Publications by authors named "Alexandre Trifilieff"

33Publications

Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

Authors:
Neil J Press Roger J Taylor Joseph D Fullerton Pamela Tranter Clive McCarthy Thomas H Keller Nicola Arnold David Beer Lyndon Brown Robert Cheung Julie Christie Alastair Denholm Sandra Haberthuer Julia D I Hatto Mark Keenan Mark K Mercer Helen Oakman Helene Sahri Andrew R Tuffnell Morris Tweed Alexandre Trifilieff

J Med Chem 2015 Sep 28;58(17):6747-52. Epub 2015 Aug 28.

Novartis Institutes for Biomedical Research , Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

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September 2015

Comparing the cardiovascular therapeutic indices of glycopyrronium and tiotropium in an integrated rat pharmacokinetic, pharmacodynamic and safety model.

Authors:
Alexandre Trifilieff Brian T Ethell David A Sykes Kenny J Watson Steve Collingwood Steven J Charlton Toby C Kent

Toxicol Appl Pharmacol 2015 Aug 27;287(1):9-16. Epub 2015 May 27.

Respiratory Disease Area, Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, United Kingdom. Electronic address:

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August 2015

The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.

Authors:
Nicola Arnold David Beattie Michelle Bradley Andrew Brearley Lyndon Brown Steven J Charlton Robin A Fairhurst David Farr John Fozard Joe Fullerton Martin Gosling Julia Hatto Diana Janus Darryl Jones Lynne Jordan Christine Lewis Janet Maas Clive McCarthy Mark Mercer Helen Oakman Neil Press Rachel Profit Friedrich Schuerch David Sykes Roger J Taylor Alexandre Trifilieff Andrew Tuffnell

Bioorg Med Chem Lett 2014 Sep 26;24(17):4341-7. Epub 2014 Jun 26.

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Horsham, United Kingdom; Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Basel, Switzerland.

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September 2014

An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.

Authors:
David Beattie David Beer Michelle E Bradley Ian Bruce Steven J Charlton Bernard M Cuenoud Robin A Fairhurst David Farr John R Fozard Diana Janus Elizabeth M Rosethorne David A Sandham David A Sykes Alexandre Trifilieff Katharine L Turner Elke Wissler

Bioorg Med Chem Lett 2012 Oct 4;22(19):6280-5. Epub 2012 Aug 4.

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Horsham, United Kingdom.

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October 2012

Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

Authors:
Neil J Press Roger J Taylor Joseph D Fullerton Pamela Tranter Clive McCarthy Thomas H Keller Nicola Arnold David Beer Lyndon Brown Robert Cheung Julie Christie Alastair Denholm Sandra Haberthuer Julia D I Hatto Mark Keenan Mark K Mercer Helen Oakman Helene Sahri Andrew R Tuffnell Morris Tweed John W Tyler Trixie Wagner John R Fozard Alexandre Trifilieff

J Med Chem 2012 Sep 30;55(17):7472-9. Epub 2012 Aug 30.

Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, U.K.

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September 2012

The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium.

Authors:
David A Sykes Mark R Dowling Juliet Leighton-Davies Toby C Kent Lindsay Fawcett Emilie Renard Alexandre Trifilieff Steven J Charlton

J Pharmacol Exp Ther 2012 Nov 1;343(2):520-8. Epub 2012 Aug 1.

Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex, RH12 5AB, United Kingdom.

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November 2012

Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.

Authors:
Alexandre Trifilieff John R Fozard

J Pharmacol Exp Ther 2012 Aug 8;342(2):399-406. Epub 2012 May 8.

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Novartis AG, Basel, Switzerland.

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August 2012

The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.

Authors:
Liz Hardaker Parmjit Bahra Benjamin Cochin de Billy Mark Freeman Natalia Kupfer Daniel Wyss Alexandre Trifilieff

Respir Res 2012 Apr 4;13:30. Epub 2012 Apr 4.

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Basel, Switzerland.

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April 2012

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

Authors:
François Baur David Beattie David Beer David Bentley Michelle Bradley Ian Bruce Steven J Charlton Bernard Cuenoud Roland Ernst Robin A Fairhurst Bernard Faller David Farr Thomas Keller John R Fozard Joe Fullerton Sheila Garman Julia Hatto Claire Hayden Handan He Colin Howes Diana Janus Zhengjin Jiang Christine Lewis Frederique Loeuillet-Ritzler Heinz Moser John Reilly Alan Steward David Sykes Lauren Tedaldi Alexandre Trifilieff Morris Tweed Simon Watson Elke Wissler Daniel Wyss

J Med Chem 2010 May;53(9):3675-84

Respiratory Diseases Area, Novartis Institutes for Biomedical Research, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK.

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May 2010

Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.

Authors:
Matthew Thomas Matthew J Edwards Elzbieta Sawicka Nicholas Duggan Emilio Hirsch Matthias P Wymann Charles Owen Alexandre Trifilieff Christoph Walker John Westwick Peter Finan

Immunology 2009 Mar 27;126(3):413-22. Epub 2008 Aug 27.

Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom.

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March 2009

Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging.

Authors:
François-Xavier Blé Catherine Cannet Stefan Zurbruegg Harry Karmouty-Quintana Reinhard Bergmann Nelly Frossard Alexandre Trifilieff Nicolau Beckmann

Radiology 2008 Sep 22;248(3):834-43. Epub 2008 Jul 22.

Respiratory Diseases Department, Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, WSJ-386.2.09, CH-4002 Basel, Switzerland.

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September 2008

Lung MRI for experimental drug research.

Authors:
Nicolau Beckmann Catherine Cannet Harry Karmouty-Quintana Bruno Tigani Stefan Zurbruegg François-Xavier Blé Yannick Crémillieux Alexandre Trifilieff

Eur J Radiol 2007 Dec 10;64(3):381-96. Epub 2007 Oct 10.

Discovery Technologies, Novartis Institutes for BioMedical Research, Lichtstr. 35, WSJ-386.2.09, CH-4002 Basel, Switzerland.

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December 2007

Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices.

Authors:
Richard G Sturton Alexandre Trifilieff Andrew G Nicholson Peter J Barnes

J Pharmacol Exp Ther 2008 Jan 4;324(1):270-5. Epub 2007 Oct 4.

Novartis Pharma AG, WSJ-386.12.16, P. O. Box, CH-4002 Basel, Switzerland.

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January 2008

Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice.

Authors:
Danielle G Souza Flávio Lopes Ferreira Caio T Fagundes Flávio A Amaral Angélica T Vieira Rodolfo Assis Lisboa Marcus Vinícius Melo Andrade Alexandre Trifilieff Mauro M Teixeira

Eur J Pharmacol 2007 Sep 12;571(1):72-80. Epub 2007 Jun 12.

Immunopharmacology, Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

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September 2007

In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action.

Authors:
Cliff Battram Steven J Charlton Bernard Cuenoud Mark R Dowling Robin A Fairhurst David Farr John R Fozard Juliet R Leighton-Davies Christine A Lewis Lorraine McEvoy Robert J Turner Alexandre Trifilieff

J Pharmacol Exp Ther 2006 May 24;317(2):762-70. Epub 2006 Jan 24.

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Horsham, United Kingdom.

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May 2006

Effect of adenosine A2A receptor activation in murine models of respiratory disorders.

Authors:
Olivier Bonneau Daniel Wyss Stephane Ferretti Clare Blaydon Christopher S Stevenson Alexandre Trifilieff

Am J Physiol Lung Cell Mol Physiol 2006 May 9;290(5):L1036-43. Epub 2005 Dec 9.

Respiratory Diseases Area, Novartis Institutes for BioMedical Research, Horsham, England, UK.

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May 2006

Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation.

Authors:
Daniel Wyss Olivier Bonneau Alexandre Trifilieff

Br J Pharmacol 2005 Aug;145(7):845-52

Novartis Institutes for BioMedical Research, Respiratory Diseases Area, Horsham RH12 5AB, UK.

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August 2005

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.

Authors:
Matthew J Thomas Alexandra Smith Denise H Head Laura Milne Andrew Nicholls Wayne Pearce Bart Vanhaesebroeck Matthias P Wymann Emilio Hirsch Alexandre Trifilieff Christoph Walker Peter Finan John Westwick

Eur J Immunol 2005 Apr;35(4):1283-91

Novartis Institutes for BioMedical Research, Horsham, UK.

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April 2005

CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities.

Authors:
Alexandre Trifilieff Thomas H Keller Neil J Press Trevor Howe Peter Gedeck David Beer Christoph Walker

Br J Pharmacol 2005 Apr;144(7):1002-10

Novartis Institutes of BioMedical Research, Respiratory Diseases Area, Wimblehurst Road, Horsham, West Sussex RH12 5AB.

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April 2005

Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment.

Authors:
Randolph Corteling Alexandre Trifilieff

BMC Pharmacol 2004 Apr 15;4. Epub 2004 Apr 15.

Respiratory Diseases Area, Novartis Institute for Biomedical Research, Horsham, UK.

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April 2004