epub 2017 Apr 17.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115

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http://dx.doi.org/10.1074/jbc.M116.763128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465503PMC
June 2017

The Logic of the 26S Proteasome.

Authors:
Galen Andrew Collins Alfred L Goldberg

Cell 2017 May;169(5):792-806

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609836PMC
May 2017

Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation.

Authors:
Emily S Weyburne Owen M Wilkins Zhe Sha David A Williams Alexandre A Pletnev Gerjan de Bruin Hermann S Overkleeft Alfred L Goldberg Michael D Cole Alexei F Kisselev

Cell Chem Biol 2017 Feb 26;24(2):218-230. Epub 2017 Jan 26.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341617PMC
February 2017

Coordinate regulation of autophagy and the ubiquitin proteasome system by MTOR.

Authors:
Jinghui Zhao Alfred L Goldberg

Autophagy 2016 10 26;12(10):1967-1970. Epub 2016 Jul 26.

a Department of Cell Biology , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15548627.2016.1205770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079674PMC
October 2016

Reply to Vangala et al.: Complete inhibition of the proteasome reduces new proteasome production by causing Nrf1 aggregation.

Authors:
Zhe Sha Alfred L Goldberg

Curr Biol 2016 09;26(18):R836-R837

Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2016.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119528PMC
September 2016

Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease.

Authors:
Kirsten Famulla Peter Sass Imran Malik Tatos Akopian Olga Kandror Marina Alber Berthold Hinzen Helga Ruebsamen-Schaeff Rainer Kalscheuer Alfred L Goldberg Heike Brötz-Oesterhelt

Mol Microbiol 2016 07 1;101(2):194-209. Epub 2016 Apr 1.

Department of Microbial Bioactive Compounds, Interfaculty Institute of Microbiology and Infection Medicine, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1111/mmi.13362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469208PMC
July 2016

The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins.

Authors:
Do Hee Lee Michael Y Sherman Alfred L Goldberg

Biochem Biophys Res Commun 2016 06 10;475(1):100-6. Epub 2016 May 10.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532745PMC
June 2016

Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis.

Authors:
Mi Li Olga Kandror Tatos Akopian Poorva Dharkar Alexander Wlodawer Michael R Maurizi Alfred L Goldberg

J Biol Chem 2016 Apr 8;291(14):7465-76. Epub 2016 Feb 8.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, and

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http://www.jbc.org/content/early/2016/02/08/jbc.M115.700344.
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http://dx.doi.org/10.1074/jbc.M115.700344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817177PMC
April 2016

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.

Authors:
Natura Myeku Catherine L Clelland Sheina Emrani Nikolay V Kukushkin Wai Haung Yu Alfred L Goldberg Karen E Duff

Nat Med 2016 Jan 21;22(1):46-53. Epub 2015 Dec 21.

Department of Pathology and Cell Biology, Taub Institute for Alzheimer's Disease Research, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1038/nm.4011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787271PMC
January 2016

Control of proteasomal proteolysis by mTOR.

Authors:
Jinghui Zhao Gonzalo A Garcia Alfred L Goldberg

Nature 2016 Jan;529(7586):E1-2

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature16472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765347PMC
January 2016

Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5.

Authors:
Donghoon Lee Alfred L Goldberg

J Biol Chem 2015 Dec 29;290(51):30269-79. Epub 2015 Oct 29.

From the Department of Cell Biology, Harvard Medical School, Boston, Masachusetts 02115

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.685164
Publisher Site
http://dx.doi.org/10.1074/jbc.M115.685164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683253PMC
December 2015

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates.

Authors:
Cristinel Sandu Nagaranjan Chandramouli Joseph Fraser Glickman Henrik Molina Chueh-Ling Kuo Nikolay Kukushkin Alfred L Goldberg Hermann Steller

J Cell Mol Med 2015 Sep 30;19(9):2181-92. Epub 2015 May 30.

Howard Hughes Medical Institute, Strang Laboratory of Apoptosis and Cancer Biology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1111/jcmm.12602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568923PMC
September 2015

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Authors:
Peter Tsvetkov Marc L Mendillo Jinghui Zhao Jan E Carette Parker H Merrill Domagoj Cikes Malini Varadarajan Ferdy R van Diemen Josef M Penninger Alfred L Goldberg Thijn R Brummelkamp Sandro Santagata Susan Lindquist

Elife 2015 Sep 1;4. Epub 2015 Sep 1.

Whitehead Institute for Biomedical Research, Cambridge, United States.

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http://dx.doi.org/10.7554/eLife.08467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4551903PMC
September 2015

Structural characterization of the interaction of Ubp6 with the 26S proteasome.

Authors:
Antje Aufderheide Florian Beck Florian Stengel Michaela Hartwig Andreas Schweitzer Günter Pfeifer Alfred L Goldberg Eri Sakata Wolfgang Baumeister Friedrich Förster

Proc Natl Acad Sci U S A 2015 Jul 30;112(28):8626-31. Epub 2015 Jun 30.

Department of Molecular Structural Biology, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany;

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http://dx.doi.org/10.1073/pnas.1510449112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507206PMC
July 2015

Blocking Cancer Growth with Less POMP or Proteasomes.

Authors:
Alfred L Goldberg Jinghui Zhao Galen A Collins

Mol Cell 2015 Jul;59(2):143-5

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4787267PMC
July 2015

Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity.

Authors:
Tatos Akopian Olga Kandror Christopher Tsu Jack H Lai Wengen Wu Yuxin Liu Peng Zhao Annie Park Lisa Wolf Lawrence R Dick Eric J Rubin William Bachovchin Alfred L Goldberg

J Biol Chem 2015 Apr 10;290(17):11008-20. Epub 2015 Mar 10.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115,

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http://dx.doi.org/10.1074/jbc.M114.625640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409261PMC
April 2015

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.

Authors:
Giulia Milan Vanina Romanello Francesca Pescatore Andrea Armani Ji-Hye Paik Laura Frasson Anke Seydel Jinghui Zhao Reimar Abraham Alfred L Goldberg Bert Blaauw Ronald A DePinho Marco Sandri

Nat Commun 2015 Apr 10;6:6670. Epub 2015 Apr 10.

1] Venetian Institute of Molecular Medicine, via Orus 2, 35129 Padova, Italy [2] Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy [3] Institute of Neuroscience, Consiglio Nazionale delle Ricerche, 35129 Padova, Italy [4] Department of Medicine, McGill University, Montreal, Quebec H3AoG4, Canada [5] Dulbecco Telethon Institute at Telethon Institute of Genetics and Medicine (TIGEM), 80131 Napoli, Italy.

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http://dx.doi.org/10.1038/ncomms7670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403316PMC
April 2015

The cyclic peptide ecumicin targeting ClpC1 is active against Mycobacterium tuberculosis in vivo.

Authors:
Wei Gao Jin-Yong Kim Jeffrey R Anderson Tatos Akopian Seungpyo Hong Ying-Yu Jin Olga Kandror Jong-Woo Kim In-Ae Lee Sun-Young Lee James B McAlpine Surafel Mulugeta Suhair Sunoqrot Yuehong Wang Seung-Hwan Yang Tae-Mi Yoon Alfred L Goldberg Guido F Pauli Joo-Won Suh Scott G Franzblau Sanghyun Cho

Antimicrob Agents Chemother 2015 Feb 24;59(2):880-9. Epub 2014 Nov 24.

Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://aac.asm.org/content/early/2014/11/18/AAC.04054-14.ful
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http://aac.asm.org/content/59/2/880.full.pdf
Web Search
http://aac.asm.org/lookup/doi/10.1128/AAC.04054-14
Publisher Site
http://dx.doi.org/10.1128/AAC.04054-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335914PMC
February 2015

Muscle wasting in disease: molecular mechanisms and promising therapies.

Authors:
Shenhav Cohen James A Nathan Alfred L Goldberg

Nat Rev Drug Discov 2015 Jan;14(1):58-74

Department of Cell Biology, 240 Longwood Ave., Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd4467DOI Listing
January 2015

Proteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97.

Authors:
Zhe Sha Alfred L Goldberg

Curr Biol 2014 Jul 3;24(14):1573-1583. Epub 2014 Jul 3.

Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108618PMC
July 2014

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.

Authors:
Henrike C Besche Zhe Sha Nikolay V Kukushkin Andreas Peth Eva-Maria Hock Woong Kim Steven Gygi Juan A Gutierrez Hua Liao Lawrence Dick Alfred L Goldberg

EMBO J 2014 May 8;33(10):1159-76. Epub 2014 May 8.

Harvard Medical School, Boston, MA, USA

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http://dx.doi.org/10.1002/embj.201386906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193922PMC
May 2014

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Authors:
Sian E Davies Penelope J Hallett Thomas Moens Gaynor Smith Emily Mangano Hyoung Tae Kim Alfred L Goldberg Ji-Long Liu Ole Isacson George K Tofaris

Neurobiol Dis 2014 Apr 31;64:79-87. Epub 2013 Dec 31.

Nuffield Department of Clinical Neurosciences, University of Oxford, UK; Oxford Parkinson's Disease Centre, University of Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988924PMC
April 2014

Re-examining class-I presentation and the DRiP hypothesis.

Authors:
Kenneth L Rock Diego J Farfán-Arribas Jeff D Colbert Alfred L Goldberg

Trends Immunol 2014 Apr 21;35(4):144-52. Epub 2014 Feb 21.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.it.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986829PMC
April 2014

Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation.

Authors:
Shenhav Cohen Donghoon Lee Bo Zhai Steven P Gygi Alfred L Goldberg

J Cell Biol 2014 Mar 24;204(5):747-58. Epub 2014 Feb 24.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115.

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http://www.jcb.org/lookup/doi/10.1083/jcb.201304167
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http://dx.doi.org/10.1083/jcb.201304167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941042PMC
March 2014

Mechanisms of muscle growth and atrophy in mammals and Drosophila.

Authors:
Rosanna Piccirillo Fabio Demontis Norbert Perrimon Alfred L Goldberg

Dev Dyn 2014 Feb 24;243(2):201-15. Epub 2013 Oct 24.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts; Department of Oncology, IRCCS, Mario Negri Institute for Pharmacological Research, Milano, Italy.

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http://dx.doi.org/10.1002/dvdy.24036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980484PMC
February 2014

The influence of skeletal muscle on systemic aging and lifespan.

Authors:
Fabio Demontis Rosanna Piccirillo Alfred L Goldberg Norbert Perrimon

Aging Cell 2013 Dec 17;12(6):943-9. Epub 2013 Jul 17.

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA; Division of Developmental Biology, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1111/acel.12126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838468PMC
December 2013

BMP signaling controls muscle mass.

Authors:
Roberta Sartori Elija Schirwis Bert Blaauw Sergia Bortolanza Jinghui Zhao Elena Enzo Amalia Stantzou Etienne Mouisel Luana Toniolo Arnaud Ferry Sigmar Stricker Alfred L Goldberg Sirio Dupont Stefano Piccolo Helge Amthor Marco Sandri

Nat Genet 2013 Nov 29;45(11):1309-18. Epub 2013 Sep 29.

1] Dulbecco Telethon Institute at the Venetian Institute of Molecular Medicine, Padova, Italy. [2] Department of Biomedical Sciences, University of Padova, Padova, Italy. [3].

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http://dx.doi.org/10.1038/ng.2772DOI Listing
November 2013

Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models.

Authors:
Fabio Demontis Rosanna Piccirillo Alfred L Goldberg Norbert Perrimon

Dis Model Mech 2013 Nov 2;6(6):1339-52. Epub 2013 Oct 2.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/dmm.012559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820258PMC
November 2013

Myostatin/activin pathway antagonism: molecular basis and therapeutic potential.

Authors:
H Q Han Xiaolan Zhou William E Mitch Alfred L Goldberg

Int J Biochem Cell Biol 2013 Oct 28;45(10):2333-47. Epub 2013 May 28.

Metabolic Disorders Department, Amgen, Thousand Oaks, CA, USA.

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http://dx.doi.org/10.1016/j.biocel.2013.05.019DOI Listing
October 2013

The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

Authors:
Andreas Peth James A Nathan Alfred L Goldberg

J Biol Chem 2013 Oct 21;288(40):29215-22. Epub 2013 Aug 21.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 and.

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http://dx.doi.org/10.1074/jbc.M113.482570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790020PMC
October 2013

SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth.

Authors:
Donghoon Lee Alfred L Goldberg

J Biol Chem 2013 Oct 3;288(42):30515-26. Epub 2013 Sep 3.

From the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1074/jbc.M113.489716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798522PMC
October 2013

Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis.

Authors:
Min-Xian Qian Ye Pang Cui Hua Liu Kousuke Haratake Bo-Yu Du Dan-Yang Ji Guang-Fei Wang Qian-Qian Zhu Wei Song Yadong Yu Xiao-Xu Zhang Hai-Tao Huang Shiying Miao Lian-Bin Chen Zi-Hui Zhang Ya-Nan Liang Shan Liu Hwangho Cha Dong Yang Yonggong Zhai Takuo Komatsu Fuminori Tsuruta Haitao Li Cheng Cao Wei Li Guo-Hong Li Yifan Cheng Tomoki Chiba Linfang Wang Alfred L Goldberg Yan Shen Xiao-Bo Qiu

Cell 2013 May;153(5):1012-24

Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, and College of Life Sciences, Beijing Normal University, 19 Xinjiekouwai Avenue, Beijing 100875, China.

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http://dx.doi.org/10.1016/j.cell.2013.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983474PMC
May 2013

Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs.

Authors:
Andreas Peth Nikolay Kukushkin Marc Bossé Alfred L Goldberg

J Biol Chem 2013 Mar 22;288(11):7781-90. Epub 2013 Jan 22.

Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.441907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597817PMC
March 2013

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

Authors:
James A Nathan Hyoung Tae Kim Lily Ting Steven P Gygi Alfred L Goldberg

EMBO J 2013 Feb 11;32(4):552-65. Epub 2013 Jan 11.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/emboj.2012.354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579138PMC
February 2013

Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.

Authors:
James A Nathan Valentina Spinnenhirn Gunter Schmidtke Michael Basler Marcus Groettrup Alfred L Goldberg

Cell 2013 Feb;152(5):1184-94

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2013.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791394PMC
February 2013

The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini.

Authors:
Dikla Berko Shira Tabachnick-Cherny Dalit Shental-Bechor Paolo Cascio Silvia Mioletti Yaakov Levy Arie Admon Tamar Ziv Boaz Tirosh Alfred L Goldberg Ami Navon

Mol Cell 2012 Nov 4;48(4):601-11. Epub 2012 Oct 4.

Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.

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http://dx.doi.org/10.1016/j.molcel.2012.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603081PMC
November 2012

Development of proteasome inhibitors as research tools and cancer drugs.

Authors:
Alfred L Goldberg

J Cell Biol 2012 Nov;199(4):583-8

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201210077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494858PMC
November 2012

Bacterial proteolytic complexes as therapeutic targets.

Authors:
Ravikiran M Raju Alfred L Goldberg Eric J Rubin

Nat Rev Drug Discov 2012 Oct;11(10):777-89

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nrd3846DOI Listing
October 2012

The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.

Authors:
Rosanna Piccirillo Alfred L Goldberg

EMBO J 2012 Aug 6;31(15):3334-50. Epub 2012 Jul 6.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/emboj.2012.178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411080PMC
August 2012

Cancer vulnerabilities unveiled by genomic loss.

Authors:
Deepak Nijhawan Travis I Zack Yin Ren Matthew R Strickland Rebecca Lamothe Steven E Schumacher Aviad Tsherniak Henrike C Besche Joseph Rosenbluh Shyemaa Shehata Glenn S Cowley Barbara A Weir Alfred L Goldberg Jill P Mesirov David E Root Sangeeta N Bhatia Rameen Beroukhim William C Hahn

Cell 2012 Aug;150(4):842-54

Departments of Cancer Biology and Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2012.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429351PMC
August 2012

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy.

Authors:
Shenhav Cohen Bo Zhai Steven P Gygi Alfred L Goldberg

J Cell Biol 2012 Aug;198(4):575-89

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.201110067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514026PMC
August 2012

Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain.

Authors:
Henrike C Besche Alfred L Goldberg

Methods Mol Biol 2012 ;832:423-32

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-474-2_29DOI Listing
July 2012

Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a.

Authors:
Hyoung Tae Kim Alfred L Goldberg

Methods Mol Biol 2012 ;832:639-52

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-474-2_45DOI Listing
July 2012

S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination.

Authors:
Hyoung Tae Kim Alfred L Goldberg

Methods Mol Biol 2012 ;832:653-60

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-474-2_46DOI Listing
July 2012

Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.

Authors:
Nidhi Bhutani Rosanna Piccirillo Raphael Hourez Prasanna Venkatraman Alfred L Goldberg

J Biol Chem 2012 May 27;287(21):17471-82. Epub 2012 Mar 27.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M112.352781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366842PMC
May 2012

The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.

Authors:
Tatos Akopian Olga Kandror Ravikiran M Raju Meera Unnikrishnan Eric J Rubin Alfred L Goldberg

EMBO J 2012 Mar 27;31(6):1529-41. Epub 2012 Jan 27.

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/emboj.2012.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321190PMC
March 2012

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection.

Authors:
Ravikiran M Raju Meera Unnikrishnan Daniel H F Rubin Vidhya Krishnamoorthy Olga Kandror Tatos N Akopian Alfred L Goldberg Eric J Rubin

PLoS Pathog 2012 Feb 16;8(2):e1002511. Epub 2012 Feb 16.

Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280978PMC
February 2012

Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism.

Authors:
Thomas Dange David Smith Tahel Noy Philipp C Rommel Lukas Jurzitza Radames J B Cordero Anne Legendre Daniel Finley Alfred L Goldberg Marion Schmidt

J Biol Chem 2011 Dec 24;286(50):42830-9. Epub 2011 Oct 24.

Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234834PMC
December 2011

Keeping proteasomes under control--a role for phosphorylation in the nucleus.

Authors:
Zhe Sha Andreas Peth Alfred L Goldberg

Proc Natl Acad Sci U S A 2011 Nov 7;108(46):18573-4. Epub 2011 Nov 7.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1115315108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219122PMC
November 2011

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.

Authors:
George K Tofaris Hyoung Tae Kim Raphael Hourez Jin-Woo Jung Kwang Pyo Kim Alfred L Goldberg

Proc Natl Acad Sci U S A 2011 Oct 27;108(41):17004-9. Epub 2011 Sep 27.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1109356108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193191PMC
October 2011

Characterization of the Brain 26S Proteasome and its Interacting Proteins.

Authors:
Hwan-Ching Tai Henrike Besche Alfred L Goldberg Erin M Schuman

Front Mol Neurosci 2010 21;3. Epub 2010 May 21.

Division of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, CA, USA.

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http://dx.doi.org/10.3389/fnmol.2010.00012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901091PMC
July 2011

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.

Authors:
Pelagia Deriziotis Ralph André David M Smith Rob Goold Kerri J Kinghorn Mark Kristiansen James A Nathan Rina Rosenzweig Dasha Krutauz Michael H Glickman John Collinge Alfred L Goldberg Sarah J Tabrizi

EMBO J 2011 Jul 8;30(15):3065-77. Epub 2011 Jul 8.

Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London, UK.

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http://dx.doi.org/10.1038/emboj.2011.224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160194PMC
July 2011

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.

Authors:
Tina T Nguyen Shih-Chung Chang Irini Evnouchidou Ian A York Christos Zikos Kenneth L Rock Alfred L Goldberg Efstratios Stratikos Lawrence J Stern

Nat Struct Mol Biol 2011 May 10;18(5):604-13. Epub 2011 Apr 10.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/nsmb.2021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087843PMC
May 2011

A conserved F box regulatory complex controls proteasome activity in Drosophila.

Authors:
Maya Bader Sigi Benjamin Orly L Wapinski David M Smith Alfred L Goldberg Hermann Steller

Cell 2011 Apr;145(3):371-82

Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.cell.2011.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108249PMC
April 2011

ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle.

Authors:
David M Smith Hugo Fraga Christian Reis Galit Kafri Alfred L Goldberg

Cell 2011 Feb;144(4):526-38

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2011.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063399PMC
February 2011

Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy.

Authors:
Fiona M Menzies Raphael Hourez Sara Imarisio Marcel Raspe Oana Sadiq Dhia Chandraratna Cahir O'Kane Kenneth L Rock Eric Reits Alfred L Goldberg David C Rubinsztein

Hum Mol Genet 2010 Dec 9;19(23):4573-86. Epub 2010 Sep 9.

Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1093/hmg/ddq385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972693PMC
December 2010

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.

Authors:
Mikael Altun Henrike C Besche Herman S Overkleeft Rosanna Piccirillo Mariola J Edelmann Benedikt M Kessler Alfred L Goldberg Brun Ulfhake

J Biol Chem 2010 Dec 12;285(51):39597-608. Epub 2010 Oct 12.

Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1074/jbc.M110.129718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000941PMC
December 2010

ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation.

Authors:
Andreas Peth Tomoaki Uchiki Alfred L Goldberg

Mol Cell 2010 Nov;40(4):671-81

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038635PMC
November 2010

Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival.

Authors:
Xiaolan Zhou Jin Lin Wang John Lu Yanping Song Keith S Kwak Qingsheng Jiao Robert Rosenfeld Qing Chen Thomas Boone W Scott Simonet David L Lacey Alfred L Goldberg H Q Han

Cell 2010 Aug;142(4):531-43

Departments of Metabolic Disorders and Protein Science, Amgen Research, Thousand Oaks, CA 91320, USA.

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http://dx.doi.org/10.1016/j.cell.2010.07.011DOI Listing
August 2010

Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.

Authors:
Jeffrey J Brault Jakob G Jespersen Alfred L Goldberg

J Biol Chem 2010 Jun 19;285(25):19460-71. Epub 2010 Apr 19.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.113092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885225PMC
June 2010

Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.

Authors:
Yadong Yu David M Smith Ho Min Kim Victor Rodriguez Alfred L Goldberg Yifan Cheng

EMBO J 2010 Feb 17;29(3):692-702. Epub 2009 Dec 17.

The W.M. Keck Advanced Microscopy Laboratory, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94132, USA.

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http://dx.doi.org/10.1038/emboj.2009.382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2830694PMC
February 2010

Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally.

Authors:
Do Hee Lee Alfred L Goldberg

Biochem Biophys Res Commun 2010 Jan 6;391(1):1056-61. Epub 2009 Dec 6.

Department of Biotechnology, Seoul Women's University, Seoul 139-774, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779135PMC
January 2010

Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening.

Authors:
Andreas Peth Henrike C Besche Alfred L Goldberg

Mol Cell 2009 Dec;36(5):794-804

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796264PMC
December 2009

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

Authors:
Hyoung Tae Kim Kwang Pyo Kim Tomoaki Uchiki Steven P Gygi Alfred L Goldberg

EMBO J 2009 Jul 23;28(13):1867-77. Epub 2009 Apr 23.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/emboj.2009.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711177PMC
July 2009

Getting to first base in proteasome assembly.

Authors:
Henrike C Besche Andreas Peth Alfred L Goldberg

Cell 2009 Jul;138(1):25-8

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740900782
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http://dx.doi.org/10.1016/j.cell.2009.06.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824964PMC
July 2009

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.

Authors:
Shenhav Cohen Jeffrey J Brault Steven P Gygi David J Glass David M Valenzuela Carlos Gartner Esther Latres Alfred L Goldberg

J Cell Biol 2009 Jun 8;185(6):1083-95. Epub 2009 Jun 8.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200901052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711608PMC
June 2009

The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition.

Authors:
Tomoaki Uchiki Hyoung Tae Kim Bo Zhai Steven P Gygi Jennifer A Johnston John P O'Bryan Alfred L Goldberg

J Biol Chem 2009 May 24;284(19):12622-32. Epub 2009 Feb 24.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M900556200
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http://dx.doi.org/10.1074/jbc.M900556200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675991PMC
May 2009

Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins.

Authors:
Henrike C Besche Wilhelm Haas Steven P Gygi Alfred L Goldberg

Biochemistry 2009 Mar;48(11):2538-49

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/bi802198qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811022PMC
March 2009

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

Authors:
Irini Evnouchidou Frank Momburg Athanasios Papakyriakou Angeliki Chroni Leondios Leondiadis Shih-Chung Chang Alfred L Goldberg Efstratios Stratikos

PLoS One 2008 6;3(11):e3658. Epub 2008 Nov 6.

National Centre for Scientific Research Demokritos, IRRP, Aghia Paraskevi, Greece.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573961PMC
December 2008

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins.

Authors:
Balasubrahmanyam Medicherla Alfred L Goldberg

J Cell Biol 2008 Aug;182(4):663-73

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1083/jcb.200803022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518706PMC
August 2008

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.

Authors:
Julius Rabl David M Smith Yadong Yu Shih-Chung Chang Alfred L Goldberg Yifan Cheng

Mol Cell 2008 May;30(3):360-8

Fachbereich Biologie, Chemie, Pharmazie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.

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http://dx.doi.org/10.1016/j.molcel.2008.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141531PMC
May 2008

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor.

Authors:
Jinghui Zhao Jeffrey J Brault Andreas Schild Alfred L Goldberg

Autophagy 2008 Apr 23;4(3):378-80. Epub 2008 Jan 23.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.4161/auto.5633DOI Listing
April 2008

New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis.

Authors:
Cui-Hua Liu Alfred L Goldberg Xiao-Bo Qiu

Chang Gung Med J 2007 Nov-Dec;30(6):469-79

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, Beijing, China.

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April 2008

Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.

Authors:
Sarah B Anderson Alfred L Goldberg Malcolm Whitman

J Biol Chem 2008 Mar 6;283(11):7027-35. Epub 2008 Jan 6.

Department of Developmental Biology, Harvard School of Dental Medicine, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M706678200DOI Listing
March 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

FoxO3 controls autophagy in skeletal muscle in vivo.

Authors:
Cristina Mammucari Giulia Milan Vanina Romanello Eva Masiero Ruediger Rudolf Paola Del Piccolo Steven J Burden Raffaella Di Lisi Claudia Sandri Jinghui Zhao Alfred L Goldberg Stefano Schiaffino Marco Sandri

Cell Metab 2007 Dec;6(6):458-71

Venetian Institute of Molecular Medicine, 35129 Padova, Italy.

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http://dx.doi.org/10.1016/j.cmet.2007.11.001DOI Listing
December 2007

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells.

Authors:
Jinghui Zhao Jeffrey J Brault Andreas Schild Peirang Cao Marco Sandri Stefano Schiaffino Stewart H Lecker Alfred L Goldberg

Cell Metab 2007 Dec;6(6):472-83

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.11.004DOI Listing
December 2007

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry.

Authors:
David M Smith Shih-Chung Chang Soyeon Park Daniel Finley Yifan Cheng Alfred L Goldberg

Mol Cell 2007 Sep;27(5):731-44

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2007.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083707PMC
September 2007

On prions, proteasomes, and mad cows.

Authors:
Alfred L Goldberg

N Engl J Med 2007 Sep;357(11):1150-2

Department of Cell Biology, Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcibr073962DOI Listing
September 2007

ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea.

Authors:
Andrew A Horwitz Ami Navon Michael Groll David M Smith Christian Reis Alfred L Goldberg

J Biol Chem 2007 Aug 6;282(31):22921-9. Epub 2007 Jun 6.

Program in Biology and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1074/jbc.M702846200DOI Listing
August 2007

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

Authors:
Hyoung Tae Kim Kwang Pyo Kim Fernando Lledias Alexei F Kisselev K Matthew Scaglione Dorota Skowyra Steven P Gygi Alfred L Goldberg

J Biol Chem 2007 Jun 10;282(24):17375-86. Epub 2007 Apr 10.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M609659200DOI Listing
June 2007

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases.

Authors:
Jennifer M Sacheck Jon-Philippe K Hyatt Anna Raffaello R Thomas Jagoe Roland R Roy V Reggie Edgerton Stewart H Lecker Alfred L Goldberg

FASEB J 2007 Jan 20;21(1):140-55. Epub 2006 Nov 20.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1096/fj.06-6604comDOI Listing
January 2007

hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.

Authors:
Xiao-Bo Qiu Song-Ying Ouyang Chao-Jun Li Shiying Miao Linfang Wang Alfred L Goldberg

EMBO J 2006 Dec 30;25(24):5742-53. Epub 2006 Nov 30.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Tsinghua University, 5 Dongdan Santiao, Beijing, China.

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http://dx.doi.org/10.1038/sj.emboj.7601450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698896PMC
December 2006

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.

Authors:
Marco Sandri Jiandie Lin Christoph Handschin Wenli Yang Zoltan P Arany Stewart H Lecker Alfred L Goldberg Bruce M Spiegelman

Proc Natl Acad Sci U S A 2006 Oct 19;103(44):16260-5. Epub 2006 Oct 19.

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0607795103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637570PMC
October 2006

Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.

Authors:
Ian A York Nidhi Bhutani Sophia Zendzian Alfred L Goldberg Kenneth L Rock

J Immunol 2006 Aug;177(3):1434-43

Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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http://dx.doi.org/10.4049/jimmunol.177.3.1434DOI Listing
August 2006

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states.

Authors:
Stewart H Lecker Alfred L Goldberg William E Mitch

J Am Soc Nephrol 2006 Jul 31;17(7):1807-19. Epub 2006 May 31.

Nephrology Division, Beth Isreal Deaconess, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1681/ASN.2006010083DOI Listing
July 2006

Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate.

Authors:
Alexei F Kisselev Alice Callard Alfred L Goldberg

J Biol Chem 2006 Mar 2;281(13):8582-90. Epub 2006 Feb 2.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M509043200
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http://dx.doi.org/10.1074/jbc.M509043200DOI Listing
March 2006

ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.

Authors:
David M Smith Galit Kafri Yifan Cheng David Ng Thomas Walz Alfred L Goldberg

Mol Cell 2005 Dec;20(5):687-98

Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2005.10.019DOI Listing
December 2005