Alexei A Aravin

Alexei A Aravin

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Alexei A Aravin

Alexei A Aravin

Publications by authors named "Alexei A Aravin"

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47Publications

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Su(var)2-10 and the SUMO Pathway Link piRNA-Guided Target Recognition to Chromatin Silencing.

Mol Cell 2020 Feb 31;77(3):556-570.e6. Epub 2019 Dec 31.

California Institute of Technology, Division of Biology and Biological Engineering, 147-75, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007863PMC
February 2020

The SUMO Ligase Su(var)2-10 Controls Hetero- and Euchromatic Gene Expression via Establishing H3K9 Trimethylation and Negative Feedback Regulation.

Mol Cell 2020 Feb 31;77(3):571-585.e4. Epub 2019 Dec 31.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.09.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007874PMC
February 2020

Genome-wide DNA sampling by Ago nuclease from the cyanobacterium .

RNA Biol 2020 Feb 16:1-12. Epub 2020 Feb 16.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

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http://dx.doi.org/10.1080/15476286.2020.1724716DOI Listing
February 2020

The control of gene expression and cell identity by H3K9 trimethylation.

Development 2019 Sep 20;146(19). Epub 2019 Sep 20.

California Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 East California Boulevard, Pasadena, CA 91125, USA

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http://dx.doi.org/10.1242/dev.181180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803365PMC
September 2019

Programmable DNA cleavage by Ago nucleases from mesophilic bacteria Clostridium butyricum and Limnothrix rosea.

Nucleic Acids Res 2019 06;47(11):5822-5836

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia.

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http://dx.doi.org/10.1093/nar/gkz379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582412PMC
June 2019

DNA interference and beyond: structure and functions of prokaryotic Argonaute proteins.

Nat Commun 2018 12 4;9(1):5165. Epub 2018 Dec 4.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182, Russia.

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http://dx.doi.org/10.1038/s41467-018-07449-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279821PMC
December 2018

The Expanded Universe of Prokaryotic Argonaute Proteins.

mBio 2018 12 18;9(6). Epub 2018 Dec 18.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

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http://dx.doi.org/10.1128/mBio.01935-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299218PMC
December 2018

piRNA Biogenesis in Drosophila melanogaster.

Trends Genet 2017 11 27;33(11):882-894. Epub 2017 Sep 27.

California Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 E. California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773129PMC
November 2017

Splicing-independent loading of TREX on nascent RNA is required for efficient expression of dual-strand piRNA clusters in Drosophila.

Genes Dev 2016 Apr;30(7):840-55

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA;

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http://dx.doi.org/10.1101/gad.276030.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826399PMC
April 2016

MIWI2 and MILI Have Differential Effects on piRNA Biogenesis and DNA Methylation.

Cell Rep 2015 Aug 13;12(8):1234-43. Epub 2015 Aug 13.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554733PMC
August 2015

Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.

Mol Cell 2015 Aug;59(4):564-75

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545750PMC
August 2015

Non-Coding RNAs in Transcriptional Regulation: The review for .

Curr Mol Biol Rep 2015 Mar;1(1):10-18

California Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 E. California Blvd., Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1007/s40610-015-0002-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479201PMC
March 2015

MORC1 represses transposable elements in the mouse male germline.

Nat Commun 2014 Dec 12;5:5795. Epub 2014 Dec 12.

1] Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, 4028 Terasaki Life Sciences Building, 610 Charles E. Young Drive East, Los Angeles, California 90095, USA [2] Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, 615 Charles E. Young Drive South, Los Angeles, California 90095, USA [3] Howard Hughes Medical Institute, University of California Los Angeles, 675 Charles E. Young Drive South, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms6795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268658PMC
December 2014

A transgenerational process defines piRNA biogenesis in Drosophila virilis.

Cell Rep 2014 Sep 4;8(6):1617-1623. Epub 2014 Sep 4.

California Institute of Technology, Division of Biology and Biological Engineering, 147-75, 1200 East California Boulevard, Pasadena, CA 91125, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054749PMC
http://dx.doi.org/10.1016/j.celrep.2014.08.013DOI Listing
September 2014

piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.

Genes Dev 2014 Jul 17;28(13):1410-28. Epub 2014 Jun 17.

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA;

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http://dx.doi.org/10.1101/gad.240895.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083086PMC
July 2014

Two waves of de novo methylation during mouse germ cell development.

Genes Dev 2014 Jul;28(14):1544-9

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA;

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http://genesdev.cshlp.org/cgi/doi/10.1101/gad.244350.114
Publisher Site
http://dx.doi.org/10.1101/gad.244350.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102761PMC
July 2014

A framework for piRNA cluster manipulation.

Methods Mol Biol 2014 ;1093:47-58

Division of Biology, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-694-8_5DOI Listing
June 2014

Prokaryotic Argonautes defend genomes against invasive DNA.

Trends Biochem Sci 2014 Jun 13;39(6):257-9. Epub 2014 May 13.

California Institute of Technology Division of Biology, 147-75 1200 E. California Blvd., Pasadena, CA 91125, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2014.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041519PMC
June 2014

Small but sturdy: small RNAs in cellular memory and epigenetics.

Genes Dev 2014 Mar;28(5):423-31

Division of Biology, California Institute of Technology, Pasadena, California 91125, USA;

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http://dx.doi.org/10.1101/gad.236414.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950340PMC
March 2014

Bacterial argonaute samples the transcriptome to identify foreign DNA.

Mol Cell 2013 Sep;51(5):594-605

Division of Biology, California Institute of Technology, 147-75, 1200E California Boulevard, Pasadena, CA 91125, USA; Institute of Molecular Genetics, Russian Academy of Sciences, Kurchatov Square 2, Moscow 123182, Russia.

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http://dx.doi.org/10.1016/j.molcel.2013.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809076PMC
September 2013

Small RNA in the nucleus: the RNA-chromatin ping-pong.

Curr Opin Genet Dev 2012 Apr 19;22(2):164-71. Epub 2012 Feb 19.

California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.gde.2012.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345048PMC
April 2012

Production of artificial piRNAs in flies and mice.

RNA 2012 Jan 17;18(1):42-52. Epub 2011 Nov 17.

Howard Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1261/rna.029769.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261743PMC
January 2012

PIWI-interacting small RNAs: the vanguard of genome defence.

Nat Rev Mol Cell Biol 2011 Apr;12(4):246-58

Keio University School of Medicine, Tokyo 160-8582, Japan.

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http://web.natur.cuni.cz/zoologie/biodiversity/prednasky/Evo
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http://www.nature.com/doifinder/10.1038/nrm3089
Publisher Site
http://dx.doi.org/10.1038/nrm3089DOI Listing
April 2011

piRNAs meet mitochondria.

Dev Cell 2011 Mar;20(3):287-8

California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.devcel.2011.03.003DOI Listing
March 2011

Cytoplasmic compartmentalization of the fetal piRNA pathway in mice.

PLoS Genet 2009 Dec 11;5(12):e1000764. Epub 2009 Dec 11.

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785470PMC
December 2009

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members.

Genes Dev 2009 Aug 7;23(15):1749-62. Epub 2009 Jul 7.

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1101/gad.1814809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720255PMC
August 2009

An epigenetic role for maternally inherited piRNAs in transposon silencing.

Science 2008 Nov;322(5906):1387-92

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory (CSHL), 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1126/science.1165171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805124PMC
November 2008

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.

Mol Cell 2008 Sep;31(6):785-99

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730041PMC
September 2008

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes.

Nature 2008 May 10;453(7194):534-8. Epub 2008 Apr 10.

Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1038/nature06904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981145PMC
May 2008

Small RNA guides for de novo DNA methylation in mammalian germ cells.

Genes Dev 2008 Apr;22(8):970-5

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.

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http://dx.doi.org/10.1101/gad.1669408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732394PMC
April 2008

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race.

Science 2007 Nov;318(5851):761-4

Watson School of Biological Sciences, Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1126/science.1146484DOI Listing
November 2007

Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline.

Nucleic Acids Res 2007 15;35(16):5430-8. Epub 2007 Aug 15.

Department of Molecular Genetics of Cell, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia.

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http://dx.doi.org/10.1093/nar/gkm576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2018648PMC
September 2007

Developmentally regulated piRNA clusters implicate MILI in transposon control.

Science 2007 May 19;316(5825):744-7. Epub 2007 Apr 19.

Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Howard Hughes Medical Institute (HHMI), 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1126/science.1142612DOI Listing
May 2007

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila.

Cell 2007 Mar 8;128(6):1089-103. Epub 2007 Mar 8.

Cold Spring Harbor Laboratory, Watson School of Biological Sciences and Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.

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http://dx.doi.org/10.1016/j.cell.2007.01.043DOI Listing
March 2007

The small RNA profile during Drosophila melanogaster development.

Dev Cell 2003 Aug;5(2):337-50

Department of Animal Molecular Genetics, Institute of Molecular Genetics, Kurchatov sq. 2, 123182, Moscow, Russia.

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http://dx.doi.org/10.1016/s1534-5807(03)00228-4DOI Listing
August 2003