Alfred L George

Alfred L George

UNVERIFIED PROFILE

Are you Alfred L George?   Register this Author

Register author
Alfred L George

Alfred L George

Publications by authors named "Alfred L George"

Are you Alfred L George?   Register this Author

100Publications

2519Reads

7Profile Views

Decoding KCNH2 variants of unknown significance.

Heart Rhythm 2019 Oct 5. Epub 2019 Oct 5.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2019.10.009DOI Listing
October 2019

Upgraded molecular models of the human KCNQ1 potassium channel.

PLoS One 2019 13;14(9):e0220415. Epub 2019 Sep 13.

Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220415PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6743773PMC
September 2019

Functional consequences of a KCNT1 variant associated with status dystonicus and early-onset infantile encephalopathy.

Ann Clin Transl Neurol 2019 Sep 15;6(9):1606-1615. Epub 2019 Jul 15.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.50847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764634PMC
September 2019

Potentiating α subunit containing perisomatic GABA receptors protects against seizures in a mouse model of Dravet syndrome.

J Physiol 2019 Aug 20;597(16):4293-4307. Epub 2019 May 20.

Department of Physiology, Northwestern University, Chicago, IL, 60611, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/JP277651DOI Listing
August 2019

Cardiac Evaluation of Children With a Family History of Sudden Death.

J Am Coll Cardiol 2019 Aug;74(6):759-770

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2019.05.062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690372PMC
August 2019

The importance of being selective.

Authors:
Alfred L George

Heart Rhythm 2019 Feb 25;16(2):279-280. Epub 2018 Sep 25.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15475271183094
Publisher Site
http://dx.doi.org/10.1016/j.hrthm.2018.09.022DOI Listing
February 2019

Protein structure aids predicting functional perturbation of missense variants in and .

Comput Struct Biotechnol J 2019 1;17:206-214. Epub 2019 Feb 1.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.csbj.2019.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383132PMC
February 2019

Modifier genes for sudden cardiac death.

Eur Heart J 2018 11;39(44):3925-3931

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Searle 8-510, East Superior Street, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/eurheartj/ehy502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247660PMC
November 2018

High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.

Circ Genom Precis Med 2018 11;11(11):e002345

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (C.G.V., R.R.D., K.L.F., S.L.G., F.P., J.-M.D., A.L.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGEN.118.002345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309341PMC
November 2018

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death.

Forensic Sci Med Pathol 2018 09 8;14(3):367-371. Epub 2018 Jun 8.

Section of Forensic Pediatric Medicine, Clinic of Laboratory Medicine, Oslo University Hospital, Oslo, Norway.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12024-018-9989-3DOI Listing
September 2018

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood.

Neurobiol Dis 2018 07 19;115:29-38. Epub 2018 Mar 19.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2018.03.009DOI Listing
July 2018

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Structure 2018 05 5;26(5):683-694.e3. Epub 2018 Apr 5.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37205, USA; Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA; Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09692126183008
Publisher Site
http://dx.doi.org/10.1016/j.str.2018.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5932218PMC
May 2018

Characterization of a variant associated with autism, intellectual disability, and epilepsy.

Neurol Genet 2017 Dec 11;3(6):e198. Epub 2017 Dec 11.

Department of Pharmacology (J.D.C., C.G.V., A.L.G., J.A.K.), Northwestern University Feinberg School of Medicine, Chicago, IL; Human Genome and Stem Cell Research Center (F.K.), Biosciences Institute, University of Sao Paulo, Brazil; and Mendelics Análise Genomica (F.K.), Sao Paulo, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733249PMC
December 2017

Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.

Circ Cardiovasc Genet 2017 Oct;10(5)

From the Department of Chemistry (B.L., J.L.M., J.M.), Center for Structural Biology (B.L., J.L.M., B.M.K., K.C.T., H.H., C.R.S., J.M.), Department of Biochemistry (B.M.K., H.H., C.R.S.), and Department of Biostatistics (D.K.S., J.D.B.), Vanderbilt University, Nashville, TN; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (B.M.K., C.R.S.); and Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (C.G.V., A.L.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.117.001754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679743PMC
October 2017

Treatment of calmodulinopathy with verapamil.

BMJ Case Rep 2017 Aug 7;2017. Epub 2017 Aug 7.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2017-220568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623240PMC
August 2017

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.

J Clin Invest 2017 Jun 22;127(7):2805-2814. Epub 2017 May 22.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

View Article

Download full-text PDF

Source
https://www.jci.org/articles/view/92373
Publisher Site
http://dx.doi.org/10.1172/JCI92373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490760PMC
June 2017

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.

Sci Rep 2017 05 10;7(1):1682. Epub 2017 May 10.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-01851-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431801PMC
May 2017

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy.

Ann Clin Transl Neurol 2017 05 26;4(5):326-339. Epub 2017 Apr 26.

Department of Pharmacology Northwestern University Feinberg School of Medicine Chicago Illinois.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420810PMC
May 2017

Research conference summary from the 2014 International Task Force on -Related Disorders.

Neurol Genet 2017 Apr 2;3(2):e139. Epub 2017 Mar 2.

Department of Pediatrics and Pediatric Neurology (H.R.), Georg August University, Göttingen, Germany; Division of Clinical Genetics (L.V.), Department of Pediatrics (T.N., M.T.S.) and Department of Neurology (M.T.S.), University of Utah, Salt Lake City; Center for Human Genetics (S.D.), University Hospitals and Case Western Reserve University, Cleveland, OH; Division of Pediatric Neurology (K.E.), Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN; Center for Human Genetics Research (L.O., M.M., K. Swoboda), Department of Neurology, Massachusetts General Hospital, Boston; Neurogenetics Unit (E.A.) and Epilepsy Research Group (E.A., F.A.), Montreal Neurological Hospital and Institute; Department of Neurology and Neurosurgery (E.A., F.A.), Department of Human Genetics (E.A.), and Department of Pediatrics (F.A.), McGill University, Quebec, Canada; Alternating Hemiplegia of Childhood Foundation (G.A., S.C., L.E., V.P.), Southfield, MI; BCBA (A. Belgrade), Belgrade Behavior Consulting, Chicago, IL; Department of Neurology (A. Brashear), Wake Forest School of Medicine, Winston-Salem, NC; Department of Pharmacology (A.L.G.), Northwestern University Feinberg School of Medicine, Chicago, IL; Department of Pediatrics (A.L.), University of Florida College of Medicine, Jacksonville; Integrative Neuropsychology (J.M.), Fairlawn, OH; Association Française de l'Hémiplégie Alternante (D.P.), Paris, France; Rare Disease Innovation Unit (S.R.), Clinical Development Program, Biogen, Cambridge, MA; Department of Child Neurology (M.S.), National Center of Neurology and Psychiatry, Kodaira, Japan; Swedish Neuroscience Institute (M.S.d.M.), Swedish Medical Center, Seattle, WA; Department of Neurosurgery (K. Sweadner), Massachusetts General Hospital and Harvard Medical School, Boston; Neuroscience Institute (M.Z.), Children's Hospital of Orange County, CA; and Departments of Pediatrics and Neurology (K. Silver), University of Chicago and Comer Children's Hospital, Chicago, IL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5335249PMC
April 2017

CaMKII modulates sodium current in neurons from epileptic mutant mice.

Proc Natl Acad Sci U S A 2017 02 30;114(7):1696-1701. Epub 2017 Jan 30.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1615774114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321040PMC
February 2017

Measuring Drug Metabolism Kinetics and Drug-Drug Interactions Using Self-Assembled Monolayers for Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry.

Anal Chem 2016 09 12;88(17):8604-9. Epub 2016 Aug 12.

Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine , Chicago, Illinois 60611, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.analchem.6b01750DOI Listing
September 2016

Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Sci Adv 2016 09 9;2(9):e1501228. Epub 2016 Sep 9.

Department of Biochemistry, Vanderbilt University, Nashville, TN 37240, USA.; Center for Structural Biology, Vanderbilt University, Nashville, TN 37240, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37240, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciadv.1501228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5017827PMC
September 2016

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Heart Rhythm 2016 08 7;13(8):1716-23. Epub 2016 May 7.

Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University, Indianapolis, Indiana. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2016.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958519PMC
August 2016

Use-Dependent Block of Human Cardiac Sodium Channels by GS967.

Mol Pharmacol 2016 07 2;90(1):52-60. Epub 2016 May 2.

Department of Pharmacology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.116.103358DOI Listing
July 2016

New approaches to establish genetic causality.

Trends Cardiovasc Med 2015 Oct 4;25(7):646-52. Epub 2015 Mar 4.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL; Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tcm.2015.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560679PMC
October 2015

Intracellular calcium attenuates late current conducted by mutant human cardiac sodium channels.

Circ Arrhythm Electrophysiol 2015 Aug 28;8(4):933-41. Epub 2015 May 28.

From the Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL (F.P., A.L.G.); and Department of Medicine (F.P., J.D.K., A.L.G.) and Department of Pharmacology (T.M.B., A.L.G.), Vanderbilt University, Nashville, TN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.115.002760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545406PMC
August 2015

Misplaced brain sodium channels in heart kindle sudden death in epilepsy.

Authors:
Alfred L George

Circ Arrhythm Electrophysiol 2015 Aug;8(4):769-71

From the Department of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.115.003261DOI Listing
August 2015

Personalized biochemistry and biophysics.

Biochemistry 2015 Apr 15;54(16):2551-9. Epub 2015 Apr 15.

†Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.biochem.5b00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415889PMC
April 2015

Calmodulinopathy: a genetic trilogy.

Authors:
Alfred L George

Heart Rhythm 2015 Feb 18;12(2):423-4. Epub 2014 Nov 18.

Department of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2014.11.017DOI Listing
February 2015

Autonomic control of heart rate and QT interval variability influences arrhythmic risk in long QT syndrome type 1.

J Am Coll Cardiol 2015 Feb;65(4):367-374

Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2014.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312415PMC
February 2015

SCN10A/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation.

Cardiovasc Res 2014 Nov 22;104(2):355-63. Epub 2014 Jul 22.

Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285A MRB IV, Nashville, TN 37323-6602, USA Division of Clinical Pharmacology, Vanderbilt University School of Medicine, 2215B Garland Avenue, Room 1285A MRB IV, Nashville, TN 37323-6602, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvu170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271018PMC
November 2014

Lessons learned from genetic testing for channelopathies.

Authors:
Alfred L George

Lancet Neurol 2014 Nov;13(11):1068-1070

Department of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1474-4422(14)70123-1DOI Listing
November 2014

Use of contemporary genetics in cardiovascular diagnosis.

Authors:
Alfred L George

Circulation 2014 Nov;130(22):1971-80

From the Department of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Chicago, IL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCULATIONAHA.114.006511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491434PMC
November 2014

AKAP9 is a genetic modifier of congenital long-QT syndrome type 1.

Circ Cardiovasc Genet 2014 Oct 2;7(5):599-606. Epub 2014 Aug 2.

From the Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Medical Research Council (MRC) Centre for Molecular and Cellular Biology, (C.P.d.V., L.v.d.M., J.C.M.-S., V.A.C.), and Department of Internal Medicine (A.G., P.A.B.), Stellenbosch University, Stellenbosch, South Africa; Department of Statistics, University of Western Cape, Bellville, South Africa (L.v.d.M.); IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy (L.C., P.J.S.); Department of Molecular Medicine, University of Pavia, Pavia, Italy (L.C.); Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany (L.C.); and Departments of Medicine and Pharmacology, and Institute for Integrative Genomics, Vanderbilt University, Nashville, TN (A.L.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270884PMC
October 2014

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

J Mol Cell Cardiol 2014 Sep 8;74:115-24. Epub 2014 May 8.

Calcium Signals Laboratory, Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2014.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262253PMC
September 2014

Novel SCN5A mutation in amiodarone-responsive multifocal ventricular ectopy-associated cardiomyopathy.

Heart Rhythm 2014 Aug 9;11(8):1446-53. Epub 2014 May 9.

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee; Division of Genetic Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2014.04.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108519PMC
August 2014

Arrhythmogenic calmodulin mutations disrupt intracellular cardiomyocyte Ca2+ regulation by distinct mechanisms.

J Am Heart Assoc 2014 Jun 23;3(3):e000996. Epub 2014 Jun 23.

Department of Physiology, University of Kentucky College of Medicine, Lexington, KY (G.Y., F.H., A.R.H., J.S.).

View Article

Download full-text PDF

Source
https://www.ahajournals.org/doi/10.1161/JAHA.114.000996
Publisher Site
http://dx.doi.org/10.1161/JAHA.114.000996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309107PMC
June 2014

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice.

Neurobiol Dis 2014 May 14;65:1-11. Epub 2014 Jan 14.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-0275, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2014.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968814PMC
May 2014

Recent genetic discoveries implicating ion channels in human cardiovascular diseases.

Authors:
Alfred L George

Curr Opin Pharmacol 2014 Apr 11;15:47-52. Epub 2013 Dec 11.

Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2013.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984451PMC
April 2014

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Circ Res 2014 Mar 21;114(7):1114-24. Epub 2014 Feb 21.

From the Departments of Medicine (H.S.H., M.F., A.L.G., B.C.K.), Biochemistry (C.N.J., W.J.C.), Chemistry (W.J.C.), and Pharmacology (A.L.G., B.C.K.), Vanderbilt University, Nashville, TN; Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis (F.R.N., R.L.C.); Department of Pharmacology, University of California, Davis (Y.Y., L.P., D.M.B.); and Department of School of Biomedical Sciences and Pharmacy, University of Newcastle, New South Wales, Australia (K.W., D.L.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.114.303391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990285PMC
March 2014

Novel SCN3A variants associated with focal epilepsy in children.

Neurobiol Dis 2014 Feb 21;62:313-22. Epub 2013 Oct 21.

Department of Medicine, Vanderbilt University, Nashville, TN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nbd.2013.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877720PMC
February 2014

Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.

Mol Pharmacol 2014 Jan 7;85(1):162-74. Epub 2013 Nov 7.

Department of Biology (Cardiovascular Therapeutic Area), Gilead Sciences, Inc., Foster City and Fremont, California (K.M.K., R.H., L.L., L.B., S.R.); Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee (A.L.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.113.088492DOI Listing
January 2014

SPARCL1 suppresses metastasis in prostate cancer.

Mol Oncol 2013 Dec 20;7(6):1019-30. Epub 2013 Jul 20.

Department of Medicine, Vanderbilt University, Nashville, TN 37232-0275, USA; Minimally Invasive Urology Center, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molonc.2013.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838491PMC
December 2013

Selective targeting of gain-of-function KCNQ1 mutations predisposing to atrial fibrillation.

Circ Arrhythm Electrophysiol 2013 Oct 4;6(5):960-6. Epub 2013 Sep 4.

Department of Pharmacology and Department of Medicine, Vanderbilt University, Nashville, TN; and Department of Engineering Management, Information, and Systems, Southern Methodist University, Dallas, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.113.000439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892565PMC
October 2013

Impact of genetics on the clinical management of channelopathies.

J Am Coll Cardiol 2013 Jul 15;62(3):169-180. Epub 2013 May 15.

Department of Cardiology, Heart Failure Research Centre, Academic Medical Centre, Amsterdam, the Netherlands; Princess Al Jawhara Albrahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2013.04.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710520PMC
July 2013

Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling.

J Gen Physiol 2013 Feb;141(2):193-202

Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1085/jgp.201210919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557314PMC
February 2013

Lipid kinase mutations in heritable glomerular microangiopathy.

Authors:
Alfred L George

J Am Soc Nephrol 2013 Feb 14;24(3):329-30. Epub 2013 Feb 14.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2013010078DOI Listing
February 2013

Molecular and genetic basis of sudden cardiac death.

Authors:
Alfred L George

J Clin Invest 2013 Jan 2;123(1):75-83. Epub 2013 Jan 2.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI62928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533278PMC
January 2013

Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression.

J Biol Chem 2012 Dec 19;287(50):42001-8. Epub 2012 Oct 19.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.421883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516746PMC
December 2012

Leaky channels make weak muscles.

Authors:
Alfred L George

J Clin Invest 2012 Dec 26;122(12):4333-6. Epub 2012 Nov 26.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI66535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512169PMC
December 2012

Genetic marker of torsades de pointes risk following myocardial infarction.

Authors:
Alfred L George

Heart Rhythm 2012 Jul 8;9(7):1113-4. Epub 2012 May 8.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrthm.2012.05.007DOI Listing
July 2012

Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome.

J Cardiovasc Pharmacol 2012 Mar;59(3):249-53

Laboratory of Cardiovascular Genetics, IRCCS Istituto Auxologico Italiano, Milan, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FJC.0b013e31823d2fd1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291794PMC
March 2012

Activation of protein kinase C alters the intracellular distribution and mobility of cardiac Na+ channels.

Am J Physiol Heart Circ Physiol 2012 Feb 18;302(3):H782-9. Epub 2011 Nov 18.

Departments of Medicine and Pharmacology Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

View Article

Download full-text PDF

Source
http://ajpheart.physiology.org/content/ajpheart/early/2011/1
Web Search
http://ajpheart.physiology.org/cgi/doi/10.1152/ajpheart.0081
Publisher Site
http://dx.doi.org/10.1152/ajpheart.00817.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353784PMC
February 2012

Transcriptional networks in epithelial-mesenchymal transition.

PLoS One 2011 30;6(9):e25354. Epub 2011 Sep 30.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025354PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184133PMC
January 2012

Apolipoprotein l1 and the genetic basis for racial disparity in chronic kidney disease.

J Am Soc Nephrol 2011 Nov 13;22(11):1955-8. Epub 2011 Oct 13.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1681/ASN.2011090932DOI Listing
November 2011

Nav 1.1 dysfunction in genetic epilepsy with febrile seizures-plus or Dravet syndrome.

Eur J Neurosci 2011 Oct 22;34(8):1268-75. Epub 2011 Aug 22.

Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1460-9568.2011.07826.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195841PMC
October 2011

Manipulating piggyBac transposon chromosomal integration site selection in human cells.

Mol Ther 2011 Sep 5;19(9):1636-44. Epub 2011 Jul 5.

Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2011.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182353PMC
September 2011

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants.

Channels (Austin) 2011 Mar-Apr;5(2):161-72. Epub 2011 Mar 1.

Department of Biology,Gilead Sciences, Palo Alto, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/chan.5.2.14851DOI Listing
July 2011

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.

Epilepsia 2011 May 31;52(5):1000-9. Epub 2011 Mar 31.

Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0275, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1528-1167.2011.03040.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093448PMC
May 2011

SCN5A variation is associated with electrocardiographic traits in the Jackson Heart Study.

Circ Cardiovasc Genet 2011 Apr 15;4(2):139-44. Epub 2011 Feb 15.

Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232-0700, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080430PMC
http://dx.doi.org/10.1161/CIRCGENETICS.110.958124DOI Listing
April 2011

Voltage-gated potassium channel KCNV2 (Kv8.2) contributes to epilepsy susceptibility.

Proc Natl Acad Sci U S A 2011 Mar 14;108(13):5443-8. Epub 2011 Mar 14.

Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN 37232-0275, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1017539108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069171PMC
March 2011