Publications by authors named "Alexei Grom"

85Publications

Platelet glycoprotein Ib alpha chain as a putative therapeutic target for juvenile idiopathic arthritis: a Mendelian randomization study.

Arthritis Rheumatol 2020 Oct 20. Epub 2020 Oct 20.

MRC Integrative Epidemiology Unit, Population Health Sciences Institute, Bristol Medical School, University of Bristol, Bristol, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.41561DOI Listing
October 2020

Proceedings from the 2 Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019.

Pediatr Rheumatol Online J 2020 Jul 15;18(Suppl 1):53. Epub 2020 Jul 15.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-020-00444-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360380PMC
July 2020

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.

N Engl J Med 2020 05;382(19):1811-1822

From the Department of Pediatrics, Sapienza, University of Rome (F.L.), and the Department of Pediatric Hematology-Oncology (F.L.) and Division of Rheumatology (F.D.B.), IRCCS Bambino Gesù Children's Hospital, Rome, Pediatric Hematology-Oncology, Woman and Child Hospital, Azienda Ospedaliera Universitaria Integrata, Verona (S.C.), the Pediatric Hematology-Oncology Unit, Department of Pediatrics, University of Milano-Bicocca, Monza Brianza per il Bambino e la sua Mamma Foundation, Monza (C.R.), the Clinic of Pediatric Hematology-Oncology, University Hospital of Padova, Padua (M.-C.P.), and the Division of Pediatric Onco-Hematology, Regina Margherita Hospital, Turin (F.F.) - all in Italy; the Divisions of Immunobiology and Bone Marrow Transplantation and Immune Deficiency, Department of Pediatrics (M.B.J.), and the Division of Rheumatology (A.G.), Cincinnati Children's Hospital Medical Center, and the University of Cincinnati College of Medicine (M.B.J.) - all in Cincinnati; the Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston (C.A.); the Department of Hematology, Great Ormond Street Hospital for Children, London (A.R.); the Department of Pediatric Hematology-Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston (B.D.); the Center for Cancer and Blood Disorders, Children's Hospital Colorado, Aurora (T.P.G.); the Departments of Pediatric Hematology-Oncology and Hematology and Oncology, Fundación para la Investigación Biomédica Hospital Infantil Universitario Niño Jesús, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid (J.S.), and the Department of Pediatric Hematology and Oncology, Hospital Universitari Vall d'Hebron, Barcelona (J.-L.D.D.); the Department of Pediatric Hematology and Oncology, University Children's Hospital, Muenster, Germany (M.A.); the Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ (M.H.); NovImmune, Plan-les-Ouates, Switzerland (G.L., M.B., C.M.); and MnS Modelling and Simulation, Dinant, Belgium (P.J.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1911326DOI Listing
May 2020

The use of S100 proteins testing in juvenile idiopathic arthritis and autoinflammatory diseases in a pediatric clinical setting: a retrospective analysis.

Pediatr Rheumatol Online J 2020 Jan 16;18(1). Epub 2020 Jan 16.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-020-0398-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966841PMC
January 2020

Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.

J Clin Invest 2020 Apr;130(4):1669-1682

Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI129301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108905PMC
April 2020

IL-18 as therapeutic target in a patient with resistant systemic juvenile idiopathic arthritis and recurrent macrophage activation syndrome.

Rheumatology (Oxford) 2020 Feb;59(2):442-445

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez284DOI Listing
February 2020

IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.

Rheumatology (Oxford) 2020 02;59(2):361-366

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571484PMC
February 2020

A Multiparameter Flow Cytometry Analysis Panel to Assess CD163 mRNA and Protein in Monocyte and Macrophage Populations in Hyperinflammatory Diseases.

J Immunol 2019 03 25;202(5):1635-1643. Epub 2019 Jan 25.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1800765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382590PMC
March 2019

MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.

J Leukoc Biol 2018 01 29;103(1):71-85. Epub 2017 Dec 29.

Division of Rheumatology, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.2A0317-107RDOI Listing
January 2018

Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis.

J Clin Rheumatol 2018 Aug;24(5):287-290

Division of Rheumatology Cincinnati Children's Hospital Medical Center Cincinnati, OH Division of Infectious Disease Cincinnati Children's Hospital Medical Center Cincinnati, OH Department of Radiology Cincinnati Children's Hospital Medical Center Cincinnati, OH Division of Infectious Disease Cincinnati Children's Hospital Medical Center Cincinnati, OH Division of Allergy Immunology, and Rheumatology University of Wisconsin School of Medicine and Public Health Madison, WI Division of Rheumatology Cincinnati Children's Hospital Medical Center Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/RHU.0000000000000653DOI Listing
August 2018

Urine S100 proteins as potential biomarkers of lupus nephritis activity.

Arthritis Res Ther 2017 Oct 24;19(1):242. Epub 2017 Oct 24.

Department of Rheumatology, Cincinnati Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13075-017-1444-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655804PMC
October 2017

Primary Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome: The Importance of Timely Clinical Differentiation.

Authors:
Alexei A Grom

J Pediatr 2017 10 21;189:19-21.e1. Epub 2017 Aug 21.

Division of Rheumatology Cincinnati Children's Hospital Medical Center Cincinnati, Ohio. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2017.07.025DOI Listing
October 2017

Systemic onset juvenile idiopathic arthritis and exposure to fine particulate air pollution.

Clin Exp Rheumatol 2016 Sep-Oct;34(5):946-952. Epub 2016 Sep 1.

Brigham Young University, Provo, UT, USA.

View Article

Download full-text PDF

Source
January 2017

Macrophage activation syndrome in the era of biologic therapy.

Nat Rev Rheumatol 2016 May 24;12(5):259-68. Epub 2016 Mar 24.

Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Piazza Sant'Onofrio, 4, Rome, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrrheum.2015.179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851441PMC
May 2016

A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.

J Immunol 2016 Mar 15;196(6):2492-503. Epub 2016 Feb 15.

Division of Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35233; Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL 35294;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1501284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779709PMC
March 2016

Reply: To PMID 25988345.

Arthritis Care Res (Hoboken) 2015 Nov;67(11):1615-6

Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acr.22623DOI Listing
November 2015

Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies.

Annu Rev Med 2015 5;66:145-59. Epub 2014 Nov 5.

Division of Pediatric Rheumatology, Children's Hospital Medical Center, Cincinnati, Ohio 45229; email: ,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-med-061813-012806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846123PMC
September 2015

Canakinumab for the treatment of systemic juvenile idiopathic arthritis.

Authors:
Alexei A Grom

Expert Rev Clin Immunol 2014 Nov 1;10(11):1427-35. Epub 2014 Oct 1.

Division of Rheumatology ML 4010, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/1744666X.2014.965149DOI Listing
November 2014

Genetic defects in cytolysis in macrophage activation syndrome.

Curr Rheumatol Rep 2014 ;16(9):439

University of Alabama at Birmingham, 1825 University Blvd., Shelby 306, Birmingham, AL, 35294, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11926-014-0439-2DOI Listing
February 2015

Biomarkers in systemic juvenile idiopathic arthritis: a comparison with biomarkers in cryopyrin-associated periodic syndromes.

Curr Opin Rheumatol 2014 Sep;26(5):543-52

aNovartis Institutes for Biomedical Research, Cambridge, Massachusetts bChildren's Hospital Medical Center, Cincinnati, Ohio, USA cNovartis Institutes for Biomedical Research, Basel, Switzerland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/BOR.0000000000000098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487522PMC
September 2014

Macrophage activation syndrome and cytokine-directed therapies.

Best Pract Res Clin Rheumatol 2014 Apr;28(2):277-92

Division of Pediatric Rheumatology, Children's Hospital Medical Center, MLC 4010, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2014.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074772PMC
April 2014

Follistatin-like protein 1 and the ferritin/erythrocyte sedimentation rate ratio are potential biomarkers for dysregulated gene expression and macrophage activation syndrome in systemic juvenile idiopathic arthritis.

J Rheumatol 2013 Jul 15;40(7):1191-9. Epub 2013 May 15.

Division of Rheumatology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center (UPMC), University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3899/jrheum.121131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3885333PMC
July 2013

Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis.

Blood 2013 Feb 20;121(7):e14-24. Epub 2012 Dec 20.

Divisions of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-05-425769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575760PMC
February 2013

Update on the pathogenesis and treatment of systemic idiopathic arthritis.

Curr Opin Pediatr 2011 Dec;23(6):640-6

William S. Rowe Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0b013e32834cba24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315376PMC
December 2011

Gene Expression Profiles from Peripheral Blood Mononuclear Cells Are Sensitive to Short Processing Delays.

Biopreserv Biobank 2010 Sep;8(3):153-162

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/bio.2010.0009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129811PMC
September 2010

Pathogenesis of systemic juvenile idiopathic arthritis: some answers, more questions.

Nat Rev Rheumatol 2011 Jun 7;7(7):416-26. Epub 2011 Jun 7.

Department of Pediatrics, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrrheum.2011.68
Publisher Site
http://dx.doi.org/10.1038/nrrheum.2011.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180659PMC
June 2011

Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis.

Blood 2011 Apr 16;117(15):e151-60. Epub 2011 Feb 16.

Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children’s Hospital Medical Center, University of Cincinnati Faculty of Medicine, Cincinnati, OH, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-08-300046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087540PMC
April 2011

Biologic similarities based on age at onset in oligoarticular and polyarticular subtypes of juvenile idiopathic arthritis.

Arthritis Rheum 2010 Nov;62(11):3249-58

William S. Rowe Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/art.27657
Publisher Site
http://dx.doi.org/10.1002/art.27657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018072PMC
November 2010

Macrophage activation syndrome: advances towards understanding pathogenesis.

Curr Opin Rheumatol 2010 Sep;22(5):561-6

Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.bor.0000381996.69261.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443835PMC
September 2010

Histiocytic disorders: recent insights into pathophysiology and practical guidelines.

Biol Blood Marrow Transplant 2010 Jan 22;16(1 Suppl):S82-9. Epub 2009 Nov 22.

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbmt.2009.11.014DOI Listing
January 2010

Systemic JIA: new developments in the understanding of the pathophysiology and therapy.

Best Pract Res Clin Rheumatol 2009 Oct;23(5):655-64

Department of Pediatric Immunology Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2009.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774820PMC
October 2009

B cell depletion: on the rise.

J Pediatr 2007 Apr;150(4):335-7

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2006.12.050DOI Listing
April 2007

Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus.

Arthritis Rheum 2006 Aug;54(8):2577-84

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.22008DOI Listing
August 2006

Feasibility and construct validity of the parent willingness-to-pay technique for children with juvenile idiopathic arthritis.

Arthritis Rheum 2004 Dec;51(6):899-908

Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio 45229-3039, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.20829DOI Listing
December 2004

Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis?

Authors:
Alexei A Grom

Arthritis Rheum 2004 Mar;50(3):689-98

Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.20198DOI Listing
March 2004

Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?

Authors:
Alexei A Grom

Curr Opin Rheumatol 2003 Sep;15(5):587-90

Cincinnati Children's Hospital Medical Center, OH 45215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00002281-200309000-00011DOI Listing
September 2003

Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome.

J Pediatr 2003 Mar;142(3):292-6

William S. Rowe Division of Rheumatology, and the Division of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1067/mpd.2003.110DOI Listing
March 2003

Interleukin-15 inhibits sodium nitroprusside-induced apoptosis of synovial fibroblasts and vascular endothelial cells.

Arthritis Rheum 2002 Nov;46(11):3010-4

Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/art.10610DOI Listing
November 2002

Interferon-gamma:interleukin 4 ratios and associated type 1 cytokine expression in juvenile rheumatoid arthritis synovial tissue.

J Rheumatol 2002 Feb;29(2):369-78

Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

View Article

Download full-text PDF

Source
February 2002