Dr Alexei von Delwig, PhD, Doctor of Medical Sciences - Innovita Research

Dr Alexei von Delwig

PhD, Doctor of Medical Sciences

Innovita Research

Vilnius | Lithuania

Main Specialties: Biotechnology, Clinical & Laboratory Immunology, Infectious Disease, Medical Microbiology

ORCID logohttps://orcid.org/0000-0003-2978-4761

Dr Alexei von Delwig, PhD, Doctor of Medical Sciences - Innovita Research

Dr Alexei von Delwig

PhD, Doctor of Medical Sciences

Introduction

12.1997 - Doctor of Medical Sciences (DSc, Post-Doctoral degree) in Immunology, Metchnikoff Research Institute for Vaccines and Sera, Moscow, Russia.Thesis: Antigen and epitope structure of major outer membrane proteins of Neisseria meningitidis serogroup B as essential components of meningococcal vaccines.
Thesis consultant: Director of the Research Institute for Vaccines and Sera, Moscow, Russia, Prof. Dr. Boris F. Semenov.

06.1989 - PhD in Immunology, Gabrichevsky Institute of Microbiology and Epidemiology, Moscow, Russia.
Thesis: The immunogenicity of meningococcal lipopolysaccharides isolated from serogroup A and B Neisseria meningitidis.
Thesis advisor: Prof. Dr. L. I. Krasnoproshina, Institute of Vaccines and Sera, Moscow, Russia
.
1976-1982 -Medical Diploma, Moscow Medical Academy (1st Medical Sechenoff Institute), Moscow, Russia.

Primary Affiliation: Innovita Research - Vilnius , Lithuania

Specialties:

Research Interests:

Publications

46Publications

266Reads

2Profile Views

CD4 T-cell epitope mapping.

Methods Mol Med 2001 ;66:349-60

Department of Microbiology and Immunology, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1385/1-59259-148-5:349DOI Listing
October 2012
1 Read

Testing meningococcal vaccines for mitogenicity and superantigenicity.

Methods Mol Med 2001 ;66:199-221

Department of Microbiology and Immunology, Newcastle University, Newcastle, UK.

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http://dx.doi.org/10.1385/1-59259-148-5:199DOI Listing
October 2012

Immunotherapy for treating metastatic colorectal cancer.

Surg Oncol 2012 Jun 2;21(2):67-77. Epub 2011 Feb 2.

Birmingham Heartlands Hospital, NHS, Birmingham, West Midlands, UK.

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http://dx.doi.org/10.1016/j.suronc.2010.10.004DOI Listing
June 2012
78 Reads
3.270 Impact Factor

Invariant natural killer T (iNKT) cell deficiency in chronic mucocutaneous candidiasis--a consequence or a cause?

Immunol Lett 2011 Mar 12;135(1-2):180-3. Epub 2010 Oct 12.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1016/j.imlet.2010.09.014DOI Listing
March 2011
4 Reads
2.512 Impact Factor

Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses.

Arthritis Rheum 2010 Dec;62(12):3656-65

Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.27756DOI Listing
December 2010
16 Reads
7.764 Impact Factor

Impaired T(H)17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy.

J Allergy Clin Immunol 2010 Nov 8;126(5):1006-15, 1015.e1-4. Epub 2010 Oct 8.

Musculoskeletal Research Group, Institute for Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2010.08.027DOI Listing
November 2010
50 Reads
11.476 Impact Factor

Profound invariant natural killer T-cell deficiency in inflammatory arthritis.

Ann Rheum Dis 2010 Oct 5;69(10):1873-9. Epub 2010 May 5.

Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1136/ard.2009.125849DOI Listing
October 2010
13 Reads
10.377 Impact Factor

Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis.

Arthritis Rheum 2010 Jan;62(1):143-9

Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.25064DOI Listing
January 2010
7 Reads
7.764 Impact Factor

LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells.

J Leukoc Biol 2009 Feb 6;85(2):243-50. Epub 2008 Nov 6.

Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

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http://doi.wiley.com/10.1189/jlb.0608374
Publisher Site
http://dx.doi.org/10.1189/jlb.0608374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700018PMC
February 2009
8 Reads
4.289 Impact Factor

T cell responses to a non-glycosylated epitope predominate in type II collagen-immunised HLA-DRB1*0101 transgenic mice.

Ann Rheum Dis 2007 May 17;66(5):599-604. Epub 2006 Nov 17.

Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1136/ard.2006.061945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1954639PMC
May 2007
9 Reads
10.377 Impact Factor

Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice.

Arthritis Res Ther 2006 ;8(4):R93

Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1186/ar1964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779380PMC
February 2007
9 Reads
3.753 Impact Factor

Mechanisms of major histocompatibility complex class II-restricted processing and presentation of the V antigen of Yersinia pestis.

Immunology 2006 Nov 18;119(3):385-92. Epub 2006 Aug 18.

Musculoskeletal Research Group, Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2006.02447.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819574PMC
November 2006
13 Reads
3.795 Impact Factor

The impact of glycosylation on HLA-DR1-restricted T cell recognition of type II collagen in a mouse model.

Arthritis Rheum 2006 Feb;54(2):482-91

Musculoskeletal Research Group, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/art.21565DOI Listing
February 2006
9 Reads
7.764 Impact Factor

Major histocompatibility class II molecules prevent destructive processing of exogenous peptides at the cell surface of macrophages for presentation to CD4 T cells.

Immunology 2005 Feb;114(2):194-203

Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom.

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http://doi.wiley.com/10.1111/j.1365-2567.2004.02085.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2567.2004.02085.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782074PMC
February 2005
4 Reads
3.795 Impact Factor

[Invariable chain (Ii-chain) as a highly important molecular chaperone of histocompatibility class II molecules].

Zh Mikrobiol Epidemiol Immunobiol 2004 Mar-Apr(2):99-106

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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October 2004
1 Read

[Potentialities of calcium dependent lectin receptors of antigen presenting cells for the immunotherapeutic preparation development].

Zh Mikrobiol Epidemiol Immunobiol 2004 Jan-Feb(1):79-84

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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October 2004
1 Read

Regulation of peptide presentation by major histocompatibility complex class II molecules at the surface of macrophages.

Eur J Immunol 2003 Dec;33(12):3359-66

Musculoskeletal Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, GB.

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http://dx.doi.org/10.1002/eji.200324461DOI Listing
December 2003
4 Reads
4.034 Impact Factor

Localization of peptide/MHC class II complexes in macrophages following antigen processing of viable Streptococcus pyogenes.

Eur J Immunol 2003 Sep;33(9):2353-60

School of Clinical Medical Sciences (Rheumatology), University of Newcastle upon Tyne, Newcastle upon Tyne, GB.

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http://dx.doi.org/10.1002/eji.200323559DOI Listing
September 2003
5 Reads
4.034 Impact Factor

The route of bacterial uptake by macrophages influences the repertoire of epitopes presented to CD4 T cells.

Eur J Immunol 2002 Dec;32(12):3714-9

Department of Rheumatology, University of Newcastle upon Tyne, Newcastle upon Tyne, GB.

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http://dx.doi.org/10.1002/1521-4141(200212)32:12<3714::AID-IMMU3714>3.0.CO;2-YDOI Listing
December 2002
8 Reads
4.034 Impact Factor

Processing of viable Salmonella typhimurium for presentation of a CD4 T cell epitope from the Salmonella invasion protein C (SipC).

Eur J Immunol 2002 Sep;32(9):2664-71

Department of Microbiology and Immunology, The Medical School, University of Newcastle upon Tyne, GB.

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http://dx.doi.org/10.1002/1521-4141(200209)32:9<2664::AID-IMMU2664>3.0.CO;2-NDOI Listing
September 2002
4 Reads
4.034 Impact Factor

TGF-beta1 and IFN-gamma cross-regulate antigen presentation to CD4 T cells by macrophages.

J Leukoc Biol 2002 Jul;72(1):163-6

Department of Rheumatology, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.

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July 2002
2 Reads
4.289 Impact Factor

Diversity in MHC class II antigen presentation.

Immunology 2002 Mar;105(3):252-62

Department of Microbiology and Immunology, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782669PMC
http://dx.doi.org/10.1046/j.0019-2805.2001.01358.xDOI Listing
March 2002
2 Reads
3.795 Impact Factor

[The structural-functional characteristics of the transferrin receptor of pathogenic Neisseria].

Zh Mikrobiol Epidemiol Immunobiol 1999 Nov-Dec(6):94-8

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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July 2000
1 Read

[The capsular polysaccharide of serogroup-B meningococci: its immunobiological properties].

Zh Mikrobiol Epidemiol Immunobiol 1999 Sep-Oct(5):52-6

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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July 2000

The role of calcium homeostasis and flux during bacterial antigen processing in murine macrophages.

Eur J Immunol 1999 08;29(8):2414-9

Department of Immunology, The Medical School, Newcastle University, Newcastle upon Tyne, GB.

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http://dx.doi.org/10.1002/(SICI)1521-4141(199908)29:08<2406::AID-IMMU2406>3.0.CO;2-FDOI Listing
August 1999
1 Read
4.034 Impact Factor

Functional activities and epitope specificity of human and murine antibodies against the class 4 outer membrane protein (Rmp) of Neisseria meningitidis.

Infect Immun 1999 Mar;67(3):1267-76

Department of Vaccinology, National Institute of Public Health, N-0403 Oslo, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC96456PMC
March 1999
3 Reads
3.731 Impact Factor

Two T cell epitopes from the M5 protein of viable Streptococcus pyogenes engage different pathways of bacterial antigen processing in mouse macrophages.

J Immunol 1998 Jun;160(11):5267-72

Department of Immunology, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.

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June 1998
1 Read
4.922 Impact Factor

[The outlook for the development of a vesicular meningococcal serogroup B vaccine].

Zh Mikrobiol Epidemiol Immunobiol 1998 Jan-Feb(1):91-6

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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June 1998

[The mechanisms of the formation of an immune response to the porin proteins of the outer membrane in meningococci of serogroup B].

Zh Mikrobiol Epidemiol Immunobiol 1997 Nov-Dec(6):92-6

Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

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April 1998
1 Read

Different endosomal proteolysis requirements for antigen processing of two T-cell epitopes of the M5 protein from viable Streptococcus pyogenes.

J Biol Chem 1998 Feb;273(6):3291-5

Department of Immunology, School of Microbiological, Virological, and Immunological Sciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, Tyne and Wear, NE2 4HH, United Kingdom.

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http://dx.doi.org/10.1074/jbc.273.6.3291DOI Listing
February 1998
4.573 Impact Factor

T-Cell epitope mapping the PorB protein of serogroup B Neisseria meningitidis in B10 congenic strains of mice.

Clin Immunol Immunopathol 1997 Nov;85(2):134-42

The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, United Kingdom.

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November 1997
1 Read

Vaccine-induced IgG antibodies to the linear epitope on the PorB outer membrane protein promote opsonophagocytosis of Neisseria meningitidis by human neutrophils.

Clin Immunol Immunopathol 1997 Jul;84(1):27-35

Department of Vaccinology, National Institute of Public Health, Oslo, Norway.

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July 1997
1 Read

Phagocytic processing of two M protein T-cell epitopes from viable group A streptococci.

Biochem Soc Trans 1997 May;25(2):205S

Department of Immunology, School of Microbiological Virological and Immunological Sciences, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1042/bst025205sDOI Listing
May 1997
3.194 Impact Factor

Immune responses to linear epitopes on the PorB protein of Neisseria meningitidis in patients with systemic meningococcal disease.

Microbiology 1996 Sep;142 ( Pt 9):2491-8

National Institute of Public Health, Department of Vaccinology, Oslo, Norway.

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http://dx.doi.org/10.1099/00221287-142-9-2491DOI Listing
September 1996
6 Reads
2.557 Impact Factor

T-cell responses to outer membrane proteins of Neisseria meningitidis: comparative study of the Opa, Opc, and PorA proteins.

Infect Immun 1996 Jan;64(1):298-304

Laboratory of Vaccine Development and Immune Mechanisms, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC173759PMC
January 1996
3.731 Impact Factor

A linear B-cell epitope on the class 3 outer-membrane protein of Neisseria meningitidis recognized after vaccination with the Norwegian group B outer-membrane vesicle vaccine.

Microbiology 1995 Jul;141 ( Pt 7):1593-600

National Institute of Public Health, Department of Vaccines, Oslo, Norway.

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http://dx.doi.org/10.1099/13500872-141-7-1593DOI Listing
July 1995
2.557 Impact Factor

Emergence of a new virulent clone within the electrophoretic type 5 complex of serogroup B meningococci in Norway.

Clin Diagn Lab Immunol 1995 May;2(3):314-21

Department of Vaccine, National Institute of Public Health, Oslo, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC170152PMC
May 1995

Anti-bacterial specificities in the human fetal B cell repertoire.

Hum Antibodies Hybridomas 1994 ;5(1-2):91-5

Clinic for Surgery, Medical Faculty (Charité), Humboldt-University, Berlin, Germany.

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March 1995

A comparison of human and murine monoclonal IgGs specific for the P1.7 PorA protein of Neisseria meningitidis.

Mol Immunol 1994 Nov;31(16):1257-67

Max Planck Institut für molekulare Genetik, Berlin, Germany.

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November 1994
2.973 Impact Factor

[The coagglutination reaction for detecting diphtheria toxin].

Zh Mikrobiol Epidemiol Immunobiol 1989 Mar(3):68-71

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March 1989
1 Read

[Cultivation of murine B-cell hybridomas in the spleen].

Zh Mikrobiol Epidemiol Immunobiol 1987 Jan(1):94-8

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January 1987