Publications by authors named "Alexandros G Georgakilas"

100Publications

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead.

Cancers (Basel) 2020 Nov 6;12(11). Epub 2020 Nov 6.

Physics Department, School of Applied Mathematical and Physical Sciences, DNA Damage Laboratory, National Technical University of Athens (NTUA), 15780 Zografou, Athens, Greece.

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http://dx.doi.org/10.3390/cancers12113288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694657PMC
November 2020

Ionizing radiation-induced circulatory and metabolic diseases.

Environ Int 2020 Nov 3;146:106235. Epub 2020 Nov 3.

Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, Finland.

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http://dx.doi.org/10.1016/j.envint.2020.106235DOI Listing
November 2020

Interphase Cytogenetic Analysis of G0 Lymphocytes Exposed to α-Particles, C-Ions, and Protons Reveals their Enhanced Effectiveness for Localized Chromosome Shattering-A Critical Risk for Chromothripsis.

Cancers (Basel) 2020 Aug 19;12(9). Epub 2020 Aug 19.

Laboratory of Health Physics, Radiobiology & Cytogenetics, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research "Demokritos", 15341 Athens, Greece.

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http://dx.doi.org/10.3390/cancers12092336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563219PMC
August 2020

Combined radiation strategies for novel and enhanced cancer treatment.

Int J Radiat Biol 2020 Sep 15;96(9):1087-1103. Epub 2020 Jul 15.

Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Athens, Greece.

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http://dx.doi.org/10.1080/09553002.2020.1787544DOI Listing
September 2020

Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?

Strahlenther Onkol 2020 08 9;196(8):679-682. Epub 2020 May 9.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00066-020-01635-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211051PMC
August 2020

Codon Usage and Phenotypic Divergences of SARS-CoV-2 Genes.

Viruses 2020 04 30;12(5). Epub 2020 Apr 30.

Izmir Biomedicine and Genome Center (IBG), 35340 Balcova, Izmir, Turkey.

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http://dx.doi.org/10.3390/v12050498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290700PMC
April 2020

Codon usage bias in radioresistant bacteria.

Gene 2020 Jun 13;742:144554. Epub 2020 Mar 13.

Physics Department, Sapienza University of Rome, Rome, Italy; INFN Roma1 Unit, Rome, Italy.

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http://dx.doi.org/10.1016/j.gene.2020.144554DOI Listing
June 2020

Microdosimetric calculations of the direct DNA damage induced by low energy electrons using the Geant4-DNA Monte Carlo code.

Phys Med Biol 2020 02 12;65(4):045007. Epub 2020 Feb 12.

Medical Physics Laboratory, University of Ioannina Medical School, 45110 Ioannina, Greece.

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http://dx.doi.org/10.1088/1361-6560/ab6b47DOI Listing
February 2020

Ionizing Radiation and Complex DNA Damage: From Prediction to Detection Challenges and Biological Significance.

Cancers (Basel) 2019 Nov 14;11(11). Epub 2019 Nov 14.

DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), 15780 Athens, Greece.

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http://dx.doi.org/10.3390/cancers11111789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895987PMC
November 2019

Phylogenetic and Structural Analyses of Plant Endogenous Danger Signaling Molecules upon Stress.

Oxid Med Cell Longev 2019 15;2019:8683054. Epub 2019 Jul 15.

DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Athens, Greece.

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http://dx.doi.org/10.1155/2019/8683054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668560PMC
January 2020

Interphase Cytogenetic Analysis of Micronucleated and Multinucleated Cells Supports the Premature Chromosome Condensation Hypothesis as the Mechanistic Origin of Chromothripsis.

Cancers (Basel) 2019 Aug 6;11(8). Epub 2019 Aug 6.

Laboratory of Health Physics, Radiobiology & Cytogenetics, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Centre for Scientific Research "Demokritos", 15341 Agia Paraskevi, Greece.

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http://dx.doi.org/10.3390/cancers11081123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721583PMC
August 2019

as a Prognostic Predictor for Diverse Human Cancers: A Meta- and Bioinformatics Analysis.

Cancers (Basel) 2019 Jun 5;11(6). Epub 2019 Jun 5.

Ιzmir International Biomedicine and Genome Institute, Dokuz Eylül University, Balcova 35340, Turkey.

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http://dx.doi.org/10.3390/cancers11060778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628152PMC
June 2019

Prediction of Gold Nanoparticle and Microwave-Induced Hyperthermia Effects on Tumor Control via a Simulation Approach.

Nanomaterials (Basel) 2019 Jan 29;9(2). Epub 2019 Jan 29.

Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou Campus, 15780 Athens, Greece.

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http://dx.doi.org/10.3390/nano9020167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410344PMC
January 2019

A Functional Immune System Is Required for the Systemic Genotoxic Effects of Localized Irradiation.

Int J Radiat Oncol Biol Phys 2019 04 6;103(5):1184-1193. Epub 2018 Dec 6.

Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia; Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2018.11.066DOI Listing
April 2019

Senescence and senotherapeutics: a new field in cancer therapy.

Pharmacol Ther 2019 01 16;193:31-49. Epub 2018 Aug 16.

Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Center for New Biotechnologies and Precision Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; Biomedical Research Foundation, Academy of Athens, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.08.006DOI Listing
January 2019

The challenge of drug resistance in cancer treatment: a current overview.

Clin Exp Metastasis 2018 04 24;35(4):309-318. Epub 2018 May 24.

1st Department of Otolaryngology Head and Neck Surgery, Hippokrateio Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.

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http://dx.doi.org/10.1007/s10585-018-9903-0DOI Listing
April 2018

Effect of 5-trans Isomer of Arachidonic Acid on Model Liposomal Membranes Studied by a Combined Simulation and Experimental Approach.

J Membr Biol 2018 06 2;251(3):475-489. Epub 2018 Apr 2.

Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou, 11527, Athens, Greece.

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http://dx.doi.org/10.1007/s00232-018-0029-8DOI Listing
June 2018

Integrating plant and animal biology for the search of novel DNA damage biomarkers.

Mutat Res 2018 Jan - Mar;775:21-38. Epub 2018 Jan 20.

Department of Biology and Biotechnology 'Lazzaro Spallanzani', University of Pavia, via Ferrata 1, 27100, Pavia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2018.01.001DOI Listing
October 2018

Targeted and Off-Target (Bystander and Abscopal) Effects of Radiation Therapy: Redox Mechanisms and Risk/Benefit Analysis.

Antioxid Redox Signal 2018 11 22;29(15):1447-1487. Epub 2018 Mar 22.

3 Univ. Grenoble Alpes , CEA, CNRS INAC SyMMES UMR 5819, Grenoble, France .

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http://dx.doi.org/10.1089/ars.2017.7267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199630PMC
November 2018

Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles.

Cancers (Basel) 2017 Dec 19;9(12). Epub 2017 Dec 19.

Atominstitut, Technische Universität Wien, Stadionallee 2, 1020 Vienna, Austria.

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http://dx.doi.org/10.3390/cancers9120173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742821PMC
December 2017

Integrative Bioinformatic Analysis of Transcriptomic Data Identifies Conserved Molecular Pathways Underlying Ionizing Radiation-Induced Bystander Effects (RIBE).

Cancers (Basel) 2017 11 25;9(12). Epub 2017 Nov 25.

Metabolic Engineering and Bioinformatics Research Team, Institute of Biology Medicinal Chemistry & Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece

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http://dx.doi.org/10.3390/cancers9120160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742808PMC
November 2017

Editorial: DNA Damage and Inflammation under Stress.

Front Genet 2017 17;8:152. Epub 2017 Oct 17.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.3389/fgene.2017.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5650959PMC
October 2017

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis.

Cancers (Basel) 2017 Jul 18;9(7). Epub 2017 Jul 18.

DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece.

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http://dx.doi.org/10.3390/cancers9070091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532627PMC
July 2017

Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach.

Cancer Lett 2017 09 12;403:37-47. Epub 2017 Jun 12.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Iroon Polytechniou 9, Zografou, 15780, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.05.023DOI Listing
September 2017

Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach.

Cancers (Basel) 2017 Jun 6;9(6). Epub 2017 Jun 6.

DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Iroon Polytechniou 9, 15780 Zografou, Greece.

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http://dx.doi.org/10.3390/cancers9060065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483884PMC
June 2017

p21: A Two-Faced Genome Guardian.

Trends Mol Med 2017 04 7;23(4):310-319. Epub 2017 Mar 7.

Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.molmed.2017.02.001DOI Listing
April 2017

Preface on application of omics technologies in cancer biology and therapy.

Cancer Lett 2016 11;382(1):A1

DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, GR 15780 Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.10.001DOI Listing
November 2016

Repair Rate of Clustered Abasic DNA Lesions by Human Endonuclease: Molecular Bases of Sequence Specificity.

J Phys Chem Lett 2016 Oct 13;7(19):3760-3765. Epub 2016 Sep 13.

Université de Lorraine-Nancy , Theory-Modeling-Simulation SRSMC, 54000 Vandoeuvre-lès-Nancy, France.

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http://dx.doi.org/10.1021/acs.jpclett.6b01692DOI Listing
October 2016

Correlation of bistranded clustered abasic DNA lesion processing with structural and dynamic DNA helix distortion.

Nucleic Acids Res 2016 Oct 1;44(18):8588-8599. Epub 2016 Sep 1.

Univ Lyon, Ens de Lyon, CNRS, Université Lyon 1, Laboratoire de Chimie UMR 5182, F-69342, Lyon, France

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http://dx.doi.org/10.1093/nar/gkw773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063003PMC
October 2016

Determinants of resistance to chemotherapy and ionizing radiation in breast cancer stem cells.

Cancer Lett 2016 10 19;380(2):485-93. Epub 2016 Jul 19.

DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Iroon Polytechniou 9, Zografou 15780, Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.07.018DOI Listing
October 2016

Systemic dna damage: Mechanisms, effects and mitigation strategies.

Semin Cancer Biol 2016 06 22;37-38:1-2. Epub 2016 Apr 22.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; Biomedical Research Foundation, Academy of Athens, Athens, Greece; Faculty Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.04.001DOI Listing
June 2016

Unraveling the mechanisms of extreme radioresistance in prokaryotes: Lessons from nature.

Mutat Res Rev Mutat Res 2016 Jan-Mar;767:92-107. Epub 2015 Nov 4.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou, 15780 Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.mrrev.2015.10.001DOI Listing
August 2016

Systemic mechanisms and effects of ionizing radiation: A new 'old' paradigm of how the bystanders and distant can become the players.

Semin Cancer Biol 2016 06 9;37-38:77-95. Epub 2016 Feb 9.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou, 15780 Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.02.002DOI Listing
June 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Molecular inhibitors of DNA repair: searching for the ultimate tumor killing weapon.

Future Med Chem 2015 Aug 26;7(12):1543-58. Epub 2015 Aug 26.

Physics Department, School of Applied Mathematical & Physical Sciences, National Technical University of Athens (NTUA), Iroon Polytechniou 9, Zografou 15780, Athens, Greece.

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http://dx.doi.org/10.4155/fmc.15.95DOI Listing
August 2015

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review.

Toxicol Res (Camb) 2016 Jan 11;5(1):12-33. Epub 2015 Aug 11.

Physics Department , School of Applied Mathematical and Physical Sciences , National Technical University of Athens (NTUA) , Zografou 15780 , Athens , Greece . Email: ; ; Tel: +30-210-7724453.

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http://dx.doi.org/10.1039/c5tx00222bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061884PMC
January 2016

Featuring the special issue editor: Professor Alexandros G. Georgakilas.

Cancer Lett 2015 Nov 29;368(2):153. Epub 2015 Jul 29.

DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, GR 15780 Athens, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.07.020DOI Listing
November 2015

Role of the immune system and inflammation in ionizing radiation effects.

Cancer Lett 2015 Nov 26;368(2):154-5. Epub 2015 Jul 26.

DNA Damage Laboratory, Department of Physics, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, GR 15780 Athens, Greece; Biology Department, East Carolina University, Greenville, NC 27858, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.07.021DOI Listing
November 2015

MicroRNAs Determining Inflammation as Novel Biomarkers and Potential Therapeutic Targets.

Curr Med Chem 2015 ;22(22):2666-79

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; and Cancer and Clinical Experimental Science Units, Faculty of Medicine, Institute for Life Sciences, Center for Proteome Research, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.2174/0929867322666150716113304DOI Listing
May 2016

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where.

Pharmacol Ther 2015 Oct 3;154:36-56. Epub 2015 Jul 3.

Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece; Biomedical Research Foundation, Academy of Athens, Athens, Greece; Institute for Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, UK; Manchester Centre for Cellular Metabolism, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.06.011DOI Listing
October 2015

Stress-induced DNA damage biomarkers: applications and limitations.

Front Chem 2015 2;3:35. Epub 2015 Jun 2.

Laboratoire des Lésions des Acides Nucléiques, Institut des Nanosciences et Cryogénie, Service de Chimie Inorgranique et Biologique, Université Grenoble Alpes Grenoble, France ; CEA, Institut des Nanosciences et Cryogénie, Service de Chimie Inorgranique et Biologique Grenoble, France.

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http://dx.doi.org/10.3389/fchem.2015.00035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451417PMC
June 2015

Emerging molecular networks common in ionizing radiation, immune and inflammatory responses by employing bioinformatics approaches.

Cancer Lett 2015 Nov 1;368(2):164-72. Epub 2015 Apr 1.

Centre of Systems Biology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou, Athens 11527, Greece. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.03.021DOI Listing
November 2015

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Semin Cancer Biol 2015 Dec 25;35 Suppl:S185-S198. Epub 2015 Mar 25.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States; Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2015.03.004DOI Listing
December 2015

Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?

Cell Mol Life Sci 2014 Dec 20;71(23):4519-44. Epub 2014 Sep 20.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou, 15780, Athens, Greece.

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http://dx.doi.org/10.1007/s00018-014-1717-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232749PMC
December 2014

Epigenetic therapy as a novel approach in hepatocellular carcinoma.

Pharmacol Ther 2015 Jan 7;145:103-19. Epub 2014 Sep 7.

School of Life Sciences, Heriot Watt University, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2014.09.005DOI Listing
January 2015

Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

Cancer Lett 2014 Oct 25;353(2):248-57. Epub 2014 Jul 25.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167057PMC
October 2014

Bystander and non-targeted effects: a unifying model from ionizing radiation to cancer.

Cancer Lett 2015 Jan 2;356(1):3-4. Epub 2014 Apr 2.

DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou Campus, Athens 15780, Greece; Biology Department, East Carolina University, Greenville, NC 27858, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.03.032DOI Listing
January 2015

Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology.

Cancer Lett 2015 Jan 13;356(1):34-42. Epub 2013 Dec 13.

Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens (NTUA), Zografou 15780, Athens, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043835130082
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http://dx.doi.org/10.1016/j.canlet.2013.11.018DOI Listing
January 2015

Toxicity and adverse effects of Tamoxifen and other anti-estrogen drugs.

Pharmacol Ther 2013 Sep 24;139(3):392-404. Epub 2013 May 24.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.pharmthera.2013.05.005DOI Listing
September 2013

Induction and repair of clustered DNA lesions: what do we know so far?

Radiat Res 2013 Jul 17;180(1):100-9. Epub 2013 May 17.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, North Carolina 27858, USA.

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http://dx.doi.org/10.1667/RR3041.1DOI Listing
July 2013

Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression.

Cancer Lett 2013 Aug 21;336(2):281-9. Epub 2013 Mar 21.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 S. Xianlie Road, Guangzhou 510060, China.

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http://dx.doi.org/10.1016/j.canlet.2013.03.015DOI Listing
August 2013

Epigenetic inactivation of DNA repair in breast cancer.

Cancer Lett 2014 Jan 23;342(2):213-22. Epub 2012 May 23.

Department of Radiation Oncology, Hazelrig-Salter Radiation Oncology Center, University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL 35294, USA.

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http://dx.doi.org/10.1016/j.canlet.2012.05.015DOI Listing
January 2014

Oxidative stress, DNA damage and repair in carcinogenesis: have we established a connection?

Cancer Lett 2012 Dec 3;327(1-2):3-4. Epub 2012 Apr 3.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.canlet.2012.03.032DOI Listing
December 2012

Featuring the special issue editor: associate professor Alexandros G. Georgakilas.

Cancer Lett 2012 Dec 20;327(1-2):1-2. Epub 2012 Mar 20.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.canlet.2012.03.012DOI Listing
December 2012

Molecular markers for cancer prognosis and treatment: have we struck gold?

Cancer Lett 2012 Dec 25;327(1-2):142-52. Epub 2011 Nov 25.

Department of Radiation Oncology, University of Alabama at Birmingham Comprehensive Cancer Center, 35294, USA.

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http://dx.doi.org/10.1016/j.canlet.2011.11.022DOI Listing
December 2012

Effects of radiation quality and oxygen on clustered DNA lesions and cell death.

Radiat Res 2011 Nov 8;176(5):587-602. Epub 2011 Aug 8.

Department of Radiation Oncology, University of Washington, Seattle, Washington 98195-6043, USA.

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http://dx.doi.org/10.1667/rr2663.1DOI Listing
November 2011

Systemic DNA damage related to cancer.

Cancer Res 2011 May 10;71(10):3437-41. Epub 2011 May 10.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-4579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096754PMC
May 2011

From chemistry of DNA damage to repair and biological significance. Comprehending the future.

Mutat Res 2011 Jun 14;711(1-2):1-2. Epub 2011 Apr 14.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.04.001DOI Listing
June 2011

Role of oxidative stress and DNA damage in human carcinogenesis.

Mutat Res 2011 Jun 7;711(1-2):193-201. Epub 2011 Jan 7.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2010.12.016DOI Listing
June 2011

Measurement of oxidatively-induced clustered DNA lesions using a novel adaptation of single cell gel electrophoresis (comet assay).

Curr Protoc Cell Biol 2010 Dec;Chapter 6:Unit 6.11.

Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, North Carolina, USA.

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http://dx.doi.org/10.1002/0471143030.cb0611s49DOI Listing
December 2010

Tumors induce complex DNA damage in distant proliferative tissues in vivo.

Proc Natl Acad Sci U S A 2010 Oct 20;107(42):17992-7. Epub 2010 Sep 20.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1008260107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964229PMC
October 2010

Duodenal carcinoma at the ligament of Treitz. A molecular and clinical perspective.

BMC Gastroenterol 2010 Sep 17;10:109. Epub 2010 Sep 17.

Methodist University Physician Assistant Program, Fayetteville, North Carolina, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949773PMC
September 2010

The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development.

Chem Biol Interact 2010 Nov 15;188(2):334-9. Epub 2010 Jul 15.

Nevada Center for Ethics & Health Policy, University of Nevada, Reno, 89557, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.07.010DOI Listing
November 2010

The role of epigenetics in environmental and occupational carcinogenesis.

Chem Biol Interact 2010 Nov 1;188(2):340-9. Epub 2010 Jul 1.

Nevada Center for Ethics and Health Policy, University of Nevada, Reno, 89557, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.06.012DOI Listing
November 2010

Viral-induced human carcinogenesis: an oxidative stress perspective.

Mol Biosyst 2010 Jul 30;6(7):1162-72. Epub 2010 Apr 30.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1039/b923958hDOI Listing
July 2010

BRCA1 role in the mitigation of radiotoxicity and chromosomal instability through repair of clustered DNA lesions.

Chem Biol Interact 2010 Nov 4;188(2):350-8. Epub 2010 Apr 4.

Department of Biology, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.cbi.2010.03.046DOI Listing
November 2010

Role of oxidatively induced DNA lesions in human pathogenesis.

Mutat Res 2010 Apr-Jun;704(1-3):152-9. Epub 2010 Jan 8.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.mrrev.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074954PMC
August 2010

BRCA1 involvement in toxicological responses and human cancer etiology.

Toxicol Lett 2009 Jul 16;188(2):77-83. Epub 2009 Apr 16.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.toxlet.2009.04.006DOI Listing
July 2009

Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells.

Mutat Res 2009 Mar 7;674(1-2):123-30. Epub 2008 Oct 7.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2008.09.014DOI Listing
March 2009

Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues.

Mutat Res 2009 Mar 2;674(1-2):131-6. Epub 2008 Oct 2.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2008.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944316PMC
March 2009

Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency.

Cancer Lett 2008 Sep 11;269(1):174-83. Epub 2008 Jun 11.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Howell Science Complex, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.04.049DOI Listing
September 2008

Formation of clustered DNA damage after high-LET irradiation: a review.

J Radiat Res 2008 May 15;49(3):203-10. Epub 2008 Apr 15.

NASA Johnson Space Center, Houston, Texas 77058, USA.

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http://dx.doi.org/10.1269/jrr.07123DOI Listing
May 2008

Oxidative stress, DNA methylation and carcinogenesis.

Cancer Lett 2008 Jul 26;266(1):6-11. Epub 2008 Mar 26.

Laboratory of Cell Biology and Signal Transduction, Biomedical Research Unit, FES-Iztacala, UNAM, Mexico, USA.

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http://dx.doi.org/10.1016/j.canlet.2008.02.026DOI Listing
July 2008

Processing of DNA damage clusters in human cells: current status of knowledge.

Mol Biosyst 2008 Jan 7;4(1):30-5. Epub 2007 Nov 7.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville NC 27858, USA.

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http://dx.doi.org/10.1039/b713178jDOI Listing
January 2008

Induction and processing of complex DNA damage in human breast cancer cells MCF-7 and nonmalignant MCF-10A cells.

Free Radic Biol Med 2008 Feb 20;44(4):558-69. Epub 2007 Nov 20.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2007.10.045DOI Listing
February 2008

Detection of complex DNA damage in gamma-irradiated acute lymphoblastic leukemia Pre-b NALM-6 cells.

Radiat Res 2007 Nov;168(5):527-34

Biology Department, East Carolina University, Greenville, NC, USA.

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http://dx.doi.org/10.1667/RR0974.1DOI Listing
November 2007

Induction and processing of oxidative clustered DNA lesions in 56Fe-ion-irradiated human monocytes.

Radiat Res 2007 Jul;168(1):87-97

Biology Department, East Carolina University, Greenville, North Carolina 27858-4353, USA.

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http://dx.doi.org/10.1667/RR0865.1DOI Listing
July 2007

Detection of oxidative clustered DNA lesions in X-irradiated mouse skin tissues and human MCF-7 breast cancer cells.

Radiat Res 2007 Feb;167(2):207-16

Biology Department, East Carolina University, Greenville, North Carolina 27858, USA.

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http://dx.doi.org/10.1667/rr0659.1DOI Listing
February 2007

Processing of bistranded abasic DNA clusters in gamma-irradiated human hematopoietic cells.

Nucleic Acids Res 2004 19;32(18):5609-20. Epub 2004 Oct 19.

Biology Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.

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http://dx.doi.org/10.1093/nar/gkh871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524283PMC
November 2004