Alexias Safi

Alexias Safi

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Alexias Safi

Alexias Safi

Publications by authors named "Alexias Safi"

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31Publications

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Human cardiac -regulatory elements, their cognate transcription factors, and regulatory DNA sequence variants.

Genome Res 2018 10 23;28(10):1577-1588. Epub 2018 Aug 23.

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

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http://dx.doi.org/10.1101/gr.234633.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169896PMC
October 2018

Pre-established Chromatin Interactions Mediate the Genomic Response to Glucocorticoids.

Cell Syst 2018 08 18;7(2):146-160.e7. Epub 2018 Jul 18.

University Program in Genetics and Genomics, Duke University, Durham, NC 27708, USA; Center for Genomic and Computational Biology, Duke University, Durham, NC 27708, USA; Computational Biology and Bioinformatics Graduate Program, Duke University, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2018.06.007DOI Listing
August 2018

Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.

Mamm Genome 2018 02 10;29(1-2):153-167. Epub 2018 Feb 10.

Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.

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http://dx.doi.org/10.1007/s00335-018-9739-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095468PMC
February 2018

Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome.

Cell 2016 Aug;166(5):1269-1281.e19

Center for Genomic & Computational Biology, Duke University, Durham, NC 27708, USA; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC 27708, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046229PMC
http://dx.doi.org/10.1016/j.cell.2016.07.049DOI Listing
August 2016

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus.

Nucleic Acids Res 2016 Apr 15;44(7):3082-94. Epub 2015 Dec 15.

Human Molecular Genetics Program, Lurie Children's Research Center, Chicago, IL 60614, USA Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA

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http://dx.doi.org/10.1093/nar/gkv1358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838340PMC
April 2016

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators.

Genome Res 2015 Aug 29;25(8):1158-69. Epub 2015 May 29.

Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA; Center for Genomic and Computational Biology, Duke University, Durham, North Carolina 27708, USA; Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://genome.cshlp.org/lookup/doi/10.1101/gr.179044.114
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http://dx.doi.org/10.1101/gr.179044.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510000PMC
August 2015

Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.

PLoS Genet 2015 Jan 8;11(1):e1004885. Epub 2015 Jan 8.

Environmental Genomics Group, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287438PMC
January 2015

A region of the nucleosome required for multiple types of transcriptional silencing in Saccharomyces cerevisiae.

Genetics 2011 Jul 5;188(3):535-48. Epub 2011 May 5.

Institute for Genome Sciences and Policy and Biochemistry Department, Duke University, Durham, North Carolina 27710, USA.

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http://www.genetics.org/lookup/doi/10.1534/genetics.111.1291
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http://dx.doi.org/10.1534/genetics.111.129197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176532PMC
July 2011

Evolution of new function through a single amino acid change in the yeast repressor Sum1p.

Mol Cell Biol 2008 Apr 11;28(8):2567-78. Epub 2008 Feb 11.

Institute for Genome Sciences and Policy, Box 3382, Duke University, Durham, NC 27710, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01785-07
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http://dx.doi.org/10.1128/MCB.01785-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293110PMC
April 2008

Autophosphorylation of Ser66 on Xenopus Myt1 is a prerequisite for meiotic inactivation of Myt1.

Cell Cycle 2006 Feb 15;5(4):421-7. Epub 2006 Feb 15.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.4161/cc.5.4.2492DOI Listing
February 2006

Experimental validation of the docking orientation of Cdc25 with its Cdk2-CycA protein substrate.

Biochemistry 2005 Dec;44(50):16563-73

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1021/bi0516879DOI Listing
December 2005

Inhibition of Cdc25 phosphatases by indolyldihydroxyquinones.

J Med Chem 2003 Jun;46(13):2580-8

Department of Biochemistry, Duke University, and Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1021/jm0300835DOI Listing
June 2003